公开(公告)号：US10081592B2

公开(公告)日：2018-09-25

申请号：US14387028

申请日：2013-03-25

申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS ,  Paul J. Hergenrother ,  Robert W. Huigens, III ,  Karen C. Morrison ,  Robert W. Hicklin, II ,  Timothy A. Flood, Jr.

发明人： Paul J. Hergenrother ,  Robert W. Huigens, III ,  Karen C. Morrison ,  Robert W. Hicklin, II ,  Timothy A. Flood, Jr.

IPC分类号： C07D401/14 ,  C07C69/757 ,  C07D311/94 ,  C07D313/06 ,  C07D223/14 ,  C07D401/04 ,  C07D471/04 ,  C07D471/08 ,  C07D493/08 ,  C07D513/04 ,  C07D519/00 ,  C07D303/10 ,  C07C59/205 ,  C07C62/32 ,  C07C62/38 ,  C07B37/06 ,  C07B37/08 ,  C07D307/93 ,  C07D313/08 ,  C07D405/06 ,  C07D405/12 ,  C07D413/06 ,  C07J21/00 ,  C07J69/00 ,  C07J71/00 ,  C07J73/00 ,  C07J75/00

CPC分类号： C07C69/757 ,  C07B37/06 ,  C07B37/08 ,  C07C59/205 ,  C07C62/32 ,  C07C62/38 ,  C07C2601/16 ,  C07C2602/44 ,  C07C2603/86 ,  C07D223/14 ,  C07D303/10 ,  C07D307/93 ,  C07D311/94 ,  C07D313/06 ,  C07D313/08 ,  C07D401/04 ,  C07D401/14 ,  C07D405/06 ,  C07D405/12 ,  C07D413/06 ,  C07D471/04 ,  C07D471/08 ,  C07D493/08 ,  C07D513/04 ,  C07D519/00 ,  C07J21/008 ,  C07J69/00 ,  C07J71/001 ,  C07J71/0031 ,  C07J73/005 ,  C07J73/008 ,  C07J75/005

摘要： The invention a novel, general, and facile strategy for the creation of small molecules with high structural and stereochemical complexity. Aspects of the methods include ring system distortion reactions that are systematically applied to rapidly convert readily available natural products to structurally complex compounds with diverse molecular architectures. Through evaluation of chemical properties including fraction of sp3 carbons, ClogP, and the number of stereogenic centers, these compounds are shown to be significantly more complex and diverse than those in standard screening collections. This approach is demonstrated with natural products (gibberellic acid, adrenosterone, and quinine) from three different structural classes, and methods are described for the application of this strategy to any suitable natural product.

公开(公告)号：US20180230079A1

公开(公告)日：2018-08-16

申请号：US15896970

申请日：2018-02-14

申请人： GENENTECH, INC. ,  XENON PHARMACEUTICALS INC.

发明人： Ivan William HEMEON ,  Brian SAFINA ,  Daniel SUTHERLIN

IPC分类号： C07C62/38 ,  C07C62/34 ,  C07D211/22 ,  C07C323/61 ,  C07C317/44 ,  C07C313/04 ,  C07C229/48 ,  A61P17/04 ,  A61P25/00 ,  A61P29/00

CPC分类号： C07C62/38 ,  A61P17/04 ,  A61P25/00 ,  A61P29/00 ,  C07C62/34 ,  C07C69/757 ,  C07C229/48 ,  C07C313/04 ,  C07C317/44 ,  C07C323/61 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2603/74 ,  C07D211/22

摘要： The invention provides compounds having the general formula I: and pharmaceutically acceptable salts thereof, wherein the variables RAA, n, ring A, X1, L, m, X2, R2, R3, R4, R5, X, and R6 have the meaning as described herein, and compositions containing such compounds and methods for using such compounds and compositions.

公开(公告)号：US20180184651A1

公开(公告)日：2018-07-05

申请号：US15738928

申请日：2016-06-28

申请人： KING ABDULLAH UNIVERSITY OF SCIENCE AND TECHNOLOGY

发明人： Salim AL-BABILI

IPC分类号： A01N35/02 ,  C07C49/242 ,  C07C59/90 ,  C07C62/38 ,  A01N37/42

CPC分类号： A01N35/02 ,  A01N37/42 ,  A01N49/00 ,  C07C49/242 ,  C07C59/90 ,  C07C62/38 ,  C07C2601/16

摘要： New plant growth regulators, including compounds and compositions, and methods of use including for promoting root growth. The compounds are carotenoid oxidation products, and a preferred example is 3-OH-β-apo-13-Carotenone. A method comprising promoting the growth of at least one plant with use of an effective amount of at least one composition comprising an effective amount of at least one compound which is represented by A-B-C, wherein B is a bivalent polyene moiety, A is a monovalent moiety linked to B by a six-membered carbon ring, wherein the ring has at least one substituent linked to the ring by an oxygen atom, and C is a monovalent moiety linked to B by a carbonyl group. Synergistic effects can be used with combinations of compounds.

公开(公告)号：US09783481B2

公开(公告)日：2017-10-10

申请号：US14615159

申请日：2015-02-05

申请人： JNC CORPORATION ,  JNC PETROCHEMICAL CORPORATION

发明人： Mayumi Goto

IPC分类号： G02F1/13 ,  C07C62/38 ,  C09K19/30 ,  C07C49/84 ,  C07C49/80 ,  C07D309/06 ,  C07D493/08 ,  C07D319/06 ,  C09K19/06 ,  C09K19/14 ,  C09K19/32 ,  C09K19/34 ,  C09K19/04

CPC分类号： C07C62/38 ,  C07C49/80 ,  C07C49/84 ,  C07C2601/14 ,  C07D309/06 ,  C07D319/06 ,  C07D493/08 ,  C09K19/062 ,  C09K19/14 ,  C09K19/3003 ,  C09K19/3028 ,  C09K19/3066 ,  C09K19/32 ,  C09K19/322 ,  C09K2019/0425 ,  C09K2019/0444 ,  C09K2019/3422 ,  C09K2019/3425

摘要： To provide a liquid crystal compound satisfying at least one of physical properties such as a high stability to heat, light and so forth, a high clearing point, a low minimum temperature of a liquid crystal phase, a small viscosity, a suitable optical anisotropy, a large dielectric anisotropy, a suitable elastic constant and an excellent compatibility with other liquid crystal compounds; a liquid crystal composition containing the compound; and a liquid crystal display device including the composition. The compound is represented by formula (1): wherein, for example, Ra and Rb are alkyl having 1 to 10 carbons, alkenyl having 2 to 10 carbons or alkoxy having 1 to 9 carbons; A1, A2 and A3 are 1,4-cyclohexylene or 1,4-phenylene; Z1 and Z2 are single bonds, —(CH2)2—, —CH═CH—, —COO—, —OCO—, —CF2O—, —OCF2—, —CH2O— or —OCH2—; Y1 is —CF2H or —CF3; Y2 is fluorine; and a, b and d are 0, 1, 2 or 3, and c is 1 or 3.

公开(公告)号：US20160031787A1

公开(公告)日：2016-02-04

申请号：US14775149

申请日：2014-03-14

申请人： BOARD OF TRUSTEES OF MICHIGAN STATE UNIVERSITY

发明人： John W. FROST

IPC分类号： C07C51/265 ,  C07C51/353 ,  C08G63/183 ,  C07C51/377

CPC分类号： C07C51/265 ,  C07C51/353 ,  C07C51/377 ,  C07C2601/16 ,  C07C2602/44 ,  C08G63/183 ,  C08G63/78 ,  C07C61/22 ,  C07C63/04 ,  C07C63/26 ,  C07C63/24 ,  C07C61/29 ,  C07C62/38

摘要： Methods for producing bio-terephthalic acid and bio-isophthalic acid. Methods comprise a cycloaddition reaction to produce bio-4-methyl-3-cyclohexene-1-carboxylic acid, and bio-3-methyl-3-cyclohexene-1-carboxylic from bio-isoprene and bio-acrylic acid. An aromatization reaction produces bio-para-toluic acid and bio-meta-toluic acid from the bio-4-methyl-3-cyclohexene-1-carboxylic acid, and bio-3-methyl-3-cyclohexene-1-carboxylic. An oxidation reaction produces the bio-terephthalic acid and isophthalic acid from the bio-para-toluic acid and bio-meta-toluic acid.

摘要翻译： 生物对苯二甲酸和生物间苯二甲酸生产方法。 方法包括产生生物-4-甲基-3-环己烯-1-羧酸的环加成反应和生物异戊二烯和生物丙烯酸的生物-3-甲基-3-环己烯-1-羧酸。 芳构化反应从生物-4-甲基-3-环己烯-1-羧酸和生物-3-甲基-3-环己烯-1-羧酸生成生物对甲苯甲酸和生物间甲苯甲酸。 氧化反应从生物对甲苯甲酸和生物间甲苯甲酸产生生物对苯二甲酸和间苯二甲酸。

公开(公告)号：US20150218452A1

公开(公告)日：2015-08-06

申请号：US14615159

申请日：2015-02-05

申请人： JNC CORPORATION ,  JNC PETROCHEMICAL CORPORATION

发明人： Mayumi GOTO

IPC分类号： C09K19/34 ,  C07C49/84 ,  C07C62/38 ,  C07D309/06 ,  C07D493/08 ,  C07D319/06 ,  C09K19/30 ,  C07C49/80

CPC分类号： C07C62/38 ,  C07C49/80 ,  C07C49/84 ,  C07C2601/14 ,  C07D309/06 ,  C07D319/06 ,  C07D493/08 ,  C09K19/062 ,  C09K19/14 ,  C09K19/3003 ,  C09K19/3028 ,  C09K19/3066 ,  C09K19/32 ,  C09K19/322 ,  C09K2019/0425 ,  C09K2019/0444 ,  C09K2019/3422 ,  C09K2019/3425

摘要： To provide a liquid crystal compound satisfying at least one of physical properties such as a high stability to heat, light and so forth, a high clearing point, a low minimum temperature of a liquid crystal phase, a small viscosity, a suitable optical anisotropy, a large dielectric anisotropy, a suitable elastic constant and an excellent compatibility with other liquid crystal compounds; a liquid crystal composition containing the compound; and a liquid crystal display device including the composition. The compound is represented by formula (1): wherein, for example, Ra and Rb are alkyl having 1 to 10 carbons, alkenyl having 2 to 10 carbons or alkoxy having 1 to 9 carbons; A1, A2 and A3 are 1,4-cyclohexylene or 1,4-phenylene; Z1 and Z2 are single bonds, —(CH2)2—, —CH═CH—, —COO—, —OCO—, —CF2O—, —OCF2—, —CH2O— or —OCH2—; Y1 is —CF2H or —CF3; Y2 is fluorine; and a, b and d are 0, 1, 2 or 3, and c is 1 or 3.

摘要翻译： 为了提供满足物理性能如热，光等的高稳定性，高透明度，液晶相的最低最低温度，小粘度，适当的光学各向异性等的液晶化合物， 大的介电各向异性，合适的弹性常数和与其它液晶化合物的优异相容性; 含有该化合物的液晶组合物; 以及包括该组合物的液晶显示装置。 该化合物由式（1）表示：其中，例如，Ra和Rb是碳数1〜10的烷基，碳数2〜10的烯基或碳原子数1〜9的烷氧基。 A1，A2和A3是1,4-亚环己基或1,4-亚苯基; Z 1和Z 2是单键， - （CH 2）2 - ， - CH = CH - ， - COO-，-OCO-，-CF 2 O-，-OCF 2 - ， - CH 2 O-或-OCH 2 - Y1是-CF2H或-CF3; Y2是氟; 和a，b和d分别为0,1,2或3，c为1或3。

公开(公告)号：US20150057238A1

公开(公告)日：2015-02-26

申请号：US14390190

申请日：2013-03-13

申请人： CHDI FOUNDATION, INC.

发明人： Leticia M. Toledo-Sherman ,  Celia Dominguez ,  Michael Prime ,  William Leonard Mitchell ,  Peter Johnson ,  Naomi Went

IPC分类号： C07C69/757 ,  C07D257/04 ,  C07H15/20 ,  C07D413/12 ,  C07D307/94 ,  C07D307/79 ,  C07D405/12 ,  C07D271/07 ,  C07D203/10

CPC分类号： C07C62/38 ,  C07C69/757 ,  C07C229/22 ,  C07C229/46 ,  C07C229/48 ,  C07C235/82 ,  C07C317/44 ,  C07C323/62 ,  C07C2601/02 ,  C07C2602/50 ,  C07D203/08 ,  C07D203/10 ,  C07D207/08 ,  C07D207/337 ,  C07D215/18 ,  C07D233/64 ,  C07D235/26 ,  C07D257/04 ,  C07D263/58 ,  C07D271/07 ,  C07D295/155 ,  C07D305/06 ,  C07D305/08 ,  C07D307/54 ,  C07D307/79 ,  C07D307/80 ,  C07D307/94 ,  C07D309/10 ,  C07D311/58 ,  C07D317/46 ,  C07D317/60 ,  C07D319/18 ,  C07D403/10 ,  C07D405/08 ,  C07D405/10 ,  C07D405/12 ,  C07D413/08 ,  C07D413/10 ,  C07D413/12 ,  C07H15/20

摘要： Certain compounds, or pharmaceutically acceptable salts or prodrugs thereof, are provided herein. Also provided are pharmaceutical compositions comprising at least one compound, or pharmaceutically acceptable salt or prodrug thereof, described herein and one or more pharmaceutically acceptable vehicle. Methods of treating patients suffering from certain diseases and disorders responsive to the inhibition of KMO activity are described, which comprise administering to such patients an amount of at least one compound, or pharmaceutically acceptable salt or prodrug thereof, described herein effective to reduce signs or symptoms of the disease or disorder are disclosed. These diseases include neurodegenerative disorders such as Huntington's disease. Also described are methods of treatment include administering at least one compound, or pharmaceutically acceptable salt or prodrug thereof, described herein as a single active agent or administering at least one compound, or pharmaceutically acceptable salt or prodrug thereof, described herein in combination with one or more other therapeutic agents. Also provided are methods for screening compounds capable of inhibiting KMO activity.

摘要翻译： 本文提供了某些化合物或其药学上可接受的盐或前药。 还提供了包含本文所述的至少一种化合物或其药学上可接受的盐或前药和一种或多种药学上可接受的载体的药物组合物。 描述了治疗患有某些对KMO活性抑制作用的疾病和病症的患者的方法，其包括对此类患者施用至少一种有效减少体征或症状的至少一种化合物或其药学上可接受的盐或前药 的疾病或病症。 这些疾病包括神经变性疾病如亨廷顿氏病。 还描述了治疗方法，包括将本文所述的至少一种化合物或其药学上可接受的盐或前药作为单一活性剂施用或施用本文所述的至少一种化合物或其药学上可接受的盐或前药， 更多其他治疗剂。 还提供了用于筛选能够抑制KMO活性的化合物的方法。

公开(公告)号：US08058210B2

公开(公告)日：2011-11-15

申请号：US12617000

申请日：2009-11-12

申请人： Folker Lieb ,  Reiner Fischer ,  Alan Graff ,  Udo Schneider ,  Thomas Bretschneider ,  Christoph Erdelen ,  Wolfram Andersch ,  Mark-Wilhelm Drewes ,  Markus Dollinger ,  Ingo Wetcholowsky ,  Randy Allen Myers

发明人： Folker Lieb ,  Reiner Fischer ,  Alan Graff ,  Udo Schneider ,  Thomas Bretschneider ,  Christoph Erdelen ,  Wolfram Andersch ,  Mark-Wilhelm Drewes ,  Markus Dollinger ,  Ingo Wetcholowsky ,  Randy Allen Myers

IPC分类号： A01N35/06 ,  A01N31/06 ,  C07C49/15

CPC分类号： A01N43/36 ,  C07C45/673 ,  C07C45/68 ,  C07C49/747 ,  C07C57/58 ,  C07C57/72 ,  C07C57/76 ,  C07C59/88 ,  C07C62/38 ,  C07C69/013 ,  C07C69/24 ,  C07C69/65 ,  C07C69/67 ,  C07C69/738 ,  C07C69/757 ,  C07C69/96 ,  C07C211/47 ,  C07C233/51 ,  C07C233/52 ,  C07C255/29 ,  C07C323/61 ,  C07C2601/14 ,  C07C2601/16 ,  C07C2602/08 ,  C07C2602/50 ,  C07D207/38 ,  C07D209/96 ,  C07D307/60 ,  C07D307/94 ,  C07D311/74 ,  C07D333/50 ,  C07D401/12 ,  C07D405/04 ,  C07D491/10 ,  C07D493/10

摘要： The present invention relates to novel arylphenyl-substituted cyclic ketoenols of the formula (I) in which X represents halogen, alkyl, alkoxy, alkenyloxy, alkylthio, alkylsulphinyl, alkylsulphonyl, halogenoalkyl, halogenoalkoxy, halogenoalkenyloxy, nitro, cyano or in each case optionally substituted phenyl, phenoxy, phenylthio, phenylalkoxy or phenylalkylthio, Y represents in each case optionally substituted cycloalkyl, aryl or hetaryl, Z represents hydrogen, halogen, alkyl, alkoxy, alkenyloxy, halogenoalkyl, halogenoalkoxy, halogenoalkenyloxy, nitro or cyano, CKE represents one of the groups in which A, B, D, G and Q1 to Q6 are each as defined in the description, to a plurality of processes for their preparation and to their use as pesticides and herbicides.

摘要翻译： 本发明涉及式（I）的新型芳基苯基取代的环酮酮，其中X表示卤素，烷基，烷氧基，烯氧基，烷硫基，烷基亚磺酰基，烷基磺酰基，卤代烷基，卤代烷氧基，卤代烯基氧基，硝基，氰基或在各种情况下任选取代 苯基，苯氧基，苯硫基，苯基烷氧基或苯基烷硫基，Y代表各自为任选取代的环烷基，芳基或杂芳基，Z表示氢，卤素，烷基，烷氧基，烯氧基，卤代烷基，卤代烷氧基，卤代烯氧基，硝基或氰基，CKE代表 其中A，B，D，G和Q1至Q6各自如本说明书所定义，其多个制备方法及其作为农药和除草剂的用途。

公开(公告)号：US20100087320A1

公开(公告)日：2010-04-08

申请号：US12617000

申请日：2009-11-12

申请人： Folker Lieb ,  Reiner Fischer ,  Alan Graff ,  Udo Schneider ,  Thomas Bretschneider ,  Christoph Erdelen ,  Wolfram Andersch ,  Mark-Wilhelm Drewes ,  Markus Dollinger ,  Ingo Wetcholowsky ,  Randy Allen Myers

发明人： Folker Lieb ,  Reiner Fischer ,  Alan Graff ,  Udo Schneider ,  Thomas Bretschneider ,  Christoph Erdelen ,  Wolfram Andersch ,  Mark-Wilhelm Drewes ,  Markus Dollinger ,  Ingo Wetcholowsky ,  Randy Allen Myers

IPC分类号： A01N43/78 ,  A01N43/08 ,  C07D305/12 ,  C07D307/94 ,  A01N43/12 ,  A01N43/38 ,  C07D209/54 ,  C07D279/06 ,  A01N43/58 ,  C07D487/00 ,  C07D405/04 ,  A01N43/40 ,  A01N37/02 ,  C07C69/00

CPC分类号： A01N43/36 ,  C07C45/673 ,  C07C45/68 ,  C07C49/747 ,  C07C57/58 ,  C07C57/72 ,  C07C57/76 ,  C07C59/88 ,  C07C62/38 ,  C07C69/013 ,  C07C69/24 ,  C07C69/65 ,  C07C69/67 ,  C07C69/738 ,  C07C69/757 ,  C07C69/96 ,  C07C211/47 ,  C07C233/51 ,  C07C233/52 ,  C07C255/29 ,  C07C323/61 ,  C07C2601/14 ,  C07C2601/16 ,  C07C2602/08 ,  C07C2602/50 ,  C07D207/38 ,  C07D209/96 ,  C07D307/60 ,  C07D307/94 ,  C07D311/74 ,  C07D333/50 ,  C07D401/12 ,  C07D405/04 ,  C07D491/10 ,  C07D493/10

摘要： The present invention relates to novel arylphenyl-substituted cyclic ketoenols of the formula (I) in which X represents halogen, alkyl, alkoxy, alkenyloxy, alkylthio, alkylsulphinyl, alkylsulphonyl, halogenoalkyl, halogenoalkoxy, halogenoalkenyloxy, nitro, cyano or in each case optionally substituted phenyl, phenoxy, phenylthio, phenylalkoxy or phenylalkylthio, Y represents in each case optionally substituted cycloalkyl, aryl or hetaryl, Z represents hydrogen, halogen, alkyl, alkoxy, alkenyloxy, halogenoalkyl, halogenoalkoxy, halogenoalkenyloxy, nitro or cyano, CKE represents one of the groups in which A, B, D, G and Q1 to Q6 are each as defined in the description, to a plurality of processes for their preparation and to their use as pesticides and herbicides.

摘要翻译： 本发明涉及式（I）的新型芳基苯基取代的环酮酮，其中X表示卤素，烷基，烷氧基，烯氧基，烷硫基，烷基亚磺酰基，烷基磺酰基，卤代烷基，卤代烷氧基，卤代烯基氧基，硝基，氰基或在各种情况下任选取代 苯基，苯氧基，苯硫基，苯基烷氧基或苯基烷硫基，Y代表各自为任选取代的环烷基，芳基或杂芳基，Z表示氢，卤素，烷基，烷氧基，烯氧基，卤代烷基，卤代烷氧基，卤代烯氧基，硝基或氰基，CKE代表 其中A，B，D，G和Q1至Q6各自如本说明书所定义，其多个制备方法及其作为农药和除草剂的用途。

公开(公告)号：US07288676B2

公开(公告)日：2007-10-30

申请号：US11330601

申请日：2006-01-12

申请人： Folker Lieb ,  Reiner Fischer ,  Alan Graff ,  Udo Schneider ,  Thomas Bretschneider ,  Christoph Erdelen ,  Wolfram Andersch ,  Mark-Wilhelm Drewes ,  Markus Dollinger ,  Ingo Wetcholowsky ,  Randy Allen Myers

发明人： Folker Lieb ,  Reiner Fischer ,  Alan Graff ,  Udo Schneider ,  Thomas Bretschneider ,  Christoph Erdelen ,  Wolfram Andersch ,  Mark-Wilhelm Drewes ,  Markus Dollinger ,  Ingo Wetcholowsky ,  Randy Allen Myers

IPC分类号： C07C57/72 ,  C07C57/76

CPC分类号： A01N43/36 ,  C07C45/673 ,  C07C45/68 ,  C07C49/747 ,  C07C57/58 ,  C07C57/72 ,  C07C57/76 ,  C07C59/88 ,  C07C62/38 ,  C07C69/013 ,  C07C69/24 ,  C07C69/65 ,  C07C69/67 ,  C07C69/738 ,  C07C69/757 ,  C07C69/96 ,  C07C211/47 ,  C07C233/51 ,  C07C233/52 ,  C07C255/29 ,  C07C323/61 ,  C07C2601/14 ,  C07C2601/16 ,  C07C2602/08 ,  C07C2602/50 ,  C07D207/38 ,  C07D209/96 ,  C07D307/60 ,  C07D307/94 ,  C07D311/74 ,  C07D333/50 ,  C07D401/12 ,  C07D405/04 ,  C07D491/10 ,  C07D493/10

摘要： The present invention relates to novel arylphenyl-substituted cyclic ketoenols of the formula (I) in which X represents halogen, alkyl, alkoxy, alkenyloxy, alkylthio, alkylsulphinyl, alkylsulphonyl, halogenoalkyl, halogenoalkoxy, halogenoalkenyloxy, nitro, cyano or in each case optionally substituted phenyl, phenoxy, phenylthio, phenylalkoxy or phenylalkylthio, Y represents in each case optionally substituted cycloalkyl, aryl or hetaryl, Z represents hydrogen, halogen, alkyl, alkoxy, alkenyloxy, halogenoalkyl, halogenoalkoxy, halogenoalkenyloxy, nitro or cyano, CKE represents one of the groups in which A, B, D, G and Q1 to Q6 are each as defined in the description, to a plurality of processes for their preparation and to their use as pesticides and herbicides.

摘要翻译： 本发明涉及式（I）的新型芳基苯基取代的环酮酮，其中X表示卤素，烷基，烷氧基，烯氧基，烷硫基，烷基亚磺酰基，烷基磺酰基，卤代烷基，卤代烷氧基，卤代烯基氧基，硝基，氰基或在各种情况下任选取代 苯基，苯氧基，苯硫基，苯基烷氧基或苯基烷硫基，Y代表各自为任选取代的环烷基，芳基或杂芳基，Z表示氢，卤素，烷基，烷氧基，烯氧基，卤代烷基，卤代烷氧基，卤代烯氧基，硝基或氰基，CKE代表 其中A，B，D，G和Q 1至Q 6的基团各自如说明书中所定义，涉及多种制备方法及其用途 作为农药和除草剂。