公开(公告)号：US20130240251A1

公开(公告)日：2013-09-19

申请号：US13641000

申请日：2011-04-12

申请人： David Kaplan ,  Fiorenzo Omenetto ,  Jason Amsden ,  Hu Tao ,  Richard Averitt ,  Andrew Strikwerda ,  Xin Zhang ,  Konstantinos Tsioris

发明人： David Kaplan ,  Fiorenzo Omenetto ,  Jason Amsden ,  Hu Tao ,  Richard Averitt ,  Andrew Strikwerda ,  Xin Zhang ,  Konstantinos Tsioris

IPC分类号： H05K1/03

CPC分类号： H05K1/032 ,  G02B1/002 ,  H01Q7/00

摘要： The invention relates to silk electronic components and methods for fabricating the same. The silk electronic components can be used as novel devices, such as implantable bioelectric and/or biophotonic devices, biosensors, surveillance devices, invisible cloaks, electromagnetic concentrators or antennas.

摘要翻译： 本发明涉及丝电子部件及其制造方法。 丝电子部件可以用作可植入生物电离和/或生物光子装置，生物传感器，监视装置，隐形斗篷，电磁集中器或天线的新型装置。

公开(公告)号：US09603243B2

公开(公告)日：2017-03-21

申请号：US13641000

申请日：2011-04-12

申请人： David Kaplan ,  Fiorenzo Omenetto ,  Hu Tao ,  Richard Averitt ,  Andrew Strikwerda ,  Xin Zhang ,  Konstantinos Tsioris

发明人： David Kaplan ,  Fiorenzo Omenetto ,  Hu Tao ,  Richard Averitt ,  Andrew Strikwerda ,  Xin Zhang ,  Konstantinos Tsioris

IPC分类号： H05K1/03 ,  H01Q7/00 ,  G02B1/00

CPC分类号： H05K1/032 ,  G02B1/002 ,  H01Q7/00

摘要： The invention relates to silk electronic components and methods for fabricating the same. The silk electronic components can be used as novel devices, such as implantable bioelectric and/or biophotonic devices, biosensors, surveillance devices, invisible cloaks, electromagnetic concentrators or antennas.

公开(公告)号：US10933173B2

公开(公告)日：2021-03-02

申请号：US13880592

申请日：2011-10-19

申请人： David L. Kaplan ,  Konstantinos Tsioris ,  Fiorenzo G. Omenetto ,  Eleanor M. Pritchard

发明人： David L. Kaplan ,  Konstantinos Tsioris ,  Fiorenzo G. Omenetto ,  Eleanor M. Pritchard

IPC分类号： A61L31/12 ,  A61B17/20 ,  A61K9/00 ,  A61L31/04 ,  A61L31/16 ,  A61M5/158 ,  A61M37/00

摘要： A microneedle or microneedle device includes a microneedle body extending from a base to a penetrating tip formed from a silk fibroin based material, which is easy to fabricate and highly biocompatible. The microneedle device can include one or more microneedles mounted to a substrate. The silk fibroin can include active agents to be transported into or across biological barriers such as skin, tissue and cell membranes. The silk fibroin microneedles can be fully or partially biodegradable and/or bioerodible. The silk fibroin is highly stable, affords room temperature storage and is implantable. The silk fibroin structure can be modulated to control the rate of active agent delivery.

公开(公告)号：US20130338632A1

公开(公告)日：2013-12-19

申请号：US13880592

申请日：2011-10-19

申请人： David L. Kaplan ,  Konstantinos Tsioris ,  Fiorenzo G. Omenetto ,  Eleanor M. Pritchard

发明人： David L. Kaplan ,  Konstantinos Tsioris ,  Fiorenzo G. Omenetto ,  Eleanor M. Pritchard

IPC分类号： A61L31/12 ,  A61M37/00

CPC分类号： A61L31/125 ,  A61B17/205 ,  A61K9/0021 ,  A61L31/047 ,  A61L31/16 ,  A61M5/158 ,  A61M37/0015 ,  A61M2037/0046 ,  A61M2037/0053

摘要： A microneedle or microneedle device includes a microneedle body extending from a base to a penetrating tip formed from a silk fibroin based material, which is easy to fabricate and highly biocompatible. The microneedle device can include one or more microneedles mounted to a substrate. The silk fibroin can include active agents to be transported into or across biological barriers such as skin, tissue and cell membranes. The silk fibroin microneedles can be fully or partially biodegradable and/or bioerodible. The silk fibroin is highly stable, affords room temperature storage and is implantable. The silk fibroin structure can be modulated to control the rate of active agent delivery.

摘要翻译： 微针或微针装置包括从基部延伸到由丝素蛋白基材料形成的穿透尖端的微针体，其易于制造和高度生物相容性。 微针装置可以包括安装到基底的一个或多个微针。 丝素蛋白可以包括被运送到生物屏障如皮肤，组织和细胞膜之中或之上的活性剂。 丝素蛋白微针可以全部或部分生物降解和/或生物侵蚀。 丝素蛋白高度稳定，提供室温储存并可植入。 可以调节丝素蛋白结构以控制活性剂递送的速率。