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    RS7 antibodies
    2.
    发明授权
    RS7 antibodies 有权
    RS7抗体

    公开(公告)号：US08084583B2

    公开(公告)日：2011-12-27

    申请号：US12389503

    申请日：2009-02-20

    申请人： Serengulam V. Govindan ,  Zhengxing Qu ,  Hans J. Hansen ,  David M. Goldenberg

    发明人： Serengulam V. Govindan ,  Zhengxing Qu ,  Hans J. Hansen ,  David M. Goldenberg

    IPC分类号： C07K16/00

    CPC分类号： A61K45/06 ,  A61K39/39558 ,  A61K51/1045 ,  A61K51/1051 ,  A61K2039/505 ,  C07K16/30 ,  C07K16/3015 ,  C07K2317/21 ,  C07K2317/24

    摘要： This invention relates to monovalent and multivalent, monospecific binding proteins and to multivalent, multispecific binding proteins. One embodiment of these binding proteins has one or more binding sites where each binding site binds with a target antigen or an epitope on a target antigen. Another embodiment of these binding proteins has two or more binding sites where each binding site has affinity towards different epitopes on a target antigen or has affinity towards either a target antigen or a hapten. The present invention further relates to recombinant vectors useful for the expression of these functional binding proteins in a host. More specifically, the present invention relates to the tumor-associated antigen binding protein designated RS7, and other EGP-1 binding-proteins. The invention further relates to humanized, human and chimeric RS7 antigen binding proteins, and the use of such binding proteins in diagnosis and therapy.

    摘要翻译： 本发明涉及单价和多价单特异性结合蛋白和多价多特异性结合蛋白。 这些结合蛋白的一个实施方案具有一个或多个结合位点，其中每个结合位点与靶抗原或靶抗原上的表位结合。 这些结合蛋白的另一个实施方案具有两个或更多个结合位点，其中每个结合位点对靶抗原上的不同表位具有亲和力，或对靶抗原或半抗原具有亲和力。 本发明还涉及可用于在宿主中表达这些功能性结合蛋白的重组载体。 更具体地，本发明涉及称为RS7的肿瘤相关抗原结合蛋白和其它EGP-1结合蛋白。 本发明还涉及人源化，人和嵌合RS7抗原结合蛋白，以及这种结合蛋白在诊断和治疗中的用途。

    Internalizing anti-CD74 antibodies and methods of use
    5.
    发明授权
    Internalizing anti-CD74 antibodies and methods of use 有权
    内化抗CD74抗体及其使用方法

    公开(公告)号：US07772373B2

    公开(公告)日：2010-08-10

    申请号：US11867775

    申请日：2007-10-05

    申请人： Hans J. Hansen ,  Zhengxing Qu ,  David M. Goldenberg

    发明人： Hans J. Hansen ,  Zhengxing Qu ,  David M. Goldenberg

    IPC分类号： C07K16/00

    CPC分类号： A61K45/06 ,  A61K38/00 ,  A61K47/6849 ,  A61K51/1027 ,  A61K2039/505 ,  C07K16/2833 ,  C07K16/2896 ,  C07K2317/24 ,  C07K2317/77

    摘要： The present invention provides humanized, chimeric and human anti-CD74 antibodies, CD74 antibody fusion proteins, immunoconjugates, vaccines and bispecific that bind to CD74, the major histocompatibility complex (MHC) class-II invariant chain, Ii, which is useful for the treatment and diagnosis of B-cell disorders, such as B-cell malignancies, other malignancies in which the cells are reactive with CD74, and autoimmune diseases, and methods of treatment and diagnosis.

    摘要翻译： 本发明提供人源化，嵌合和人抗CD74抗体，CD74抗体融合蛋白，免疫缀合物，疫苗和结合CD74的双特异性，主要组织相容性复合体（MHC）II类不变链I 1可用于治疗 B细胞病变，B细胞恶性肿瘤，其他细胞与CD74反应的其他恶性肿瘤，以及自身免疫性疾病以及治疗和诊断方法的诊断。

    RS7 antibodies
    7.
    发明授权
    RS7 antibodies 有权

    公开(公告)号：US08574575B2

    公开(公告)日：2013-11-05

    申请号：US13293608

    申请日：2011-11-10

    申请人： Serengulam V. Govindan ,  Zhengxing Qu ,  Hans J. Hansen ,  David M. Goldenberg

    发明人： Serengulam V. Govindan ,  Zhengxing Qu ,  Hans J. Hansen ,  David M. Goldenberg

    IPC分类号： A61K39/395

    CPC分类号： A61K45/06 ,  A61K39/39558 ,  A61K51/1045 ,  A61K51/1051 ,  A61K2039/505 ,  C07K16/30 ,  C07K16/3015 ,  C07K2317/21 ,  C07K2317/24

    摘要： This invention relates to monovalent and multivalent, monospecific binding proteins and to multivalent, multispecific binding proteins. One embodiment of these binding proteins has one or more binding sites where each binding site binds with a target antigen or an epitope on a target antigen. Another embodiment of these binding proteins has two or more binding sites where each binding site has affinity towards different epitopes on a target antigen or has affinity towards either a target antigen or a hapten. The present invention further relates to recombinant vectors useful for the expression of these functional binding proteins in a host. More specifically, the present invention relates to the tumor-associated antigen binding protein designated RS7, and other EGP-1 binding-proteins. The invention further relates to humanized, human and chimeric RS7 antigen binding proteins, and the use of such binding proteins in diagnosis and therapy.

    RS7 Antibodies
    8.
    发明申请
    RS7 Antibodies 有权
    RS7抗体

    公开(公告)号：US20120141372A1

    公开(公告)日：2012-06-07

    申请号：US13293608

    申请日：2011-11-10

    申请人： Serengulam V. Govindan ,  Zhengxing Qu ,  Hans J. Hansen ,  David M. Goldenberg

    发明人： Serengulam V. Govindan ,  Zhengxing Qu ,  Hans J. Hansen ,  David M. Goldenberg

    IPC分类号： A61K39/395 ,  A61P31/00 ,  A61P37/02 ,  A61K51/10 ,  A61P35/00

    CPC分类号： A61K45/06 ,  A61K39/39558 ,  A61K51/1045 ,  A61K51/1051 ,  A61K2039/505 ,  C07K16/30 ,  C07K16/3015 ,  C07K2317/21 ,  C07K2317/24

    摘要： This invention relates to monovalent and multivalent, monospecific binding proteins and to multivalent, multispecific binding proteins. One embodiment of these binding proteins has one or more binding sites where each binding site binds with a target antigen or an epitope on a target antigen. Another embodiment of these binding proteins has two or more binding sites where each binding site has affinity towards different epitopes on a target antigen or has affinity towards either a target antigen or a hapten. The present invention further relates to recombinant vectors useful for the expression of these functional binding proteins in a host. More specifically, the present invention relates to the tumor-associated antigen binding protein designated RS7, and other EGP-1 binding-proteins. The invention further relates to humanized, human and chimeric RS7 antigen binding proteins, and the use of such binding proteins in diagnosis and therapy.

    摘要翻译： 本发明涉及单价和多价单特异性结合蛋白和多价多特异性结合蛋白。 这些结合蛋白的一个实施方案具有一个或多个结合位点，其中每个结合位点与靶抗原或靶抗原上的表位结合。 这些结合蛋白的另一个实施方案具有两个或多个结合位点，其中每个结合位点对靶抗原上的不同表位具有亲和力，或对靶抗原或半抗原具有亲和力。 本发明还涉及可用于在宿主中表达这些功能性结合蛋白的重组载体。 更具体地，本发明涉及称为RS7的肿瘤相关抗原结合蛋白和其它EGP-1结合蛋白。 本发明还涉及人源化，人和嵌合RS7抗原结合蛋白，以及这种结合蛋白在诊断和治疗中的用途。