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    Molecular diagnosis and typing of lung cancer variants
    1.
    发明授权
    Molecular diagnosis and typing of lung cancer variants 有权
    分子诊断和分型肺癌变异

    公开(公告)号：US08822153B2

    公开(公告)日：2014-09-02

    申请号：US12602649

    申请日：2008-06-02

    申请人： David N. Hayes ,  Charles M. Perou ,  Philip Bernard

    发明人： David N. Hayes ,  Charles M. Perou ,  Philip Bernard

    IPC分类号： C12Q1/68 ,  G01N33/574

    CPC分类号： C12Q1/686 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/156 ,  G01N33/57423

    摘要： Compositions and methods useful in determining the major morphological types of lung cancer are provided. The methods include detecting expression of at least one gene or biomarker in a sample. The expression of the gene or biomarker is indicative of the lung tumor subtype. The compositions include subsets of genes that are monitored for gene expression. The gene expression is capable of distinguishing between normal lung parenchyma and the major morphological types of lung cancer. The gene expression and somatic mutation data are useful in developing a complete classification of lung cancer that is prognostic and predictive for therapeutic response. The methods are suited for analysis of paraffin-embedded tissues. Methods of the invention include means for monitoring gene or biomarker expression including PCR and antibody-based detection. The biomarkers of the invention are genes and/or proteins that are selectively expressed at a high or low level in certain tumor subtypes. Biomarker expression can be assessed at the protein or nucleic acid level.

    摘要翻译： 提供了有助于确定肺癌主要形态类型的组合物和方法。 所述方法包括检测样品中至少一种基因或生物标志物的表达。 该基因或生物标志物的表达指示肺肿瘤亚型。 组合物包括监测基因表达的基因亚群。 基因表达能够区分正常肺实质和肺癌的主要形态类型。 基因表达和体细胞突变数据可用于开发预后和预测治疗反应的肺癌的完整分类。 该方法适用于石蜡包埋组织的分析。 本发明的方法包括用于监测基因或生物标志物表达的手段，包括PCR和基于抗体的检测。 本发明的生物标志物是在某些肿瘤亚型中以高或低水平选择性表达的基因和/或蛋白质。 可以在蛋白质或核酸水平评估生物标志物表达。

    MOLECULAR DIAGNOSIS AND TYPING OF LUNG CANCER VARIANTS
    2.
    发明申请
    MOLECULAR DIAGNOSIS AND TYPING OF LUNG CANCER VARIANTS 有权
    分子诊断和肺癌变种的分型

    公开(公告)号：US20100233695A1

    公开(公告)日：2010-09-16

    申请号：US12602649

    申请日：2008-06-02

    申请人： David N. Hayes ,  Charles M. Perou ,  Philip Bernard

    发明人： David N. Hayes ,  Charles M. Perou ,  Philip Bernard

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/686 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/156 ,  G01N33/57423

    摘要： Compositions and methods useful in determining the major morphological types of lung cancer are provided. The methods include detecting expression of at least one gene or biomarker in a sample. The expression of the gene or biomarker is indicative of the lung tumor subtype. The compositions include subsets of genes that are monitored for gene expression. The gene expression is capable of distinguishing between normal lung parenchyma and the major morphological types of lung cancer. The gene expression and somatic mutation data are useful in developing a complete classification of lung cancer that is prognostic and predictive for therapeutic response. The methods are suited for analysis of paraffin-embedded tissues. Methods of the invention include means for monitoring gene or biomarker expression including PCR and antibody-based detection. The biomarkers of the invention are genes and/or proteins that are selectively expressed at a high or low level in certain tumor subtypes. Biomarker expression can be assessed at the protein or nucleic acid level.

    摘要翻译： 提供了有助于确定肺癌主要形态类型的组合物和方法。 所述方法包括检测样品中至少一种基因或生物标志物的表达。 该基因或生物标志物的表达指示肺肿瘤亚型。 组合物包括监测基因表达的基因亚群。 基因表达能够区分正常肺实质和肺癌的主要形态类型。 基因表达和体细胞突变数据可用于开发预后和预测治疗反应的肺癌的完整分类。 该方法适用于石蜡包埋组织的分析。 本发明的方法包括用于监测基因或生物标志物表达的手段，包括PCR和基于抗体的检测。 本发明的生物标志物是在某些肿瘤亚型中以高或低水平选择性表达的基因和/或蛋白质。 可以在蛋白质或核酸水平评估生物标志物表达。

    Methods of classifying, diagnosing, stratifying and treating cancer patients and their tumors
    6.
    发明授权
    Methods of classifying, diagnosing, stratifying and treating cancer patients and their tumors 失效
    分类，诊断，分层和治疗癌症患者及其肿瘤的方法

    公开(公告)号：US07118853B2

    公开(公告)日：2006-10-10

    申请号：US09916849

    申请日：2001-07-26

    申请人： David Botstein ,  Patrick O. Brown ,  Charles M. Perou ,  Brian Ring ,  Douglas Ross ,  Rob Seitz ,  Jan Matthijs van de Rijn

    发明人： David Botstein ,  Patrick O. Brown ,  Charles M. Perou ,  Brian Ring ,  Douglas Ross ,  Rob Seitz ,  Jan Matthijs van de Rijn

    IPC分类号： G01N33/50 ,  G01N33/53 ,  G01N33/536 ,  C12Q1/68

    CPC分类号： C07K14/4748 ,  A61K38/00 ,  C07K16/18

    摘要： The invention provides a variety of reagents for use in the diagnosis and management of breast cancer. The invention utilizes cDNA microarray technology to identify genes whose expression profile across a large group of tumor samples correlates with that of cytokeratin 5 and cytokeratin 17, markers for basal cells of the normal mammary lactation gland. The invention demonstrates that tumors that express cytokeratin 5/6 and/or 17 have a poor prognosis relative to tumors overall. The invention provides basal marker genes and their expression products and uses of these genes for diagnosis of breast cancer and for identification of therapies for breast cancer. In particular, the invention provides basal marker genes including cadherin3, matrix metalloproteinase 14, and cadherin EGF LAG seven-pass G-type receptor 2. The invention provides antibodies to the polypeptides expressed by these genes and methods of use thereof.

    摘要翻译： 本发明提供用于诊断和治疗乳腺癌的各种试剂。 本发明利用cDNA微阵列技术鉴定了大量肿瘤样本的表达谱与细胞角蛋白5和细胞角蛋白17（正常乳腺泌乳腺基底细胞的标记）相关的基因。 本发明表明，表达细胞角蛋白5/6和/或17的肿瘤总体上相对于肿瘤的预后差。 本发明提供了基础标记基因及其表达产物和这些基因用于乳腺癌诊断和鉴定乳腺癌疗法的用途。 特别地，本发明提供了包括钙粘蛋白3，基质金属蛋白酶14和钙粘蛋白EGF LAG七通G型受体2的基础标记基因。本发明提供了由这些基因表达的多肽的抗体及其使用方法。

    Compositions for the diagnosis and treatment of Chediak-Higashi syndrome
    7.
    发明授权
    Compositions for the diagnosis and treatment of Chediak-Higashi syndrome 失效
    Chediak-Higashi综合征的诊断和治疗组合

    公开(公告)号：US06310182B1

    公开(公告)日：2001-10-30

    申请号：US09396540

    申请日：1999-09-14

    申请人： Jerry Kaplan ,  Charles M. Perou ,  Karen J. Moore

    发明人： Jerry Kaplan ,  Charles M. Perou ,  Karen J. Moore

    IPC分类号： C07K14435

    CPC分类号： C12Q1/6883 ,  A61K38/00 ,  C07K14/47 ,  C12Q2600/156 ,  C12Q2600/158

    摘要： The present invention relates to the identification of novel nucleic acid molecules and proteins encoded by such nucleic acid molecules or degenerate variants thereof, that participate in the differentiation and/or function of intracellular vesicles. The nucleic acid molecules of the present invention represent the genes corresponding to the mammalian bg gene, a gene that, when mutated, is responsible or the human Chediak-Higashi syndrome.

    摘要翻译： 本发明涉及鉴定参与细胞内小泡分化和/或功能的由此类核酸分子或其简并变体编码的新的核酸分子和蛋白质。 本发明的核酸分子代表与哺乳动物bg基因相对应的基因，突变后负责的基因或人Chediak-Higashi综合征。