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公开(公告)号：US20130244940A1
公开(公告)日：2013-09-19
申请号：US13989174
申请日：2011-11-25
申请人： Daniel Steiner , Hans Kaspar Binz , Maya Gulotti-Georgieva , Frieder W. Merz , Douglas Phillips , Ivo Sonderegger
发明人： Daniel Steiner , Hans Kaspar Binz , Maya Gulotti-Georgieva , Frieder W. Merz , Douglas Phillips , Ivo Sonderegger
IPC分类号： C07K14/00
CPC分类号： A61K47/64 , A61K38/00 , C07K14/001 , C07K14/47 , C07K14/4702 , C07K16/00 , C07K2318/20 , C07K2319/00 , C07K2319/21 , C07K2319/22 , C07K2319/30 , C07K2319/31 , C07K2319/55 , C07K2319/60
摘要： New designed repeat proteins with binding specificity for serum albumin are described, as well as nucleic acids encoding such serum albumin binding proteins, pharmaceutical compositions comprising such proteins, the use of such proteins to modify the pharmacokinetics of therapeutic relevant polypeptides and the use of such proteins in the treatment of diseases. The repeat proteins of the invention have a substantially increased half-life in plasma compared to proteins not binding serum albumin.
摘要翻译： 描述了对血清白蛋白具有结合特异性的新设计的重复蛋白质，以及编码这种血清白蛋白结合蛋白的核酸，包含这种蛋白质的药物组合物，使用这些蛋白质来改变治疗性相关多肽的药代动力学和使用这种蛋白质 在治疗疾病。 与不结合血清白蛋白的蛋白质相比，本发明的重复蛋白质具有显着增加的血浆半衰期。
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公开(公告)号：US09284361B2
公开(公告)日：2016-03-15
申请号：US13989174
申请日：2011-11-25
申请人： Daniel Steiner , Hans Kaspar Binz , Maya Gulotti-Georgieva , Frieder W. Merz , Douglas Phillips , Ivo Sonderegger
发明人： Daniel Steiner , Hans Kaspar Binz , Maya Gulotti-Georgieva , Frieder W. Merz , Douglas Phillips , Ivo Sonderegger
CPC分类号： A61K47/64 , A61K38/00 , C07K14/001 , C07K14/47 , C07K14/4702 , C07K16/00 , C07K2318/20 , C07K2319/00 , C07K2319/21 , C07K2319/22 , C07K2319/30 , C07K2319/31 , C07K2319/55 , C07K2319/60
摘要： New designed repeat proteins with binding specificity for serum albumin are described, as well as nucleic acids encoding such serum albumin binding proteins, pharmaceutical compositions comprising such proteins, the use of such proteins to modify the pharmacokinetics of therapeutic relevant polypeptides and the use of such proteins in the treatment of diseases. The repeat proteins of the invention have a substantially increased half-life in plasma compared to proteins not binding serum albumin.
摘要翻译： 描述了对血清白蛋白具有结合特异性的新设计的重复蛋白质，以及编码这种血清白蛋白结合蛋白的核酸，包含这种蛋白质的药物组合物，使用这些蛋白质来改变治疗性相关多肽的药代动力学和使用这种蛋白质 在治疗疾病。 与不结合血清白蛋白的蛋白质相比，本发明的重复蛋白质具有显着增加的血浆半衰期。
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3.发明授权公开(公告)号：US08846577B2
公开(公告)日：2014-09-30
申请号：US11988389
申请日：2006-06-30
CPC分类号： C07K1/047 , C07K2319/034 , C07K2319/43 , C07K2319/50 , C07K2319/735 , C12N15/1037 , C12N15/625 , C12N15/63 , C40B40/02
摘要： The present invention relates to a filamentous phage display method wherein the polypeptides of interest displayed on the phage particle are cotranslationally translocated across the cytoplasmic membrane of Gram-negative bacteria based on the signal recognition particle pathway. This method is particularly suitable for polypeptides, which are known to be difficult to display on phages, and for proteins of cDNA libraries and other combinatorial libraries, in particular when derived from very fast folding, stable protein scaffolds. The invention further relates to phage or phagemid vectors useful in the method comprising a gene construct coding for a fusion polypeptide comprising the polypeptide to be displayed on the phage particle and an N-terminal signal sequence promoting cotranslational translocation.
摘要翻译： 本发明涉及一种丝状噬菌体展示法，其中显示在噬菌体颗粒上的感兴趣多肽基于信号识别颗粒途径共转移穿过革兰氏阴性细菌的细胞质膜。 该方法特别适用于已知难以在噬菌体上显示的多肽，以及cDNA文库和其他组合文库的蛋白质，特别是当从非常快的折叠的稳定的蛋白质支架衍生时。 本发明还涉及可用于包含编码融合多肽的基因构建体的噬菌体或噬菌粒载体，所述融合多肽包含要显示在噬菌体颗粒上的多肽和促进共翻译易位的N末端信号序列。
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公开(公告)号：USD564405S1
公开(公告)日：2008-03-18
申请号：US29276640
申请日：2007-01-31
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公开(公告)号：USD546243S1
公开(公告)日：2007-07-10
申请号：US29212569
申请日：2004-09-02
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6.发明申请公开(公告)号：US20110118146A1
公开(公告)日：2011-05-19
申请号：US11988389
申请日：2006-06-30
CPC分类号： C07K1/047 , C07K2319/034 , C07K2319/43 , C07K2319/50 , C07K2319/735 , C12N15/1037 , C12N15/625 , C12N15/63 , C40B40/02
摘要： The present invention relates to a filamentous phage display method wherein the polypeptides of interest displayed on the phage particle are cotranslationally translocated across the cytoplasmic membrane of Gram-negative bacteria based on the signal recognition particle pathway. This method is particularly suitable for polypeptides, which are known to be difficult to display on phages, and for proteins of cDNA libraries and other combinatorial libraries, in particular when derived from very fast folding, stable protein scaffolds. The invention further relates to phage or phagemid vectors useful in the method comprising a gene construct coding for a fusion polypeptide comprising the polypeptide to be displayed on the phage particle and an N-terminal signal sequence promoting cotranslational translocation.
摘要翻译： 本发明涉及一种丝状噬菌体展示法，其中显示在噬菌体颗粒上的感兴趣多肽基于信号识别颗粒途径共转移穿过革兰氏阴性细菌的细胞质膜。 该方法特别适用于已知难以在噬菌体上显示的多肽，以及cDNA文库和其他组合文库的蛋白质，特别是当从非常快的折叠的稳定的蛋白质支架衍生时。 本发明还涉及可用于包含编码融合多肽的基因构建体的噬菌体或噬菌粒载体，所述融合多肽包含要显示在噬菌体颗粒上的多肽和促进共翻译易位的N末端信号序列。
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7.发明授权Apparatus for suspending at least one current-carrying contact wire for current collectors of overhead line buses or trams 失效用于悬挂用于架空线路总线或电车的集电器的至少一个载流接触线的装置
公开(公告)号：US5542511A
公开(公告)日：1996-08-06
申请号：US18898
申请日：1993-02-17
申请人： Daniel Steiner , Willy Brassel , Karl Hagmann
发明人： Daniel Steiner , Willy Brassel , Karl Hagmann
IPC分类号： B60M1/225
CPC分类号： B60M1/225
摘要： An apparatus for suspending at least one current-carrying contact wire for current collectors of overhead line buses or trams comprises a connecting element is fixed to a support cable. The connecting element is formed from an insulating plastic material, preferably a glass fiber-reinforced polyamide, and forms a unitary shaped body having a receiving member for a support element which is adjustable relative thereto, for supporting the gripping member. The connecting element includes a support shoe with connection eye for an insert which can be fixed therein, for receiving the support element in a pivotable manner and a clamping cover which can be screwed to the support shoe. The support shoe and clamping cover are provided with a longitudinal groove for receiving the support cable in a non-slip fashion.
摘要翻译： 用于悬挂用于架空线路总线或电车的集电器的至少一个载流接触线的装置包括固定到支撑电缆的连接元件。 连接元件由绝缘塑料材料形成，优选由玻璃纤维增强聚酰胺形成，并且形成一个整体形状的主体，该主体具有可相对于其调节的用于支撑元件的接收构件，用于支撑夹持构件。 连接元件包括支撑靴，其具有用于可固定在其中的插入件的连接眼，用于以可枢转的方式接收支撑元件，以及夹紧盖可以被拧到支撑靴上。 支撑靴和夹紧盖设置有用于以非滑动方式接收支撑缆索的纵向凹槽。
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8.发明申请公开(公告)号：US20070171394A1
公开(公告)日：2007-07-26
申请号：US11339417
申请日：2006-01-25
IPC分类号： G01C3/08
摘要： A system is provided for determining a distance to a target. In an exemplary embodiment, the system includes a pole and a distance measuring device. The pole includes a plurality of sockets formed in a surface of the pole above a selected lower reflecting point and a reflector mounted in each of the plurality of sockets. The lower reflecting point defines a minimum distance from a first end of the pole above which the reflectors are located for use with the distance measuring device. At least a portion of a signal received from the distance measuring device is reflected back to the distance measuring device by a receiving reflector. The distance measuring device includes a transmitter that transmits the signal at a first time, a receptor that receives the reflected signal from the receiving reflector at a second time, and a processor to determine the distance from the transmitter to the receiving reflector using the first time and the second time.
摘要翻译： 提供用于确定到目标的距离的系统。 在示例性实施例中，系统包括极和距离测量装置。 极包括形成在选定的下反射点上方的极的表面中的多个插座和安装在多个插座中的每一个中的反射器。 下反射点定义了距反射器所在的极的第一端的最小距离，以便与距离测量装置一起使用。 从距离测量装置接收的信号的至少一部分被接收反射器反射回距离测量装置。 距离测量装置包括：第一时间发送信号的发射器;第二时间从接收反射器接收反射信号的接收器;以及处理器，用于使用第一次确定从发射器到接收反射器的距离 和第二次。
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公开(公告)号：US20060044544A1
公开(公告)日：2006-03-02
申请号：US10931947
申请日：2004-09-01
CPC分类号： G01C3/08
摘要： A system and method are provided for determining a distance to a target. The method includes sending light, at a first time, to a light reflector mounted in a reflector device, receiving light reflected from the light reflector at a second time, and determining the distance to the reflector device using the difference between the first time and the second time. The reflector device has a first lateral surface, a second lateral surface parallel to the first lateral surface, and a rod surface extending from the first lateral surface to the second lateral surface. The reflector device includes sockets arranged in the rod surface with a light reflector mounted in each socket. The sockets may be arranged in a plurality of rows with possibly a plurality of sockets in each row. The reflector device may be mounted as an insert to or at the top of a target to determine the distance to the target.
摘要翻译： 提供了一种用于确定到目标的距离的系统和方法。 该方法包括：第一时间将光发送到安装在反射器装置中的光反射器，在第二时间接收从光反射器反射的光;以及使用第一次和第二次之间的差来确定与反射器装置的距离 第二次。 反射器装置具有第一侧表面，平行于第一侧表面的第二侧表面和从第一侧表面延伸到第二侧表面的杆表面。 反射器装置包括布置在杆表面中的插座，安装在每个插座中的光反射器。 插座可以布置成多行，每排可能有多个插座。 反射器装置可以作为插入物安装在目标的顶部或顶部，以确定到目标的距离。
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公开(公告)号：US07215412B2
公开(公告)日：2007-05-08
申请号：US10931947
申请日：2004-09-01
IPC分类号： G01C3/08
CPC分类号： G01C3/08
摘要： A system and method are provided for determining a distance to a target. The method includes sending light, at a first time, to a light reflector mounted in a reflector device, receiving light reflected from the light reflector at a second time, and determining the distance to the reflector device using the difference between the first time and the second time. The reflector device has a first lateral surface, a second lateral surface parallel to the first lateral surface, and a rod surface extending from the first lateral surface to the second lateral surface. The reflector device includes sockets arranged in the rod surface with a light reflector mounted in each socket. The sockets may be arranged in a plurality of rows with possibly a plurality of sockets in each row. The reflector device may be mounted as an insert to or at the top of a target to determine the distance to the target.
摘要翻译： 提供了一种用于确定到目标的距离的系统和方法。 该方法包括：第一时间将光发送到安装在反射器装置中的光反射器，在第二时间接收从光反射器反射的光;以及使用第一次和第二次之间的差来确定与反射器装置的距离 第二次。 反射器装置具有第一侧表面，平行于第一侧表面的第二侧表面和从第一侧表面延伸到第二侧表面的杆表面。 反射器装置包括布置在杆表面中的插座，安装在每个插座中的光反射器。 插座可以布置成多行，每排可能有多个插座。 反射器装置可以作为插入物安装在目标的顶部或顶部，以确定到目标的距离。
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