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1.发明申请Methods and arrays for target analyte detection and determination of reaction components that affect a reaction 有权用于目标分析物检测和测定影响反应的反应组分的方法和阵列公开(公告)号：US20070259381A1
公开(公告)日：2007-11-08
申请号：US11707384
申请日：2007-02-16
申请人： David Rissin , Hans-Heiner Gorris , David Walt
发明人： David Rissin , Hans-Heiner Gorris , David Walt
IPC分类号： G01N33/573
CPC分类号： G01N33/581 , C12Q1/6837 , G01N33/543 , G01N33/54346 , G01N33/54366 , G01N33/54386 , G01N2333/938 , C12Q2527/143
摘要： Methods are described for detecting reaction components with affect a reaction. Biomolecules such as enzymes can be addressed at the single molecule level in order to discover function, detect binding partners or inhibitors, and/or measure rate constants.
摘要翻译： 描述了用于检测影响反应的反应组分的方法。 为了发现功能，检测结合配偶体或抑制剂和/或测量速率常数，可以在单分子水平处理生物分子如酶。
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公开(公告)号：US20090258381A1
公开(公告)日：2009-10-15
申请号：US12084204
申请日：2006-10-31
IPC分类号： C12Q1/37 , G01N33/531 , C07K17/00
摘要： The invention relates to methods for examining the enzymatic cleavability of substrates. In the methods, compounds, which have a cleavability of the section to be examined, are firstly synthesized on a first solid phase, separated therefrom, the cleavage reaction is carried out in solution and the cleaved and uncleaved compounds are immobilized on a second solid phase and the cleavability is determined.
摘要翻译： 本发明涉及检查底物的酶切割性的方法。 在该方法中，首先在第一固相上合成具有待检测区段的可裂解性的化合物，将其与溶液分离，裂解反应在溶液中进行，并将裂解和未裂解的化合物固定在第二固相 并确定切割性。
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公开(公告)号：US20090104633A1
公开(公告)日：2009-04-23
申请号：US12084246
申请日：2006-10-31
IPC分类号： G01N33/53 , G01N33/543 , C12P19/34
CPC分类号： G01N33/582 , C07D207/46 , C07K16/44 , G01N33/532
摘要： The present invention relates to kits comprising 2,4-dichlorophenoxyacetate derivatives as well as antibodies that bind to these derivatives. Inter alia, the kits can be used to label biomolecules for analytical and diagnostic applications. Some of the compounds described here can be used to label biomolecules under physiological conditions and without having to apply in situ activation. Furthermore, the presence of spacers within the 2,4-dichlorophenoxyacetate derivatives improves their binding to antibodies.
摘要翻译： 本发明涉及包含2,4-二氯苯氧基乙酸酯衍生物的试剂盒以及与这些衍生物结合的抗体。 特别地，该试剂盒可用于标记用于分析和诊断应用的生物分子。 这里描述的一些化合物可用于在生理条件下标记生物分子，而不必施加原位活化。 此外，2,4-二氯苯氧基乙酸酯衍生物中间隔物的存在改善了其与抗体的结合。
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4.发明授权Methods and arrays for target analyte detection and determination of reaction components that affect a reaction 有权用于目标分析物检测和测定影响反应的反应组分的方法和阵列公开(公告)号：US08492098B2
公开(公告)日：2013-07-23
申请号：US11707384
申请日：2007-02-16
IPC分类号： G01N33/53 , G01N33/569 , C12Q1/00 , C12Q1/68
CPC分类号： G01N33/581 , C12Q1/6837 , G01N33/543 , G01N33/54346 , G01N33/54366 , G01N33/54386 , G01N2333/938 , C12Q2527/143
摘要： Methods are described for detecting reaction components with affect a reaction. Biomolecules such as enzymes can be addressed at the single molecule level in order to discover function, detect binding partners or inhibitors, and/or measure rate constants.
摘要翻译： 描述了用于检测影响反应的反应组分的方法。 为了发现功能，检测结合配偶体或抑制剂和/或测量速率常数，可以在单分子水平处理生物分子如酶。
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