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公开(公告)号：US20110190141A1
公开(公告)日：2011-08-04
申请号：US12834072
申请日：2010-07-12
申请人： David R. Liu , Zev J. Gartner , Jeffrey B. Doyon , Christopher T. Calderone , Matthew W. Kanan , Xiaoyu Li , Thomas M. Snyder , Daniel M. Rosenbaum
发明人： David R. Liu , Zev J. Gartner , Jeffrey B. Doyon , Christopher T. Calderone , Matthew W. Kanan , Xiaoyu Li , Thomas M. Snyder , Daniel M. Rosenbaum
IPC分类号： C40B10/00
CPC分类号： C12Q1/68 , C12N15/1068
摘要： Nature evolves biological molecules such as proteins through iterated rounds of diversification, selection, and amplification. The power of Nature and the flexibility of organic synthesis are combined in nucleic acid-templated synthesis. The present invention provides a variety of template architectures for performing nucleic acid-templated synthesis, methods for increasing the selectivity of nucleic acid-templated reactions, methods for performing stereoselective nucleic acid-templated reactions, methods of selecting for reaction products resulting from nucleic acid-templated synthesis, and methods of identifying new chemical reactions based on nucleic acid-templated synthesis.
摘要翻译： 自然会通过迭代多样化，选择和扩增进化生物分子，如蛋白质。 自然的力量和有机合成的灵活性结合在核酸模板合成中。 本发明提供用于进行核酸模板合成的多种模板结构，用于增加核酸模板化反应的选择性的方法，用于进行立体选择性核酸模板化反应的方法，选择由核酸 - 模板合成，以及基于核酸模板合成鉴定新化学反应的方法。
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公开(公告)号：US07223545B2
公开(公告)日：2007-05-29
申请号：US10949163
申请日：2004-09-24
申请人： David R. Liu , Zev J. Gartner , Matthew W. Kanan
发明人： David R. Liu , Zev J. Gartner , Matthew W. Kanan
CPC分类号： C12N15/1068 , C12P1/00 , C12P19/34 , C12P21/00
摘要： Nature evolves biological molecules such as proteins through iterated rounds of diversification, selection, and amplification. The present invention provides methods, compositions, and systems for synthesizing, selecting, amplifying, and evolving non-natural molecules based on nucleic acid templates. The sequence of a nucleic acid template is used to direct the synthesis of non-natural molecules such as unnatural polymers and small molecules. Using this method combinatorial libraries of these molecules can be prepared and screened. Upon selection of a molecule, its encoding nucleic acid template may be amplified and/or evolved to yield the same molecule or related molecules for re-screening. The inventive methods and compositions of the present invention allow for the amplification and evolution of non-natural molecules in a manner analogous to the amplification of natural biopolymer such as polynucleotides and protein.
摘要翻译： 自然会通过迭代多样化，选择和扩增进化生物分子，如蛋白质。 本发明提供了基于核酸模板合成，选择，扩增和演化非天然分子的方法，组合物和系统。 核酸模板的序列用于引导非天然分子如非天然聚合物和小分子的合成。 使用这种方法可以制备和筛选这些分子的组合文库。 在选择分子时，其编码核酸模板可以被扩增和/或进化以产生用于重新筛选的相同分子或相关分子。 本发明的本发明的方法和组合物以与天然生物聚合物如多核苷酸和蛋白质的扩增类似的方式允许非天然分子的扩增和进化。
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公开(公告)号：US07442160B2
公开(公告)日：2008-10-28
申请号：US11141542
申请日：2005-05-31
申请人： David R. Liu , Zev J. Gartner , Matthew W. Kanan
发明人： David R. Liu , Zev J. Gartner , Matthew W. Kanan
IPC分类号： C40B30/04 , C40B10/00 , C40B30/08 , C40B40/00 , C40B50/10 , C40B70/00 , C12Q1/68 , C07H21/02
CPC分类号： C12N15/1068 , C12P1/00 , C12P19/34 , C12P21/00
摘要： Nature evolves biological molecules such as proteins through iterated rounds of diversification, selection, and amplification. The present invention provides methods, compositions, and systems for synthesizing, selecting, amplifying, and evolving non-natural molecules based on nucleic acid templates. The sequence of a nucleic acid template is used to direct the synthesis of non-natural molecules such as unnatural polymers and small molecules. Using this method combinatorial libraries of these molecules can be prepared and screened. Upon selection of a molecule, its encoding nucleic acid template may be amplified and/or evolved to yield the same molecule or related molecules for re-screening. The inventive methods and compositions of the present invention allow for the amplification and evolution of non-natural molecules in a manner analogous to the amplification of natural biopolymer such as polynucleotides and protein.
摘要翻译： 自然会通过迭代多样化，选择和扩增进化生物分子，如蛋白质。 本发明提供了基于核酸模板合成，选择，扩增和演化非天然分子的方法，组合物和系统。 核酸模板的序列用于引导非天然分子如非天然聚合物和小分子的合成。 使用这种方法可以制备和筛选这些分子的组合文库。 在选择分子时，其编码核酸模板可以被扩增和/或进化以产生用于重新筛选的相同分子或相关分子。 本发明的本发明的方法和组合物以与天然生物聚合物如多核苷酸和蛋白质的扩增类似的方式允许非天然分子的扩增和进化。
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公开(公告)号：US07557068B2
公开(公告)日：2009-07-07
申请号：US10744605
申请日：2003-12-23
申请人： David R. Liu , Zev J. Gartner , Matthew W. Kanan
发明人： David R. Liu , Zev J. Gartner , Matthew W. Kanan
IPC分类号： C40B50/00 , C40B30/00 , C40B20/04 , C40B50/10 , C40B50/16 , C40B40/00 , C07H21/02 , C12Q1/68
CPC分类号： C12N15/1068 , C12P1/00 , C12P19/34 , C12P21/00
摘要： Nature evolves biological molecules such as proteins through iterated rounds of diversification, selection, and amplification. The present invention provides methods, compositions, and systems for synthesizing, selecting, amplifying, and evolving non-natural molecules based on nucleic acid templates. The sequence of a nucleic acid template is used to direct the synthesis of non-natural molecules such as unnatural polymers and small molecules. Using this method combinatorial libraries of these molecules can be prepared and screened. Upon selection of a molecule, its encoding nucleic acid template may be amplified and/or evolved to yield the same molecule or related molecules for re-screening. The inventive methods and compositions of the present invention allow for the amplification and evolution of non-natural molecules in a manner analogous to the amplification of natural biopolymer such as polynucleotides and protein.
摘要翻译： 自然会通过迭代多样化，选择和扩增进化生物分子，如蛋白质。 本发明提供了基于核酸模板合成，选择，扩增和演化非天然分子的方法，组合物和系统。 核酸模板的序列用于引导非天然分子如非天然聚合物和小分子的合成。 使用这种方法可以制备和筛选这些分子的组合文库。 在选择分子时，其编码核酸模板可以被扩增和/或进化以产生用于重新筛选的相同分子或相关分子。 本发明的本发明的方法和组合物以与天然生物聚合物如多核苷酸和蛋白质的扩增类似的方式允许非天然分子的扩增和进化。
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公开(公告)号：US08206914B2
公开(公告)日：2012-06-26
申请号：US12834072
申请日：2010-07-12
申请人： David R. Liu , Zev J. Gartner , Jeffrey B. Doyon , Christopher T. Calderone , Matthew W. Kanan , Xiaoyu Li , Thomas M. Snyder , Daniel M. Rosenbaum
发明人： David R. Liu , Zev J. Gartner , Jeffrey B. Doyon , Christopher T. Calderone , Matthew W. Kanan , Xiaoyu Li , Thomas M. Snyder , Daniel M. Rosenbaum
IPC分类号： C12Q1/68
CPC分类号： C12Q1/68 , C12N15/1068
摘要： Nature evolves biological molecules such as proteins through iterated rounds of diversification, selection, and amplification. The power of Nature and the flexibility of organic synthesis are combined in nucleic acid-templated synthesis. The present invention provides a variety of template architectures for performing nucleic acid-templated synthesis, methods for increasing the selectivity of nucleic acid-templated reactions, methods for performing stereoselective nucleic acid-templated reactions, methods of selecting for reaction products resulting from nucleic acid-templated synthesis, and methods of identifying new chemical reactions based on nucleic acid-templated synthesis.
摘要翻译： 自然会通过迭代多样化，选择和扩增进化生物分子，如蛋白质。 自然的力量和有机合成的灵活性结合在核酸模板合成中。 本发明提供用于进行核酸模板合成的多种模板结构，用于增加核酸模板化反应的选择性的方法，用于进行立体选择性核酸模板化反应的方法，选择由核酸 - 模板合成，以及基于核酸模板合成鉴定新化学反应的方法。
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公开(公告)号：US07998904B2
公开(公告)日：2011-08-16
申请号：US11141164
申请日：2005-05-31
申请人： David R. Liu , Zev J. Gartner , Matthew W. Kanan
发明人： David R. Liu , Zev J. Gartner , Matthew W. Kanan
IPC分类号： C40B50/00 , C40B30/00 , C40B20/04 , C40B50/10 , C40B50/16 , C40B40/00 , C07H21/02 , C12Q1/68
CPC分类号： C12N15/1068 , C12P1/00 , C12P19/34 , C12P21/00
摘要： Nature evolves biological molecules such as proteins through iterated rounds of diversification, selection, and amplification. The present invention provides methods, compositions, and systems for synthesizing, selecting, amplifying, and evolving non-natural molecules based on nucleic acid templates. The sequence of a nucleic acid template is used to direct the synthesis of non-natural molecules such as unnatural polymers and small molecules. Using this method combinatorial libraries of these molecules can be prepared and screened. Upon selection of a molecule, its encoding nucleic acid template may be amplified and/or evolved to yield the same molecule or related molecules for re-screening. The inventive methods and compositions of the present invention allow for the amplification and evolution of non-natural molecules in a manner analogous to the amplification of natural biopolymer such as polynucleotides and protein.
摘要翻译： 自然会通过迭代多样化，选择和扩增进化生物分子，如蛋白质。 本发明提供了基于核酸模板合成，选择，扩增和演化非天然分子的方法，组合物和系统。 核酸模板的序列用于引导非天然分子如非天然聚合物和小分子的合成。 使用这种方法可以制备和筛选这些分子的组合文库。 在选择分子时，其编码核酸模板可以被扩增和/或进化以产生用于重新筛选的相同分子或相关分子。 本发明的本发明的方法和组合物以与天然生物聚合物如多核苷酸和蛋白质的扩增类似的方式允许非天然分子的扩增和进化。
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公开(公告)号：US07491494B2
公开(公告)日：2009-02-17
申请号：US10643752
申请日：2003-08-19
IPC分类号： C12Q1/68
CPC分类号： C12Q1/68 , C12N15/1068
摘要： Nature evolves biological molecules such as proteins through iterated rounds of diversification, selection, and amplification. The power of Nature and the flexibility of organic synthesis are combined in nucleic acid-templated synthesis. The present invention provides a variety of template architectures for performing nucleic acid-templated synthesis, methods for increasing the selectivity of nucleic acid-templated reactions, methods for performing stereoselective nucleic acid-templated reactions, methods of selecting for reaction products resulting from nucleic acid-templated synthesis, and methods of identifying new chemical reactions based on nucleic acid-templated synthesis.
摘要翻译： 自然会通过迭代多样化，选择和扩增进化生物分子，如蛋白质。 自然的力量和有机合成的灵活性结合在核酸模板合成中。 本发明提供用于进行核酸模板合成的多种模板结构，用于增加核酸模板化反应的选择性的方法，用于进行立体选择性核酸模板化反应的方法，选择由核酸 - 模板合成，以及基于核酸模板合成鉴定新化学反应的方法。
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公开(公告)号：US07771935B2
公开(公告)日：2010-08-10
申请号：US10950367
申请日：2004-09-24
IPC分类号： C12Q1/68
CPC分类号： C12Q1/68 , C12N15/1068
摘要： Nature evolves biological molecules such as proteins through iterated rounds of diversification, selection, and amplification. The power of Nature and the flexibility of organic synthesis are combined in nucleic acid-templated synthesis. The present invention provides a variety of template architectures for performing nucleic acid-templated synthesis, methods for increasing the selectivity of nucleic acid-templated reactions, methods for performing stereoselective nucleic acid-templated reactions, methods of selecting for reaction products resulting from nucleic acid-templated synthesis, and methods of identifying new chemical reactions based on nucleic acid-templated synthesis.
摘要翻译： 自然会通过迭代多样化，选择和扩增进化生物分子，如蛋白质。 自然的力量和有机合成的灵活性结合在核酸模板合成中。 本发明提供用于进行核酸模板合成的多种模板结构，用于增加核酸模板化反应的选择性的方法，用于进行立体选择性核酸模板化反应的方法，选择由核酸 - 模板合成，以及基于核酸模板合成鉴定新化学反应的方法。
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