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    APO A-I MIMETIC PEPTIDES AND METHODS OF TREATMENT
    5.
    发明申请
    APO A-I MIMETIC PEPTIDES AND METHODS OF TREATMENT 有权
    APO A-I MIME技术和治疗方法

    公开(公告)号：US20110263497A1

    公开(公告)日：2011-10-27

    申请号：US13177473

    申请日：2011-07-06

    申请人： Katsuyuki Murase ,  Li Zhao ,  Irina Astafieva ,  Paul M. Consigny

    发明人： Katsuyuki Murase ,  Li Zhao ,  Irina Astafieva ,  Paul M. Consigny

    IPC分类号： A61K38/10 ,  A61P9/10

    CPC分类号： A61K38/17 ,  A61K31/661 ,  A61K38/10 ,  A61K38/1709

    摘要： A method including advancing a delivery device through a lumen of a blood vessel to a particular region in the blood vessel; and introducing a synthetic apolipoprotein A-1 (Apo A-I) mimetic peptide into a wall of the blood vessel at the particular region, wherein the peptide has a property that renders the peptide effective in reverse cholesterol transport. A composition including a synthetic apolipoprotein A-I (Apo A-I) mimetic peptide, or combination of an Apo A-I synthetic peptide and an Acyl CoA cholesterol: acyltransferase (ACAT) inhibitor in a form suitable for delivery into a blood vessel, the peptide including an amino acid sequence in an order reverse to an order of an endogenous Apo A-I related peptide. A composition including an apolipoprotein A-1 (Apo A-I) synthetic peptide in a form suitable for delivery into a blood vessel, the peptide including an amino acid backbone that has less amino acid residues relative to endogenous Apo A-I and a chimera of helix 1 and helix 9 of Apo A-I.

    摘要翻译： 一种方法，包括使输送装置通过血管的内腔前进到血管中的特定区域; 并将合成的载脂蛋白A-1（Apo A-I）模拟肽引入特定区域的血管壁，其中该肽具有使肽在反向胆固醇转运中有效的性质。 包含合适的载脂蛋白AI（Apo AI）模拟肽或Apo AI合成肽和Acyl CoA胆固醇：酰基转移酶（ACAT）抑制剂的组合的组合物，其形式适于递送到血管中，所述肽包含氨基酸 序列以与内源性Apo AI相关肽的顺序相反的顺序。 一种组合物，其包含适于递送至血管的形式的载脂蛋白A-1（Apo AI）合成肽，所述肽包含相对于内源性Apo AI具有较少氨基酸残基的氨基酸主链和螺旋1的嵌合体， Apo AI的螺旋9。