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6 条记录 (耗时 0.159 秒)

    Substituted piperazines of azepines, oxazepines and thiazepines
    3.
    发明申请
    Substituted piperazines of azepines, oxazepines and thiazepines 审中-公开

    公开(公告)号：US20060270656A1

    公开(公告)日：2006-11-30

    申请号：US10569244

    申请日：2004-09-07

    申请人： John He ,  Vincent Rocco ,  John Schaus ,  Fionna Martin ,  William Owton ,  David Tupper

    发明人： John He ,  Vincent Rocco ,  John Schaus ,  Fionna Martin ,  William Owton ,  David Tupper

    IPC分类号： A61K31/554 ,  A61K31/55 ,  A61K31/553 ,  C07D498/02 ,  C07D491/02

    CPC分类号： C07D417/04 ,  C07D495/04 ,  C07D513/04

    摘要： Described herein are antipyschotic compounds of formula (I) wherein: is an optionally benzo-fused five or six member aromatic ring having zero to three hetero atoms independently selected from N, O, and S; R1 is hydrogen, (C1-6) fluoroalkyl, (C3-6) cycloalkyl, or (C1-4) alkyl, wherein the (C1-4) alkyl is unsubstituted or substituted with hydroxy, methoxy, ethoxy, OCH2CH2OH, —CN, imidazolidin-2-one, phenyl, or tetrazole wherein tetrazole is unsubstituted or substituted with (C1-4) alkyl; R2 is H, halogen, (C1-6) fluoroalkyl, (C3-6) cycloalkyl, OR6, SR6, NO2, CN, COR6, C(O)OR6, C(OH)R6, CONR7R8, phenyl or (C1-6) alkyl, wherein the (C1-6) alkyl is unsubstituted or substituted with a hydroxy; R3 is hydrogen, (C1-6)fluoroalkyl , (C3-6) cycloalkyl, (C2-6) alkenyl, phenyl, monocyclic heteroaromatic, bicyclic heteroaromatic, or (C1-4)alkyl wherein (C1-4) alkyl is unsubstituted or substituted with a phenyl; R4 and R5 are independently selected from hydrogen, halogen, (C1-6) alkyl, (C1-6) fluoroalkyl, OR9, SR9, NO2, CN, or COR9; R6 is hydrogen, (C1-6) fluoroalkyl, or (C1-6) alkyl; R7 and R8 are independently hydrogen, or (C1-6) alkyl; R9 is hydrogen, (C1-6) fluoroalkyl, (C1-6) alkyl; Alk is (C1-4) alkylene unsubstituted or substituted with a hydroxy; Y is oxygen, sulfur, SO2, or a bond; X is CH2, C═O, S, O, or SO2; Z is hydrogen, halogen, (C1-6) alkyl, (C1-6)fluoroalkyl, —OH, (C1-6) alkoxy, (C1-6) fluoroalkoxy, (C1-6) alkylthio, (C1-6) acyl, (C1-4)alkylsulfonyl, —OCF3, —NO2, —CN, carboxamido which may be substituted on the nitrogen by one or two (C1-4) alkyl groups, and —NH2 in which one of the hydrogens may be replaced by a (C1-4) alkyl group and the other hydrogen may be replaced by either a (C1-4) alkyl group, a (C1-6) acyl group, or a (C1-4) alkylsulfonyl group; the phenyl of R1, R2 or R3 is independently unsubstituted or substituted with one to three substituents independently selected from Z; the monocyclic heteroaromatic of R3 is unsubstituted or substituted with one to three substituents independently selected from Z; the bicyclic heteroaromatic of R3 is unsubstituted or substituted with one to three substituents independently selected from Z; and salts, solvates, and crystal forms thereof. Also described are the use of the compounds of formula (I) as antagonists of the dopamine D2 receptor and as agents for the treatment of psychosis and bipolar disorders, and pharmaceutical formulations of the compounds of formula (I).

    Glass-forming die and method
    4.
    发明申请
    Glass-forming die and method 审中-公开
    玻璃成型模具及方法

    公开(公告)号：US20060213632A1

    公开(公告)日：2006-09-28

    申请号：US11371184

    申请日：2006-03-08

    申请人： Russell Vogt ,  Kenneth Murphy ,  John He ,  Robert Hrubec ,  Gail Cole ,  Robert Grunstra

    发明人： Russell Vogt ,  Kenneth Murphy ,  John He ,  Robert Hrubec ,  Gail Cole ,  Robert Grunstra

    IPC分类号： B22D7/10 ,  C03B9/38 ,  C03B9/48 ,  C03B11/12

    CPC分类号： B22C9/065 ,  B22C7/02 ,  B22C9/04 ,  B22C9/10 ,  B22C9/24 ,  B22D29/002 ,  C03B9/3875 ,  C03B9/48 ,  C03B11/12

    摘要： Glass-forming die, such as a parsain-forming or bottle-forming die, includes a die body having a molding surface with a curved contour to form at least a portion of a glass bottle or other article to be made. The die body has one or more cooling passages inside the body wherein the cooling passages is/are non-linear (non-straight) along at least a portion of their length to improve temperature control of the die during the glass forming operation. To this end, the cooling passages are curved in a manner to generally follow the curved contour along at least a portion of the length of the curved contour, and may include heat radiating or turbulating elements in the cooling passage. The glass-forming die alternately, or in addition, can include integral cooling fins, ribs or other heat radiating element on one or more exterior regions of the die.

    摘要翻译： 玻璃成型模具，例如形成成型或成型模具的模具包括具有弯曲轮廓的模制表面的模具主体，以形成玻璃瓶或其他制品的至少一部分。 模具本体在主体内具有一个或多个冷却通道，其中冷却通道沿其长度的至少一部分是非线性（非直的），以改善在玻璃成形操作期间模具的温度控制。 为此，冷却通道以沿着弯曲轮廓长度的至少一部分大致跟随弯曲轮廓的方式弯曲，并且可以包括冷却通道中的散热或紊流元件。 玻璃成形模具交替地或者另外可以包括在模具的一个或多个外部区域上的整体散热片，肋或其它散热元件。

    DIGITAL PRESSURE GAUGE
    5.
    发明申请
    DIGITAL PRESSURE GAUGE 有权
    数字压力表

    公开(公告)号：US20130160561A1

    公开(公告)日：2013-06-27

    申请号：US13454773

    申请日：2012-04-24

    申请人： Andy Chen ,  John He

    发明人： Andy Chen ,  John He

    IPC分类号： G01L9/00

    CPC分类号： G01L19/147 ,  G01L19/083

    摘要： A digital pressure gauge is configured for coupling with an external fluid pipe, and includes a housing, a pressure sensing unit, a battery seat and a cover. The housing includes an inlet for coupling with the external fluid pipe to permit flow of fluid from the external fluid pipe into the housing. The pressure sensing unit is operable to sense fluid pressure of the fluid flowing through the inlet. The battery seat is disposed in the housing for receiving a battery. The housing is formed with an opening registered with the battery seat to permit placement of the battery in and removal of the battery from the battery seat through the opening. The cover is removably attached to the housing.

    摘要翻译： 数字压力表被配置为与外部流体管连接，并且包括壳体，压力感测单元，电池座和盖。 壳体包括用于与外部流体管连接的入口，以允许流体从外部流体管流入壳体。 压力感测单元可操作以感测流过入口的流体的流体压力。 电池座设置在壳体中以接收电池。 壳体形成有与电池座对准的开口，以允许电池通过开口从电池座放置并从电池座移除。 盖可拆卸地连接到壳体。

    Digital pressure gauge
    6.
    发明授权
    Digital pressure gauge 有权
    数字压力表

    公开(公告)号：US08863581B2

    公开(公告)日：2014-10-21

    申请号：US13454773

    申请日：2012-04-24

    申请人： Andy Chen ,  John He

    发明人： Andy Chen ,  John He

    IPC分类号： G01L9/00

    CPC分类号： G01L19/147 ,  G01L19/083

    摘要： A digital pressure gauge is configured for coupling with an external fluid pipe, and includes a housing, a pressure sensing unit, a battery seat and a cover. The housing includes an inlet for coupling with the external fluid pipe to permit flow of fluid from the external fluid pipe into the housing. The pressure sensing unit is operable to sense fluid pressure of the fluid flowing through the inlet. The battery seat is disposed in the housing for receiving a battery. The housing is formed with an opening registered with the battery seat to permit placement of the battery in and removal of the battery from the battery seat through the opening. The cover is removably attached to the housing.

    摘要翻译： 数字压力表被配置为与外部流体管连接，并且包括壳体，压力感测单元，电池座和盖。 壳体包括用于与外部流体管连接的入口，以允许流体从外部流体管流入壳体。 压力感测单元可操作以感测流过入口的流体的流体压力。 电池座设置在壳体中以接收电池。 壳体形成有与电池座对准的开口，以允许电池通过开口从电池座放置并从电池座移除。 盖可拆卸地连接到壳体。