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1.发明授权Method and apparatus for filtering suspension of medical and biological fluids or the like 有权用于过滤医疗和生物流体等的悬浮液的方法和装置公开(公告)号：US06491819B2
公开(公告)日：2002-12-10
申请号：US09954734
申请日：2001-09-18
IPC分类号： B01D6114
CPC分类号： B01D65/08 , A61M1/262 , A61M1/265 , A61M1/34 , A61M1/3403 , A61M1/341 , A61M2202/0429 , A61M2202/0439 , A61M2205/3334 , B01D39/1692 , B01D61/147 , B01D61/22 , B01D63/16 , B01D69/02 , B01D2321/20 , B01D2321/2025 , B01D2321/2058 , B01D2321/2066 , A61M2202/0042 , A61M2202/0035
摘要： An apparatus is disclosed for separating a suspension comprising at least two types of particles which are differently sized or shaped and in which the first type of particle may be deformable at a relatively lower force or faster rate than the second type of particle. A housing is provided having a generally cylindrical inner surface in which is mounted a rotor having a generally cylindrical outer surface. The outer surface of the rotor is spaced from the inner surface of the housing to define a suspension processing gap. A filter membrane is provided on the surface of the rotor or the housing that has pores with substantially precisely dimensioned shapes and sizes to correspond substantially to the shape of the first type of particle, thus allowing passage of the first type of particle and blocking passage of the second type of particle. A suspension is directed into the processing gap for either a selected residence time in contact with the filter membrane and/or at a selected force.
摘要翻译： 公开了一种用于分离包含至少两种不同尺寸或形状的颗粒的悬浮液的装置，其中第一类型的颗粒可以以比第二类型的颗粒更低的力或更快的速率变形。 提供具有大致圆柱形内表面的壳体，其中安装有具有大致圆柱形外表面的转子。 转子的外表面与壳体的内表面间隔开以限定悬挂处理间隙。 在转子或壳体的表面上提供过滤膜，其具有基本上精确尺寸的形状和尺寸的孔，其基本上对应于第一类型的颗粒的形状，从而允许第一类型的颗粒和阻挡通道 第二种类型的粒子。 将悬浮液引导到处理间隙中以选择与过滤膜接触的停留时间和/或以选定的力。
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2.发明授权公开(公告)号：US06497821B1
公开(公告)日：2002-12-24
申请号：US09312883
申请日：1999-05-17
IPC分类号： B01D6100
CPC分类号： B01D65/08 , A61M1/262 , A61M1/265 , A61M1/34 , A61M1/3403 , A61M1/341 , A61M2202/0429 , A61M2202/0439 , A61M2205/3334 , B01D39/1692 , B01D61/147 , B01D61/22 , B01D63/16 , B01D69/02 , B01D2321/20 , B01D2321/2025 , B01D2321/2058 , B01D2321/2066 , A61M2202/0042 , A61M2202/0035
摘要： A method and apparatus for filtering suspensions of medical and biological fluids, one aspect of which is separating a suspension comprising at least two types of particles which are differently sized or shaped and in which the first type of particle may be deformable at a relatively lower force and/or faster rate than the second type of particle. A filter member is provided having substantially precisely dimensioned pore sizes, with the pores being dimensioned to allow passage of the first type of suspended particle without distortion or only minimal distortion and passage of the second type of particle only with substantial distortion. Because the filter membrane has precisely dimensioned pores, with spacing between the pores being maintained despite the smaller interval between the pores, the porosity of the membrane may be much greater than nominal pore size membranes, allowing faster filtration rates and/or smaller membranes for a given filtration rate, while reducing the exposure time of the cells within the shear environment, and consequently reducing particle damage. Various methods for preventing clogging of the membrane are also disclosed.
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