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公开(公告)号:US06936601B2
公开(公告)日:2005-08-30
申请号:US10224224
申请日:2002-08-15
IPC分类号: A61K31/495 , A61K31/00 , A61K31/165 , A61K31/167 , A61K31/19 , A61K31/192 , A61K31/38 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/454 , A61K31/496 , A61K31/519 , A61K31/55 , A61K31/5513 , A61K31/554 , A61K31/60 , A61K31/612 , A61K31/616 , A61K45/06 , A61P29/00
CPC分类号: A61K45/06 , A61K31/38 , A61K31/454 , A61K31/496 , A61K31/519 , A61K31/5513 , A61K31/554
摘要: The present invention provides compositions for treating pain using an atypical antipsychotic compound that is seroquel in combination with another Drug Used in the Treatment of Pain.
摘要翻译: 本发明提供了使用与用于治疗疼痛的另一种药物组合的血清型非典型抗精神病药化合物来治疗疼痛的组合物。
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公开(公告)号:US5882671A
公开(公告)日:1999-03-16
申请号:US786170
申请日:1997-01-21
申请人: David Reed Helton , Mary Jeanne Kallman , James Allen Monn , Darryle Darwin Schoepp , Joseph Patrick Tizzano
发明人: David Reed Helton , Mary Jeanne Kallman , James Allen Monn , Darryle Darwin Schoepp , Joseph Patrick Tizzano
IPC分类号: A61K45/00 , A61K31/00 , A61K31/19 , A61K31/195 , A61K31/198 , A61K31/215 , A61P25/20 , A61P43/00 , C07C62/38 , C07C229/50 , C07D235/02 , A61K9/64
CPC分类号: C07D235/02 , A61K31/00 , A61K31/198 , A61K31/215 , C07C229/50 , C07C62/38 , C07C2102/18 , Y10S514/811 , Y10S514/82
摘要: The present invention provides a method of treating anxiety and related disorders using an agonist which acts at negatively coupled cAMP-linked metabotropic glutamate receptors.
摘要翻译: 本发明提供使用以负相关联的cAMP连接的代谢型谷氨酸受体作用的激动剂来治疗焦虑和相关疾病的方法。
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公开(公告)号:US20110245275A1
公开(公告)日:2011-10-06
申请号:US13124366
申请日:2009-10-16
申请人: David Reed Helton
发明人: David Reed Helton
IPC分类号: A61K31/519 , A61P39/00
CPC分类号: A61K31/519
摘要: A method of treating exposure to organophosphate agents and preventing morbidity due to such exposure through the administration of a pyrazolopyrimidine compound such as ocinaplon, zaleplon, indiplon, or divaplon.
摘要翻译: 一种治疗暴露于有机磷酸酯试剂并通过施用吡唑并嘧啶化合物如ocinaplon,zaleplon,indiplon或divaplon而导致这种暴露的发病率的方法。
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公开(公告)号:US20200085808A1
公开(公告)日:2020-03-19
申请号:US16556140
申请日:2019-08-29
IPC分类号: A61K31/451 , A61K31/5513 , A61K31/46
摘要: A method of treating exposure to an organophosphate compound by administering a cyproheptadine compound to a subject in need thereof.
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公开(公告)号:US10398687B2
公开(公告)日:2019-09-03
申请号:US13232917
申请日:2011-09-14
IPC分类号: A61K31/451 , A61K31/46 , A61K31/5513
摘要: A method of treating exposure to an organophosphate compound by administering a cyproheptadine compound to a subject in need thereof.
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公开(公告)号:US08637263B1
公开(公告)日:2014-01-28
申请号:US13274106
申请日:2011-10-14
IPC分类号: G01N33/53
CPC分类号: G01N33/942 , G01N2800/40
摘要: A screening method for identifying compounds with anti-emetic properties by evaluating binding affinity and efficacy of the compounds with respect to the 5-HT1a, 5-HT1d, and 5-HT7 receptors.
摘要翻译: 通过评估化合物相对于5-HT1a,5-HT1d和5-HT7受体的结合亲和力和功效来鉴定具有抗呕吐性质的化合物的筛选方法。
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公开(公告)号:US10478438B2
公开(公告)日:2019-11-19
申请号:US13124366
申请日:2009-10-16
IPC分类号: A61K31/519
摘要: A method of treating exposure to organophosphate agents and preventing morbidity due to such exposure through the administration of a pyrazolopyrimidine compound such as ocinaplon, zaleplon, indiplon, or divaplon.
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公开(公告)号:US08598180B2
公开(公告)日:2013-12-03
申请号:US12852251
申请日:2010-08-06
IPC分类号: A61K31/497 , C07D403/00
CPC分类号: A61K31/33 , A61K31/496 , A61K31/506 , C07D209/08 , Y02A50/401
摘要: Compositions comprising tetrahydroindolone derivatives in which the tetrahydroindolone moiety is covalently linked to a substituted arylpiperazine moiety and methods for treating neurological and psychiatric conditions using such compositions are disclosed.
摘要翻译: 公开了包含四氢吲哚酮衍生物的组合物,其中四氢吲哚酮部分与取代的芳基哌嗪部分共价连接,并且使用这些组合物治疗神经和精神病症的方法。
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公开(公告)号:US5916920A
公开(公告)日:1999-06-29
申请号:US749301
申请日:1996-11-14
IPC分类号: A61K20060101 , C07C229/50 , C07C255/47 , C07D20060101 , C07D235/02 , A61K31/19 , A61K31/21 , C07C61/13 , C07C69/74
CPC分类号: C07C229/50 , C07C255/47 , C07D235/02 , C07C2102/18
摘要: Compounds of the formula ##STR1## in which X represents a bond, S, O or NR.sup.a ; and R is as defined in the specification are useful as modulators of metabotropic glutamate receptor function.
摘要翻译: 其中X表示键,S,O或NR a的式的化合物; 并且R如说明书中所定义的可用作代谢型谷氨酸受体功能的调节剂。
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