公开(公告)号：US08492348B2

公开(公告)日：2013-07-23

申请号：US12490097

申请日：2009-06-23

申请人： Daria Mochly-Rosen ,  Rachel Bright

发明人： Daria Mochly-Rosen ,  Rachel Bright

IPC分类号： A61K38/08 ,  A61K38/16

CPC分类号： A61K38/45 ,  A61K38/08

摘要： Methods of increasing blood flow in a mammalian brain blood vessel characterized by, or otherwise experiencing, decreased blood flow due to an ischemic or other hypoxic event, vasoconstriction or vasospasm following hemorrhagic stroke; due to chronic high blood pressure; and/or due to idiopathic causes are provided. The method for increasing blood flow in such a mammalian brain blood vessel includes administering to a patient in need thereof a therapeutically effective amount of an inhibitor of δ protein kinase C. In certain embodiments, the inhibitor can be chronically administered without causing desensitization of the patient to the inhibitor. Kits for increasing blood flow in a mammalian brain blood vessel characterized by, or otherwise experiencing, decreased blood flow due to an ischemic or other hypoxic event, vasoconstriction or vasospasm following hemorrhagic stroke; due to chronic high blood pressure; and/or due to idiopathic causes are provided.

公开(公告)号：US08697120B2

公开(公告)日：2014-04-15

申请号：US11799573

申请日：2007-05-01

申请人： Corinne Bright ,  Rachel Bright ,  Eric Churchill ,  Kam W. Leong ,  Daria Mochly-Rosen

发明人： Corinne Bright ,  Rachel Bright ,  Eric Churchill ,  Kam W. Leong ,  Daria Mochly-Rosen

IPC分类号： A61K9/127 ,  A61K9/14

CPC分类号： A61K9/14 ,  A61K9/5138 ,  A61K31/765 ,  A61K31/78 ,  A61K45/06

摘要： A method for protection of tissues subject to ischemic and/or reperfusion damage is provided. The method includes administering to the tissue a composition comprising nanodevices. The nanodevices can take the form of, for example, polymeric nanoparticles or lipidic nanoparticles. The nanodevices also find use in methods for reducing ischemic injury in tissue at risk of such injury, such as heart and brain tissue.

摘要翻译： 提供了一种保护缺血和/或再灌注损伤的组织的方法。 该方法包括向组织施用包含纳米装置的组合物。 纳米装置可以采用例如聚合物纳米颗粒或脂质纳米颗粒的形式。 纳米装置还可用于减少患有这种损伤风险的组织中的缺血性损伤的方法，例如心脏和脑组织。

公开(公告)号：US20070066526A1

公开(公告)日：2007-03-22

申请号：US11514666

申请日：2006-09-01

申请人： Daria Mochly-Rosen ,  Koichi Inagaki ,  Rachel Bright

发明人： Daria Mochly-Rosen ,  Koichi Inagaki ,  Rachel Bright

IPC分类号： A61K38/55

CPC分类号： A61K38/08 ,  A61K9/0004 ,  A61K38/45 ,  A61K47/64

摘要： A method for reducing the risk of stroke in a subject with hypertension is described. The method includes administering an inhibitor of delta protein kinase C (PKC) to the subject. Also described is a method for improving the survival from stroke in a subject with chronic hypertension by treating the subject with an inhibitor of delta PKC.

摘要翻译： 描述了降低高血压患者中风风险的方法。 该方法包括向受试者施用δ蛋白激酶C（PKC）抑制剂。 还描述了通过用抑制剂PKC治疗受试者来改善慢性高血压患者的卒中存活的方法。

公开(公告)号：US20090270328A1

公开(公告)日：2009-10-29

申请号：US12490097

申请日：2009-06-23

申请人： Daria Mochly-Rosen ,  Rachel Bright

发明人： Daria Mochly-Rosen ,  Rachel Bright

IPC分类号： A61K38/17 ,  A61K38/08 ,  A61K38/10 ,  A61P7/00

CPC分类号： A61K38/45 ,  A61K38/08

摘要： Methods of increasing blood flow in a mammalian brain blood vessel characterized by, or otherwise experiencing, decreased blood flow due to an ischemic or other hypoxic event, vasoconstriction or vasospasm following hemorrhagic stroke; due to chronic high blood pressure; and/or due to idiopathic causes are provided. The method for increasing blood flow in such a mammalian brain blood vessel includes administering to a patient in need thereof a therapeutically effective amount of an inhibitor of δ protein kinase C. In certain embodiments, the inhibitor can be chronically administered without causing desensitization of the patient to the inhibitor. Kits for increasing blood flow in a mammalian brain blood vessel characterized by, or otherwise experiencing, decreased blood flow due to an ischemic or other hypoxic event, vasoconstriction or vasospasm following hemorrhagic stroke; due to chronic high blood pressure; and/or due to idiopathic causes are provided.

摘要翻译： 增加哺乳动物脑血管中血流量的方法，其特征在于或以其他方式经历由于缺血性或其他缺氧事件导致的血流减少，出血性中风后的血管收缩或血管痉挛; 由于慢性高血压; 和/或由于特发原因而提供。 用于增加这种哺乳动物脑血管中的血流量的方法包括向有需要的患者施用治疗有效量的δ-蛋白激酶C抑制剂。在某些实施方案中，抑制剂可以长期施用而不引起患者的脱敏 到抑制剂。 用于增加哺乳动物脑血管中的血液流动，其特征在于或以其他方式经历由于缺血性或其他缺氧事件引起的血流减少，出血性中风后的血管收缩或血管痉挛; 由于慢性高血压; 和/或由于特发原因而提供。

公开(公告)号：US20060148702A1

公开(公告)日：2006-07-06

申请号：US11317806

申请日：2005-12-23

申请人： Daria Mochly-Rosen ,  Rachel Bright

发明人： Daria Mochly-Rosen ,  Rachel Bright

IPC分类号： A61K38/17 ,  A61K38/10 ,  A61K38/08

CPC分类号： A61K38/45 ,  A61K38/08

摘要： Methods of increasing blood flow in a mammalian brain blood vessel characterized by, or otherwise experiencing, decreased blood flow due to an ischemic or other hypoxic event, vasoconstriction or vasospasm following hemorrhagic stroke; due to chronic high blood pressure; and/or due to idiopathic causes are provided. The method for increasing blood flow in such a mammalian brain blood vessel includes administering to a patient in need thereof a therapeutically effective amount of an inhibitor of δ protein kinase C. In certain embodiments, the inhibitor can be chronically administered without causing desensitization of the patient to the inhibitor. Kits for increasing blood flow in a mammalian brain blood vessel characterized by, or otherwise experiencing, decreased blood flow due to an ischemic or other hypoxic event, vasoconstriction or vasospasm following hemorrhagic stroke; due to chronic high blood pressure; and/or due to idiopathic causes are provided.

公开(公告)号：US07563772B2

公开(公告)日：2009-07-21

申请号：US11317806

申请日：2005-12-23

申请人： Daria Mochly-Rosen ,  Rachel Bright

发明人： Daria Mochly-Rosen ,  Rachel Bright

IPC分类号： A61K38/08

CPC分类号： A61K38/45 ,  A61K38/08

摘要： Methods of increasing blood flow in a mammalian brain blood vessel characterized by, or otherwise experiencing, decreased blood flow due to an ischemic or other hypoxic event, vasoconstriction or vasospasm following hemorrhagic stroke; due to chronic high blood pressure; and/or due to idiopathic causes are provided. The method for increasing blood flow in such a mammalian brain blood vessel includes administering to a patient in need thereof a therapeutically effective amount of an inhibitor of δ protein kinase C. In certain embodiments, the inhibitor can be chronically administered without causing desensitization of the patient to the inhibitor. Kits for increasing blood flow in a mammalian brain blood vessel characterized by, or otherwise experiencing, decreased blood flow due to an ischemic or other hypoxic event, vasoconstriction or vasospasm following hemorrhagic stroke; due to chronic high blood pressure; and/or due to idiopathic causes are provided.

摘要翻译： 增加哺乳动物脑血管中血流量的方法，其特征在于或以其他方式经历由于缺血性或其他缺氧事件导致的血流减少，出血性中风后的血管收缩或血管痉挛; 由于慢性高血压; 和/或由于特发原因而提供。 用于增加这种哺乳动物脑血管中的血流量的方法包括向有需要的患者施用治疗有效量的δ-蛋白激酶C抑制剂。在某些实施方案中，抑制剂可以长期施用而不引起患者的脱敏 到抑制剂。 用于增加哺乳动物脑血管中的血液流动，其特征在于或以其他方式经历由于缺血性或其他缺氧事件引起的血流减少，出血性中风后的血管收缩或血管痉挛; 由于慢性高血压; 和/或由于特发原因而提供。

公开(公告)号：US20110196474A1

公开(公告)日：2011-08-11

申请号：US12704136

申请日：2010-02-11

申请人： Dariush Davalian ,  Syed Faiyaz Ahmed Hossainy ,  Rachel Bright ,  Jinping Wan ,  Florian Niklas Ludwig

发明人： Dariush Davalian ,  Syed Faiyaz Ahmed Hossainy ,  Rachel Bright ,  Jinping Wan ,  Florian Niklas Ludwig

IPC分类号： A61F2/82 ,  A61K47/02 ,  A61K9/14 ,  A61K9/127 ,  A61P35/00 ,  A61P9/10

CPC分类号： A61K31/436 ,  A61K9/0009 ,  A61K9/0019 ,  A61K9/19 ,  A61K9/5094

摘要： Compositions of matter comprising a magnetically sensitive drug carrier and a related drug as well as methods for administering these compositions and causing them to localize within the patient using an internal or external magnetic field are described.

摘要翻译： 描述了包含磁敏感药物载体和相关药物的物质组合物以及用于施用这些组合物并使其使用内部或外部磁场定位在患者体内的方法。

公开(公告)号：US07985728B1

公开(公告)日：2011-07-26

申请号：US11858862

申请日：2007-09-20

申请人： Katsuyuki Murase ,  Li Zhao ,  Irina Astafieva ,  Paul M. Consigny ,  Stephen D. Pacetti ,  Dariush Davalian ,  Syed Fayaiz Ahmed Hossainy ,  Florian N. Ludwig ,  Jinping Wan ,  John Stankus ,  Rachel Bright

发明人： Katsuyuki Murase ,  Li Zhao ,  Irina Astafieva ,  Paul M. Consigny ,  Stephen D. Pacetti ,  Dariush Davalian ,  Syed Fayaiz Ahmed Hossainy ,  Florian N. Ludwig ,  Jinping Wan ,  John Stankus ,  Rachel Bright

IPC分类号： C07K14/00 ,  A61K38/00

CPC分类号： C07K14/775 ,  A61K38/00

摘要： A method including advancing a delivery device through a lumen of a blood vessel to a particular region in the blood vessel; and introducing a composition including a sustained-release carrier and an apolipoprotein A-I (Apo A-I) synthetic mimetic peptide into a wall of the blood vessel at the particular region, wherein the peptide has a property that renders the peptide effective in reverse cholesterol transport. A composition including an apolipoprotein A-I (Apo A-I) synthetic peptide, or combination of an Apo A-I synthetic mimetic peptide and an Acyl CoA cholesterol: acyltransferase (ACAT) inhibitor in a form suitable for delivery into a blood vessel, the peptide including an amino acid sequence in an order reverse to an order of various Apo A-I mimetic peptides, or endogenous Apo A-I analogs, or a chimera of helix 1 and helix 9 of endogenous Apo A-I.

摘要翻译： 一种方法，包括使输送装置通过血管的内腔前进到血管中的特定区域; 并将包含持续释放载体和载脂蛋白A-I（Apo A-I）合成模拟肽的组合物引入所述特定区域的血管壁中，其中所述肽具有使所述肽在反向胆固醇转运中有效的性质。 一种包含载体载脂蛋白AI（Apo AI）合成肽或Apo AI合成模拟肽和Acyl CoA胆固醇：酰基转移酶（ACAT）抑制剂的组合的组合物，其形式适于递送到血管中，所述肽包含氨基酸 序列的顺序与各种Apo AI模拟肽或内源性Apo AI类似物的顺序相反，或内源Apo AI的螺旋1和螺旋9的嵌合体。

公开(公告)号：US08735344B2

公开(公告)日：2014-05-27

申请号：US13177476

申请日：2011-07-06

申请人： Katsuyuki Murase ,  Li Zhao ,  Irina Astafieva ,  Paul M. Consigny ,  Stephen D. Pacetti ,  Dariush Davalian ,  Syed Fayaiz Ahmed Hossainy ,  Florian N. Ludwig ,  Jinping Wan ,  John Stankus ,  Rachel Bright

发明人： Katsuyuki Murase ,  Li Zhao ,  Irina Astafieva ,  Paul M. Consigny ,  Stephen D. Pacetti ,  Dariush Davalian ,  Syed Fayaiz Ahmed Hossainy ,  Florian N. Ludwig ,  Jinping Wan ,  John Stankus ,  Rachel Bright

IPC分类号： C07K14/00 ,  A61K38/00

CPC分类号： C07K14/775 ,  A61K38/00

摘要： A method including advancing a delivery device through a lumen of a blood vessel to a particular region in the blood vessel; and introducing a composition including a sustained-release carrier and an apolipoprotein A-I (Apo A-I) synthetic mimetic peptide into a wall of the blood vessel at the particular region, wherein the peptide has a property that renders the peptide effective in reverse cholesterol transport. A composition including an apolipoprotein A-I (Apo A-I) synthetic peptide, or combination of an Apo A-I synthetic mimetic peptide and an Acyl CoA cholesterol: acyltransferase (ACAT) inhibitor in a form suitable for delivery into a blood vessel, the peptide including an amino acid sequence in an order reverse to an order of various Apo A-I mimetic peptides, or endogenous Apo A-I analogs, or a chimera of helix 1 and helix 9 of endogenous Apo A-I.

摘要翻译： 一种方法，包括使输送装置通过血管的内腔前进到血管中的特定区域; 并将包含持续释放载体和载脂蛋白A-I（Apo A-I）合成模拟肽的组合物引入所述特定区域的血管壁中，其中所述肽具有使所述肽在反向胆固醇转运中有效的性质。 一种包含载体载脂蛋白AI（Apo AI）合成肽或Apo AI合成模拟肽和Acyl CoA胆固醇：酰基转移酶（ACAT）抑制剂的组合的组合物，其形式适于递送到血管中，所述肽包含氨基酸 序列的顺序与各种Apo AI模拟肽或内源性Apo AI类似物的顺序相反，或内源Apo AI的螺旋1和螺旋9的嵌合体。

公开(公告)号：US20090270787A1

公开(公告)日：2009-10-29

申请号：US12108167

申请日：2008-04-23

申请人： Randolf von Oepen ,  Travis R. Yribarren ,  Kevin J. Ehrenreich ,  William E. Webler, JR. ,  Binh T. Nguyen ,  Mina Chow ,  Gregory W. Chan ,  Rachel Bright

发明人： Randolf von Oepen ,  Travis R. Yribarren ,  Kevin J. Ehrenreich ,  William E. Webler, JR. ,  Binh T. Nguyen ,  Mina Chow ,  Gregory W. Chan ,  Rachel Bright

IPC分类号： A61M25/00

CPC分类号： A61M25/10 ,  A61B18/1492 ,  A61B18/24 ,  A61B2017/22051 ,  A61B2018/00238 ,  A61B2018/2272 ,  A61M2025/0024 ,  A61M2025/105 ,  A61M2025/1086

摘要： A system for enlarging endothelium migration channels at a treatment site in a coronary vessel wall, to enable enhanced delivery of a therapeutic agent thereto. The system includes an enlarging agent, for enlarging endothelium migration channels at a treatment site in a coronary vessel wall. It also includes a delivery system, for delivering the enlarging agent to the treatment site, so that the enlarging agent will be delivered thereby to enlarge the endothelium migration channels at the treatment site, and for delivering the therapeutic agent to the delivery site. The therapeutic agent will thereby be delivered into the enlarged migration channels at the treatment site, to treat the treatment site with the therapeutic agent.

摘要翻译： 一种用于在冠状血管壁的治疗部位扩大内皮迁移通道的系统，以便能够增强治疗剂的递送。 该系统包括放大剂，用于在冠状血管壁的治疗部位扩大内皮迁移通道。 它还包括用于将放大剂递送到治疗部位的递送系统，以便扩大剂将被递送，从而扩大治疗部位的内皮迁移通道，并将治疗剂输送到递送部位。 因此，治疗剂将被输送到治疗部位的扩大的移植通道中，用治疗剂治疗治疗部位。