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15 条记录 (耗时 0.047 秒)

    Treatment of atrial fibrillation
    4.
    发明授权
    Treatment of atrial fibrillation 有权
    心房颤动的治疗

    公开(公告)号：US08541464B2

    公开(公告)日：2013-09-24

    申请号：US13509752

    申请日：2010-11-16

    申请人： Gary T. Elliott

    发明人： Gary T. Elliott

    IPC分类号： A61K31/4025

    CPC分类号： A61K31/4025 ,  A61K31/18 ,  A61P9/00 ,  A61P9/06

    摘要： Atrial fibrillation (AF) can be treated or prevented by administering to a subject who suffers from or is at risk of suffering from AF a composition comprised of an amount of an active agent, which is 4-methoxy-N-(3,5-bis(1-pyrrolidinyl)-4-hydroxy benzyl)benzene sulfonamide (sulcardine) or a pharmaceutically acceptable salt thereof, such that the Cmax value the active agent in the subject is in the range from about 1 μM to about 20 μM.

    摘要翻译： 可以通过给患有AF或患有AF风险的受试者施用由一定量的活性剂组成的组合物来治疗或预防心房颤动（AF），所述活性剂是4-甲氧基-N- 双（1-吡咯烷基）-4-羟基苄基）苯磺酰胺（sulcardine）或其药学上可接受的盐，使得受试者中活性剂的C max值在约1μM至约20μM的范围内。

    Slow infusion of sulcardine and its salts
    7.
    发明授权
    Slow infusion of sulcardine and its salts 有权
    慢性输注苏美卡因及其盐

    公开(公告)号：US08637566B2

    公开(公告)日：2014-01-28

    申请号：US13509739

    申请日：2010-11-16

    申请人： Gary T. Elliott

    发明人： Gary T. Elliott

    IPC分类号： A61K31/4025

    CPC分类号： A61K31/4025 ,  A61K9/0019

    摘要： A composition comprised of an active agent that is 4-methoxy-N-(3,5-bis-(1-pyrrolidinyl)-4-hydroxy benzyl)benzene sulfonamide or a pharmaceutically acceptable salt thereof is intravenously administered to a subject, substantially evenly over a period of greater than about 15 minutes, to avoid disadvantageous hemodynamic effects, including systemic diastolic and systolic hypotension, to can occur with rapid intravenous or even short-term infusion administration of the active agent.

    摘要翻译： 将由4-甲氧基-N-（3,5-双 - （1-吡咯烷基）-4-羟基苄基）苯磺酰胺或其药学上可接受的盐组成的组合物静脉内施用于受试者， 在大于约15分钟的时间内，以避免不利的血液动力学作用，包括系统性舒张和收缩期低血压，可以通过快速静脉内或甚至短期输注给药活性剂而发生。

    TREATMENT OF ATRIAL FIBRILLATION
    9.
    发明申请
    TREATMENT OF ATRIAL FIBRILLATION 有权
    ATRIAL FIBRILLATION治疗

    公开(公告)号：US20120309810A1

    公开(公告)日：2012-12-06

    申请号：US13509752

    申请日：2010-11-16

    申请人： Gary T. Elliott

    发明人： Gary T. Elliott

    IPC分类号： A61K31/4025 ,  A61P9/06

    CPC分类号： A61K31/4025 ,  A61K31/18 ,  A61P9/00 ,  A61P9/06

    摘要： Atrial fibrillation (AF) can be treated or prevented by administering to a subject who suffers from or is at risk of suffering from AF a composition comprised of an amount of an active agent, which is 4-methoxy-N-(3,5-bis(1-pyrrolidayl)-4-hydroxy benzyl) benzene sulfonamide (sulcardine) or a pharmaceutically acceptable salt thereof, such that the Cmax value the active agent in the subject is in the range from about 1 μM to about 20 μM.

    摘要翻译： 可以通过给患有AF或患有AF风险的受试者施用由一定量的活性剂组成的组合物来治疗或预防心房颤动（AF），所述活性剂是4-甲氧基-N- 双（1-吡咯烷基）-4-羟基苄基）苯磺酰胺（sulcardine）或其药学上可接受的盐，使得受试者中活性剂的C max值在约1μM至约20μM的范围内。

    AEROSOLIZED NITRITE AND NITRIC OXIDE -DONATING COMPOUNDS AND USES THEREOF
    10.
    发明申请
    AEROSOLIZED NITRITE AND NITRIC OXIDE -DONATING COMPOUNDS AND USES THEREOF 审中-公开
    含氮硝酸盐和氮氧化物的化合物及其用途

    公开(公告)号：US20090196930A1

    公开(公告)日：2009-08-06

    申请号：US12343920

    申请日：2008-12-24

    申请人： Mark W. Surber ,  Gary T. Elliott ,  Geoffrey Eugene Barker

    发明人： Mark W. Surber ,  Gary T. Elliott ,  Geoffrey Eugene Barker

    IPC分类号： A61K9/14 ,  A61K33/00 ,  A61P11/00 ,  A61M15/00

    CPC分类号： A61K33/00 ,  A61K9/0043 ,  A61K9/0075 ,  A61K9/0078 ,  A61K9/008

    摘要： Disclosed herein are formulations of nitrite, nitrite salt, or nitrite- or nitric oxide-producing compounds suitable for aerosolization and use of such formulations for aerosol administration of nitrite, nitrite salt, or nitrite- or nitric oxide-donating compounds for the treatment of pulmonary arterial hypertension, intra-nasal or pulmonary bacterial infections, or to treat or prevent ischemic reperfusion injury of the heart, brain and organs involved in transplantation. In particular, inhaled nitrite, nitrite salt, or nitrite- or nitric oxide-donating compound specifically formulated and delivered to the respiratory tract for the indications is described. Compositions include all formulations, kits, and device combinations described herein. Methods include inhalation procedures and manufacturing processes for production and use of the compositions described.

    摘要翻译： 本文公开了适用于气溶胶化的亚硝酸盐，亚硝酸盐或产生亚硝酸盐或一氧化一氮的化合物的制剂，并且用于这种制剂用于气雾剂施用亚硝酸盐，亚硝酸盐或用于治疗肺的亚硝酸盐或一氧化氮的化合物 动脉高血压，鼻内或肺部细菌感染，或治疗或预防参与移植的心脏，脑和器官的缺血再灌注损伤。 特别地，描述了特别配制并输送到呼吸道用于适应症的吸入亚硝酸盐，亚硝酸盐或亚硝酸盐或一氧化氮供体化合物。 组合物包括本文所述的所有制剂，试剂盒和装置组合。 方法包括用于生产和使用所述组合物的吸入程序和制造方法。