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1.发明授权公开(公告)号：US08426443B2
公开(公告)日：2013-04-23
申请号：US13592785
申请日：2012-08-23
申请人： David Gwyn Cooper , Ian Thomson Forbes , Vincenzo Garzya , Dale James Johnson , Graeme Irvine Stevenson , Paul Adrian Wyman
发明人： David Gwyn Cooper , Ian Thomson Forbes , Vincenzo Garzya , Dale James Johnson , Graeme Irvine Stevenson , Paul Adrian Wyman
IPC分类号： A61K31/445 , A61K31/425 , A61K31/42
CPC分类号： C07D498/04 , C07D209/34 , C07D215/227
摘要： Compounds of formula (I) or a salt thereof are provided: wherein R4, R5, R6, Q, A, Y and R are as defined in the description. Uses of the compounds as medicaments and in the manufacture of medicaments for treating psychotic disorders, cognitive impairments and Alzheimer's Disease are disclosed. The invention further discloses pharmaceutical compositions comprising the compounds.
摘要翻译： 提供式（I）化合物或其盐：其中R 4，R 5，R 6，Q，A，Y和R如说明书中所定义。 公开了化合物作为药物的用途和用于治疗精神病，认知障碍和阿尔茨海默氏病的药物的制备。 本发明还公开了包含该化合物的药物组合物。
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2.发明授权公开(公告)号：US08344000B2
公开(公告)日：2013-01-01
申请号：US12678360
申请日：2008-09-18
申请人： David Gwyn Cooper , Ian Thomson Forbes , Vincenzo Garzya , Dale James Johnson , Paul Adrian Wyman
发明人： David Gwyn Cooper , Ian Thomson Forbes , Vincenzo Garzya , Dale James Johnson , Paul Adrian Wyman
IPC分类号： C07D401/14 , A61K31/454 , A61P25/18 , A61P25/28
CPC分类号： C07D413/14
摘要： Compounds of formula (I) and salts thereof are provided: wherein R4, R5, R6, Q, A, and Y are as defined in the description. Uses of the compounds as medicaments and in the manufacture of medicaments for treating psychotic disorders, cognitive impairments and Alzheimer's Disease are disclosed. The invention further discloses pharmaceutical compositions comprising the compounds.
摘要翻译： 提供式（I）化合物及其盐：其中R4，R5，R6，Q，A和Y如说明书中所定义。 公开了化合物作为药物的用途和用于治疗精神病，认知障碍和阿尔茨海默氏病的药物的制备。 本发明还公开了包含该化合物的药物组合物。
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3.发明申请公开(公告)号：US20120316196A1
公开(公告)日：2012-12-13
申请号：US13592785
申请日：2012-08-23
申请人： David Gwyn Cooper , Ian Thomson Forbes , Vincenzo Garzya , Dale James Johnson , Graeme Irvine Stevenson , Paul Adrian Wyman
发明人： David Gwyn Cooper , Ian Thomson Forbes , Vincenzo Garzya , Dale James Johnson , Graeme Irvine Stevenson , Paul Adrian Wyman
IPC分类号： A61K31/454 , A61P25/28 , A61P25/18 , A61K31/4545
CPC分类号： C07D498/04 , C07D209/34 , C07D215/227
摘要： Compounds of formula (I) or a salt thereof are provided: wherein R4, R5, R6, Q, A, Y and R are as defined in the description. Uses of the compounds as medicaments and in the manufacture of medicaments for treating psychotic disorders, cognitive impairments and Alzheimer's Disease are disclosed. The invention further discloses pharmaceutical compositions comprising the compounds.
摘要翻译： 提供式（I）化合物或其盐：其中R 4，R 5，R 6，Q，A，Y和R如说明书中所定义。 公开了化合物作为药物的用途和用于治疗精神病，认知障碍和阿尔茨海默氏病的药物的制备。 本发明还公开了包含该化合物的药物组合物。
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4.发明授权公开(公告)号：US08299257B2
公开(公告)日：2012-10-30
申请号：US12678353
申请日：2008-09-18
申请人： David Gwyn Cooper , Ian Thomson Forbes , Vincenzo Garzya , Dale James Johnson , Graeme Irvine Stevenson , Paul Adrian Wyman
发明人： David Gwyn Cooper , Ian Thomson Forbes , Vincenzo Garzya , Dale James Johnson , Graeme Irvine Stevenson , Paul Adrian Wyman
IPC分类号： C07D261/20 , A61K31/445
CPC分类号： C07D413/04
摘要： Compounds of formula (I) or a salt thereof are provided: wherein R4, R5, R6, Q, A, Y and R are as defined in the description. Uses of the compounds as medicaments and in the manufacture of medicaments for treating psychotic disorders, cognitive impairments and Alzheimer's Disease are disclosed. The invention further discloses pharmaceutical compositions comprising the compounds.
摘要翻译： 提供式（I）化合物或其盐：其中R 4，R 5，R 6，Q，A，Y和R如说明书中所定义。 公开了化合物作为药物的用途和用于治疗精神病，认知障碍和阿尔茨海默氏病的药物的制备。 本发明还公开了包含该化合物的药物组合物。
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5.发明申请公开(公告)号：US20100204272A1
公开(公告)日：2010-08-12
申请号：US12678347
申请日：2008-09-18
申请人： David Gwyn Cooper , Ian Thomson Forbes , Vincenzo Garzya , Dale James Johnson , Graeme Irvine Stevenson , Paul Adrian Wyman
发明人： David Gwyn Cooper , Ian Thomson Forbes , Vincenzo Garzya , Dale James Johnson , Graeme Irvine Stevenson , Paul Adrian Wyman
IPC分类号： A61K31/47 , C07D401/04 , A61K31/454 , A61P25/18 , A61P25/28
CPC分类号： C07D498/04 , C07D209/34 , C07D215/227
摘要： Compounds of formula (I) or a salt thereof are provided: wherein R4, R5, R6, Q, A, Y and R are as defined in the description. Uses of the compounds as medicaments and in the manufacture of medicaments for treating psychotic disorders, cognitive impairments and Alzheimer's Disease are disclosed. The invention further discloses pharmaceutical compositions comprising the compounds.
摘要翻译： 提供式（I）化合物或其盐：其中R 4，R 5，R 6，Q，A，Y和R如说明书中所定义。 公开了化合物作为药物的用途和用于治疗精神病，认知障碍和阿尔茨海默氏病的药物的制备。 本发明还公开了包含该化合物的药物组合物。
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6.发明授权公开(公告)号：US08278328B2
公开(公告)日：2012-10-02
申请号：US12678347
申请日：2008-09-18
申请人： David Gwyn Cooper , Ian Thomson Forbes , Vincenzo Garzya , Dale James Johnson , Graeme Irvine Stevenson , Paul Adrian Wyman
发明人： David Gwyn Cooper , Ian Thomson Forbes , Vincenzo Garzya , Dale James Johnson , Graeme Irvine Stevenson , Paul Adrian Wyman
IPC分类号： A61K31/445 , A61K31/425 , A61K31/42 , C07D401/00 , C07D277/00 , C07D263/00
CPC分类号： C07D498/04 , C07D209/34 , C07D215/227
摘要： Compounds of formula (I) or a salt thereof are provided: wherein R4, R5, R6, Q, A, Y and R are as defined in the description. Uses of the compounds as medicaments and in the manufacture of medicaments for treating psychotic disorders, cognitive impairments and Alzheimer's Disease are disclosed. The invention further discloses pharmaceutical compositions comprising the compounds.
摘要翻译： 提供式（I）化合物或其盐：其中R 4，R 5，R 6，Q，A，Y和R如说明书中所定义。 公开了化合物作为药物的用途和用于治疗精神病，认知障碍和阿尔茨海默氏病的药物的制备。 本发明还公开了包含该化合物的药物组合物。
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7.发明申请BENZIMIDAZOLES WHICH HAVE ACTIVITY AT M1 RECEPTOR AND THEIR USES IN MEDICINE 审中-公开在M1受体上具有活性的BENZIMIDAZOLES及其在医学中的用途公开(公告)号：US20100190825A1
公开(公告)日：2010-07-29
申请号：US12293572
申请日：2007-03-20
申请人： David Gwyn Cooper , Ian Thomson Forbes , Vincenzo Garzya , Jian Jin , Yann Louchart , Graham Walker , Paul Adrian Wyman
发明人： David Gwyn Cooper , Ian Thomson Forbes , Vincenzo Garzya , Jian Jin , Yann Louchart , Graham Walker , Paul Adrian Wyman
IPC分类号： A61K31/454 , C07D401/04 , A61P25/18 , A61P25/00
CPC分类号： C07D235/26
摘要： Compounds of formula (I) and salts and solvates are provided: whereinUses of the compounds for the treatment of psychotic disorders and cognitive mpairment, are also disclosed.
摘要翻译： 提供式（I）化合物和盐和溶剂合物：其中还公开了用于治疗精神病和认知功能的化合物的用途。
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8.发明申请公开(公告)号：US20120316202A1
公开(公告)日：2012-12-13
申请号：US13584956
申请日：2012-08-14
申请人： David Gwyn COOPER , Ian Thomson Forbes , Vincenzo Garzya , Jian Jin , Yann Louchart , Graham Walker , Paul Adrian Wyman
发明人： David Gwyn COOPER , Ian Thomson Forbes , Vincenzo Garzya , Jian Jin , Yann Louchart , Graham Walker , Paul Adrian Wyman
IPC分类号： A61K31/454 , A61P25/00 , A61P25/28 , C07D401/04
CPC分类号： C07D235/26
摘要： Compounds of the general formula And their use in the treatment of psychotic disorders and cognitive impairment are disclosed.
摘要翻译： 公开了通式的化合物及其在治疗精神病和认知障碍中的用途。
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9.发明申请BENZIMIDAZOLES WHICH HAVE ACTIVITY AT M1 RECEPTOR AND THEIR USES IN MEDICINE 审中-公开在M1受体上具有活性的BENZIMIDAZOLES及其在医学中的用途公开(公告)号：US20100280071A1
公开(公告)日：2010-11-04
申请号：US12293625
申请日：2007-03-20
申请人： David Gwyn Cooper , Ian Thomson Forbes , Vincenzo Garzya , Jian Jin , Yann Louchart , Graham Walker , Paul Adrian Wyman
发明人： David Gwyn Cooper , Ian Thomson Forbes , Vincenzo Garzya , Jian Jin , Yann Louchart , Graham Walker , Paul Adrian Wyman
IPC分类号： A61K31/454 , C07D401/04 , C07D211/58 , A61P25/18 , A61P25/28
CPC分类号： C07D235/26
摘要： Compounds of formula (I), salts and solvates are provided: Uses of the compounds for therapy, for example in the treatment of psychotic disorders and cognitive impairment, are also disclosed.
摘要翻译： 提供式（I）化合物，盐和溶剂合物：还公开了用于治疗的化合物的用途，例如治疗精神病和认知障碍。
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10.发明申请BENZIMIDAZOLES WHICH HAVE ACTIVITY AT M1 RECEPTOR AND THEIR USES IN MEDICINE 审中-公开在M1受体上具有活性的BENZIMIDAZOLES及其在医学中的用途公开(公告)号：US20120041027A1
公开(公告)日：2012-02-16
申请号：US13282604
申请日：2011-10-27
申请人： David Gwyn COOPER , Ian Thomson Forbes , Vincenzo Garzya , Jian Jin , Yann Louchart , Graham Walker , Paul Adrian Wyman
发明人： David Gwyn COOPER , Ian Thomson Forbes , Vincenzo Garzya , Jian Jin , Yann Louchart , Graham Walker , Paul Adrian Wyman
IPC分类号： A61K31/454 , A61P25/18 , A61P25/28 , C07D401/04
CPC分类号： C07D235/26
摘要： Compounds of formula (I) and salts and solvates are provided: wherein Uses of the compounds for therapy, for example in the treatment of psychotic disorders and cognitive impairment, are also disclosed.
摘要翻译： 提供式（I）化合物和盐和溶剂合物：其中还公开了化合物用于治疗的用途，例如治疗精神病和认知障碍。
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