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公开(公告)号：US20060063731A1
公开(公告)日：2006-03-23
申请号：US11234947
申请日：2005-09-26
申请人： David Lewis , Jon Wolff , Hans Herweijer , James Hagstrom , Aaron Loomis
发明人： David Lewis , Jon Wolff , Hans Herweijer , James Hagstrom , Aaron Loomis
IPC分类号： A61K48/00
CPC分类号： A61K31/07 , C07K14/005 , C12N15/111 , C12N15/1131 , C12N15/1137 , C12N15/1138 , C12N2310/11 , C12N2310/14 , C12N2310/3233 , C12N2320/31 , C12N2320/32 , C12N2730/10122 , C12Y101/01034 , C12Y206/01002
摘要： A process is provided to deliver polynucleotide-based gene expression inhibitors to cells in a mammal in vivo for the purpose of inhibiting gene expression in the cells. Inhibition is sequence-specific and relies on sequence similarity to of the polynucleotide-based gene expression inhibitor and the target nucleic acid molecule. Delivery of the polynucleotide-based gene expression inhibitor can enhance the efficacy of co-delivered small molecule drugs.
摘要翻译： 为了抑制细胞中的基因表达，提供了一种用于在体内向哺乳动物中的细胞递送基于多核苷酸的基因表达抑制剂的方法。 抑制是序列特异性的，并且依赖于基于多核苷酸的基因表达抑制剂和靶核酸分子的序列相似性。 基于多核苷酸的基因表达抑制剂的递送可以增强共同递送的小分子药物的功效。
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2.发明申请Inhibition of gene expression by delivery of small interfering RNA to post-embryonic animal cells in vivo 审中-公开通过在体内将小干扰RNA递送至胚胎后动物细胞来抑制基因表达公开(公告)号：US20050260270A1
公开(公告)日：2005-11-24
申请号：US11113586
申请日：2005-04-25
申请人： David Lewis , Hans Herweijer , Jon Wolff , James Hagstrom , Aaron Loomis
发明人： David Lewis , Hans Herweijer , Jon Wolff , James Hagstrom , Aaron Loomis
CPC分类号： C12N15/111 , A61K48/0008 , A61K48/0041 , A61K48/0083 , C12N2320/32
摘要： A process is provided to deliver small interfering RNA to cells in vivo for the purpose of inhibiting gene expression in that cell. The small interfering RNA is less than 50 base-pairs in length. This process is practiced on post-embryonic animals. Inhibition is sequence-specific and relies on sequence identity of the small interfering RNA and the target nucleic acid molecule.
摘要翻译： 提供了一种方法，用于在体内将小干扰RNA递送至细胞，以抑制该细胞中的基因表达。 小干扰RNA的长度小于50个碱基对。 这个过程是在胚胎后的动物上进行的。 抑制是序列特异性的，并且依赖于小干扰RNA和靶核酸分子的序列同一性。
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3.发明申请Compositions and processes using siRNA, amphipathic compounds and polycations 有权使用siRNA，两亲性化合物和聚阳离子的组合物和方法公开(公告)号：US20050143332A1
公开(公告)日：2005-06-30
申请号：US10845968
申请日：2004-05-14
申请人： Sean Monahan , David Lewis , Hans Herweijer , Jon Wolff , James Hagstrom , Aaron Loomis , Vladimir Trubetskoy , Lori Higgs
发明人： Sean Monahan , David Lewis , Hans Herweijer , Jon Wolff , James Hagstrom , Aaron Loomis , Vladimir Trubetskoy , Lori Higgs
IPC分类号： A61K31/495 , A61K31/58 , A61K31/7105 , A61K31/74 , A61K48/00 , C07H21/04 , C12N15/11 , C12N15/88 , G01N33/53
CPC分类号： C12N15/111 , A61K31/495 , A61K31/58 , A61K31/7105 , A61K31/74 , A61K48/0025 , A61K48/0041 , C07H21/04 , C12N15/88 , C12N2310/14 , C12N2320/32 , A61K2300/00
摘要： Described is a deliverable composition with low toxicity comprising an amphipathic compound, a polycation, and a siRNA. The composition may be used in the process of delivering a siRNA to an animal cell or more particularly, a mammal cell.
摘要翻译： 描述了具有低毒性的可递送组合物，其包含两亲性化合物，聚阳离子和siRNA。 组合物可以用于将siRNA递送到动物细胞或更特别是哺乳动物细胞的过程中。
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4.发明申请Inhibition of gene function by delivery of polynucleotide-based gene expression inhibitors to mammalian cells in vivo 审中-公开通过在体内向哺乳动物细胞递送基于多核苷酸的基因表达抑制剂来抑制基因功能公开(公告)号：US20050037989A1
公开(公告)日：2005-02-17
申请号：US10874528
申请日：2004-06-23
申请人： David Lewis , Jon Wolff , Hans Herweijer , James Hagstrom , Aaron Loomis , Andrew Spencer
发明人： David Lewis , Jon Wolff , Hans Herweijer , James Hagstrom , Aaron Loomis , Andrew Spencer
IPC分类号： A61K38/00 , A61K48/00 , C12N15/11 , C12N15/113 , C12N15/87
CPC分类号： C12N15/111 , A61K38/00 , A61K48/00 , C12N15/1137 , C12N15/87 , C12N2310/14 , C12N2320/32 , C12Y206/01002
摘要： A process is provided to deliver polynucleotide-based gene expression inhibitors to cells in a mammal in vivo for the purpose of inhibiting gene expression in the cells. Inhibition is sequence-specific and relies on sequence similaroty of the polynucleotide-based gene expression inhibitor and the target nucleic acid molecule. Delivery of the polynucleotide-based gene expression inhibitor can enhance the efficacy of co-delivered small molecule drugs.
摘要翻译： 为了抑制细胞中的基因表达，提供了一种用于在体内向哺乳动物中的细胞递送基于多核苷酸的基因表达抑制剂的方法。 抑制是序列特异性的，并且依赖于基于多核苷酸的基因表达抑制剂和靶核酸分子的序列相似性。 基于多核苷酸的基因表达抑制剂的递送可以增强共同递送的小分子药物的功效。
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5.发明申请Inhibition of gene expression by delivery of polynucleotides to animal cells in vivo 审中-公开通过在体内将多核苷酸递送到动物细胞来抑制基因表达公开(公告)号：US20070128169A1
公开(公告)日：2007-06-07
申请号：US11649502
申请日：2007-01-04
申请人： David Lewis , Jon Wolff , Vladimir Budker , Hans Herweijer , James Hagstrom
发明人： David Lewis , Jon Wolff , Vladimir Budker , Hans Herweijer , James Hagstrom
IPC分类号： A61K48/00
CPC分类号： C12N15/1137 , A61K31/58 , A61K31/74 , A61K38/00 , A61K48/00 , C12N15/111 , C12N15/88 , C12N2310/14 , C12N2320/32 , C12N2710/24111 , C12Y206/01002 , A61K2300/00
摘要： Described is a process for intravascular delivery of a polynucleotide to an extravascular cell of a mammal to inhibit gene expression. A polynucleotide containing sequence that is similar to a sequence in the gene to be expressed is made and inserted into a vessel in the mammal. The polynucleotide is delivered to a cell wherein expression of the gene is inhibited.
摘要翻译： 描述了将多核苷酸血管内递送至哺乳动物血管外细胞以抑制基因表达的方法。 制备含有与待表达基因中的序列相似的序列的多核苷酸，并将其插入哺乳动物的血管。 将多核苷酸递送至细胞，其中基因的表达被抑制。
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公开(公告)号：US20070021364A1
公开(公告)日：2007-01-25
申请号：US11437933
申请日：2006-05-19
申请人： Hans Herweijer , Jon Wolff , Mary Bates , Aaron Loomis , Vladimir Trubetskoy
发明人： Hans Herweijer , Jon Wolff , Mary Bates , Aaron Loomis , Vladimir Trubetskoy
CPC分类号： A61K39/0005 , A61K39/12 , A61K39/292 , A61K2039/53 , A61K2039/54 , A61K2039/6093 , C07K16/00 , C12N2730/10134
摘要： The present invention relates to methods for delivering a genetic immunogen, comprising a nucleic acid capable of expressing an antigen, optionally complexed with a polymer. The nucleic acid is delivered to the host via hydrodynamic intravascular injection resulting in expression of an encoded antigen in extravascular cells and induction of an antigen-specific immune response.
摘要翻译： 本发明涉及递送遗传免疫原的方法，其包含能够表达抗原的核酸，任选与聚合物配合。 通过流体动力学血管内注射将核酸递送至宿主，导致编码的抗原在血管外细胞中的表达和诱导抗原特异性免疫应答。
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公开(公告)号：US20060093584A1
公开(公告)日：2006-05-04
申请号：US11268276
申请日：2005-11-07
申请人： Jon Wolff , James Hagstrom , Hans Herweijer , Vladimir Budker , Julia Hegge
发明人： Jon Wolff , James Hagstrom , Hans Herweijer , Vladimir Budker , Julia Hegge
CPC分类号： A61K48/0041 , A61K38/00 , A61K48/00 , A61K48/0008 , A61K48/0075 , A61K48/0083 , C12N15/87
摘要： Disclosed is a process for providing for expression of an exogenous nucleic acid in an extravascular parenchymal cell of a mammal. The nucleic acid is inserted into a vessel of a mammal and the permeability of the vessel is increased. Increasing permeability of the vessel allows delivery of the nucleic acid to an extravascular parenchymal cell.
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8.发明申请Process of delivering a virally encapsulated polynucleotide or viral vector to a parenchymal cell via the vascular system 审中-公开通过血管系统将病毒包封的多核苷酸或病毒载体递送至实质细胞的过程公开(公告)号：US20050129660A1
公开(公告)日：2005-06-16
申请号：US10733706
申请日：2003-12-11
申请人： James Hagstrom , Jon Wolff , Vladimir Budker , Julia Hegge , Hans Herweijer
发明人： James Hagstrom , Jon Wolff , Vladimir Budker , Julia Hegge , Hans Herweijer
IPC分类号： A61K48/00 , A61M31/00 , C12N15/861
CPC分类号： A61K48/0075
摘要： A process for delivering a polynucleotide into a parenchymal cell in a mammal, comprising, transporting the polynucleotide into a vessel communicating with the parenchymal cell in tissue or organ of the mammal such that the polynucleotide is transfected into the parenchymal cell. More specifically, the polynucleotide consists of a viral vector.
摘要翻译： 一种将多核苷酸递送到哺乳动物的实质细胞中的方法，包括将多核苷酸转运到与哺乳动物的组织或器官中的实质细胞连通的血管中，使得多核苷酸被转染到实质细胞中。 更具体地，多核苷酸由病毒载体组成。
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公开(公告)号：US20050153451A1
公开(公告)日：2005-07-14
申请号：US10977025
申请日：2004-10-28
申请人： Jon Wolff , Vladimir Budker , James Hagstrom , Hans Herweijer , Julia Hegge , Paul Slattum , Sean Monahan , David Rozema
发明人： Jon Wolff , Vladimir Budker , James Hagstrom , Hans Herweijer , Julia Hegge , Paul Slattum , Sean Monahan , David Rozema
CPC分类号： A61K48/0083 , A61K38/00 , A61K48/00 , A61K48/0008 , A61K48/0016 , A61K48/0041 , A61K48/0075 , C12N15/87
摘要： Disclosed is a process for providing for expression of an exogenous nucleic acid in an extravascular parenchymal cell of a mammal. The nucleic acid is inserted into a vessel of a mammal and the permeability of the vessel is increased. Increasing permeability of the vessel allows delivery of the nucleic acid to an extravascular parenchymal cell.
摘要翻译： 公开了一种提供外源核酸在哺乳动物血管外实质细胞中表达的方法。 将核酸插入哺乳动物的容器中并增加血管的渗透性。 增加容器的渗透性允许将核酸递送至血管外实质细胞。
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公开(公告)号：US20050222075A1
公开(公告)日：2005-10-06
申请号：US11137317
申请日：2005-05-25
申请人： Hans Herweijer , Jon Wolff , Matthew Wolff , Larry Whitesell
发明人： Hans Herweijer , Jon Wolff , Matthew Wolff , Larry Whitesell
CPC分类号： A61K48/0016 , A61K48/005 , A61K48/0075 , A61K48/0083
摘要： A process for delivering a nucleic acid to a cardiac tissue cell in a mammal is described, comprising introducing a composition consisting of a nucleic acid to a blood vessel, which subsequently delivers the nucleic acid to the cardiac tissue cell. The nucleic acid can be DNA or RNA or plasmid DNA or viral. This process is for purposes of gene therapy, and research.
摘要翻译： 描述了将核酸递送至哺乳动物心脏组织细胞的方法，包括将由核酸组成的组合物导入血管，随后将核酸递送至心脏组织细胞。 核酸可以是DNA或RNA或质粒DNA或病毒。 这个过程是为了基因治疗和研究的目的。
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