公开(公告)号：US11098314B2

公开(公告)日：2021-08-24

申请号：US15536872

申请日：2015-12-16

Applicant: Danisco US Inc.

Inventor： Jing Ge ,  Xiaogang Gu ,  Susan Mampusti Madrid ,  Danfeng Song ,  Mingmin Song ,  Michael Ward

IPC: C12N15/80 ,  C12N9/22 ,  C12N15/11

Abstract: Compositions and methods are provided for genome modification at a target site in the genome of a fungal cell. Aspects of methods and compositions are drawn to a guide polynucleotide/Cas endonuclease system for promoting insertion of a donor DNA at a desired target site in a fungal host cell genome.

公开(公告)号：US20190093114A1

公开(公告)日：2019-03-28

申请号：US15536933

申请日：2015-12-16

Applicant: Danisco US Inc.

Inventor： Benjamin S. Bower ,  Jimmy Chan ,  Jing Ge ,  Xiaogang Gu ,  Susan Mampusti Madrid ,  Danfeng Song ,  Mingmin Song ,  Michael Ward ,  Steven Sungin Kim

IPC: C12N15/80 ,  C12N9/22 ,  C12N15/11

Abstract: Compositions and methods are provided for genome modification at a target site in the genome of a fungal cell. The methods and compositions are drawn to a guide polynucleotide/Cas endonuclease system for promoting modification of the DNA sequence at a target site in a fungal host cell genome.

公开(公告)号：US11427829B2

公开(公告)日：2022-08-30

申请号：US15536836

申请日：2015-12-15

Applicant: Danisco US Inc.

Inventor： Benjamin S. Bower ,  Jimmy Chan ,  Jing Ge ,  Xiaogang Gu ,  Susan Mampusti Madrid ,  Danfeng Song ,  Mingmin Song ,  Michael Ward

IPC: C12N15/00 ,  C12N15/80 ,  C12N9/22 ,  C12N15/11

Abstract: Compositions and methods are provided for genome modification at a target site in the genome of a filamentous fungal cell. The methods and compositions are drawn to a guide polynucleotide/Cas endonuclease system for modifying or altering the target site. Aspects in which the filamentous fungal cell being modified has a defective non-homologous end joining pathway are also provided.

公开(公告)号：US20180002710A1

公开(公告)日：2018-01-04

申请号：US15536836

申请日：2015-12-15

Applicant: Danisco US Inc.

Inventor： Benjamin S. Bower ,  Jimmy Chan ,  Jing Ge ,  Xiaogang Gu ,  Susan Mampusti Madrid ,  Danfeng Song ,  Mingmin Song ,  Michael Ward

IPC: C12N15/80 ,  C12N9/22

CPC classification number: C12N15/80 ,  C12N9/22 ,  C12N15/11 ,  C12N2310/20

Abstract: Compositions and methods are provided for genome modification at a target site in the genome of a filamentous fungal cell. The methods and compositions are drawn to a guide polynucleotide/Cas endonuclease system for modifying or altering the target site. Aspects in which the filamentous fungal cell being modified has a defective non-homologous end joining pathway are also provided.

公开(公告)号：US20170369891A1

公开(公告)日：2017-12-28

申请号：US15536872

申请日：2015-12-16

Applicant: Danisco US Inc.

Inventor： Jing Ge ,  Xiaogang Gu ,  Susan Mampusti Madrid ,  Danfeng Song ,  Mingmin Song ,  Michael Ward

IPC: C12N15/80 ,  C12N9/22

CPC classification number: C12N15/80 ,  C12N9/22 ,  C12N15/11 ,  C12N2310/20

Abstract: Compositions and methods are provided for genome modification at a target site in the genome of a fungal cell. Aspects of methods and compositions are drawn to a guide polynucleotide/Cas endonuclease system for promoting insertion of a donor DNA at a desired target site in a fungal host cell genome.