公开(公告)号：US20240026317A1

公开(公告)日：2024-01-25

申请号：US18249023

申请日：2021-10-13

申请人： Dong SHEN ,  David BROWN ,  Renxiang CHEN ,  RNAimmune, Inc

发明人： Dong Shen ,  David Brown ,  Renxiang Chen

IPC分类号： C12N9/14 ,  C12P19/30 ,  A61K39/00 ,  A61K9/127 ,  A61K47/69 ,  A61P35/00 ,  A61K47/54

CPC分类号： C12N9/14 ,  C12Y306/05002 ,  C12P19/30 ,  A61K39/001164 ,  A61K9/1273 ,  A61K47/6911 ,  A61P35/00 ,  A61K47/54 ,  A61K2039/53 ,  A61K2039/585 ,  A61K2039/55555

摘要： Compositions and methods are provided for potent mRNA vaccines for treatment of cancers with a mutation in the ras gene family. The compositions include a pharmaceutical composition comprising, or consisting essentially of, or yet further comprising mRNA molecules encoding at least one of multiple peptides of a group of somatic mutants and a pharmaceutically acceptable carrier. Methods for stimulating system immune responses and treatment are provided, including intratumoral, intravenous, intramuscular, intradermal, or subcutaneous injection of the composition as disclosed herein.

公开(公告)号：US20240294580A1

公开(公告)日：2024-09-05

申请号：US18666691

申请日：2024-05-16

申请人： RNAimmune, Inc.

发明人： David Brown ,  Neeti Ananthaswamy ,  Renxiang Chen

IPC分类号： C07K14/005 ,  A61K39/00 ,  A61P31/14

CPC分类号： C07K14/005 ,  A61P31/14 ,  A61K39/00 ,  A61K2039/53 ,  A61K2039/55555 ,  C07K2319/02 ,  C07K2319/03 ,  C12N2760/18522 ,  C12N2760/18534 ,  C12N2760/18541

摘要： Provided herein is a ribonucleic acid (RNA) encoding a fusion glycoprotein (F) protein or an immunogenic fragment thereof of a respiratory syncytial virus (RSV) comprising at least one non-naturally occurring amino acid mutation. Additionally provided are relevant polynucleotides, vectors, cells, compositions, kits, production methods and methods of use.

公开(公告)号：US20230355527A1

公开(公告)日：2023-11-09

申请号：US18297255

申请日：2023-04-07

申请人： RNAimmune, Inc.

发明人： Evan Michael Lewoczko ,  Renxiang Chen ,  Neeti Ananthaswamy ,  Dong Shen

IPC分类号： A61K9/127 ,  C07C233/47 ,  C07C229/14 ,  C07C323/30 ,  C07C327/22 ,  C07C323/60 ,  C07C229/12 ,  C07C229/16 ,  C07C239/16 ,  C07C237/06 ,  C07C271/20 ,  C07C237/12 ,  C07C309/14 ,  C07C239/18

CPC分类号： A61K9/1272 ,  C07C229/12 ,  C07C229/14 ,  C07C229/16 ,  C07C233/47 ,  C07C237/06 ,  C07C237/12 ,  C07C239/16 ,  C07C239/18 ,  C07C271/20 ,  C07C309/14 ,  C07C323/30 ,  C07C323/60 ,  C07C327/22 ,  C07C2601/04

摘要： Novel lipids, compositions, and methods of using the novel lipids and compositions are disclosed. Three-component lipid nanoparticle compositions comprising the novel lipids or other types of lipids, and methods of using the three-component lipid nanoparticle compositions are disclosed. Three-component lipid nanoparticle compositions contain a steroidal or structural lipid-containing component, a PEGylated lipid-containing component, a cationic or ionizable lipid-containing component, and are free of phospholipids. Pharmaceutical formulations including the three-component lipid nanoparticle compositions and further including therapeutic and/or prophylactics such as mRNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs.

公开(公告)号：US20240226275A1

公开(公告)日：2024-07-11

申请号：US18438342

申请日：2024-02-09

申请人： RNAimmune, Inc.

发明人： Neeti Ananthaswamy ,  Yong-Sik Bong ,  David Brown ,  Renxiang Chen ,  Ju Hyeong Jeon ,  Zhifeng Long ,  Dong Shen ,  Chun Lu ,  Patrick Y. Lu ,  Shenggao Tang ,  Jiaxi He ,  Ziyang He

IPC分类号： A61K39/215 ,  A61K9/127 ,  A61P37/04 ,  C07K14/005 ,  A61K39/00

CPC分类号： A61K39/215 ,  A61K9/1271 ,  A61P37/04 ,  C07K14/005 ,  A61K2039/53 ,  C12N2770/18022 ,  C12N2770/18034

摘要： Provided herein is a ribonucleic acid (RNA) encoding a spike (S) protein or an immunogenic fragment thereof of a severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) comprising at least one non-naturally occurring amino acid mutation. In some embodiments, the S protein is derived from a delta variant. Additionally provided are relevant polynucleotides, vectors, cells, compositions, kits, production methods and methods of use.