公开(公告)号：US5464579A

公开(公告)日：1995-11-07

申请号：US381028

申请日：1995-01-31

申请人： David Brown ,  Harald Gaul ,  Yosif Kushnir ,  Nick Travaglini ,  Victor Wilson

发明人： David Brown ,  Harald Gaul ,  Yosif Kushnir ,  Nick Travaglini ,  Victor Wilson

IPC分类号： B29C45/27 ,  B29C45/32

CPC分类号： B29C45/2758 ,  B29C45/322

摘要： An injection mold for use with a molding press has four mold levels in axially stacked relation, permitting a substantial doubling of output for a given size of press as compared with a back-to-back two level stacked mold. The mold feeder flow path extends axially from the injector head to a flow distribution block located at the centre of the stacked mold block series. The centrally located distribution block is connected, in sealed relation with the injector head, being axially displaceable therefrom in continuing sealed relation upon the opening of the mold. A drool prevention valve system, located at two of the mold interfaces, to preclude drooling of fluid plastic stock upon opening of the molds includes pressure fluid actuators for operating the valves, wherein the pressure fluid may comprise the fluid plastic stock. The valve system also includes a depressurizing valve provision, wherein, upon opening of the mold interfaces the stock distribution passages are substantially depressurized, to thereby reduce any tendency to drool. The mold includes axial adjustment means to compensate for differential variations in overall mold length within the press, due to changes in effective mold temperature.

摘要翻译： 与模压机一起使用的注射模具具有四个模具级别的轴向堆叠关系，与背对背两层堆叠模具相比，允许给定尺寸的压力机的输出大大加倍。 模具给料器流动路径从注射器头部轴向延伸到位于堆叠的模块系列的中心处的流量分配块。 位于中心的分配块与注射器头密封地连接，在模具的开口处以连续的密封关系从其中轴向移位。 位于两个模具界面的流口防止阀系统在打开模具时排除流体塑料原料的流出包括用于操作阀的压力流体致动器，其中压力流体可以包括流体塑料原料。 阀系统还包括减压阀的设置，其中，在打开模具界面时，库存分配通道基本上减压，从而减少流口水的倾向。 模具包括轴向调节装置，以补偿由于有效模具温度的变化而在压机内的整个模具长度的差异变化。

公开(公告)号：US5229145A

公开(公告)日：1993-07-20

申请号：US544453

申请日：1990-06-27

申请人： David Brown ,  Harald Gaul ,  Yosif Kushnir ,  Nick Travaglini ,  Victor Wilson

发明人： David Brown ,  Harald Gaul ,  Yosif Kushnir ,  Nick Travaglini ,  Victor Wilson

IPC分类号： B29C45/27 ,  B29C45/32

CPC分类号： B29C45/2758 ,  B29C45/322

摘要： An injection mold for use with a molding press has four mold levels in axially stacked relation, permitting a substantial doubling of output for a given size of press as compared with a back-to-back two level stacked mold. The mold feeder flow path extends axially from the injector head to a flow distribution block located at the center of the stacked mold block series. The centrally located distribution block is connected, in use isolation, sealed relation with the injector head, being axially displaceable therefrom in continuing sealed relation upon the opening of the mold. A drool prevention valve system, located at two of the mold interfaces, to preclude drooling of fluid plastic stock upon opening of the molds includes pressure fluid actuators for operating the valves, wherein the pressure fluid may comprise the fluid plastic stock. The valve system also includes a depressurizing valve provision, wherein, upon opening of the mold interfaces the stock distribution passages are substantially depressurized, to thereby reduce any tendency to drool. The mold includes axial adjustment means to compensate for differential variations in overall mold length within the press, due to changes in effective mold temperature.

摘要翻译： 与模压机一起使用的注射模具具有四个模具级别的轴向堆叠关系，与背对背两层堆叠模具相比，允许给定尺寸的压力机的输出大大加倍。 模具给料器流动路径从注射器头部轴向延伸到位于堆叠的模块系列的中心处的流量分配块。 位于中心的分配块在使用隔离中与注射器头连接，在模具的开口处以连续的密封关系从其中轴向移位。 位于两个模具界面的流口防止阀系统在打开模具时排除流体塑料原料的流出包括用于操作阀的压力流体致动器，其中压力流体可以包括流体塑料原料。 阀系统还包括减压阀的设置，其中，在打开模具界面时，库存分配通道基本上减压，从而减少流口水的倾向。 模具包括轴向调节装置，以补偿由于有效模具温度的变化而在压机内的整个模具长度的差异变化。

公开(公告)号：US5458843A

公开(公告)日：1995-10-17

申请号：US334837

申请日：1994-11-04

申请人： David Brown ,  Nick Travaglini

发明人： David Brown ,  Nick Travaglini

IPC分类号： B29C45/27 ,  B29C45/32

CPC分类号： B29C45/322 ,  B29C45/2758

摘要： A multi-level stacked mold having at least two and as many as four levels of cavities has a stock distribution mold block centred axially of the stacked mold blocks, the axially extending stock inlet passage to the distribution block connecting with radially off-set stock transfer passages that cross the axially openable mold block interfaces, into the adjoining mold blocks. These openable stock transfer passages, are each provided at their respective, non-encapsulated, radially off-set, opening interfaces with a valveless anti-drool arrangement. The mold flow passage system is subject to continual, extreme, thermal cycling and cyclical mechanical loading, during the repeated opening-and-closing cycles of the mold. Each separable anti-drool sealing interface has a relatively axially displaceable portion extending to bridge the initial gap opening between adjacent mold blocks and serving as an expansible piston means. This extension of the displaceable "expansible piston means" portion is pressure responsive and serves to increase the internal volume of the adjacent transfer passage, while permitting equalizing the pressure of stock in the passage to atmospheric pressure, thus reducing the likelihood of the drooling of liquid plastic into the opening interspace, or the induction of atmospheric air into the flow passages.

摘要翻译： 具有至少两个且多达四个等级的空腔的多层堆叠模具具有沿着堆叠的模块的轴向定位的坯料分配模块，通向分配块的轴向延伸的料料入口通道与径向偏移的原料转移 穿过可轴向打开的模块接口的通道进入相邻的模具块。 这些可开启的库存传送通道分别以其无密封的防流离子排列设置在它们各自的未封装的径向离开的开口界面处。 在模具的重复打开和关闭循环期间，模具流动通道系统经受持续，极端，热循环和循环机械负载。 每个可分离的防液口密封界面具有相对轴向移动的部分，其延伸以桥接相邻模块之间的初始间隙开口并用作可膨胀的活塞装置。 可移动的“可膨胀活塞装置”部分的这种延伸是压力响应的，并且用于增加相邻输送通道的内部容积，同时允许通道中的库存压力达到大气压力，从而降低液体流出的可能性 塑料进入开口间隙，或将大气进入到流动通道中。

公开(公告)号：US20070249615A1

公开(公告)日：2007-10-25

申请号：US11737966

申请日：2007-04-20

申请人： Robert Hughes ,  Andrew Bell ,  David Brown ,  Dafydd Owen ,  Michael Palmer ,  Christopher Phillips ,  David Brown ,  Yvette Fobian ,  John Freskos ,  Steven Heasley ,  E. Jacobsen ,  Todd Maddux ,  Brent Mischke ,  John Molyneaux ,  Joseph Moon ,  D. Rogier ,  Michael Tollefson ,  John Walker

发明人： Robert Hughes ,  Andrew Bell ,  David Brown ,  Dafydd Owen ,  Michael Palmer ,  Christopher Phillips ,  David Brown ,  Yvette Fobian ,  John Freskos ,  Steven Heasley ,  E. Jacobsen ,  Todd Maddux ,  Brent Mischke ,  John Molyneaux ,  Joseph Moon ,  D. Rogier ,  Michael Tollefson ,  John Walker

IPC分类号： A61K31/498 ,  C07D487/02

CPC分类号： C07D471/04

摘要： Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I: wherein R2, R6A, R6B and R8 are as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, synthetic methods, and intermediates are also disclosed.

摘要翻译： 公开了化合物的化合物和药学上可接受的盐，其中所述化合物具有式I的结构：其中R 2，R 6A，R 6B， >和R＆gt; 8如说明书中所定义。 还公开了相应的药物组合物，治疗方法，合成方法和中间体。

公开(公告)号：US20240026317A1

公开(公告)日：2024-01-25

申请号：US18249023

申请日：2021-10-13

申请人： Dong SHEN ,  David BROWN ,  Renxiang CHEN ,  RNAimmune, Inc

发明人： Dong Shen ,  David Brown ,  Renxiang Chen

IPC分类号： C12N9/14 ,  C12P19/30 ,  A61K39/00 ,  A61K9/127 ,  A61K47/69 ,  A61P35/00 ,  A61K47/54

CPC分类号： C12N9/14 ,  C12Y306/05002 ,  C12P19/30 ,  A61K39/001164 ,  A61K9/1273 ,  A61K47/6911 ,  A61P35/00 ,  A61K47/54 ,  A61K2039/53 ,  A61K2039/585 ,  A61K2039/55555

摘要： Compositions and methods are provided for potent mRNA vaccines for treatment of cancers with a mutation in the ras gene family. The compositions include a pharmaceutical composition comprising, or consisting essentially of, or yet further comprising mRNA molecules encoding at least one of multiple peptides of a group of somatic mutants and a pharmaceutically acceptable carrier. Methods for stimulating system immune responses and treatment are provided, including intratumoral, intravenous, intramuscular, intradermal, or subcutaneous injection of the composition as disclosed herein.

公开(公告)号：US11345606B2

公开(公告)日：2022-05-31

申请号：US15435318

申请日：2017-02-17

申请人： David Brown

发明人： David Brown

IPC分类号： G02B6/02 ,  C01G23/053 ,  C01G49/06 ,  C01B33/18

摘要： Disclosed is a method for producing deposition particles or intermediate particles, characterized in that the method comprises: forming a solution comprising a solvent and one or more deposit sources, aerosolizing the formed solution to produce an aerosol of precursor particles comprising the deposit source, conditioning the precursor particles to produce deposition particles or intermediate particles from the deposit source and collecting said particles. The particles may be collected as a deposit or precursor deposit on a substrate. The particles may include a matrix material and a dopant. The conditioning may be quenched to produce a desired substructure. The matrix material may be essentially optically clear. The substrate may comprise an optical fiber or an optical fiber preform or mandrel.

公开(公告)号：USD819777S1

公开(公告)日：2018-06-05

申请号：US29581051

申请日：2016-10-14

申请人： David Brown

设计人： David Brown

公开(公告)号：US20170128079A1

公开(公告)日：2017-05-11

申请号：US15343765

申请日：2016-11-04

申请人： David Brown

发明人： David Brown

IPC分类号： A61B17/15

CPC分类号： A61B17/155

摘要： An integrated instrument for arthroplasty planning comprises a cutting block having an adjustable distance between an anterior cut guide and a posterior cut guide, and a sizer mounted to the cutting block, the sizer comprising medial and lateral posterior feet having an adjustable distance from one of the cut guides and an adjustable angular position relative to the one of the cut guides.

公开(公告)号：US09612287B2

公开(公告)日：2017-04-04

申请号：US13461862

申请日：2012-05-02

申请人： David Brown ,  Christopher James Belcher ,  Duncan Joseph Brown ,  Dat Tan Chau

发明人： David Brown ,  Christopher James Belcher ,  Duncan Joseph Brown ,  Dat Tan Chau

IPC分类号： H02J7/00 ,  G01R31/36 ,  H02J9/04

CPC分类号： G01R31/3631 ,  G01R31/3658 ,  G01R31/3662 ,  H02J7/0021 ,  H02J9/04

摘要： Non-sequential monitoring of battery cells in battery monitoring systems, and related components, systems, and methods are disclosed. In one embodiment, a battery monitoring system control unit is provided. The battery monitoring system control unit is configured to control battery monitoring devices. Each battery monitoring device is configured to be coupled to a subset of battery cells electrically connected in series in a sequential order to form a battery. The battery monitoring system control unit is further configured to instruct the battery monitoring devices to test an ohmic value of each battery cell of the battery cells of the battery in a non-sequential order. In this manner, heat generated in the battery monitoring devices from the testing may be more effectively dissipated, which can also allow for the battery monitoring devices to be employed in higher operating temperature environments.

公开(公告)号：US20160130026A1

公开(公告)日：2016-05-12

申请号：US14534692

申请日：2014-11-06

申请人： David Brown ,  Sheletia Brown

发明人： David Brown ,  Sheletia Brown

IPC分类号： B65D1/02 ,  B65D41/04 ,  B65D47/06 ,  B65D1/40

CPC分类号： B65D1/0292 ,  B65D1/0284 ,  B65D1/40 ,  B65D2501/0036

摘要： A collapsible beverage containment assembly includes a bottle. The bottle has an outer wall extending between a top end and a bottom end of the bottle to contain a carbonated fluid. The outer wall is structured such that the bottle is collapsible. A sleeve is coupled to the bottom end. The sleeve is positioned within an interior of the bottle. A lid is movably coupled to the top end so the lid may be rotated. A screw is coupled to the lid such that the screw extends downwardly into the bottle. The screw engages the sleeve. Thus, the outer wall is collapsed when the lid is rotated to reduce a volume of the bottle, preserving the carbonation in the carbonated beverage.

摘要翻译： 可折叠的饮料容纳组件包括瓶子。 瓶子具有在瓶的顶端和底端之间延伸以容纳碳酸液体的外壁。 外壁的结构使得瓶子可折叠。 套筒连接到底端。 套筒位于瓶子的内部。 盖子可移动地联接到顶端，因此盖子可以旋转。 螺钉联接到盖上，使得螺钉向下延伸到瓶中。 螺钉接合套筒。 因此，当盖旋转以减小瓶的体积时，外壁被折叠，从而保持碳酸饮料中的碳酸化。