公开(公告)号：US20190093114A1

公开(公告)日：2019-03-28

申请号：US15536933

申请日：2015-12-16

申请人： Danisco US Inc.

发明人： Benjamin S. Bower ,  Jimmy Chan ,  Jing Ge ,  Xiaogang Gu ,  Susan Mampusti Madrid ,  Danfeng Song ,  Mingmin Song ,  Michael Ward ,  Steven Sungin Kim

IPC分类号： C12N15/80 ,  C12N9/22 ,  C12N15/11

摘要： Compositions and methods are provided for genome modification at a target site in the genome of a fungal cell. The methods and compositions are drawn to a guide polynucleotide/Cas endonuclease system for promoting modification of the DNA sequence at a target site in a fungal host cell genome.

公开(公告)号：US20160160199A1

公开(公告)日：2016-06-09

申请号：US14907718

申请日：2014-09-19

申请人： DANISCO US INC.

发明人： Guoqing Liu ,  Ling Hua ,  Zhen Qian ,  Danfeng Song ,  Zhongmei Tang ,  Xie Zhiyong ,  Bo Zhang ,  Zhengzheng Zou ,  Wei Xu

IPC分类号： C12N9/28 ,  C11D3/386

摘要： Disclosed are compositions and methods relating to alpha-amylase from Exiguobacterium. The compositions and methods are useful, for example, for starch liquefaction and saccharification, for cleaning starchy stains in laundry, dishwashing, and other applications, for textile processing (e.g., desizing), in animal feed for improving digestibility, and and for baking and brewing.

摘要翻译： 公开了与来自Exiguobacterium的α-淀粉酶相关的组合物和方法。 组合物和方法可用于例如淀粉液化和糖化，用于清洁衣物，餐具洗涤和其它用途中的淀粉污渍，用于织物加工（例如脱浆），动物饲料中用于改善消化率，以及用于烘烤和 酿造。

公开(公告)号：US11427829B2

公开(公告)日：2022-08-30

申请号：US15536836

申请日：2015-12-15

申请人： Danisco US Inc.

发明人： Benjamin S. Bower ,  Jimmy Chan ,  Jing Ge ,  Xiaogang Gu ,  Susan Mampusti Madrid ,  Danfeng Song ,  Mingmin Song ,  Michael Ward

IPC分类号： C12N15/00 ,  C12N15/80 ,  C12N9/22 ,  C12N15/11

摘要： Compositions and methods are provided for genome modification at a target site in the genome of a filamentous fungal cell. The methods and compositions are drawn to a guide polynucleotide/Cas endonuclease system for modifying or altering the target site. Aspects in which the filamentous fungal cell being modified has a defective non-homologous end joining pathway are also provided.

公开(公告)号：US11098314B2

公开(公告)日：2021-08-24

申请号：US15536872

申请日：2015-12-16

申请人： Danisco US Inc.

发明人： Jing Ge ,  Xiaogang Gu ,  Susan Mampusti Madrid ,  Danfeng Song ,  Mingmin Song ,  Michael Ward

IPC分类号： C12N15/80 ,  C12N9/22 ,  C12N15/11

摘要： Compositions and methods are provided for genome modification at a target site in the genome of a fungal cell. Aspects of methods and compositions are drawn to a guide polynucleotide/Cas endonuclease system for promoting insertion of a donor DNA at a desired target site in a fungal host cell genome.

公开(公告)号：US20180002710A1

公开(公告)日：2018-01-04

申请号：US15536836

申请日：2015-12-15

申请人： Danisco US Inc.

发明人： Benjamin S. Bower ,  Jimmy Chan ,  Jing Ge ,  Xiaogang Gu ,  Susan Mampusti Madrid ,  Danfeng Song ,  Mingmin Song ,  Michael Ward

IPC分类号： C12N15/80 ,  C12N9/22

CPC分类号： C12N15/80 ,  C12N9/22 ,  C12N15/11 ,  C12N2310/20

摘要： Compositions and methods are provided for genome modification at a target site in the genome of a filamentous fungal cell. The methods and compositions are drawn to a guide polynucleotide/Cas endonuclease system for modifying or altering the target site. Aspects in which the filamentous fungal cell being modified has a defective non-homologous end joining pathway are also provided.

公开(公告)号：US20170369891A1

公开(公告)日：2017-12-28

申请号：US15536872

申请日：2015-12-16

申请人： Danisco US Inc.

发明人： Jing Ge ,  Xiaogang Gu ,  Susan Mampusti Madrid ,  Danfeng Song ,  Mingmin Song ,  Michael Ward

IPC分类号： C12N15/80 ,  C12N9/22

CPC分类号： C12N15/80 ,  C12N9/22 ,  C12N15/11 ,  C12N2310/20

摘要： Compositions and methods are provided for genome modification at a target site in the genome of a fungal cell. Aspects of methods and compositions are drawn to a guide polynucleotide/Cas endonuclease system for promoting insertion of a donor DNA at a desired target site in a fungal host cell genome.

公开(公告)号：US20160186102A1

公开(公告)日：2016-06-30

申请号：US14907707

申请日：2014-09-19

申请人： DANISCO US INC.

发明人： Guoqing Liu ,  Ling Hua ,  Zhen Qian ,  Danfeng Song ,  Zhongmei Tang ,  Xi Zhiyong ,  Bo Zhang ,  Zhengzheng Zou ,  Wei Xu ,  Richard R. Bott

IPC分类号： C11D3/386 ,  C12N9/28

CPC分类号： C11D3/386 ,  C12N9/2417 ,  C12Y302/01001

摘要： Disclosed are compositions and methods relating to alpha-amylase from a subset of Exiguobacterium. The compositions and methods are useful, for example, for starch liquefaction and saccharification, for cleaning starchy stains in laundry, dishwashing, and other applications, for textile processing (e.g., desizing), in animal feed for improving digestibility, and for baking and brewing.

摘要翻译： 公开了与来自Exiguobacterium的子集的α-淀粉酶有关的组合物和方法。 组合物和方法可用于例如淀粉液化和糖化，用于清洁衣物，餐具洗涤和其它应用中的淀粉污渍，用于织物加工（例如脱浆），用于改善消化率的动物饲料中，以及烘烤和酿造 。