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    Luminescent lanthanide complexes
    1.
    发明授权
    Luminescent lanthanide complexes 有权
    发光镧系元素络合物

    公开(公告)号：US07517701B2

    公开(公告)日：2009-04-14

    申请号：US11250722

    申请日：2005-10-14

    申请人： David Parker ,  Paul Atkinson ,  Filip Kielar ,  Annegret Boge ,  J. Richard Sportsman ,  Elizabeth Gaudet ,  George G. Yi

    发明人： David Parker ,  Paul Atkinson ,  Filip Kielar ,  Annegret Boge ,  J. Richard Sportsman ,  Elizabeth Gaudet ,  George G. Yi

    IPC分类号： G01N33/535 ,  G01N33/532 ,  G01N33/24 ,  G01N21/76 ,  G01N33/53 ,  A61K51/06

    CPC分类号： C07D471/04 ,  C07D403/02 ,  C07D471/14 ,  C07D491/04 ,  C07D495/04 ,  C09B57/10 ,  G01N33/582 ,  G01N2458/40 ,  Y10T436/13

    摘要： Systems, including compositions, kits, and methods, particularly for photoluminescence applications. The systems may include, among others, (1) organic chelators, (2) complexes between the chelators and lanthanide ions, and (3) precursors, derivatives, and uses thereof. The chelators may include a 1,4,7,10-tetraazacyclododecane ring system, for example, having the formula: Here, R1, R2, and R3 are substituents of the tetraazacyclododecane ring system, that is further substituted at the 10-position by a sensitizer Z that is typically a polyheterocyclic ring system. The organic chelator may be capable of forming a luminescent complex with a lanthanide ion, and is optionally further substituted by a reactive functional group or a conjugated substance. The resulting lanthanide complex may be useful in luminescence-based assays, such as energy transfer assays, among others.

    摘要翻译： 系统，包括组合物，试剂盒和方法，特别是用于光致发光应用。 该系统可以包括（1）有机螯合剂，（2）螯合剂和镧系元素离子之间的络合物，和（3）前体，衍生物及其用途。 螯合剂可以包括例如具有下式的1,4,7,10-四氮杂环十二烷环体系：这里，R 1，R 2和R 3是四氮杂环十二烷环体系的取代基，其在10位被 通常是多杂环系统的敏化剂Z。 有机螯合剂可能能够与镧系元素离子形成发光配合物，并且任选地进一步被反应性官能团或共轭物质取代。 所得镧系元素络合物可用于基于发光的测定，例如能量转移测定等。

    Luminescent lanthanide complexes
    2.
    发明申请
    Luminescent lanthanide complexes 有权
    发光镧系元素络合物

    公开(公告)号：US20070087452A1

    公开(公告)日：2007-04-19

    申请号：US11250722

    申请日：2005-10-14

    申请人： David Parker ,  Paul Atkinson ,  Filip Kielar ,  Annegret Boge ,  J. Sportsman ,  Elizabeth Gaudet ,  George Yi

    发明人： David Parker ,  Paul Atkinson ,  Filip Kielar ,  Annegret Boge ,  J. Sportsman ,  Elizabeth Gaudet ,  George Yi

    IPC分类号： G01N33/543 ,  C07F5/00 ,  C07D403/02 ,  C07K16/46

    CPC分类号： C07D471/04 ,  C07D403/02 ,  C07D471/14 ,  C07D491/04 ,  C07D495/04 ,  C09B57/10 ,  G01N33/582 ,  G01N2458/40 ,  Y10T436/13

    摘要： Systems, including compositions, kits, and methods, particularly for photoluminescence applications. The systems may include, among others, (1) organic chelators, (2) complexes between the chelators and lanthanide ions, and (3) precursors, derivatives, and uses thereof. The chelators may include a 1,4,7,10-tetraazacyclododecane ring system, for example, having the formula: Here, R1, R2, and R3 are substituents of the tetraazacyclododecane ring system, that is further substituted at the 10-position by a sensitizer Z that is typically a polyheterocyclic ring system. The organic chelator may be capable of forming a luminescent complex with a lanthanide ion, and is optionally further substituted by a reactive functional group or a conjugated substance. The resulting lanthanide complex may be useful in luminescence-based assays, such as energy transfer assays, among others.

    摘要翻译： 系统，包括组合物，试剂盒和方法，特别是用于光致发光应用。 该系统可以包括（1）有机螯合剂，（2）螯合剂和镧系元素离子之间的络合物，和（3）前体，衍生物及其用途。 螯合剂可以包括例如具有下式的1,4,7,10-四氮杂环十二烷环体系：这里，R 1，R 2和R 2 > 3是四氮杂环十二烷环系的取代基，其在10位被通常为多杂环系的敏化剂Z进一步取代。 有机螯合剂可能能够与镧系元素离子形成发光配合物，并且任选地进一步被反应性官能团或共轭物质取代。 所得镧系元素络合物可用于基于发光的测定，例如能量转移测定等。

    Molecular modification assays involving lipids
    5.
    发明申请
    Molecular modification assays involving lipids 审中-公开
    涉及脂质的分子修饰测定

    公开(公告)号：US20050227294A1

    公开(公告)日：2005-10-13

    申请号：US11146553

    申请日：2005-06-06

    申请人： Elizabeth Gaudet ,  J. Sportsman

    发明人： Elizabeth Gaudet ,  J. Sportsman

    IPC分类号： G01N33/53 ,  G01N33/92

    CPC分类号： G01N33/92 ,  G01N2800/044

    摘要： Assays for detecting molecular modifications, such as phosphorylation, dephosphorylation, and/or cleavage, among others, of lipids, lipid fragments, and/or lipid precursors. These assays may be used to detect the presence and/or activity of enzymes and/or other agents, such as drugs, involved in facilitating, inhibiting, and/or otherwise regulating such modifications.

    摘要翻译： 用于检测脂质，脂质片段和/或脂质前体等分子修饰，例如磷酸化，去磷酸化和/或切割等的测定。 这些测定法可用于检测参与有助于，抑制和/或以其它方式调节这些修饰的酶和/或其它试剂（例如药物）的存在和/或活性。