公开(公告)号：US09655530B2

公开(公告)日：2017-05-23

申请号：US13098344

申请日：2011-04-29

申请人： Dave Eshbaugh ,  Oliver Goedje ,  Matthias Bohn

发明人： Dave Eshbaugh ,  Oliver Goedje ,  Matthias Bohn

IPC分类号： A61B5/02 ,  A61B5/021 ,  A61B5/00

CPC分类号： A61B5/02141 ,  A61B5/6824 ,  A61B5/684 ,  A61B2560/0406 ,  A61B2562/16

摘要： Improved apparatus and methods for non-invasively assessing one or more physiologic (e.g., hemodynamic) parameters associated with a living organism. In one embodiment, the invention comprises an apparatus adapted to automatically and accurately place and maintain a sensor (e.g., tonometric pressure sensor) with respect to the anatomy of the subject. The apparatus is comprised of a sensor device removably coupled to a host device which is used to position the sensor during measurements. Methods for positioning the alignment apparatus and sensor, and operating the apparatus, are also disclosed.

公开(公告)号：US20120277597A1

公开(公告)日：2012-11-01

申请号：US13098344

申请日：2011-04-29

申请人： Dave Eshbaugh ,  Oliver Goedje ,  Matthias Bohn

发明人： Dave Eshbaugh ,  Oliver Goedje ,  Matthias Bohn

IPC分类号： A61B5/02

CPC分类号： A61B5/02141 ,  A61B5/6824 ,  A61B5/684 ,  A61B2560/0406 ,  A61B2562/16

摘要： Improved apparatus and methods for non-invasively assessing one or more physiologic (e.g., hemodynamic) parameters associated with a living organism. In one embodiment, the invention comprises an apparatus adapted to automatically and accurately place and maintain a sensor (e.g., tonometric pressure sensor) with respect to the anatomy of the subject. The apparatus is comprised of a sensor device removably coupled to a host device which is used to position the sensor during measurements. Methods for positioning the alignment apparatus and sensor, and operating the apparatus, are also disclosed.

摘要翻译： 用于非侵入性评估与活生物体相关联的一种或多种生理（例如，血液动力学）参数的改进的装置和方法。 在一个实施例中，本发明包括适于相对于对象的解剖结构自动且精确地放置和维持传感器（例如，压力计传感器）的装置。 该装置包括可拆卸地耦合到主机装置的传感器装置，其用于在测量期间定位传感器。 还公开了用于定位对准装置和传感器以及操作该装置的方法。

公开(公告)号：US08521248B2

公开(公告)日：2013-08-27

申请号：US12583345

申请日：2009-08-19

申请人： Marcus Veeck ,  Oliver Goedje ,  Robert Herz ,  Thomas Thalmeier ,  Christoph Manegold ,  Matthias Bohn

发明人： Marcus Veeck ,  Oliver Goedje ,  Robert Herz ,  Thomas Thalmeier ,  Christoph Manegold ,  Matthias Bohn

IPC分类号： A61B5/1455

CPC分类号： A61B5/14542 ,  A61B5/1459 ,  G02B6/443

摘要： In a fiber-optic probe for intravascular measurements, e.g. oxygen saturation measurements, the fiber-optical core has only two fibers. A single fiber core is also possible. A reinforcement fiber improves stiffness, kink resistance and overall strength of the probe. The reinforcement fiber is arranged essentially parallel to the core fibers. The reinforcement fiber may also be wound around the core in a helical manner thus improving the mechanical properties to an even higher degree. The outside of the sheath is coated with an antithrombogenic coating for reducing the danger of clots forming at the surface. The reinforcement fiber may be made of carbon, metal, ceramics or aramide.

摘要翻译： 在用于血管内测量的光纤探针中，例如， 氧饱和度测量，光纤芯只有两根光纤。 单个纤芯也是可能的。 增强纤维提高了探头的刚度，扭结阻力和总体强度。 加强纤维基本上平行于芯纤维布置。 增强纤维也可以以螺旋方式缠绕在芯上，从而将机械性能提高到更高的程度。 护套的外侧涂有抗血栓形成的涂层，以减少在表面形成凝块的危险。 增强纤维可以由碳，金属，陶瓷或芳族聚酰胺制成。

公开(公告)号：US20070287929A1

公开(公告)日：2007-12-13

申请号：US11784003

申请日：2007-04-05

申请人： Oliver Goedje ,  Manu Malbrain ,  Stefan Joeken ,  Matthias Bohn

发明人： Oliver Goedje ,  Manu Malbrain ,  Stefan Joeken ,  Matthias Bohn

IPC分类号： A61B5/02

CPC分类号： A61B5/412 ,  A61B5/02028 ,  A61B5/028 ,  A61B5/029

摘要： From the global enddiastolic volume GEDV and the global ejection fraction GEF the patient monitor (4) determines a corrected global enddiastolic volume cGEDV according to cGEDV=GEDV/f(GEF) which is used as a novel paramater for volume responsiveness of the patient (3). In the above formula, f(GEF) is a correction function depending on global ejection fraction GEF. Further, from the right ventricular enddiastolic volume RVEDV and the right ventricular ejection fraction RVEF the patient monitor (4) determines a corrected right ventricular enddiastolic volume cRVEDV according to cRVEDV=RVEDV/f(RVEF) which is used as another novel paramater for volume responsiveness of the patient (3). In the above formula, f(RVEF) is a correction function depending on right ventricular ejection fraction RVEF.

摘要翻译： 根据全球末期舒张压体积GEDV和全局射血分数GEF，患者监护仪（4）根据<？in-line-formula description =“In-Line Formulas”end =“lead”？> cGEDV确定校正的全球末期舒张压体积cGEDV = GEDV / f（GEF）<？in-line-formula description =“In-line Formulas”end =“tail”？>，用作病人体积响应性的新型参数（3）。 在上述公式中，f（GEF）是取决于全局射血分数GEF的校正函数。 此外，从右心室舒张末期容积RVEDV和右心室射血分数RVEF，患者监护仪（4）根据<？线内公式描述=“在线公式”结束=“确定右心室末端舒张压体积cRVEDV” 引线“？> cRVEDV = RVEDV / f（RVEF）<？in-line-formula description =”In-line Formulas“end =”tail“？>它被用作患者体积响应性的另一个新型参数（3） 。 在上述公式中，f（RVEF）是取决于右心室射血分数RVEF的校正函数。

公开(公告)号：US20070073180A1

公开(公告)日：2007-03-29

申请号：US11527223

申请日：2006-09-26

申请人： Matthias Bohn ,  Oliver Goedje ,  Thomas Thalmeier

发明人： Matthias Bohn ,  Oliver Goedje ,  Thomas Thalmeier

IPC分类号： A61B5/02 ,  A61B5/00

CPC分类号： A61B5/029

摘要： Disclosed is an apparatus, a computer system, a computer program, a temperature sensor device and a heat transfer device by which thermodilution measurements can be carried out in a non-invasive or less invasive manner by using extravascular (transcutaneous or subcutaneous) temperature sensor devices and/or extravascular heat transfer devices.

摘要翻译： 公开了一种装置，计算机系统，计算机程序，温度传感器装置和热传递装置，通过使用血管外（经皮或皮下）温度传感器装置，可以以非侵入性或侵入性较小的方式进行热稀释测量 和/或血管外传热装置。

公开(公告)号：US20110238020A1

公开(公告)日：2011-09-29

申请号：US12737953

申请日：2009-09-02

申请人： Oliver Goedje ,  Marcus Veeck ,  Robert Herz ,  Matthias Bohn ,  Stephan Joeken

发明人： Oliver Goedje ,  Marcus Veeck ,  Robert Herz ,  Matthias Bohn ,  Stephan Joeken

IPC分类号： A61M5/32 ,  A61B5/00

CPC分类号： A61B5/02154 ,  A61B5/0261 ,  A61B5/028

摘要： The invention relates to a catheter device with an integrated fiber optic, in particular for use in thermodilution measurement and pulse contour analysis. The device comprises an arterial catheter (2) with a suitable intravascular part and a suitable extravascular part and an optical sensor unit for combined pressure and temperature measurement at a measurement location at the distal end of the suitable intravascular part or proximate to the distal end of the proper intravascular part of the catheter (2). The optical sensor unit comprises a fiber optic conductor (11) that runs from the measurement location to a proximal port.

摘要翻译： 本发明涉及具有集成光纤的导管装置，特别是用于热稀释测量和脉冲轮廓分析。 该装置包括具有合适的血管内部分和合适的血管外部分的动脉导管（2）和用于在合适的血管内部分的远端处或靠近远端的测量位置处的组合的压力和温度测量的光学传感器单元 导管（2）的适当的血管内部分。 光学传感器单元包括从测量位置延伸到近端口的光纤导体（11）。

公开(公告)号：US07850617B2

公开(公告)日：2010-12-14

申请号：US11784003

申请日：2007-04-05

申请人： Oliver Goedje ,  Manu Malbrain ,  Stephan Joeken ,  Matthias Bohn

发明人： Oliver Goedje ,  Manu Malbrain ,  Stephan Joeken ,  Matthias Bohn

IPC分类号： A61B5/02

CPC分类号： A61B5/412 ,  A61B5/02028 ,  A61B5/028 ,  A61B5/029

摘要： From the global end-diastolic volume GEDV and the global ejection fraction GEF the patient monitor (4) determines a corrected global end-diastolic volume cGEDV according to cGEDV=GEDV/ƒ(GEF) which is used as a novel parameter for volume responsiveness of the patient (3). In the above formula, f(GEF) is a correction function depending on global ejection fraction GEF. Further, from the right ventricular end-diastolic volume RVEDV and the right ventricular ejection fraction RVEF the patient monitor (4) determines a corrected right ventricular end-diastolic volume cRVEDV according to cRVEDV=RVEDV1f(RVEF) which is used as another novel parameter for volume responsiveness of the patient (3). In the above formula, f(RVEF) is a correction function depending on right ventricular ejection fraction RVEF.

摘要翻译： 从全球舒张末期容量GEDV和全球射血分数GEF，患者监护仪（4）根据cGEDV = GEDV /ƒ（GEF）确定校正的全身舒张末期容量cGEDV，其用作体积响应性的新参数 患者（3）。 在上述公式中，f（GEF）是取决于全局射血分数GEF的校正函数。 此外，从右心室舒张末期容积RVEDV和右心室射血分数RVEF，患者监测器（4）根据cRVEDV = RVEDV1f（RVEF）确定校正的右心室舒张末期容积cRVEDV，其用作另一新颖参数 患者的体积响应性（3）。 在上述公式中，f（RVEF）是取决于右心室射血分数RVEF的校正函数。

公开(公告)号：US20100049019A1

公开(公告)日：2010-02-25

申请号：US12583345

申请日：2009-08-19

申请人： Marcus Veeck ,  Oliver Goedje ,  Robert Herz ,  Thomas Thalmeier ,  Christoph Manegold ,  Matthias Bohn

发明人： Marcus Veeck ,  Oliver Goedje ,  Robert Herz ,  Thomas Thalmeier ,  Christoph Manegold ,  Matthias Bohn

IPC分类号： A61B5/1455

CPC分类号： A61B5/14542 ,  A61B5/1459 ,  G02B6/443

摘要： In a fiber-optic probe for intravascular measurements, e.g. oxygen saturation measurements, the fiber-optical core has only two fibers. A single fiber core is also possible. A reinforcement fiber improves stiffness, kink resistance and overall strength of the probe. The reinforcement fiber is arranged essentially parallel to the core fibers. The reinforcement fiber may also be wound around the core in a helical manner thus improving the mechanical properties to an even higher degree. The outside of the sheath is coated with an antithrombogenic coating for reducing the danger of clots forming at the surface. The reinforcement fiber may be made of carbon, metal, ceramics or aramide.

摘要翻译： 在用于血管内测量的光纤探针中，例如， 氧饱和度测量，光纤芯只有两根光纤。 单个纤芯也是可能的。 增强纤维提高了探头的刚度，扭结阻力和总体强度。 加强纤维基本上平行于芯纤维布置。 增强纤维也可以以螺旋方式缠绕在芯上，从而将机械性能提高到更高的程度。 护套的外侧涂有抗血栓形成的涂层，以减少在表面形成凝块的危险。 增强纤维可以由碳，金属，陶瓷或芳族聚酰胺制成。

公开(公告)号：US20080077043A1

公开(公告)日：2008-03-27

申请号：US11894204

申请日：2007-08-20

申请人： Manu Malbrain ,  Robert Herz ,  Matthias Bohn ,  Oliver Goedje

发明人： Manu Malbrain ,  Robert Herz ,  Matthias Bohn ,  Oliver Goedje

IPC分类号： A61B5/053 ,  A61M25/098 ,  A61M25/10

CPC分类号： A61M25/1011 ,  A61B5/036 ,  A61J15/0003 ,  A61J15/0049 ,  A61J15/0069 ,  A61J15/0073 ,  A61J15/0076 ,  A61J15/0084 ,  A61J15/0088 ,  A61M25/0032 ,  A61M2025/0002 ,  A61M2025/0036

摘要： The catheter has a proximal port with an opening of a feeding lumen. There are two further openings in another proximal port with a connector, to which a source/sink of gas pressure and a pressure gauge can be connected. The interior of a distal balloon communicates with the opening and can hence be inflated and deflated through that opening in order to measure intra-abdominal pressure using the pressure gauge. A reflux filter is integrated into the connector. In the upper connector piece or lower connector piece a recess surrounding the measurement lumen is provided at the contact surface between the connector pieces. The gas-permeable filter membrane is disposed in the recess for preventing liquids in the lumen from entering from the lower connector piece into the upper connector piece and thus from passing through the opening in case of rupture or leakage of the distal balloon.

摘要翻译： 导管具有近端端口，其具有进料腔的开口。 在具有连接器的另一个近端口中还有两个进一步的开口，可以连接气体压力的源/汇点和压力表。 远侧气囊的内部与开口连通，因此可以通过该开口膨胀和放气，以便使用压力计来测量腹内压力。 回流过滤器集成到连接器中。 在上连接件或下连接器件中，在连接件之间的接触表面处设置有围绕测量管腔的凹槽。 透气性过滤膜设置在凹部中，用于防止内腔中的液体从下连接件进入上连接件，从而在远端气囊破裂或泄漏的情况下穿过开口。

公开(公告)号：US20070175828A1

公开(公告)日：2007-08-02

申请号：US11699608

申请日：2007-01-30

申请人： Oliver Goedje ,  Thomas Thalmeier ,  Matthias Bohn

发明人： Oliver Goedje ,  Thomas Thalmeier ,  Matthias Bohn

IPC分类号： B01D61/00

CPC分类号： A61M1/30 ,  A61B5/028 ,  A61M1/367 ,  A61M2230/20

摘要： The device according to the invention serves to set up a dilution measurement site on a hemodialyzer. Using such a measurement site, it is possible to determine the filling status of a dialysis patient during dialysis treatment, by means of dilution measurements. Checking the fluid balance by means of weighing the dialysis patient, which is subject to error, can be eliminated. The arterial connection piece is connected with an arterial fistula needle, and the venous connection piece is connected with a venous fistula needle as the blood vessel access. The venous connection piece has an injection channel through which a bolus required to perform a dilution measurement can be injected into the blood, which flows through the venous connection piece coming from the hemodialyzer, in the direction of the venous blood vessel access. The arterial connection piece has a temperature sensor by means of which the temperature of the blood, which flows through the venous connection piece coming from the arterial blood vessel access, in the direction of the hemodialyzer, can be measured. The system response to the disruption caused in the bloodstream of the dialysis patient by means of the bolus injection can be determined by way of this temperature measurement, and the bloodstream filling status can be determined from this.

摘要翻译： 根据本发明的装置用于在血液透析器上建立稀释测量部位。 使用这样的测量部位，可以通过稀释测量来确定透析治疗期间透析患者的填充状态。 通过称量透析患者的误差检查液体平衡，可以消除。 动脉连接片与动脉瘘针连接，静脉连接片与静脉瘘针连接，作为血管通路。 静脉连接片具有注射通道，通过该注入通道可以进行进行稀释测量所需的推注物，其沿着静脉血管通路的方向注入流经血液透析器的静脉连接件的血液。 动脉连接片具有温度传感器，通过该温度传感器可以测量流过血液透析器方向的动脉血管的静脉连接片的血液的温度。 可以通过这种温度测量来确定通过推注注射在透析患者的血液中引起的破裂的系统响应，并且可以从此确定血流填充状态。