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1.发明授权Substituted heterocyclic acyl-tripeptides useful as thrombin receptor modulators 有权用作凝血酶受体调节剂的取代的杂环酰基三肽公开(公告)号：US07312306B2
公开(公告)日：2007-12-25
申请号：US10606422
申请日：2003-06-26
IPC分类号： C07K5/08
CPC分类号： C07K5/0202 , A61K38/00 , C07K5/0812 , C07K5/1024
摘要： The invention is directed to substituted heterocyclic acyl-tripeptides useful as thrombin receptor modulators, their use in wound healing and preventing platelet aggregation. Pharmaceutical compositions comprising the substituted heterocyclic acyl-tripeptides of the present invention and methods of treating conditions mediated by the thrombin receptor are also disclosed.
摘要翻译： 本发明涉及用作凝血酶受体调节剂的取代杂环酰基三肽，其用于伤口愈合和预防血小板聚集。 还公开了包含本发明的取代的杂环酰基三肽和治疗由凝血酶受体介导的病症的方法的药物组合物。
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2.发明授权Substituted heterocyclic acyl-tripeptides useful as thrombin receptor modulators 有权用作凝血酶受体调节剂的取代的杂环酰基三肽公开(公告)号：US06747127B1
公开(公告)日：2004-06-08
申请号：US09565715
申请日：2000-05-05
IPC分类号： C07K508
CPC分类号： C07K5/0202 , A61K38/00 , C07K5/0812 , C07K5/1024
摘要： The invention is directed to substituted heterocyclic acyl-tripeptides useful as thrombin receptor modulators, their use in wound healing and preventing platelet aggregation. Pharmaceutical compositions comprising the substituted heterocyclic acyl-tripeptides of the present invention and methods of treating conditions mediated by the thrombin receptor are also disclosed.
摘要翻译： 本发明涉及用作凝血酶受体调节剂的取代杂环酰基三肽，其用于伤口愈合和预防血小板聚集。 还公开了包含本发明的取代的杂环酰基三肽和治疗由凝血酶受体介导的病症的方法的药物组合物。
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公开(公告)号：US20120022022A1
公开(公告)日：2012-01-26
申请号：US13245208
申请日：2011-09-26
申请人： Michael J. Hawkins , Michael N. Greco , Eugene Powell , Lawrence de Garavilla , Bruce E. Maryanoff
发明人： Michael J. Hawkins , Michael N. Greco , Eugene Powell , Lawrence de Garavilla , Bruce E. Maryanoff
CPC分类号： A61K31/381 , A61K31/445 , A61K31/4535 , A61K31/662
摘要： The present invention is directed to a compound of formula (I), methods for preparing these compounds, compositions, intermediates and derivatives thereof, and methods for treating inflammatory and serine protease mediated disorders.
摘要翻译： 本发明涉及式（I）化合物，这些化合物的制备方法，组合物，中间体及其衍生物，以及治疗炎性和丝氨酸蛋白酶介导的病症的方法。
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公开(公告)号：US06890939B2
公开(公告)日：2005-05-10
申请号：US10439884
申请日：2003-05-16
IPC分类号： A61P11/00 , A61P43/00 , C07D207/14 , C07D207/48 , A61K31/40 , C07D207/02
CPC分类号： C07D207/14 , C07D207/48
摘要： The present invention is directed to compounds useful as selective serine protease or dual-serine protease inhibitors, compositions thereof and methods for treating serine protease or dual-serine protease mediated disorders.
摘要翻译： 本发明涉及可用作选择性丝氨酸蛋白酶或双丝氨酸蛋白酶抑制剂的化合物，其组合物和治疗丝氨酸蛋白酶或双丝氨酸蛋白酶介导的病症的方法。
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公开(公告)号：US06538017B2
公开(公告)日：2003-03-25
申请号：US10090872
申请日：2002-03-05
IPC分类号： A61K3140
CPC分类号： C07D207/14 , C07D207/48
摘要： The present invention is directed to compounds useful as selective serine protease or dual-serine protease inhibitors, compositions thereof and methods for treating serine protease or dual-serine protease mediated disorders.
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公开(公告)号：US08546358B2
公开(公告)日：2013-10-01
申请号：US13245208
申请日：2011-09-26
申请人： Michael J. Hawkins , Michael N. Greco , Eugene Powell , Lawrence de Garavilla , Bruce E. Maryanoff
发明人： Michael J. Hawkins , Michael N. Greco , Eugene Powell , Lawrence de Garavilla , Bruce E. Maryanoff
IPC分类号： A61K31/67
CPC分类号： A61K31/381 , A61K31/445 , A61K31/4535 , A61K31/662
摘要： The present invention is directed to a method for treating or ameliorating asthma in a subject in need thereof comprising administering to the subject a therapeutically effective amount of compound 17:
摘要翻译： 本发明涉及一种用于治疗或改善有需要的受试者的哮喘的方法，包括向受试者施用治疗有效量的化合物17：
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公开(公告)号：US06630505B2
公开(公告)日：2003-10-07
申请号：US10303229
申请日：2002-11-25
IPC分类号： A61K3140
CPC分类号： C07D207/14 , C07D207/48
摘要： The present invention is directed to compounds useful as selective serine protease or dual-serine protease inhibitors, compositions thereof and methods for treating serine protease or dual-serine protease mediated disorders.
摘要翻译： 本发明涉及可用作选择性丝氨酸蛋白酶或双丝氨酸蛋白酶抑制剂的化合物，其组合物和治疗丝氨酸蛋白酶或双丝氨酸蛋白酶介导的病症的方法。
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公开(公告)号：US20100048513A1
公开(公告)日：2010-02-25
申请号：US12229089
申请日：2008-08-20
申请人： Michael J. Hawkins , Michael N. Greco , Eugene Powell , Lawrence de Garavilla , Bruce E. Maryanoff
发明人： Michael J. Hawkins , Michael N. Greco , Eugene Powell , Lawrence de Garavilla , Bruce E. Maryanoff
IPC分类号： A61K31/381 , A61K31/445 , A61K31/4535 , A61K31/662 , A61P11/00
CPC分类号： A61K31/381 , A61K31/445 , A61K31/4535 , A61K31/662
摘要： The present invention is directed to a compound of formula (I), methods for preparing these compounds, compositions, intermediates and derivatives thereof, and methods for treating inflammatory and serine protease mediated disorders.
摘要翻译： 本发明涉及式（I）化合物，这些化合物的制备方法，组合物，中间体及其衍生物，以及治疗炎性和丝氨酸蛋白酶介导的病症的方法。
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公开(公告)号：US20090036409A1
公开(公告)日：2009-02-05
申请号：US12229077
申请日：2008-08-20
申请人： Michael J. Hawkins , Michael N. Greco , Eugene Powell , Lawrence De Garavilla , Bruce E. Maryanoff
发明人： Michael J. Hawkins , Michael N. Greco , Eugene Powell , Lawrence De Garavilla , Bruce E. Maryanoff
IPC分类号： A61K31/662 , C07F1/00 , C07F9/572 , C07F9/576 , C07F9/58 , A61K31/665 , A61K31/675 , C07F9/60 , C07F9/6518 , C07F9/6541 , C07F9/40
CPC分类号： C07F9/6561 , C07F9/4006 , C07F9/572 , C07F9/5728 , C07F9/59 , C07F9/60 , C07F9/62 , C07F9/65517 , C07F9/655354 , C07F9/65583 , C07F9/65586 , C07F9/657181
摘要： The present invention is directed to a compound of formula (I), methods for preparing these compounds, compositions, intermediates and derivatives thereof, and methods for treating inflammatory and serine protease mediated disorders.
摘要翻译： 本发明涉及式（I）化合物，这些化合物的制备方法，组合物，中间体及其衍生物，以及治疗炎性和丝氨酸蛋白酶介导的病症的方法。
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公开(公告)号：US07459444B2
公开(公告)日：2008-12-02
申请号：US11037938
申请日：2005-01-18
申请人： Michael J. Hawkins , Michael N. Greco , Eugene Powell , Lawrence de Garavilla , Bruce E. Maryanoff
发明人： Michael J. Hawkins , Michael N. Greco , Eugene Powell , Lawrence de Garavilla , Bruce E. Maryanoff
CPC分类号： C07F9/6561 , C07F9/4006 , C07F9/572 , C07F9/5728 , C07F9/59 , C07F9/60 , C07F9/62 , C07F9/65517 , C07F9/655354 , C07F9/65583 , C07F9/65586 , C07F9/657181
摘要： The present invention is directed to a compound of formula (I), methods for preparing these compounds, compositions, intermediates and derivatives thereof, and methods for treating inflammatory and serine protease mediated disorders.
摘要翻译： 本发明涉及式（I）化合物，这些化合物的制备方法，组合物，中间体及其衍生物，以及治疗炎性和丝氨酸蛋白酶介导的病症的方法。
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