公开(公告)号：US08580266B2

公开(公告)日：2013-11-12

申请号：US12669940

申请日：2008-07-21

申请人： David Sancho-Madrid ,  Oliver Schulz ,  Neil Charles Rogers ,  Caetano Reis E Sousa ,  Olivier Pierre Joffre ,  Daniel Pennington

发明人： David Sancho-Madrid ,  Oliver Schulz ,  Neil Charles Rogers ,  Caetano Reis E Sousa ,  Olivier Pierre Joffre ,  Daniel Pennington

IPC分类号： A61K39/395 ,  A61K39/00

CPC分类号： A61K47/48415 ,  A61K39/0005 ,  A61K39/0011 ,  A61K47/6811 ,  A61K2039/507 ,  A61K2039/57 ,  A61K2039/6056 ,  C07K16/2851 ,  C07K16/2878 ,  C07K2317/55 ,  C07K2317/74 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2319/33

摘要： The invention relates to the regulation of the immune system, and in particular to the finding that the CLEC9a molecule is a marker for dendritic cells which are capable of cross-presenting extracellular antigens via the MHC class I pathway. This makes them particularly suitable for generation of cytotoxic T lymphocyte responses. Materials and methods are provided both for the induction of immune responses against target antigens, and for the inhibition or suppression of undesirable immune responses in which these cells are involved.

公开(公告)号：US20100221265A1

公开(公告)日：2010-09-02

申请号：US12669940

申请日：2008-07-21

申请人： David Sancho-Madrid ,  Oliver Schulz ,  Neil Charles Rogers ,  Caetano Reis E. Sousa ,  Olivier Pierre Joffre ,  Daniel Pennington

发明人： David Sancho-Madrid ,  Oliver Schulz ,  Neil Charles Rogers ,  Caetano Reis E. Sousa ,  Olivier Pierre Joffre ,  Daniel Pennington

IPC分类号： A61K39/395 ,  C12N5/0784 ,  A61K39/00 ,  C07K14/00 ,  C07K16/00 ,  A61K31/7052 ,  A61K38/43 ,  C12N9/00 ,  G01N33/53 ,  C12N5/0783 ,  A61K35/12 ,  A61P37/00

CPC分类号： A61K47/48415 ,  A61K39/0005 ,  A61K39/0011 ,  A61K47/6811 ,  A61K2039/507 ,  A61K2039/57 ,  A61K2039/6056 ,  C07K16/2851 ,  C07K16/2878 ,  C07K2317/55 ,  C07K2317/74 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2319/33

摘要： The invention relates to the regulation of the immune system, and in particular to the finding that the CLEC9a molecule is a marker for dendritic cells which are capable of cross-presenting extracellular antigens via the MHC class I pathway. This makes them particularly suitable for generation of cytotoxic T lymphocyte responses. Materials and methods are provided both for the induction of immune responses against target antigens, and for the inhibition or suppression of undesirable immune responses in which these cells are involved.

摘要翻译： 本发明涉及免疫系统的调节，特别是关于CLEC9a分子是能够通过MHC I类途径交叉呈递细胞外抗原的树突状细胞的标记的发现。 这使得它们特别适合于产生细胞毒性T淋巴细胞应答。 提供材料和方法用于诱导针对靶抗原的免疫应答，以及用于抑制或抑制其中涉及这些细胞的不期望的免疫应答。