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公开(公告)号:US20080051395A1
公开(公告)日:2008-02-28
申请号:US11721504
申请日:2005-12-06
申请人: David Uehling , Kirk Stevens , Scott Dickerson , Alex Waterson , Philip Harris , Douglas Sammond , Robert Hubbard , Holly Emerson , Joseph Wilson
发明人: David Uehling , Kirk Stevens , Scott Dickerson , Alex Waterson , Philip Harris , Douglas Sammond , Robert Hubbard , Holly Emerson , Joseph Wilson
IPC分类号: A61K31/506 , A61K31/5377 , A61P35/00 , C07D239/24 , C07D413/14
CPC分类号: C07D471/04
摘要: The present invention provides 2-pyrimidinyl pyrazolopyridine compounds, compositions containing the same, as well as processes for the preparation and their use as pharmaceutical agents.
摘要翻译: 本发明提供2-嘧啶基吡唑并吡啶化合物,含有它们的组合物,以及制备方法及其作为药剂的用途。
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公开(公告)号:US20050234083A1
公开(公告)日:2005-10-20
申请号:US10506447
申请日:2003-02-28
申请人: Stanley Chamberlain , Mui Cheung , Holly Emerson , Neil Johnson , Kristen Nailor , Douglas Sammond , Marcus Semones
发明人: Stanley Chamberlain , Mui Cheung , Holly Emerson , Neil Johnson , Kristen Nailor , Douglas Sammond , Marcus Semones
IPC分类号: A61K31/506 , A61K31/5377 , A61K45/00 , A61P9/10 , A61P9/14 , A61P29/00 , A61P35/00 , A61P43/00 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D43/02
CPC分类号: C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14
摘要: Benzimidazole derivatives, which are useful as TIE-2 and/or VEGFR-2 inhibitors are described herein. The described invention also includes methods of making such benzimidazole derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.
摘要翻译: 本文描述了可用作TIE-2和/或VEGFR-2抑制剂的苯并咪唑衍生物。 所述的发明还包括制备这种苯并咪唑衍生物的方法以及使用它们在治疗过度增殖性疾病中的方法。
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公开(公告)号:US20070010540A1
公开(公告)日:2007-01-11
申请号:US11430342
申请日:2006-05-09
申请人: Lisa Shewchuk , Anne Hassell , William Holmes , James Veal , Holly Emerson , David Musso , Stanley Chamberlain , Gregory Peckham
发明人: Lisa Shewchuk , Anne Hassell , William Holmes , James Veal , Holly Emerson , David Musso , Stanley Chamberlain , Gregory Peckham
IPC分类号: A61K31/505 , C07D403/02 , C07D239/48
CPC分类号: C12N9/12 , C07K14/7153 , C07K2299/00 , G06F19/16
摘要: A crystal structure of the cfms kinase domain, co-crystal structure with a bound small molecule, as well as methods of using the same in the discovery of cfms inhibitors and in the treatment of diseases mediated by inappropriate cfms activity.
摘要翻译: 具有结合的小分子的cfms激酶结构域,共晶体结构的晶体结构,以及在发现cfms抑制剂以及治疗不适当cfms活性介导的疾病的方法。
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