公开(公告)号：US20140017662A1

公开(公告)日：2014-01-16

申请号：US13545281

申请日：2012-07-10

申请人： David KRAVITZ ,  Christopher P. STEINMAN ,  Jeffrey S. LOUIS ,  Matthew COPITHORNE ,  Brian L. OTTS ,  Peter DEMUYLDER

发明人： David KRAVITZ ,  Christopher P. STEINMAN ,  Jeffrey S. LOUIS ,  Matthew COPITHORNE ,  Brian L. OTTS ,  Peter DEMUYLDER

IPC分类号： A01N1/02

CPC分类号： A01N1/0247

摘要： An organ perfusion apparatus may include at least two tubes connected to an organ or tissue. A method of perfusing an organ or tissue may include connecting a first end of each of the at least two tubes to an organ or tissue, applying a fluid motive force to a perfusion fluid in the two tubes to force the fluid through the two tubes into the organ or tissue, and perfusing the organ or tissue through the at least two tubes such that the fluid motive force, provided by, e.g., a pump, and backpressure generated by the organ or tissue, establishes a flow balance between the at least two tubes. The flow balance may be altered without altering the fluid motive force that is applied.

摘要翻译： 器官灌注装置可以包括连接到器官或组织的至少两个管。 灌注器官或组织的方法可以包括将至少两个管中的每一个的第一端连接到器官或组织，将流体动力施加到两个管中的灌注流体，以迫使流体通过两个管进入 所述器官或组织，并且通过所述至少两个管灌注所述器官或组织，使得由例如泵提供的流体动力和由所述器官或组织产生的背压在所述至少两个管之间建立流动平衡 管。 可以改变流动平衡而不改变施加的流体动力。

公开(公告)号：US20140017770A1

公开(公告)日：2014-01-16

申请号：US13545321

申请日：2012-07-10

申请人： Christopher P. STEINMAN ,  Rick W. WALKER ,  Kirk C. PALMERTON ,  Jeffrey S. LOUIS ,  David PETTINATO ,  Matthew COPITHORNE ,  Brian L OTTS ,  Peter DEMUYLDER ,  James GUARRERA ,  Ben O. ARRINGTON

发明人： Christopher P. STEINMAN ,  Rick W. WALKER ,  Kirk C. PALMERTON ,  Jeffrey S. LOUIS ,  David PETTINATO ,  Matthew COPITHORNE ,  Brian L OTTS ,  Peter DEMUYLDER ,  James GUARRERA ,  Ben O. ARRINGTON

IPC分类号： A01N1/02

CPC分类号： A01N1/0247 ,  A01N1/0273

摘要： A perfusion apparatus includes a coolant container having a basin-receiving recess that is at least partly surrounded by an inner chamber; a basin that is shaped to fit within the basin-receiving recess of the coolant container; and a cradle that is shaped to accept an organ and fit within the basin. The basin-receiving recess of the coolant container, the basin and the cradle each have positioning elements that are oriented such that the cradle is keyed to fit within the basin and the basin is keyed to fit within the coolant container, each in a single predetermined orientation. The plurality of positioning elements on the basin may include a plurality of protrusions on an outer surface of the basin.

摘要翻译： 灌注装置包括：冷却剂容器，其具有至少部分地被内腔包围的盆容纳凹部; 成形为容纳在冷却剂容器的盆接收凹部内的盆; 和一个成形为接受器官并装配在盆内的摇篮。 冷却剂容器，盆和托架的盆容纳凹槽各自具有定位元件，其定位成使得支架被键合以配合在盆内，并且盆被键合以装配在冷却剂容器内，每个以单一预定 方向。 盆上的多个定位元件可以包括在盆的外表面上的多个突起。

公开(公告)号：US20140017657A1

公开(公告)日：2014-01-16

申请号：US13545210

申请日：2012-07-10

申请人： David KRAVITZ ,  Christopher P. STEINMAN ,  David PETTINATO ,  Matthew COPITHORNE ,  Brian L. OTTS ,  Robert J. ALLEN ,  Frank P. NANNA ,  Peter DEMUYLDER

发明人： David KRAVITZ ,  Christopher P. STEINMAN ,  David PETTINATO ,  Matthew COPITHORNE ,  Brian L. OTTS ,  Robert J. ALLEN ,  Frank P. NANNA ,  Peter DEMUYLDER

IPC分类号： A01N1/02

CPC分类号： A01N1/0252 ,  A01N1/0247 ,  A01N1/0273

摘要： An apparatus for at least one of storage, treatment, assessment and transport of an organ or tissue includes a coolant container configured to cool the organ or tissue, a perfusion circuit configured to perfuse the organ or tissue, and a sample compartment for holding a biological sample. Preferred apparatus has a first internal compartment under a first cover (lid) of the apparatus that includes the coolant container and the sample compartment. The apparatus can include a second internal compartment under a second cover (lid) of the apparatus, the second internal compartment including at least part of the perfusion circuit and a sample compartment.

摘要翻译： 用于器官或组织的储存，处理，评估和运输中的至少一个的装置包括构造成冷却器官或组织的冷却剂容器，构造成灌注器官或组织的灌注回路，以及用于保持生物 样品。 优选的装置在装置的第一盖（盖）下方具有包括冷却剂容器和样品室的第一内部隔室。 该装置可以包括设备的第二盖（盖）下的第二内部隔室，第二内部隔室包括至少部分灌注回路和样品室。

公开(公告)号：US20140017659A1

公开(公告)日：2014-01-16

申请号：US13545184

申请日：2012-07-10

申请人： Christopher P. STEINMAN ,  Robert J. ALLEN ,  David PETTINATO ,  Matthew COPITHORNE ,  Brian L. OTTS ,  Peter DEMUYLDER

发明人： Christopher P. STEINMAN ,  Robert J. ALLEN ,  David PETTINATO ,  Matthew COPITHORNE ,  Brian L. OTTS ,  Peter DEMUYLDER

IPC分类号： A01N1/02

CPC分类号： A01N1/0247 ,  A01N1/0273

摘要： A perfusion apparatus including a perfusion circuit that perfuses an organ or tissue has a compartment that supports an organ or tissue during perfusion, an internal cover, and an external cover that closes the apparatus. A wall portion may extend substantially perpendicularly between the internal cover and the external cover to define a document compartment between the internal cover, the external cover and the wall portion. A tamper evident seal will not permit the external cover to open without creating a record of whether the external cover has been opened after the tamper evident seal has been activated.

摘要翻译： 包括灌注器官或组织的灌注电路的灌注装置具有在灌注期间支撑器官或组织的隔室，内盖和封闭装置的外盖。 壁部分可以在内盖和外盖之间基本上垂直地延伸，以在内盖，外盖和壁部之间限定文件舱。 防篡改密封件将不允许外盖打开，而不会创建在启用篡改显示密封件后外盖是否打开的记录。

公开(公告)号：US20130177897A1

公开(公告)日：2013-07-11

申请号：US13348195

申请日：2012-01-11

申请人： David C. KRAVITZ ,  Peter DEMUYLDER ,  Brian OTTS ,  Stephan MERKLE ,  Jeremiah P. O'LEARY ,  Christopher E. SVENSRUD

发明人： David C. KRAVITZ ,  Peter DEMUYLDER ,  Brian OTTS ,  Stephan MERKLE ,  Jeremiah P. O'LEARY ,  Christopher E. SVENSRUD

IPC分类号： A01N1/02 ,  B65D33/02 ,  B65D33/06

CPC分类号： A01N1/0273 ,  A61B10/0096

摘要： A bag includes an organ transporter compartment to contain an organ transporter disposed in the transporter compartment. The bag may include openings to access portions of the organ transporter, such as a battery or power cable, when the organ transporter is disposed in the bag. The bag may also include a frame and handles. The handles may include structure adapted to mate with handles on the organ transporter. The bag may also include a single cover that provides access to multiple compartments with their own internal covers. Also, the bag may include windows to view documents stored in the bag and/or to view and/or display control panels on the organ transporter.

摘要翻译： 袋子包括器官运送室，用于容纳设置在运输车厢内的器官运送器。 当器官输送器设置在袋中时，该袋可以包括用于进入器官运送器的部分的开口，例如电池或电力电缆。 袋子还可以包括框架和把手。 手柄可以包括适于与器官运送器上的手柄配合的结构。 该袋还可以包括单个盖，其提供通过其自己的内盖进入多个隔间的单个盖。 此外，袋可以包括用于观察存储在袋中的文件的窗口和/或用于观察和/或显示器官运送器上的控制面板。