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    Inhibitors of L1 and ADAM10 for the treatment of carcinomas
    5.
    发明授权
    Inhibitors of L1 and ADAM10 for the treatment of carcinomas 有权
    L1和ADAM10抑制剂用于治疗癌症

    公开(公告)号：US08003599B2

    公开(公告)日：2011-08-23

    申请号：US11573269

    申请日：2005-07-27

    申请人： Peter Altevogt ,  Daniela Kelm ,  Mina Fogel

    发明人： Peter Altevogt ,  Daniela Kelm ,  Mina Fogel

    IPC分类号： A61K38/00 ,  C12N15/11

    CPC分类号： C12N9/6489 ,  C07K14/70503

    摘要： Described is a pharmaceutical composition comprising a compound(s) interfering with the biological activity of L1 and/or ADAM10 or their expression. Also described is the use of said compound(s) for the prevention/treatment of carcinomas like ovarian and endometrial carcinoma. Finally, the diagnosis of highly malignant forms of carcinomas which is based on the determination of the activity/expression of L1 and/or ADAM10 is described.

    摘要翻译： 描述了包含干扰L1和/或ADAM10的生物学活性或其表达的化合物的药物组合物。 还描述了所述化合物用于预防/治疗诸如卵巢和子宫内膜癌的癌症的用途。 最后，描述了基于L1和/或ADAM10的活性/表达的确定的高度恶性形式的癌症的诊断。

    Method for prenatal diagnosis
    6.
    发明授权
    Method for prenatal diagnosis 失效
    产前诊断方法

    公开(公告)号：US08568994B2

    公开(公告)日：2013-10-29

    申请号：US12671196

    申请日：2008-08-01

    申请人： Peter Altevogt ,  Sascha Keller

    发明人： Peter Altevogt ,  Sascha Keller

    IPC分类号： G01N33/567 ,  G01N33/48 ,  G01N1/18

    CPC分类号： G01N33/689 ,  G01N2333/70596 ,  G01N2800/38

    摘要： The invention discloses a method of prenatal diagnosis comprising the step of isolating exosomes from an isolated fluid, wherein the exosomes are identified by biomarker detection. Furthermore, the invention discloses the isolation of exosomes from an isolated fluid and the use of a biomarker, particularly CD24 to isolate exosomes from an isolated fluid.

    摘要翻译： 本发明公开了一种产前诊断方法，包括从分离的流体中分离外来体的步骤，其中通过生物标志物检测鉴定外来体。 此外，本发明公开了从分离的流体中分离外来体和使用生物标志物，特别是CD24从分离的流体中分离外来体。

    System for enhancing decoding performance of text indexes
    7.
    发明授权
    System for enhancing decoding performance of text indexes 失效
    提高文本索引解码性能的系统

    公开(公告)号：US08234270B2

    公开(公告)日：2012-07-31

    申请号：US12775546

    申请日：2010-05-07

    申请人： Peter Altevogt ,  Silvio Weidrich

    发明人： Peter Altevogt ,  Silvio Weidrich

    IPC分类号： G06F7/00 ,  G06F17/30

    CPC分类号： G06F17/30864 ,  G06F17/30622

    摘要： The present invention is a system for enhancing the decoding performance of text indexes of an indexed collection of text documents. The posting list includes a plurality of list entries being of variable size depending on the value stored in each posting list entry. The inventive system is based on a statistical analysis of the posting list entries of the plurality of list entries. Prior to decoding, the system can select a decoding routine being appropriate to decode the most frequent type of posting list entries or of a plurality of various posting list entries. After selecting a particular decoding routine and executing the decoding routine for decoding of the entire posting list, a failure check is performed. In the exceptional case that a failure has occurred, a second alternative decoding routine is selected and executed.

    摘要翻译： 本发明是一种用于增强索引的文本文档集合的文本索引的解码性能的系统。 发布列表包括根据存储在每个发布列表条目中的值而具有可变大小的多个列表条目。 本发明的系统基于对多个列表条目的发布列表条目的统计分析。 在解码之前，系统可以选择适合于解码最频繁类型的发布列表条目或多个各种发布列表条目的解码例程。 在选择特定解码例程并执行用于解码整个发布列表的解码程序之后，执行故障检查。 在发生故障的特殊情况下，选择并执行第二替代解码程序。

    Method of generating a distributed text index for parallel query processing
    8.
    发明授权
    Method of generating a distributed text index for parallel query processing 有权
    生成用于并行查询处理的分布式文本索引的方法

    公开(公告)号：US07966332B2

    公开(公告)日：2011-06-21

    申请号：US11868757

    申请日：2007-10-08

    申请人： Peter Altevogt ,  Raiko Nitzsche

    发明人： Peter Altevogt ,  Raiko Nitzsche

    IPC分类号： G06F7/00

    CPC分类号： G06F17/30619 ,  G06F17/3069 ,  Y10S707/99933

    摘要： The present invention relates to a method of generating a distributed text index for parallel query processing by a number of nodes. A set of node indices is generated for text indexing a set of documents, each node text index covering a subset of the documents. For each node text index, a local frequency measure for each term of the node text index is calculated on the basis of a frequency of documents containing the term in the subset of the documents of the node. A global frequency measure for each term is calculated on the basis of a frequency of documents containing the term in the set of documents. A quality measure for each node text index is calculated on the basis of the local frequency measures of the terms of the node and the global frequency measure of the terms of the node.

    摘要翻译： 本发明涉及一种生成用于多个节点的并行查询处理的分布式文本索引的方法。 生成一组节点索引，用于文本索引一组文档，每个节点文本索引覆盖文档的一个子集。 对于每个节点文本索引，基于节点文档子集中包含术语的文档的频率来计算节点文本索引的每个术语的本地频率测量。 每个术语的全球频率测量是根据包含该组文件中的术语的文档的频率计算的。 基于节点的本地频率测量和节点项的全局频率测量，计算每个节点文本索引的质量度量。

    IMPROVED METHOD FOR PRENATAL DIAGNOSIS
    9.
    发明申请
    IMPROVED METHOD FOR PRENATAL DIAGNOSIS 失效
    改进的临床诊断方法

    公开(公告)号：US20100279315A1

    公开(公告)日：2010-11-04

    申请号：US12671196

    申请日：2008-08-01

    申请人： Peter Altevogt ,  Sascha Keller

    发明人： Peter Altevogt ,  Sascha Keller

    IPC分类号： G01N33/53

    CPC分类号： G01N33/689 ,  G01N2333/70596 ,  G01N2800/38

    摘要： The invention discloses a method of prenatal diagnosis comprising the step of isolating exosomes from an isolated fluid, wherein the exosomes are identified by biomarker detection. Furthermore, the invention discloses the isolation of exosomes from an isolated fluid and the use of a biomarker, particularly CD24 to isolate exosomes from an isolated fluid.

    摘要翻译： 本发明公开了一种产前诊断方法，包括从分离的流体中分离外来体的步骤，其中通过生物标志物检测鉴定外来体。 此外，本发明公开了从分离的流体中分离外来体和使用生物标志物，特别是CD24从分离的流体中分离外来体。

    METHOD OF GENERATING A DISTRIBUTED TEXT INDEX FOR PARALLEL QUERY PROCESSING
    10.
    发明申请
    METHOD OF GENERATING A DISTRIBUTED TEXT INDEX FOR PARALLEL QUERY PROCESSING 有权
    生成用于并行查询处理的分布式文本索引的方法

    公开(公告)号：US20080027918A1

    公开(公告)日：2008-01-31

    申请号：US11868757

    申请日：2007-10-08

    申请人： Peter Altevogt ,  Raiko Nitzsche

    发明人： Peter Altevogt ,  Raiko Nitzsche

    IPC分类号： G06F17/30

    CPC分类号： G06F17/30619 ,  G06F17/3069 ,  Y10S707/99933

    摘要： The present invention relates to a method of generating a distributed text index for parallel query processing by a number of nodes. A set of node indices is generated for text indexing a set of documents, each node text index covering a subset of the documents. For each node text index, a local frequency measure for each term of the node text index is calculated on the basis of a frequency of documents containing the term in the subset of the documents of the node. A global frequency measure for each term is calculated on the basis of a frequency of documents containing the term in the set of documents. A quality measure for each node text index is calculated on the basis of the local frequency measures of the terms of the node and the global frequency measure of the terms of the node.

    摘要翻译： 本发明涉及一种生成用于多个节点的并行查询处理的分布式文本索引的方法。 生成一组节点索引，用于文本索引一组文档，每个节点文本索引覆盖文档的一个子集。 对于每个节点文本索引，基于节点文档子集中包含术语的文档的频率来计算节点文本索引的每个术语的本地频率测量。 每个术语的全球频率测量是根据包含该组文件中的术语的文档的频率计算的。 基于节点的本地频率测量和节点项的全局频率测量，计算每个节点文本索引的质量度量。