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21 条记录 (耗时 0.044 秒)

    Controlled release dosage form including a banded engine
    4.
    发明申请
    Controlled release dosage form including a banded engine 审中-公开
    受控释放剂型，包括带状发动机

    公开(公告)号：US20050186273A1

    公开(公告)日：2005-08-25

    申请号：US10950039

    申请日：2004-09-24

    申请人： Si-Hong Yum ,  Crystal Pollock-Dove ,  Liang-Chang Dong ,  Patrick Wong

    发明人： Si-Hong Yum ,  Crystal Pollock-Dove ,  Liang-Chang Dong ,  Patrick Wong

    IPC分类号： A61K9/00 ,  A61K9/20 ,  A61K9/22

    CPC分类号： A61K9/0004

    摘要： The present invention includes a dosage form configured to provide the controlled release of an active agent formulation. A dosage form according to the present invention includes a reservoir containing an active agent formulation and an engine positioned at least partially within the reservoir. In order to reduce the possibility that the engine included in a dosage form of the present invention will separate from the reservoir either during or after fabrication, the dosage form of the present invention includes a band that binds the engine to the reservoir. The band is provided over an outside surface of the both the engine and the reservoir at or near the interface formed where the engine enters the opening provided in the reservoir. The present invention also includes a method of fabricating controlled release dosage forms having banded engine.

    摘要翻译： 本发明包括配制成提供活性剂制剂的受控释放的剂型。 根据本发明的剂型包括含有活性剂制剂的储存器和至少部分地位于储存器内的发动机。 为了减少包含在本发明的剂型中的发动机在制造期间或之后与储存器分离的可能性，本发明的剂型包括将发动机结合到储存器的带。 该带被设置在发动机进入设置在储存器中的开口所形成的界面处或附近的发动机和储存器两侧的外表面上。 本发明还包括制造具有带状发动机的控释剂型的方法。

    Dosage form comprising liquid formulation
    5.
    发明申请
    Dosage form comprising liquid formulation 失效
    包含液体制剂的剂型

    公开(公告)号：US20070048368A1

    公开(公告)日：2007-03-01

    申请号：US11589558

    申请日：2006-10-30

    申请人： Liang-Chang Dong ,  Steven Espinal ,  Patrick Wong

    发明人： Liang-Chang Dong ,  Steven Espinal ,  Patrick Wong

    IPC分类号： A61K9/52

    CPC分类号： A61K9/4858 ,  A61K9/0004 ,  A61K9/1075 ,  A61K9/4866

    摘要： A sustained release dosage form includes a capsule made of a thermoplastic polymer having a softening point below 200° C. and an orifice formed or formable within the capsule, an emulsion formulation contained within the capsule, and an expandable composition within the capsule remote from the orifice. The emulsion formulation comprises a drug, an emulsifying surfactant, and an oil. The expandable composition is configured to expand and expel the emulsion formulation through the orifice.

    摘要翻译： 持续释放剂型包括由软化点低于200℃的热塑性聚合物制成的胶囊，以及在胶囊内形成或可形成的孔，包含在胶囊内的乳剂，以及远离胶囊内的胶囊内的可膨胀组合物 孔。 乳液制剂包含药物，乳化表面活性剂和油。 可膨胀组合物构造成通过孔膨胀和排出乳液制剂。

    Oral delivery system comprising a drug/polymer complex
    7.
    发明申请
    Oral delivery system comprising a drug/polymer complex 审中-公开
    包含药物/聚合物复合物的口服递送系统

    公开(公告)号：US20050287212A1

    公开(公告)日：2005-12-29

    申请号：US11148673

    申请日：2005-06-08

    申请人： Liang-Chang Dong ,  Jasmine Han ,  Crystal Pollock-Dove ,  Patrick Wong

    发明人： Liang-Chang Dong ,  Jasmine Han ,  Crystal Pollock-Dove ,  Patrick Wong

    IPC分类号： A61K9/00 ,  A61K9/14 ,  A61K9/19 ,  A61K9/20 ,  A61K9/24 ,  A61K9/48 ,  A61K47/10 ,  A61K47/38

    CPC分类号： A61K9/19 ,  A61K9/0004 ,  A61K9/146 ,  A61K9/2013 ,  A61K9/2031 ,  A61K9/2054 ,  A61K47/10 ,  A61K47/38

    摘要： This invention pertains to the enhanced delivery of orally administered pharmaceutical agents and methods, dosage forms and devices thereof. In particular, the invention is directed to methods including providing a low solubility drug having a pKa between about 6 and about 9; dissolving the low solubility drug in an aqueous solution, wherein a pH of the aqueous solution is less than about 6.0; dissolving a hydrophilic polymer in the aqueous solution, wherein the weight ratio of the hydrophilic polymer to the low solubility drug is less than or equal to about 0.15; lyophilizing the aqueous solution to obtain a lyophilized powder. Also disclosed are drug formulations made according to the method, and dosage forms that include the drug formulations.

    摘要翻译： 本发明涉及口服给药药剂的增强递送及其方法，剂型及其装置。 特别地，本发明涉及包括提供具有约6至约9的pKa的低溶解度药物的方法; 将低溶解度药物溶解在水溶液中，其中水溶液的pH小于约6.0; 将亲水性聚合物溶解在水溶液中，其中亲水性聚合物与低溶解度药物的重量比小于或等于约0.15; 冻干该水溶液以获得冻干粉末。 还公开了根据该方法制备的药物制剂以及包括药物制剂的剂型。