公开(公告)号：US20130317079A1

公开(公告)日：2013-11-28

申请号：US13592403

申请日：2012-08-23

申请人： Darren H. Wakefield ,  David B. Rozema ,  Nicholas Rossi ,  Lauren Almeida ,  Anthony L. Perillo-Nicholas

发明人： Darren H. Wakefield ,  David B. Rozema ,  Nicholas Rossi ,  Lauren Almeida ,  Anthony L. Perillo-Nicholas

IPC分类号： A61K47/32

CPC分类号： B25F5/02 ,  A61K47/32 ,  A61K47/58 ,  B23D45/16 ,  B23Q13/00 ,  B27B5/29 ,  B27B9/00 ,  C08F220/00 ,  C08F220/34 ,  C08F220/36 ,  C08F220/18

摘要： The present invention is directed membrane active poly(acrylate) polymers and compositions for targeted delivery of RNA interference (RNAi) polynucleotides cells in vivo. RNAi polynucleotides are conjugated to the poly(acrylate) polymers and the polymers are reversibly modified to enable in vivo targeted delivery. Membrane activity of the poly(acrylate) provides for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness.

公开(公告)号：US08933047B2

公开(公告)日：2015-01-13

申请号：US13592403

申请日：2012-08-23

申请人： Darren H. Wakefield ,  David B. Rozema ,  Nicholas Rossi ,  Lauren Almeida ,  Anthony L. Perillo-Nicholas

发明人： Darren H. Wakefield ,  David B. Rozema ,  Nicholas Rossi ,  Lauren Almeida ,  Anthony L. Perillo-Nicholas

IPC分类号： C12N15/11 ,  C08F20/10 ,  C08F120/10 ,  C08F220/10 ,  A61K47/32 ,  C08F220/00 ,  C08F220/36

CPC分类号： B25F5/02 ,  A61K47/32 ,  A61K47/58 ,  B23D45/16 ,  B23Q13/00 ,  B27B5/29 ,  B27B9/00 ,  C08F220/00 ,  C08F220/34 ,  C08F220/36 ,  C08F220/18

摘要： The present invention is directed membrane active poly(acrylate) polymers and compositions for targeted delivery of RNA interference (RNAi) polynucleotides cells in vivo. RNAi polynucleotides are conjugated to the poly(acrylate) polymers and the polymers are reversibly modified to enable in vivo targeted delivery. Membrane activity of the poly(acrylate) provides for movement of the RNAi polynucleotides from outside the cell to inside the cell. Reversible modification provides physiological responsiveness.

摘要翻译： 本发明涉及膜活性聚（丙烯酸酯）聚合物和用于在体内靶向递送RNA干扰（RNAi）多核苷酸细胞的组合物。 RNAi多核苷酸与聚（丙烯酸酯）聚合物缀合，并且可逆地修饰聚合物以实现体内靶向递送。 聚（丙烯酸酯）的膜活性提供了从细胞外部到细胞内的RNAi多核苷酸的移动。 可逆修饰提供生理反应。