公开(公告)号：US20210340127A1

公开(公告)日：2021-11-04

申请号：US16976363

申请日：2019-02-26

Applicant: Dart NeuroScience, LLC

Inventor： Jillian Basinger Thompson ,  Brett C. Bookser ,  Scott Burley ,  Pablo Garcia-Reynaga ,  Andrew Hudson ,  Marco Peters ,  Benjamin Pratt ,  Aaron Thompson ,  Joe Tran ,  Lino Valdez

IPC: C07D405/12 ,  A61P25/28 ,  C07D309/14 ,  C07C211/40 ,  C07C237/24 ,  C07C255/46 ,  C07D213/38 ,  C07D401/12 ,  C07D211/96 ,  C07D211/58 ,  C07D207/14 ,  C07D211/76 ,  C07D207/273

Abstract: Substituted cyclohexyl chemical entities of Formula (I): wherein Ra, G, and Rb have any of the values described herein, and compositions comprising such chemical entities; methods of making them; and their use in a wide range of methods, including metabolic and reaction kinetic studies; detection and imaging techniques; radioactive therapies; modulating and treating disorders mediated by nociceptin activity or dopamine signaling; treating neurological disorders, neurodegenerative diseases, depression, and schizophrenia; enhancing the efficiency of cognitive and motor training; and treating peripheral disorders, including renal, respiratory, gastrointestinal, liver, genitourinary, metabolic, and inflammatory disorders.

公开(公告)号：US20230144411A1

公开(公告)日：2023-05-11

申请号：US17841570

申请日：2022-06-15

Applicant: Dart NeuroScience, LLC

Inventor： Jillian Basinger Thompson ,  Brett C. Bookser ,  Scott Burley ,  Pablo Garcia-Reynaga ,  Andrew Hudson ,  Marco Peters ,  Benjamin Pratt ,  Aaron Thompson ,  Joe Tran ,  Lino Valdez

IPC: C07D405/12 ,  A61P25/28 ,  C07C211/40 ,  C07C237/24 ,  C07C255/46 ,  C07D207/14 ,  C07D207/273 ,  C07D211/58 ,  C07D211/76 ,  C07D211/96 ,  C07D213/38 ,  C07D309/14 ,  C07D401/12

CPC classification number: C07D405/12 ,  A61P25/28 ,  C07C211/40 ,  C07C237/24 ,  C07C255/46 ,  C07D207/14 ,  C07D207/273 ,  C07D211/58 ,  C07D211/76 ,  C07D211/96 ,  C07D213/38 ,  C07D309/14 ,  C07D401/12 ,  C07C2601/08 ,  C07C2601/16 ,  C07C2601/14

Abstract: Substituted cyclohexyl chemical entities of Formula (I):






wherein Ra, G, and Rb have any of the values described herein, and compositions comprising such chemical entities; methods of making them; and their use in a wide range of methods, including metabolic and reaction kinetic studies; detection and imaging techniques; radioactive therapies; modulating and treating disorders mediated by nociceptin activity or dopamine signaling; treating neurological disorders, neurodegenerative diseases, depression, and schizophrenia; enhancing the efficiency of cognitive and motor training; and treating peripheral disorders, including renal, respiratory, gastrointestinal, liver, genitourinary, metabolic, and inflammatory disorders.

公开(公告)号：US11365191B2

公开(公告)日：2022-06-21

申请号：US16976363

申请日：2019-02-26

Applicant: Dart NeuroScience, LLC

Inventor： Jillian Basinger Thompson ,  Brett C. Bookser ,  Scott Burley ,  Pablo Garcia-Reynaga ,  Andrew Hudson ,  Marco Peters ,  Benjamin Pratt ,  Aaron Thompson ,  Joe Tran ,  Lino Valdez

IPC: C07D405/12 ,  C07D213/38 ,  C07C255/46 ,  C07D211/76 ,  C07D207/14 ,  C07D207/273 ,  C07C211/40 ,  C07D211/58 ,  C07D309/14 ,  C07D401/12 ,  C07C237/24 ,  C07D211/96 ,  A61P25/28

Abstract: Substituted cyclohexyl chemical entities of Formula (I): wherein Ra, G, and Rb have any of the values described herein, and compositions comprising such chemical entities; methods of making them; and their use in a wide range of methods, including metabolic and reaction kinetic studies; detection and imaging techniques; radioactive therapies; modulating and treating disorders mediated by nociceptin activity or dopamine signaling; treating neurological disorders, neurodegenerative diseases, depression, and schizophrenia; enhancing the efficiency of cognitive and motor training; and treating peripheral disorders, including renal, respiratory, gastrointestinal, liver, genitourinary, metabolic, and inflammatory disorders.

公开(公告)号：US11945808B2

公开(公告)日：2024-04-02

申请号：US17841570

申请日：2022-06-15

Applicant: Dart NeuroScience, LLC

Inventor： Jillian Basinger Thompson ,  Brett C. Bookser ,  Scott Burley ,  Pablo Garcia-Reynaga ,  Andrew Hudson ,  Marco Peters ,  Benjamin Pratt ,  Aaron Thompson ,  Joe Tran ,  Lino Valdez

IPC: C07D309/14 ,  A61P25/28 ,  C07C211/40 ,  C07C237/24 ,  C07C255/46 ,  C07D207/14 ,  C07D207/273 ,  C07D211/58 ,  C07D211/76 ,  C07D211/96 ,  C07D213/38 ,  C07D401/12 ,  C07D405/12

CPC classification number: C07D405/12 ,  A61P25/28 ,  C07C211/40 ,  C07C237/24 ,  C07C255/46 ,  C07D207/14 ,  C07D207/273 ,  C07D211/58 ,  C07D211/76 ,  C07D211/96 ,  C07D213/38 ,  C07D309/14 ,  C07D401/12 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2601/16

Abstract: Substituted cyclohexyl chemical entities of Formula (I):






wherein Ra, G, and Rb have any of the values described herein, and compositions comprising such chemical entities; methods of making them; and their use in a wide range of methods, including metabolic and reaction kinetic studies; detection and imaging techniques; radioactive therapies; modulating and treating disorders mediated by nociceptin activity or dopamine signaling; treating neurological disorders, neurodegenerative diseases, depression, and schizophrenia; enhancing the efficiency of cognitive and motor training; and treating peripheral disorders, including renal, respiratory, gastrointestinal, liver, genitourinary, metabolic, and inflammatory disorders.