公开(公告)号：US20050218616A1

公开(公告)日：2005-10-06

申请号：US10816199

申请日：2004-03-31

申请人： David Copeland ,  Aidan Petrie ,  Ryan White ,  Blaine Adams ,  Alexander Newman ,  Robert Garay

发明人： David Copeland ,  Aidan Petrie ,  Ryan White ,  Blaine Adams ,  Alexander Newman ,  Robert Garay

IPC分类号： B62B3/00 ,  B62B5/06 ,  G09B23/18

CPC分类号： B62B3/006 ,  B62B5/061 ,  G09B23/187

摘要： Systems and techniques relating to a microscope storage unit. In one implementation, a storage unit includes a base, a top and multiple receptacles configured between the base and the top. Each receptacle is configured to house a microscope. The storage unit includes multiple charging devices, where each charging device is configured to recharge a battery of a battery-powered microscope. An electrical cord can be electrically connected to the multiple charging devices, and include a plug configured to mate with an electrical outlet to supply electrical power to the charging devices. One or more wheels can be connected to a lower surface of the base.

摘要翻译： 与显微镜存储单元相关的系统和技术。 在一个实施方式中，存储单元包括配置在基座和顶部之间的基座，顶部和多个插座。 每个插座配置为容纳显微镜。 存储单元包括多个充电装置，其中每个充电装置被配置为对电池供电的显微镜的电池充电。 电线可以电连接到多个充电装置，并且包括配置成与电源插座配合以向充电装置提供电力的插头。 一个或多个轮可以连接到底座的下表面。

公开(公告)号：US20050219685A1

公开(公告)日：2005-10-06

申请号：US10815967

申请日：2004-03-31

申请人： Alison Swift ,  David Copeland ,  Daniel Nelsen ,  Aidan Petrie ,  Ryan White ,  Robert Garay ,  Jacques Valiquette

发明人： Alison Swift ,  David Copeland ,  Daniel Nelsen ,  Aidan Petrie ,  Ryan White ,  Robert Garay ,  Jacques Valiquette

IPC分类号： G02B21/00 ,  G02B21/24 ,  G02B21/26

CPC分类号： G02B21/0008 ,  G02B21/248

摘要： Systems and techniques relating to a microscope with an adjustable stage are described. A microscope includes a base, a support arm attached to and extending upwardly from the base, a head attached to the support arm, the head including a lens, and an eyepiece attached to the head. A stage is releasably attachable to the support arm between the head and the base at multiple locations, providing multiple working distances between a lower surface of the head and an upper surface of the stage. When the stage is attached to the support arm at a location, a working distance between the lower surface of the head and the upper surface of the stage is further adjustable to an either greater or lesser working distance. In another embodiment, microscopic and macroscopic viewing can both be provided using a lens changer with multiple lens positioned radially about an axis of rotation.

摘要翻译： 描述与具有可调节级的显微镜相关的系统和技术。 显微镜包括底座，从底座附接并向上延伸的支撑臂，附接到支撑臂的头部，头部包括透镜，以及附接到头部的目镜。 舞台可在多个位置处可释放地附接到头部和底座之间的支撑臂，从而在头部的下表面和舞台的上表面之间提供多个工作距离。 当舞台在一个位置附接到支撑臂时，头部的下表面和舞台的上表面之间的工作距离进一步可调节到更大或更小的工作距离。 在另一个实施例中，可以使用具有围绕旋转轴径向放置的多个透镜的透镜更换器来提供微观和宏观的观察。

公开(公告)号：US09828628B2

公开(公告)日：2017-11-28

申请号：US13988487

申请日：2011-11-21

申请人： Alexis Vallé- Bélisle ,  Francesco Ricci ,  Ryan White ,  Andrew J. Bonham ,  Kevin W. Plaxco

发明人： Alexis Vallé- Bélisle ,  Francesco Ricci ,  Ryan White ,  Andrew J. Bonham ,  Kevin W. Plaxco

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6825 ,  C12Q1/6818 ,  C12Q2525/301 ,  C12Q2565/1015 ,  C12Q2565/1025 ,  C12Q2545/113 ,  C12Q2563/131

摘要： Provided are unimolecular oligonucleotide probes for detecting a target in a sample. The probes use target binding-induced structural changes to detect the presence of the target in the sample. Also provided are methods of using the probes to detect a target in a sample.

公开(公告)号：US08957083B2

公开(公告)日：2015-02-17

申请号：US13988745

申请日：2011-11-18

申请人： Ana Elena Minatti ,  Oleg Epstein ,  Ryan White ,  Matthew Weiss ,  Wenge Zhong ,  Jonathan D. Low

发明人： Ana Elena Minatti ,  Oleg Epstein ,  Ryan White ,  Matthew Weiss ,  Wenge Zhong ,  Jonathan D. Low

IPC分类号： C07D491/107 ,  C07D491/20

CPC分类号： C07D491/107 ,  C07D491/20

摘要： The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I: wherein variables A1, A3, A4, A5, A6, A8, L, R2, R7, R9, W and Y of Formula I are defined herein. The invention also provides pharmaceutical compositions comprising the compounds, and corresponding uses of the compounds and compositions for treatment of disorders and/or conditions related to plaque formation and deposition, resulting from the activity of BACE. Such BACE mediated disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairments, schizophrenia and other central nervous system conditions. The invention further provides compounds of Formulas II and III, sub-Formula embodiments of Formulas I, II and III, intermediates and processes and methods useful for the preparation of compounds of Formulae I-III.

摘要翻译： 本发明提供了一类可用于调节β-分泌酶（BACE）活性的化合物。 化合物具有通式I：其中式I的变量A1，A3，A4，A5，A6，A8，L，R2，R7，R9，W和Y在本文中定义。 本发明还提供包含该化合物的药物组合物，以及用于治疗由于BACE的活性而导致的斑块形成和沉积相关疾病和/或病症的化合物和组合物的相应用途。 这种BACE介导的疾病包括例如阿尔茨海默病，认知缺陷，认知障碍，精神分裂症和其他中枢神经系统疾病。 本发明还提供式II和III的化合物，式I，II和III的次级实施方案，可用于制备式I-III化合物的中间体和方法和方法。

公开(公告)号：US20140038954A1

公开(公告)日：2014-02-06

申请号：US13982096

申请日：2012-02-13

申请人： Oleg Epstein ,  Ryan White ,  Vinod F. Patel ,  Jason Human

发明人： Oleg Epstein ,  Ryan White ,  Vinod F. Patel ,  Jason Human

IPC分类号： C07D491/20

CPC分类号： C07D491/20 ,  A61K31/353

摘要： The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula I, wherein variables A1, A3, A4, A5, A6, A8, R2, R7, X, Y and Z of Formula I are defined herein. The invention also provides pharmaceutical compositions comprising the compounds, and corresponding uses of the compounds and compositions for treatment of disorders and/or conditions related to plaque formation and deposition, resulting from the activity of BACE. Such BACE mediated disorders include, for example, Alzheimer's Disease, cognitive deficits and impairments, schizophrenia and other central nervous system conditions and disorders. The invention further provides compounds of Formulas II and III, and of sub-formulas of Formulas I, II and III, intermediates and processes and methods useful for the preparation of compounds of Formulas I-III.

摘要翻译： 本发明提供了一类可用于调节β-分泌酶（BACE）活性的化合物。 化合物具有通式I，其中式I的变量A1，A3，A4，A5，A6，A8，R2，R7，X，Y和Z如本文所定义。 本发明还提供包含该化合物的药物组合物，以及用于治疗由于BACE的活性而导致的斑块形成和沉积相关疾病和/或病症的化合物和组合物的相应用途。 这种BACE介导的病症包括例如阿尔茨海默病，认知缺陷和损伤，精神分裂症和其他中枢神经系统病症和障碍。 本发明还提供了式II和III的化合物和式I，II和III的分子式，可用于制备式I-III化合物的中间体和方法和方法。

公开(公告)号：US20130338177A1

公开(公告)日：2013-12-19

申请号：US13988745

申请日：2011-11-18

申请人： Ana Elena Minatti ,  Oleg Epstein ,  Ryan White ,  Matthew Weiss ,  Wenge Zhong ,  Jonathan D. Low

发明人： Ana Elena Minatti ,  Oleg Epstein ,  Ryan White ,  Matthew Weiss ,  Wenge Zhong ,  Jonathan D. Low

IPC分类号： C07D491/107 ,  C07D491/20

CPC分类号： C07D491/107 ,  C07D491/20

摘要： The present invention provides a new class of compounds useful for the modulation of beta-secretase enzyme (BACE) activity. The compounds have a general Formula (I), wherein variables A1, A3, A4, A5, A6, A8, L, R2, R7, R9, W and Y of Formula (I) are defined herein. The invention also provides pharmaceutical compositions comprising the compounds, and corresponding uses of the compounds and compositions for treatment of disorders and/or conditions related to plaque formation and deposition, resulting from the activity of BACE. Such BACE mediated disorders include, for example, Alzheimer's Disease, cognitive deficits, cognitive impairments, schizophrenia and other central nervous system conditions. The invention further provides compounds of Formulas (II) and (III), sub-Formula embodiments of Formulas (I), (II) and (III), intermediates and processes and methods useful for the preparation of compounds of Formulae (I-III).

摘要翻译： 本发明提供了一类可用于调节β-分泌酶（BACE）活性的化合物。 化合物具有通式（I），其中式（I）的变量A1，A3，A4，A5，A6，A8，L，R2，R7，R9，W和Y如本文所定义。 本发明还提供包含该化合物的药物组合物，以及用于治疗由于BACE的活性而导致的斑块形成和沉积相关疾病和/或病症的化合物和组合物的相应用途。 这种BACE介导的疾病包括例如阿尔茨海默病，认知缺陷，认知障碍，精神分裂症和其他中枢神经系统疾病。 本发明还提供式（II）和（III）的化合物，式（I），（II）和（III）的分式实施方案，可用于制备式（I-III）化合物的中间体和方法和方法 ）。

公开(公告)号：US08557816B2

公开(公告)日：2013-10-15

申请号：US13157195

申请日：2011-06-09

申请人： Stephanie Geuns-Meyer ,  Victor J. Cee ,  Isaac Marx ,  Laurie Schenkel ,  Ryan White

发明人： Stephanie Geuns-Meyer ,  Victor J. Cee ,  Isaac Marx ,  Laurie Schenkel ,  Ryan White

IPC分类号： A61K31/502

CPC分类号： C07D471/04 ,  C07D401/12 ,  C07D401/14 ,  C07D487/04 ,  C07D493/04 ,  C07D495/04

摘要： The present invention relates to chemical compounds having a general formula I wherein A1-8, D′, L1, L2, R1, R6-8 and n are defined herein, and synthetic intermediates, which are capable of modulating various protein kinase receptor enzymes and, thereby, influencing various disease states and conditions related to the activities of such kinases. For example, the compounds are capable of modulating Aurora kinase thereby influencing the process of cell cycle and cell proliferation to treat cancer and cancer-related diseases. The invention also includes pharmaceutical compositions, including the compounds, and methods of treating disease states related to the activity of Aurora kinase.

公开(公告)号：US07893061B2

公开(公告)日：2011-02-22

申请号：US11827910

申请日：2007-07-13

申请人： Ryan White

发明人： Ryan White

IPC分类号： C07D401/14 ,  A61K31/506

CPC分类号： C07D401/06 ,  C07D401/04 ,  C07D401/14 ,  C07D405/14

摘要： The present invention comprises a new class of compounds capable of modulating the c-kit receptor and, accordingly, useful for treatment of c-kit mediated diseases, including various inflammatory, fibrotic and/or mast cell mediated diseases such as mastocytosis. The compounds have a general Formula I wherein A1-3, R1 and R3-6 are defined herein. The invention further comprises pharmaceutical compositions, methods for treatment of c-kit mediated diseases, and intermediates and processes useful for the preparation of compounds of the invention.

摘要翻译： 本发明包括能够调节c-kit受体的新一类化合物，因此可用于治疗c-kit介导的疾病，包括各种炎性，纤维化和/或肥大细胞介导的疾病如肥大细胞增多症。 该化合物具有通式I，其中A1-3，R1和R3-6在本文中定义。 本发明还包括药物组合物，用于治疗c-kit介导的疾病的方法，以及可用于制备本发明化合物的中间体和方法。

公开(公告)号：US07700607B2

公开(公告)日：2010-04-20

申请号：US11879830

申请日：2007-07-18

申请人： Essa Hu ,  Jason Brooks Human ,  Roxanne Kunz ,  Andrew Tasker ,  Ryan White

发明人： Essa Hu ,  Jason Brooks Human ,  Roxanne Kunz ,  Andrew Tasker ,  Ryan White

IPC分类号： A61K31/517

CPC分类号： C07D471/04 ,  C07D401/04

摘要： The present invention comprises a new class of compounds capable of modulating the c-kit receptor and, accordingly, useful for treatment of c-kit mediated diseases, including various inflammatory, fibrotic and/or mast cell mediated diseases such as mastocytosis. The compounds have a general Formula I wherein R1-6 are defined herein. The invention further comprises pharmaceutical compositions, methods for treatment of c-kit mediated diseases, and intermediates and processes useful for the preparation of compounds of the invention.

摘要翻译： 本发明包括能够调节c-kit受体的新一类化合物，因此可用于治疗c-kit介导的疾病，包括各种炎性，纤维化和/或肥大细胞介导的疾病如肥大细胞增多症。 化合物具有通式I，其中R1-6在本文中定义。 本发明还包括药物组合物，用于治疗c-kit介导的疾病的方法，以及可用于制备本发明化合物的中间体和方法。

公开(公告)号：US20090095034A1

公开(公告)日：2009-04-16

申请号：US11872394

申请日：2007-10-15

申请人： Ryan White ,  John Hung

发明人： Ryan White ,  John Hung

IPC分类号： E05B65/00 ,  E05B37/02

CPC分类号： E05B73/0005 ,  E05B37/0058 ,  E05B37/025 ,  E05B73/0082 ,  Y10T70/25 ,  Y10T70/40 ,  Y10T70/50 ,  Y10T70/5009 ,  Y10T70/554 ,  Y10T70/7305 ,  Y10T70/7316 ,  Y10T70/7418

摘要： A security apparatus, a security system that uses the security apparatus, and a method of using the securing apparatus to secure a portable electronic device to an immovable object. The security apparatus comprises a combination locking mechanism with dials and tumblers, a body coupled to the dials, a reset device coupled to the tumblers, and a reset key configured to interact with the reset device to allow the user to reset the combination associated with the combination locking mechanism.

摘要翻译： 一种安全装置，使用该安全装置的安全系统以及使用该固定装置将便携式电子装置固定在不可移动物体上的方法。 安全装置包括具有拨盘和翻转开关的组合锁定机构，耦合到拨盘的主体，耦合到翻转开关的复位装置以及配置成与复位装置相互作用的复位键，以允许用户重置与 组合锁定机构。