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公开(公告)号：US20050170382A1
公开(公告)日：2005-08-04
申请号：US10990310
申请日：2004-11-15
申请人： David Stern , Kevan Herold , Shi Yan , Ann Schmidt , Ira Lamster
发明人： David Stern , Kevan Herold , Shi Yan , Ann Schmidt , Ira Lamster
IPC分类号： A61K31/00 , A61K38/17 , C07K16/18 , C12Q1/68 , A01K67/00 , C07H21/04 , C07K14/705 , C07K16/28
CPC分类号： A61K31/00 , A61K38/1774 , A61K2039/505 , C07K16/18
摘要： The present invention provides for an isolated human EN-RAGE peptide. The present invention also provides for a method for determining whether a compound is capable of inhibiting the interaction of an EN-RAGE peptide with a RAGE peptide, which comprises: (a) admixing: (i) a RAGE peptide or an sRAGE peptide or a fragment of either thereof, (ii) an EN-RAGE peptide or a fragment thereof, and (iii) the compound; (b) measuring the level of interaction between the peptide of step (a) (i) and the peptide of step (a) (ii), and (c) comparing the amount of interaction meausred in step (b) with the amount measured between the petpide of step (a) (i) and the peptide of step (a) (ii) in the absence of the compound, thereby determining whether the compound is capable of inhibiting the interaction of the EN-RAGE peptide with the RAGE peptide, wherein a reduction in the amount of interaction in the presence of the compound indicates that the compound is capable of inhibiting the interaction. The present invention also provides for a method for inhibiting inflammation in a subject which comprises administering to the subject a compound capable of interfering with the interaction between EN-RAGE peptide and receptor for advanced glycation endproduct (RAGE) in the subject thereby inhibiting inflammation in the subject.
摘要翻译： 本发明提供了分离的人类EN-RAGE肽。 本发明还提供了一种用于确定化合物是否能够抑制EN-RAGE肽与RAGE肽的相互作用的方法，其包括：（a）混合：（i）RAGE肽或sRAGE肽或 片段，（ii）EN-RAGE肽或其片段，和（iii）化合物; （b）测量步骤（a）（i）的肽与步骤（a）（ii）的肽之间的相互作用水平，和（c）将步骤（b）中所发生的相互作用的量与测量的量进行比较 在不存在化合物的情况下，步骤（a）（i）的petpide和步骤（a）（ii）的肽之间，从而确定化合物是否能够抑制EN-RAGE肽与RAGE肽的相互作用 其中在化合物存在下相互作用量的减少表明该化合物能够抑制相互作用。 本发明还提供了一种抑制受试者的炎症的方法，其包括向受试者施用能够干扰受试者的EN-RAGE肽和受体之间相互作用的晚期糖基化终产物（RAGE）的相互作用，从而抑制受试者的炎症 学科。
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2.发明申请Methods of inhibiting binding of beta-sheet fibril to rage and consequences thereof 审中-公开抑制β-片原纤维结合的愤怒及其后果的方法公开(公告)号：US20080019986A1
公开(公告)日：2008-01-24
申请号：US11805164
申请日：2007-05-21
申请人： David Stern , Shi Yan , Ann Schmidt
发明人： David Stern , Shi Yan , Ann Schmidt
CPC分类号： C07K16/2803 , A61K2039/505 , C07K2317/54
摘要： This invention provides a method of inhibiting the binding of a β-sheet fibril to RAGE on the surface of a cell which comprises contacting the cell with a binding inhibiting amount of a compound capable of inhibiting binding of the β-sheet fibril to RAGE so as to thereby inhibit binding of the β-sheet fibril to RAGE. In one embodiment the β-sheet fibril is amyloid fibril. In one embodiment, the compound is sRAGE or a fragment thereof. In another embodiment, the compound is an anti-RAGE antibody or portion thereof. This invention provides the above method wherein the inhibition of binding of the β-sheet fibril to RAGE has the consequences of decreasing the load of β-sheet fibril in the tissue, inhibiting fibril-induced programmed cell death, inhibiting fibril-induced cell stress. This invention also provides methods of determining whether a compound inhibits binding of a β-sheet fibril to RAGE on the surface of a cell.
摘要翻译： 本发明提供了抑制细胞表面上的β-片原纤维与RAGE的结合的方法，其包括使细胞与结合抑制量的能够抑制β-片原纤维结合的化合物与RAGE接触，以便 从而抑制β-片原纤维与RAGE的结合。 在一个实施方案中，β-片原纤维是淀粉样蛋白原纤维。 在一个实施方案中，化合物是sRAGE或其片段。 在另一个实施方案中，化合物是抗RAGE抗体或其部分。 本发明提供了上述方法，其中抑制β-片原纤维与RAGE的结合具有降低组织中β-片原纤维的负荷，抑制原纤维诱导的程序性细胞死亡，抑制原纤维诱导的细胞应激的后果。 本发明还提供了确定化合物是否抑制β片原纤维与细胞表面上的RAGE结合的方法。
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公开(公告)号：US20070167360A1
公开(公告)日：2007-07-19
申请号：US10577506
申请日：2004-10-28
申请人： Shi Yan , David Stern
发明人： Shi Yan , David Stern
IPC分类号： A61K38/17
CPC分类号： A61K31/00 , A61K38/1774
摘要： This invention provides a method for treating a subject afflicted with multiple sclerosis comprising administering to the subject a therapeutically effective amount of soluble receptor for advanced glycation endproducts (sRAGE). This invention further provides a method for inhibiting CD4+ T-cell migration comprising contacting the CD4+ T-cell with soluble receptor for advanced glycation endproducts (sRAGE). This invention further provides a method for inhibiting chemokine receptor activation in a subject comprising administering to the subject a therapeutically effective amount of soluble receptor for advanced glycation endproducts (sRAGE).
摘要翻译： 本发明提供了治疗患有多发性硬化症的受试者的方法，其包括向受试者施用治疗有效量的晚期糖基化终产物（sRAGE）的可溶性受体。 本发明进一步提供了一种抑制CD4 + T细胞迁移的方法，包括使CD4 + T细胞与晚期糖基化终产物（sRAGE）的可溶性受体接触。 本发明进一步提供了一种用于抑制受试者中趋化因子受体活化的方法，包括向受试者施用治疗有效量的晚期糖基化终产物（sRAGE）的可溶性受体。
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4.发明申请公开(公告)号：US20210187532A1
公开(公告)日：2021-06-24
申请号：US16724269
申请日：2019-12-21
申请人： Gabriel Thurston Sibley , Curtis Dale Garner , Andre Robert Daniel Michelin , Lorenzo Ibarria , Patrick Christopher Leger , Benjamin Rewis , Shi Yan
发明人： Gabriel Thurston Sibley , Curtis Dale Garner , Andre Robert Daniel Michelin , Lorenzo Ibarria , Patrick Christopher Leger , Benjamin Rewis , Shi Yan
摘要： Various embodiments relate generally to computer vision and automation to autonomously identify and deliver for application a treatment to an object among other objects, data science and data analysis, including machine learning, deep learning, and other disciplines of computer-based artificial intelligence to facilitate identification and treatment of objects, and robotics and mobility technologies to navigate a delivery system, more specifically, to an agricultural delivery system configured to identify and apply, for example, an agricultural treatment to an identified agricultural object. In some examples, a method may include calculating an amount of light originating from a light source sensed at a location in which an agricultural object is interposed between the light source and an image capture device, causing emission of an obscurant, and directing the obscurant to a region interposed between the light source and the agricultural object.
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公开(公告)号：US20210185942A1
公开(公告)日：2021-06-24
申请号：US16724268
申请日：2019-12-21
申请人： Gabriel Thurston Sibley , Curtis Dale Garner , Andre Robert Daniel Michelin , Lorenzo Ibarria , Patrick Christopher Leger , Benjamin Rewis , Shi Yan
发明人： Gabriel Thurston Sibley , Curtis Dale Garner , Andre Robert Daniel Michelin , Lorenzo Ibarria , Patrick Christopher Leger , Benjamin Rewis , Shi Yan
摘要： Various embodiments relate generally to computer vision and automation to autonomously identify and deliver for application a treatment to an object among other objects, data science and data analysis, including machine learning, deep learning, and other disciplines of computer-based artificial intelligence to facilitate identification and treatment of objects, and robotics and mobility technologies to navigate a delivery system, more specifically, to an agricultural delivery system configured to identify and apply, for example, an agricultural treatment to an identified agricultural object. In some examples, a method may include identifying an agricultural object being associated with a subset of agricultural objects, identifying an action corresponding to a subset of agricultural objects responsive, selecting an emitter with which to perform an action associated with the agricultural object, configuring an agricultural projectile delivery system to activate an emitter to propel an agricultural projectile to intercept an agricultural object.
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公开(公告)号：US10907699B2
公开(公告)日：2021-02-02
申请号：US16473253
申请日：2017-01-03
申请人： Shi Yan
发明人： Shi Yan
摘要： A frequency dependent piston assembly (1) for a shock absorber comprising:
a piston (10) slidably disposed within a portion of cylinder (20), dividing volume defined within said portion of cylinder (20) into a first chamber (21) and a second chamber (22), said piston (10) comprising a flow channel (11) connecting said first chamber (21) and said second chamber (22); characterized in that said piston assembly (1) further comprises:
a valve assembly (100) controlling fluid flow (150) between said first chamber (21) and said second chamber (22), configured for its preload to be changed by movement of said piston (10);
a pressure chamber (300) comprising a chamber wall (301), configured to be moved by said piston (10) to change volume of said pressure chamber (300).-
公开(公告)号：US07130883B2
公开(公告)日：2006-10-31
申请号：US09751424
申请日：2000-12-29
申请人： Min Zhu , Jian Shen , Steven Li , Guanghong Yang , Bin Zhao , Shi Yan , Zheng Yuan
发明人： Min Zhu , Jian Shen , Steven Li , Guanghong Yang , Bin Zhao , Shi Yan , Zheng Yuan
IPC分类号： G06F13/00
CPC分类号： H04L12/1827 , H04L67/1095 , H04L69/329 , H04L69/40
摘要： A distributed collaborative computer system is provided that comprises a plurality of server computers interconnected via a high-speed link. Client computers can connect to any available server computer and start or join a conference hosted on either the server computer to which the client computer is connected or any other server in the system. As a result, the system and method of the present invention is easily scalable to support an arbitrary number of participants to a conference by merely adding the appropriate number of server computers to the system. In addition, by replicating the conference information on more than one server computer, the single point of failure limitation is eliminated. In fact, if a server hosting or participating in a conference malfunctions, the failure is detected by other server computers and the client computer is able to reconnect to the conference through a new server computer.
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公开(公告)号：US07069298B2
公开(公告)日：2006-06-27
申请号：US09751807
申请日：2000-12-29
IPC分类号： G06F13/00
CPC分类号： H04L12/1827 , H04L12/1868 , Y10S707/99953
摘要： A fault-tolerant distributed collaborative computer system is provided that comprises a plurality of server computers interconnected via a high-speed link. By replicating the conference information on more than one server computer, the single point of failure limitation is eliminated. In fact, if a server hosting or participating in a conference malfunctions, the failure is detected by other server computers and the client computer is able to reconnect to the conference through a new server computer. In addition, the state of processes executed by the server computers is periodically replicated, so that when failure of a process is detected a new processes can be spawned and the replicated state information loaded onto the new process, allowing the on-line conference to continue.
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公开(公告)号：US20200158204A1
公开(公告)日：2020-05-21
申请号：US16473253
申请日：2017-01-03
申请人： Shi Yan
发明人： Shi Yan
摘要： A frequency dependent piston assembly (1) for a shock absorber comprising:a piston (10) slidably disposed within a portion of cylinder (20), dividing volume defined within said portion of cylinder (20) into a first chamber (21) and a second chamber (22), said piston (10) comprising a flow channel (11) connecting said first chamber (21) and said second chamber (22); characterized in that said piston assembly (1) further comprises:a valve assembly (100) controlling fluid flow (150) between said first chamber (21) and said second chamber (22), configured for its preload to be changed by movement of said piston (10);a pressure chamber (300) comprising a chamber wall (301), configured to be moved by said piston (10) to change volume of said pressure chamber (300).
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公开(公告)号：US20110154192A1
公开(公告)日：2011-06-23
申请号：US13001805
申请日：2010-06-25
申请人： Jinyu Yang , Xuan Zhang , Shi Yan , Bing Tang , Zhiwei Shen
发明人： Jinyu Yang , Xuan Zhang , Shi Yan , Bing Tang , Zhiwei Shen
CPC分类号： G06F17/2288 , G06F17/241 , G06F17/242
摘要： A collaboration system includes a remote server system and one or more client devices connected to the remote server system, at least one of which being a first client device that includes a touch screen display. Upon receipt of a user instruction, the collaboration system opens a document at the first client device and displays the document on the touch screen display to a first user. The collaboration system detects a first comment on the document from the first user through interacting with the touch screen display. The collaboration system receives a second comment on the document from the remote server system. The second comment is generated by a second user of a second client device and transmitted to the remote server system through a computer network. The collaboration system displays, concurrently, the first comment and the second comment on the touch screen display.
摘要翻译： 协作系统包括远程服务器系统和连接到远程服务器系统的一个或多个客户端设备，其中至少一个是包括触摸屏显示器的第一客户端设备。 在接收到用户指令之后，协作系统在第一客户端设备处打开文档，并且将触摸屏显示器上的文档显示给第一用户。 协作系统通过与触摸屏显示器交互来检测来自第一用户的文档的第一注释。 协作系统从远程服务器系统接收关于文档的第二个注释。 第二个注释由第二个客户端设备的第二个用户生成，并通过计算机网络发送到远程服务器系统。 协作系统同时显示触摸屏显示器上的第一个注释和第二个注释。
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