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公开(公告)号：US20120022022A1
公开(公告)日：2012-01-26
申请号：US13245208
申请日：2011-09-26
申请人： Michael J. Hawkins , Michael N. Greco , Eugene Powell , Lawrence de Garavilla , Bruce E. Maryanoff
发明人： Michael J. Hawkins , Michael N. Greco , Eugene Powell , Lawrence de Garavilla , Bruce E. Maryanoff
CPC分类号： A61K31/381 , A61K31/445 , A61K31/4535 , A61K31/662
摘要： The present invention is directed to a compound of formula (I), methods for preparing these compounds, compositions, intermediates and derivatives thereof, and methods for treating inflammatory and serine protease mediated disorders.
摘要翻译： 本发明涉及式（I）化合物，这些化合物的制备方法，组合物，中间体及其衍生物，以及治疗炎性和丝氨酸蛋白酶介导的病症的方法。
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公开(公告)号：US08546358B2
公开(公告)日：2013-10-01
申请号：US13245208
申请日：2011-09-26
申请人： Michael J. Hawkins , Michael N. Greco , Eugene Powell , Lawrence de Garavilla , Bruce E. Maryanoff
发明人： Michael J. Hawkins , Michael N. Greco , Eugene Powell , Lawrence de Garavilla , Bruce E. Maryanoff
IPC分类号： A61K31/67
CPC分类号： A61K31/381 , A61K31/445 , A61K31/4535 , A61K31/662
摘要： The present invention is directed to a method for treating or ameliorating asthma in a subject in need thereof comprising administering to the subject a therapeutically effective amount of compound 17:
摘要翻译： 本发明涉及一种用于治疗或改善有需要的受试者的哮喘的方法，包括向受试者施用治疗有效量的化合物17：
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公开(公告)号：US20100048513A1
公开(公告)日：2010-02-25
申请号：US12229089
申请日：2008-08-20
申请人： Michael J. Hawkins , Michael N. Greco , Eugene Powell , Lawrence de Garavilla , Bruce E. Maryanoff
发明人： Michael J. Hawkins , Michael N. Greco , Eugene Powell , Lawrence de Garavilla , Bruce E. Maryanoff
IPC分类号： A61K31/381 , A61K31/445 , A61K31/4535 , A61K31/662 , A61P11/00
CPC分类号： A61K31/381 , A61K31/445 , A61K31/4535 , A61K31/662
摘要： The present invention is directed to a compound of formula (I), methods for preparing these compounds, compositions, intermediates and derivatives thereof, and methods for treating inflammatory and serine protease mediated disorders.
摘要翻译： 本发明涉及式（I）化合物，这些化合物的制备方法，组合物，中间体及其衍生物，以及治疗炎性和丝氨酸蛋白酶介导的病症的方法。
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公开(公告)号：US20090036409A1
公开(公告)日：2009-02-05
申请号：US12229077
申请日：2008-08-20
申请人： Michael J. Hawkins , Michael N. Greco , Eugene Powell , Lawrence De Garavilla , Bruce E. Maryanoff
发明人： Michael J. Hawkins , Michael N. Greco , Eugene Powell , Lawrence De Garavilla , Bruce E. Maryanoff
IPC分类号： A61K31/662 , C07F1/00 , C07F9/572 , C07F9/576 , C07F9/58 , A61K31/665 , A61K31/675 , C07F9/60 , C07F9/6518 , C07F9/6541 , C07F9/40
CPC分类号： C07F9/6561 , C07F9/4006 , C07F9/572 , C07F9/5728 , C07F9/59 , C07F9/60 , C07F9/62 , C07F9/65517 , C07F9/655354 , C07F9/65583 , C07F9/65586 , C07F9/657181
摘要： The present invention is directed to a compound of formula (I), methods for preparing these compounds, compositions, intermediates and derivatives thereof, and methods for treating inflammatory and serine protease mediated disorders.
摘要翻译： 本发明涉及式（I）化合物，这些化合物的制备方法，组合物，中间体及其衍生物，以及治疗炎性和丝氨酸蛋白酶介导的病症的方法。
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公开(公告)号：US07459444B2
公开(公告)日：2008-12-02
申请号：US11037938
申请日：2005-01-18
申请人： Michael J. Hawkins , Michael N. Greco , Eugene Powell , Lawrence de Garavilla , Bruce E. Maryanoff
发明人： Michael J. Hawkins , Michael N. Greco , Eugene Powell , Lawrence de Garavilla , Bruce E. Maryanoff
CPC分类号： C07F9/6561 , C07F9/4006 , C07F9/572 , C07F9/5728 , C07F9/59 , C07F9/60 , C07F9/62 , C07F9/65517 , C07F9/655354 , C07F9/65583 , C07F9/65586 , C07F9/657181
摘要： The present invention is directed to a compound of formula (I), methods for preparing these compounds, compositions, intermediates and derivatives thereof, and methods for treating inflammatory and serine protease mediated disorders.
摘要翻译： 本发明涉及式（I）化合物，这些化合物的制备方法，组合物，中间体及其衍生物，以及治疗炎性和丝氨酸蛋白酶介导的病症的方法。
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公开(公告)号：US20120283221A1
公开(公告)日：2012-11-08
申请号：US13550963
申请日：2012-07-17
申请人： Michael N. Greco , Harold R. Almond, JR. , Lawrence de Garavilla , Michael J. Hawkins , Michael J. Humora , Yun Qian , Donald Gilmore Walker , Sergio Cesco-Cancian , Christopher Norman Nillsen , Mitul N. Patel , Kirk Leonard Sorgi , Eugene Powell
发明人： Michael N. Greco , Harold R. Almond, JR. , Lawrence de Garavilla , Michael J. Hawkins , Michael J. Humora , Yun Qian , Donald Gilmore Walker , Sergio Cesco-Cancian , Christopher Norman Nillsen , Mitul N. Patel , Kirk Leonard Sorgi , Eugene Powell
IPC分类号： A61K31/675 , C07F9/40 , C07F9/576 , A61K31/662 , C07F9/6509
CPC分类号： C07F9/65586 , C07F9/3882 , C07F9/572 , C07F9/59 , C07F9/650952 , C07F9/65517 , C07F9/65583 , C07F9/6561
摘要： The present invention is directed to phosphonic acid compounds useful as serine protease inhibitors, compositions thereof and methods for treating inflammatory and serine protease mediated disorders.
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公开(公告)号：US20090118504A1
公开(公告)日：2009-05-07
申请号：US12289000
申请日：2008-10-24
申请人： Michael N. Greco , Harold R. Almond, JR. , Lawrence de Garavilla , Michael J. Hawkins , Michael J. Humora , Yun Qian , Donald Gilmore Walker , Sergio Cesco-Cancian , Christopher Norman Nilsen , Mitul N. Patel , Kirk Leonard Sorgi , Eugene Powell
发明人： Michael N. Greco , Harold R. Almond, JR. , Lawrence de Garavilla , Michael J. Hawkins , Michael J. Humora , Yun Qian , Donald Gilmore Walker , Sergio Cesco-Cancian , Christopher Norman Nilsen , Mitul N. Patel , Kirk Leonard Sorgi , Eugene Powell
IPC分类号： C07F9/6509
CPC分类号： C07F9/65586 , C07F9/3882 , C07F9/572 , C07F9/59 , C07F9/650952 , C07F9/65517 , C07F9/65583 , C07F9/6561
摘要： The present invention is directed to phosphonic acid compounds useful as serine protease inhibitors, compositions thereof and methods for treating inflammatory and serine protease mediated disorders.
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公开(公告)号：US08497373B2
公开(公告)日：2013-07-30
申请号：US13471876
申请日：2012-05-15
申请人： Michael N. Greco , Harold R. Almond, Jr. , Lawrence de Garavilla , Michael J. Hawkins , Michael J. Humora , Yun Qian , Donald Gilmore Walker , Sergio Cesco-Cancian , Christopher Norman Nilsen , Mitul N. Patel , Kirk Leonard Sorgi , Eugene Powell
发明人： Michael N. Greco , Harold R. Almond, Jr. , Lawrence de Garavilla , Michael J. Hawkins , Michael J. Humora , Yun Qian , Donald Gilmore Walker , Sergio Cesco-Cancian , Christopher Norman Nilsen , Mitul N. Patel , Kirk Leonard Sorgi , Eugene Powell
IPC分类号： C07D241/02 , C07F9/02 , A61K31/4965
CPC分类号： C07F9/65586 , C07F9/3882 , C07F9/572 , C07F9/59 , C07F9/650952 , C07F9/65517 , C07F9/65583 , C07F9/6561
摘要： The present invention is directed to phosphonic acid compounds useful as serine protease inhibitors, compositions thereof and methods for treating inflammatory and serine protease mediated disorders.
摘要翻译： 本发明涉及可用作丝氨酸蛋白酶抑制剂的膦酸化合物，其组合物和用于治疗炎性和丝氨酸蛋白酶介导的病症的方法。
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公开(公告)号：US20090137528A1
公开(公告)日：2009-05-28
申请号：US12288993
申请日：2008-10-24
申请人： Michael N. Greco , Harold R. Almond, JR. , Lawrence de Garavilla , Michael J. Hawkins , Michael J. Humora , Yun Qian , Donald Gilmore Walker , Sergio Cesco-Cancian , Christopher Norman Nilsen , Mitul N. Patel , Kirk Leonard Sorgi , Eugene Powell
发明人： Michael N. Greco , Harold R. Almond, JR. , Lawrence de Garavilla , Michael J. Hawkins , Michael J. Humora , Yun Qian , Donald Gilmore Walker , Sergio Cesco-Cancian , Christopher Norman Nilsen , Mitul N. Patel , Kirk Leonard Sorgi , Eugene Powell
IPC分类号： A61K31/675 , C07F9/547
CPC分类号： C07F9/65586 , C07F9/3882 , C07F9/572 , C07F9/59 , C07F9/650952 , C07F9/65517 , C07F9/65583 , C07F9/6561
摘要： The present invention is directed to phosphonic acid compounds useful as serine protease inhibitors, compositions thereof and methods for treating inflammatory and serine protease mediated disorders.
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公开(公告)号：US20090131371A1
公开(公告)日：2009-05-21
申请号：US12288998
申请日：2008-10-24
申请人： Michael N. Greco , Harold R. Almond, JR. , Lawrence de Garavilla , Michael J. Hawkins , Michael J. Humora , Yun Qian , Donald Gilmore Walker , Sergio Cesco-Cancian , Christopher Norman Nilsen , Mitul N. Patel , Kirk Leonard Sorgi , Eugene Powell
发明人： Michael N. Greco , Harold R. Almond, JR. , Lawrence de Garavilla , Michael J. Hawkins , Michael J. Humora , Yun Qian , Donald Gilmore Walker , Sergio Cesco-Cancian , Christopher Norman Nilsen , Mitul N. Patel , Kirk Leonard Sorgi , Eugene Powell
IPC分类号： A61K31/675 , C07F9/6509
CPC分类号： C07F9/65586 , C07F9/3882 , C07F9/572 , C07F9/59 , C07F9/650952 , C07F9/65517 , C07F9/65583 , C07F9/6561
摘要： The present invention is directed to phosphonic acid compounds useful as serine protease inhibitors, compositions thereof and methods for treating inflammatory and serine protease mediated disorders.
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