公开(公告)号：US20160238597A1

公开(公告)日：2016-08-18

申请号：US15040631

申请日：2016-02-10

申请人： Darya Y. Orlova ,  David R. Parks ,  Leonore A. Herzenberg ,  Andrei V. Chernyshev ,  Alexander E. Moskalensky

发明人： Darya Y. Orlova ,  David R. Parks ,  Leonore A. Herzenberg ,  Andrei V. Chernyshev ,  Alexander E. Moskalensky

IPC分类号： G01N33/557

CPC分类号： G01N33/557 ,  G01N15/14 ,  G01N33/4915 ,  G01N2333/7051 ,  G01N2333/70517

摘要： The described invention provides a method for quantifying cellular antigens that is independent of specially prepared calibration beads and antibody reagents. The described method can be applied to both low and high affinity antibodies, under both saturating and non-saturating binding conditions.

摘要翻译： 所述的发明提供了一种定量细胞抗原的方法，其独立于专门制备的校准珠和抗体试剂。 所描述的方法可以在饱和和非饱和结合条件下应用于低亲和力高亲和力抗体。

公开(公告)号：US20180018386A1

公开(公告)日：2018-01-18

申请号：US15652194

申请日：2017-07-17

申请人： Darya Y. Orlova ,  Stephen W. Meehan ,  Wayne A. Moore ,  Guenther Walther ,  David R. Parks ,  Leonore A. Herzenberg

发明人： Darya Y. Orlova ,  Stephen W. Meehan ,  Wayne A. Moore ,  Guenther Walther ,  David R. Parks ,  Leonore A. Herzenberg

IPC分类号： G06F17/30 ,  G01N15/14 ,  G06F3/0484 ,  G06T11/20 ,  G06F3/0482 ,  G01N15/10 ,  G01N15/00

摘要： Some embodiments provide methods, systems and computer-readable media that employ adaptive binning and dissimilarity scores based on a quadratic form distance for multidimensional data for matching clusters in data corresponding to different sample. Some embodiments provide methods, systems and computer-readable media for rendering a first interactive display including a two-dimensional plot of at least a portion of a multidimensional data set and a corresponding second interactive display including a plurality of single parameter charts or histograms, each displaying information corresponding to one-dimensional measurements of a different parameter in the multidimensional data set.

公开(公告)号：US10685045B2

公开(公告)日：2020-06-16

申请号：US15652194

申请日：2017-07-17

申请人： Darya Y. Orlova ,  Stephen W. Meehan ,  Wayne A. Moore ,  Guenther Walther ,  David R. Parks ,  Leonore A. Herzenberg ,  Connor Meehan

发明人： Darya Y. Orlova ,  Stephen W. Meehan ,  Wayne A. Moore ,  Guenther Walther ,  David R. Parks ,  Leonore A. Herzenberg ,  Connor Meehan

IPC分类号： G06F7/02 ,  G06F16/00 ,  G06F16/28 ,  G06F3/0482 ,  G06F3/0484 ,  G06T11/20 ,  G01N15/14 ,  G06F16/2457 ,  G01N15/10 ,  G01N15/00

摘要： Some embodiments provide methods, systems and computer-readable media that employ adaptive binning and dissimilarity scores based on a quadratic form distance for multidimensional data for matching clusters in data corresponding to different sample. Some embodiments provide methods, systems and computer-readable media for rendering a first interactive display including a two-dimensional plot of at least a portion of a multidimensional data set and a corresponding second interactive display including a plurality of single parameter charts or histograms, each displaying information corresponding to one-dimensional measurements of a different parameter in the multidimensional data set.

公开(公告)号：US20150293992A1

公开(公告)日：2015-10-15

申请号：US14691044

申请日：2015-04-20

申请人： Stephen W. Meehan ,  Wayne A. Moore ,  Guenther Walther ,  Darya Y. Orlova ,  Connor G.W. Meehan ,  David R. Parks ,  Leonore A. Herzenberg

发明人： Stephen W. Meehan ,  Wayne A. Moore ,  Guenther Walther ,  Darya Y. Orlova ,  Connor G.W. Meehan ,  David R. Parks ,  Leonore A. Herzenberg

IPC分类号： G06F17/30

CPC分类号： G06F16/285 ,  G01N15/1459 ,  G01N2015/1402 ,  G01N2015/1477 ,  G01N2015/1488 ,  G06F16/2237 ,  G06F16/2246 ,  G06F17/18 ,  G06K9/00147 ,  G06K9/627

摘要： The described invention provides a method and/or system for analyzing data using population clustering through density based merging, and a method for guiding clustering strategy through entropy-based ranking score.

摘要翻译： 所描述的发明提供了一种使用基于密度的合并的群体聚类来分析数据的方法和/或系统，以及通过基于熵的排名得分来指导聚类策略的方法。