公开(公告)号：US5719667A

公开(公告)日：1998-02-17

申请号：US692931

申请日：1996-07-30

Applicant: David R. Miers

Inventor： David R. Miers

IPC: G01N15/14 ,  G01N21/00

CPC classification number: G01N15/1436 ,  G01N15/1459 ,  G01N2015/1447 ,  G01N2201/0633

Abstract: An optical illuminator assembly for an analytical instrument, such as a clinical hematology or a flow cytometer instrument, including a laser diode having a diverging laser beam output, a collimating lens to collimate the diverging laser beam, a spatial filter operating on the collimated laser beam to spatially filter the beam, and a focussing lens to focus the spatially filtered beam into a flow cell containing particles suspended in a moving stream. A beam shaping aperture is preferably inserted between the spatial filter and the focussing lens to shape the laser beam. The spatial filter preferably includes an objective lens, a collimating lens, and a filter aperture interposed between the objective and imaging lenses. The filter aperture is preferably rectangular, having a height to width ratio in the range of 1:2 to 1:3 such that each dimension is on the order of tens of micrometers. The beam shaping aperture is preferably a rectangular aperture having a height to width ratio in a range of from 3:1 to 5:1 such that each dimension is on the order of hundreds of micrometers.

Abstract translation: 用于分析仪器的光学照明器组件，例如临床血液学或流式细胞仪器，包括具有发散激光束输出的激光二极管，准直发散激光束的准直透镜，在准直激光束上操作的空间滤光器 空间上过滤光束，以及聚焦透镜将空间过滤的光束聚焦到包含悬浮在移动流中的颗粒的流动池中。 光束整形孔优选地插入在空间滤光器和聚焦透镜之间以使激光束成形。 空间滤波器优选地包括物镜，准直透镜和介于物镜和成像透镜之间的滤光器孔。 过滤器孔径优选是矩形的，其高度与宽度之比在1:2至1:3的范围内，使得每个尺寸在几十微米的量级上。 光束成形孔优选地是具有在3:1至5:1范围内的高宽比的矩形孔，使得每个尺寸都在数百微米级。

公开(公告)号：US4860586A

公开(公告)日：1989-08-29

申请号：US146052

申请日：1988-01-20

Applicant: David R. Miers ,  David Raj ,  Deepak Varshneya

Inventor： David R. Miers ,  David Raj ,  Deepak Varshneya

IPC: G01P15/093

CPC classification number: G01P15/093

Abstract: An accelerometer comprises a base and cover together defining a chamber which receives an inertial mass. A diaphragm carries the inertial mass and is bolted between the base and the cover. The inertial mass and the base have facing corrugated surfaces with offset teeth in each of the corrugated surfaces. An optical fiber is clamped between the teeth and extends between the corrugated surfaces. The intensity of light passing through the fiber changes with movement of the inertial mass with respect to the base. The inertial mass moves through the resiliency of the diaphragm, when the base is subjected to accelerations, such as those caused by vibrations. A reference optical fiber may also extend through the chamber above the inertial mass. The same light is supplied to both fibers and the intensity of light from both fibers is subtracted to leave the variation in intensity due to bending of the sensing optical fiber.

Abstract translation: 加速度计包括基部和盖，所述基座和盖一起限定容纳惯性质量的腔室。 隔膜携带惯性块，并在基座和盖子之间螺栓连接。 在每个波纹表面中，惯性质量块和底座具有带有偏心齿的波纹状表面。 光纤夹在齿之间并在波纹表面之间延伸。 穿过纤维的光的强度随着惯性质量相对于底座的运动而变化。 当基座经受加速度（例如由振动引起的加速度）时，惯性质量通过隔膜的弹性移动。 参考光纤还可以延伸穿过惯性块上方的腔室。 相同的光被提供给两个光纤，并且来自两个光纤的光的强度被减去以由于感测光纤的弯曲而留下强度的变化。

公开(公告)号：US5872627A

公开(公告)日：1999-02-16

申请号：US692934

申请日：1996-07-30

Applicant: David R. Miers

Inventor： David R. Miers

IPC: G01N15/14 ,  G01N21/00

CPC classification number: G01N15/1431 ,  G01N15/1436 ,  G01N2201/0633

Abstract: A light scatter detector assembly for an analytical instrument, such as a laser flow cytometer or clinical hematology instrument having at least two angles of scatter. A high numerical aperture lens system is used, preferably a system using only two lenses to collect light after interacting with suspended particles passing through a flow cell into a collimated beam. A dark stop having apertures in different locations is interposed in the collimated beam light detected to produce therefrom two optical beams, respectively corresponding to the two scatter signals, e.g., high angle scatter and low angle scatter. The apertures are preferably radial sectors. The two scatter beams are passed to a beam separating element and through a collimating lens onto respective photodetectors. The beam separating element may be a split mirror having two mirrors mounted at an angle to each other, e.g., less than 15.degree., preferably 51/2.degree., to direct the beams in different directions to the two photodetectors. Alternatively, the beam separating element may be a multifaceted prism having at least two refracting portions to direct the two beam outputs to different photodetectors. The same lens may be used to pass the beams directed in different directions by the beam separating element to the two different photodetectors. The two photodetectors are preferably mounted on a single printed circuit board (pcb) in a prealigned manner using conventional pcb component mounting technology.

Abstract translation: 用于分析仪器的光散射检测器组件，例如具有至少两个散射角的激光流式细胞仪或临床血液仪器。 使用高数值孔径透镜系统，优选地是仅使用两个透镜在与通过流动池进入准直束的悬浮颗粒相互作用之后收集光的系统。 在被检测到的准直光束光中插入具有不同位置的孔的暗停止器，分别对应于两个散射信号，例如高角散射和低角度散射。 孔优选为径向扇形。 两个散射光束通过光束分离元件并通过准直透镜传递到相应的光电探测器上。 光束分离元件可以是具有彼此成角度安装的两个反射镜的分光镜，例如小于15°，优选为5 + E，1/2 + EE°，以将光束沿不同方向引导到两个 光电探测器 或者，光束分离元件可以是具有至少两个折射部分的多向棱镜，以将两个光束输出引导到不同的光电检测器。 可以使用相同的透镜将由不同方向引导的光束通过光束分离元件传递到两个不同的光电检测器。 两个光电探测器优选地使用传统的pcb部件安装技术以预先对准的方式安装在单个印刷电路板（pcb）上。

公开(公告)号：US4930862A

公开(公告)日：1990-06-05

申请号：US340186

申请日：1989-04-19

Applicant: David R. Miers ,  David Raj ,  Deepak Varshneya

Inventor： David R. Miers ,  David Raj ,  Deepak Varshneya

IPC: G01P15/093

CPC classification number: G01P15/093

Abstract: An accelerometer comprises a base and cover together defining a chamber which receives an inertial mass. The diaphragm carries the inertial mass and is bolted between the base and the cover. The inertial mass and the base have facing incorrugated surfaces with offset teeth in each of the corrugated surfaces. An optical fiber is clamped between the teeth and extends between the corrugated surfaces. The intensity of light passing through the fiber changes with movement of the inertial mass with respect to the base. The inertial mass moves through the resiliency of the diaphragm, when the base is subjected to accelerations, such as those caused by vibrations. A reference optical fiber may also extend through the chamber above the inertial mass. The same light is supplied to both fibers and the intensity of light from both fibers is subtracted to leave the variation in intensity due to bending of the sensing optical fiber. Also, an electronics circuit employing a log-ratio amplifier device measures the light signals from the optical fibers and converts them to electrical signals which are proportional to the acceleration measured with the foregoing accelerometer.

Abstract translation: 加速度计包括基部和盖，所述基座和盖一起限定容纳惯性质量的腔室。 隔膜携带惯性质量块，并在基座和盖子之间螺栓连接。 惯性质量和基体在每个波纹表面中都具有带有偏移齿的波纹状表面。 光纤夹在齿之间并在波纹表面之间延伸。 穿过纤维的光的强度随着惯性质量相对于底座的运动而变化。 当基座经受加速度（例如由振动引起的加速度）时，惯性质量通过隔膜的弹性移动。 参考光纤还可以延伸穿过惯性块上方的腔室。 相同的光被提供给两个光纤，并且来自两个光纤的光的强度被减去以由于感测光纤的弯曲而留下强度的变化。 此外，采用对数比放大器装置的电子电路测量来自光纤的光信号，并将其转换成与用前述加速度计测量的加速度成正比的电信号。