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公开(公告)号：US09200047B2
公开(公告)日：2015-12-01
申请号：US13028953
申请日：2011-02-16
申请人： Danila Valmori , Maha Ayyoub
发明人： Danila Valmori , Maha Ayyoub
CPC分类号： C07K14/4748 , A61K38/00
摘要： The invention describes HLA class II binding peptides encoded by the SSX-2 tumor associated gene, as well as nucleic acids encoding such peptides and antibodies relating thereto. The peptides stimulate the activity and proliferation of CD4+ T lymphocytes. Methods and products also are provided for diagnosing and treating conditions characterized by expression of the SSX-2 gene.
摘要翻译： 本发明描述了由SSX-2肿瘤相关基因编码的HLA II类结合肽，以及编码与其有关的这些肽和抗体的核酸。 肽刺激CD4 + T淋巴细胞的活性和增殖。 还提供了用于诊断和治疗以SSX-2基因表达为特征的病症的方法和产品。
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公开(公告)号：US20060189001A1
公开(公告)日：2006-08-24
申请号：US10565315
申请日：2004-07-21
申请人： Danila Valmori , Maha Ayyoub
发明人： Danila Valmori , Maha Ayyoub
IPC分类号： C07H21/04 , C12P21/06 , G01N33/543 , C07K14/74
CPC分类号： C07K14/4748 , A61K38/00
摘要： The invention describes HLA class II binding peptides encoded by the SSX-2 tumor associated gene, as well as nucleic acids encoding such peptides and antibodies relating thereto. The peptides stimulate the activity and proliferation of CD4+ T lymphocytes. Methods and products also are provided for diagnosing and treating conditions characterized by expression of the SSX-2 gene.
摘要翻译： 本发明描述了由SSX-2肿瘤相关基因编码的HLA II类结合肽，以及编码与其有关的这些肽和抗体的核酸。 肽刺激CD4 + T淋巴细胞的活性和增殖。 还提供了用于诊断和治疗以SSX-2基因表达为特征的病症的方法和产品。
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公开(公告)号：US20060051772A1
公开(公告)日：2006-03-09
申请号：US10936888
申请日：2004-09-09
申请人： Danila Valmori , Maha Ayyoub
发明人： Danila Valmori , Maha Ayyoub
CPC分类号： C07K14/4748 , A61K38/00 , C07K16/2833 , C07K16/30 , C12Q1/6886 , C12Q2600/158
摘要： The invention describes HLA class II binding peptides encoded by the SSX-4 tumor associated gene, as well as nucleic acids encoding such peptides and antibodies relating thereto. The peptides stimulate the activity and proliferation of CD4+ T lymphocytes. Methods and products also are provided for diagnosing and treating conditions characterized by expression of the SSX-4 gene.
摘要翻译： 本发明描述了由SSX-4肿瘤相关基因编码的HLA II类结合肽，以及编码与其相关的这些肽和抗体的核酸。 肽刺激CD4 + T淋巴细胞的活性和增殖。 还提供了用于诊断和治疗以SSX-4基因表达为特征的病症的方法和产品。
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公开(公告)号：US20050079553A1
公开(公告)日：2005-04-14
申请号：US10937794
申请日：2004-09-09
申请人： Maha Ayyoub , Danila Valmori
发明人： Maha Ayyoub , Danila Valmori
CPC分类号： C07K14/4748 , A61K38/00
摘要： The invention describes HLA class II binding peptides encoded by the SSX-2 tumor associated gene, as well as nucleic acids encoding such peptides and antibodies relating thereto. The peptides stimulate the activity and proliferation of CD4+ T lymphocytes. Methods and products also are provided for diagnosing and treating conditions characterized by expression of the SSX-2 gene.
摘要翻译： 本发明描述了由SSX-2肿瘤相关基因编码的HLA II类结合肽，以及编码与其有关的这些肽和抗体的核酸。 肽刺激CD4 + T淋巴细胞的活性和增殖。 还提供了用于诊断和治疗以SSX-2基因表达为特征的病症的方法和产品。
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公开(公告)号：US20110144186A1
公开(公告)日：2011-06-16
申请号：US13028953
申请日：2011-02-16
申请人： Danila Valmori , Maha Ayyoub
发明人： Danila Valmori , Maha Ayyoub
IPC分类号： A61K31/7088 , C07H21/00 , A61P35/00
CPC分类号： C07K14/4748 , A61K38/00
摘要： The invention describes HLA class II binding peptides encoded by the SSX-2 tumor associated gene, as well as nucleic acids encoding such peptides and antibodies relating thereto. The peptides stimulate the activity and proliferation of CD4+ T lymphocytes. Methods and products also are provided for diagnosing and treating conditions characterized by expression of the SSX-2 gene.
摘要翻译： 本发明描述了由SSX-2肿瘤相关基因编码的HLA II类结合肽，以及编码与其有关的这些肽和抗体的核酸。 肽刺激CD4 + T淋巴细胞的活性和增殖。 还提供了用于诊断和治疗以SSX-2基因表达为特征的病症的方法和产品。
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公开(公告)号：US07910696B2
公开(公告)日：2011-03-22
申请号：US10565315
申请日：2004-07-21
申请人： Danila Valmori , Maha Ayyoub
发明人： Danila Valmori , Maha Ayyoub
IPC分类号： C12P21/06
CPC分类号： C07K14/4748 , A61K38/00
摘要： The invention describes HLA class II binding peptides encoded by the SSX-2 tumor associated gene, as well as nucleic acids encoding such peptides and antibodies relating thereto. The peptides stimulate the activity and proliferation of CD4+ T lymphocytes. Methods and products also are provided for diagnosing and treating conditions characterized by expression of the SSX-2 gene.
摘要翻译： 本发明描述了由SSX-2肿瘤相关基因编码的HLA II类结合肽，以及编码与其有关的这些肽和抗体的核酸。 肽刺激CD4 + T淋巴细胞的活性和增殖。 还提供了用于诊断和治疗以SSX-2基因表达为特征的病症的方法和产品。
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公开(公告)号：US07858743B2
公开(公告)日：2010-12-28
申请号：US10936888
申请日：2004-09-09
申请人： Danila Valmori , Maha Ayyoub
发明人： Danila Valmori , Maha Ayyoub
IPC分类号： C07K7/00
CPC分类号： C07K14/4748 , A61K38/00 , C07K16/2833 , C07K16/30 , C12Q1/6886 , C12Q2600/158
摘要： The invention describes HLA class II binding peptides encoded by the SSX-4 tumor associated gene, as well as nucleic acids encoding such peptides and antibodies relating thereto. The peptides stimulate the activity and proliferation of CD4+ T lymphocytes. Methods and products also are provided for diagnosing and treating conditions characterized by expression of the SSX-4 gene.
摘要翻译： 本发明描述了由SSX-4肿瘤相关基因编码的HLA II类结合肽，以及编码与其有关的这些肽和抗体的核酸。 肽刺激CD4 + T淋巴细胞的活性和增殖。 还提供了用于诊断和治疗以SSX-4基因表达为特征的病症的方法和产品。
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公开(公告)号：US20090099063A1
公开(公告)日：2009-04-16
申请号：US12233964
申请日：2008-09-19
申请人： Maha Ayyoub , Danila Valmori
发明人： Maha Ayyoub , Danila Valmori
IPC分类号： A61K38/02
CPC分类号： C07K14/4748 , A61K38/00
摘要： The invention describes HLA class II binding peptides encoded by the SSX-2 tumor associated gene, as well as nucleic acids encoding such peptides and antibodies relating to the peptides. The peptides stimulate the activity and proliferation of CD4+T lymphocytes. Methods and products also are provided for diagnosing and treating conditions characterized by expression of the SSX-2 gene.
摘要翻译： 本发明描述了由SSX-2肿瘤相关基因编码的HLA II类结合肽，以及编码与肽有关的这些肽和抗体的核酸。 肽刺激CD4 + T淋巴细胞的活性和增殖。 还提供了用于诊断和治疗以SSX-2基因表达为特征的病症的方法和产品。
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9.发明申请IMMUNODOMINANT MHC DR52B RESTRICTED NY-ESO-1 EPITOPES, MHC CLASS II MONOMERS AND MULTIMERS, AND USES THEREOF 审中-公开免疫组织化学MHC DR52B限制性NY-ESO-1抗原决定簇，MHC II类单体和多聚体及其用途公开(公告)号：US20130029358A1
公开(公告)日：2013-01-31
申请号：US13499771
申请日：2010-10-01
CPC分类号： C07K14/70539 , C07K14/4748 , C07K2319/73 , G01N33/56972 , G01N33/56977 , G01N33/6878
摘要： Immunostimulatory NY-ESO-1 epitopes recognized by MHC-DRB3*0202 (DR52b) or DRB1*0101 (DR1) restricted T cells are described. Methods for their use in diagnostic and therapeutic approaches are also provided. Further, methods for the generation and isolation of MHC class II molecules, either “empty” or peptide-loaded, are provided. Methods for the assembly of MHC class II multimers, for example, tetramers, are also provided. Methods for the detection of T cells binding to specific peptide-loaded MHC class II molecules are also described herein.
摘要翻译： 描述了由MHC-DRB3 * 0202（DR52b）或DRB1 * 0101（DR1）限制性T细胞识别的免疫刺激性NY-ESO-1表位。 还提供了用于诊断和治疗方法的方法。 此外，提供用于产生和分离MHC II类分子的方法，其为空载体或肽载体。 还提供了组装MHC II类多聚体的方法，例如四聚体。 本文还描述了检测结合特异性肽负载型MHC II类分子的T细胞的方法。
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公开(公告)号：US08008464B2
公开(公告)日：2011-08-30
申请号：US12960878
申请日：2010-12-06
申请人： Danila Valmori , Maha Ayyoub
发明人： Danila Valmori , Maha Ayyoub
IPC分类号： C07H21/04
CPC分类号： C07K14/4748 , A61K38/00 , C07K16/2833 , C07K16/30 , C12Q1/6886 , C12Q2600/158
摘要： The invention describes HLA class II binding peptides encoded by the SSX-4 tumor associated gene, as well as nucleic acids encoding such peptides and antibodies relating thereto. The peptides stimulate the activity and proliferation of CD4+ T lymphocytes. Methods and products also are provided for diagnosing and treating conditions characterized by expression of the SSX-4 gene.
摘要翻译： 本发明描述了由SSX-4肿瘤相关基因编码的HLA II类结合肽，以及编码与其有关的这些肽和抗体的核酸。 肽刺激CD4 + T淋巴细胞的活性和增殖。 还提供了用于诊断和治疗以SSX-4基因表达为特征的病症的方法和产品。
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