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公开(公告)号:US20070010540A1
公开(公告)日:2007-01-11
申请号:US11430342
申请日:2006-05-09
申请人: Lisa Shewchuk , Anne Hassell , William Holmes , James Veal , Holly Emerson , David Musso , Stanley Chamberlain , Gregory Peckham
发明人: Lisa Shewchuk , Anne Hassell , William Holmes , James Veal , Holly Emerson , David Musso , Stanley Chamberlain , Gregory Peckham
IPC分类号: A61K31/505 , C07D403/02 , C07D239/48
CPC分类号: C12N9/12 , C07K14/7153 , C07K2299/00 , G06F19/16
摘要: A crystal structure of the cfms kinase domain, co-crystal structure with a bound small molecule, as well as methods of using the same in the discovery of cfms inhibitors and in the treatment of diseases mediated by inappropriate cfms activity.
摘要翻译: 具有结合的小分子的cfms激酶结构域,共晶体结构的晶体结构,以及在发现cfms抑制剂以及治疗不适当cfms活性介导的疾病的方法。
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公开(公告)号:US07678803B2
公开(公告)日:2010-03-16
申请号:US11844584
申请日:2007-08-24
申请人: Kenneth He Huang , James Veal , Thomas Barta , Emilie D. Smith , Wei Ma , Andy Ommen
发明人: Kenneth He Huang , James Veal , Thomas Barta , Emilie D. Smith , Wei Ma , Andy Ommen
IPC分类号: A61K31/517
CPC分类号: C07D403/04 , C07D401/04 , C07D401/14 , C07D471/04
摘要: The current invention is directed toward compounds and pharmaceutically acceptable salts of Formula I wherein Q1 is CR1, Q2 is N, Q4 and Q5 are each CR1, Q3 is CR2, X1 is N or CRc, Y is CRc, X2 and X3 are each C(R5)(R6), R7 is O. Compounds of Formula I are useful in the treatment of diseases and/or conditions related to cell proliferation, such as cancer The current invention is also directed toward pharmaceutical compositions comprising compounds of the invention.
摘要翻译: 本发明涉及其中Q1是CR1,Q2是N,Q4和Q5各自是CR1,Q3是CR2,X1是N或CRc,Y是CRc,X2和X3各自为C的化合物和药学上可接受的盐 (R 5)(R 6),R 7为O.式I的化合物可用于治疗与细胞增殖相关的疾病和/或病症,例如癌症。本发明还涉及包含本发明化合物的药物组合物。
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公开(公告)号:US20080076800A1
公开(公告)日:2008-03-27
申请号:US11844629
申请日:2007-08-24
申请人: Kenneth Huang , Thomas Barta , Emilie Smith , Steven Hall , James Veal
发明人: Kenneth Huang , Thomas Barta , Emilie Smith , Steven Hall , James Veal
IPC分类号: A61K31/44 , A61K31/166 , A61K31/196 , A61K31/216 , A61K31/443 , A61P19/02 , A61P29/00 , A61P35/00 , A61P9/00 , C07D405/12 , C07D335/02 , C07D309/14 , C07D213/85 , C07D213/82 , C07D211/58 , C07C255/58 , C07C233/65 , C07C229/42 , A61P37/00 , A61P31/00 , A61P25/00 , A61K31/4465 , A61K31/277 , A61K31/351 , A61K31/382
CPC分类号: C07D213/84 , C07C255/58 , C07C255/59 , C07D211/58 , C07D213/81 , C07D213/82 , C07D213/85 , C07D309/14 , C07D335/02 , C07D405/12
摘要: Disclosed are compounds and pharmaceutically acceptable salts of Formula I wherein A, Q1, Q2, Q3, R3, R4, R5, RO, m, and p are as defined herein. Compounds of Formula I are useful in the treatment of diseases and/or conditions related to cell proliferation, such as cancer, inflammation, arthritis, angiogenesis, or the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.
摘要翻译: 公开了式I的化合物和药学上可接受的盐,其中A 1,Q 1,Q 2,Q 3,R 3, R 4,R 5,R 5,R O,m和p如本文所定义。 式I化合物可用于治疗与细胞增殖相关的疾病和/或病症,例如癌症,炎症,关节炎,血管生成等。 还公开了包含本发明化合物的药物组合物和使用这些化合物治疗上述病症的方法。
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公开(公告)号:US20050085637A1
公开(公告)日:2005-04-21
申请号:US10503874
申请日:2003-02-07
申请人: Mui Cheung , Kristen Nailor , Douglas Sammond , James Veal
发明人: Mui Cheung , Kristen Nailor , Douglas Sammond , James Veal
IPC分类号: A61K31/505 , A61K31/506 , A61K45/00 , A61P9/00 , A61P9/10 , A61P17/02 , A61P27/02 , A61P29/00 , A61P35/00 , A61P43/00 , C07D239/02 , C07D239/48 , C07D251/48
CPC分类号: C07D239/48
摘要: Pyrimidine derivatives, which are useful as TIE-2 and/or VEGFR-2 inhibitors are described herein. The described invention also includes methods of making such pyrimidine derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.
摘要翻译: 本文描述了可用作TIE-2和/或VEGFR-2抑制剂的嘧啶衍生物。 所述的发明还包括制备此类嘧啶衍生物的方法以及使用该嘧啶衍生物的方法来治疗过度增殖性疾病。
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公开(公告)号:US20110183977A1
公开(公告)日:2011-07-28
申请号:US13081637
申请日:2011-04-07
申请人: Kenneth He Huang , Jeron Eaves , Gunnar J. Hanson , James Veal , Thomas Barta , Lifeng Geng , Lindsay Hinkley
发明人: Kenneth He Huang , Jeron Eaves , Gunnar J. Hanson , James Veal , Thomas Barta , Lifeng Geng , Lindsay Hinkley
IPC分类号: A61K31/5377 , A61K31/454 , A61K31/415 , A61K31/405 , C07D413/12 , C07D401/12 , C07D403/12 , C07D209/04 , A61P31/10 , C07D409/12 , C07D405/12 , A61P29/00 , A61P35/00 , A61P31/00 , A61P19/02 , A61P37/00 , A61P25/00 , A61P9/00 , A61P35/02 , A61P3/00 , A61P11/00
CPC分类号: C07D409/12 , A61K31/404 , A61K31/416 , A61K31/4439 , A61K31/454 , A61K31/5377 , A61K45/00 , A61K45/06 , A61N5/10 , C07D209/08 , C07D209/14 , C07D231/54 , C07D231/56 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12
摘要: Disclosed are compounds and pharmaceutically acceptable salts of Formula I wherein R1, R2, R3, R4, R5, R6, R7, n, Q1, Q2, Q3, Y, and X1-X4 are as defined herein. Compounds of Formula I are useful in the treatment of diseases and/or conditions related to cell proliferation, such as cancer, inflammation, arthritis, angiogenesis, or the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.
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公开(公告)号:US20080070935A1
公开(公告)日:2008-03-20
申请号:US11844584
申请日:2007-08-24
申请人: Kenneth Huang , James Veal , Thomas Barta , Emilie Smith , Wei Ma , Andy Ommen
发明人: Kenneth Huang , James Veal , Thomas Barta , Emilie Smith , Wei Ma , Andy Ommen
IPC分类号: A61K31/517 , A61K31/47 , A61K31/519 , A61P25/00 , A61P3/00 , A61P31/10 , A61P37/00 , C07D217/22 , C07D401/10 , C07D403/02 , C07D401/14 , C07D239/72 , A61P9/00 , A61P35/00 , A61P31/00 , A61P29/00 , A61P19/02 , A61K31/4725
CPC分类号: C07D403/04 , C07D401/04 , C07D401/14 , C07D471/04
摘要: Disclosed are compounds and pharmaceutically acceptable salts of Formula I wherein R0, R5, R6, R7, n, Q1-Q5, Y, and X1-X3 are as defined herein. Compounds of Formula I are useful in the treatment of diseases and/or conditions related to cell proliferation, such as cancer, inflammation, arthritis, angiogenesis, or the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.
摘要翻译: 公开了式I的化合物和药学上可接受的盐,其中R 0,R 5,R 6,R 7, ,n,Q 1 -Q 5,Y和X 1 -X 3 -X如本文所定义。 式I化合物可用于治疗与细胞增殖相关的疾病和/或病症,例如癌症,炎症,关节炎,血管生成等。 还公开了包含本发明化合物的药物组合物和使用这些化合物治疗上述病症的方法。
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公开(公告)号:US07928135B2
公开(公告)日:2011-04-19
申请号:US12907571
申请日:2010-10-19
申请人: Kenneth He Huang , Jeron Eaves , Gunnar Hanson , James Veal , Thomas Barta , Lifeng Geng , Lindsay Hinkley
发明人: Kenneth He Huang , Jeron Eaves , Gunnar Hanson , James Veal , Thomas Barta , Lifeng Geng , Lindsay Hinkley
IPC分类号: C07D231/54 , A01N43/56
CPC分类号: C07D409/12 , A61K31/404 , A61K31/416 , A61K31/4439 , A61K31/454 , A61K31/5377 , A61K45/00 , A61K45/06 , A61N5/10 , C07D209/08 , C07D209/14 , C07D231/54 , C07D231/56 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12
摘要: Disclosed are compounds and pharmaceutically acceptable salts of Formula I wherein R1, R2, R3, R4, R5, R6, R7, n, Q1, Q2, Q3, Y, and X1-X4 are as defined herein. Compounds of Formula I are useful in the treatment of diseases and/or conditions related to cell proliferation, such as cancer, inflammation, arthritis, angiogenesis, or the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.
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公开(公告)号:US20110034529A1
公开(公告)日:2011-02-10
申请号:US12907571
申请日:2010-10-19
申请人: Kenneth He Huang , Jeron Eaves , Gunnar J. Hanson , James Veal , Thomas Barta , Lifeng Geng , Lindsay Hinkley
发明人: Kenneth He Huang , Jeron Eaves , Gunnar J. Hanson , James Veal , Thomas Barta , Lifeng Geng , Lindsay Hinkley
IPC分类号: A61K31/416 , C07D231/56 , A61P35/00
CPC分类号: C07D409/12 , A61K31/404 , A61K31/416 , A61K31/4439 , A61K31/454 , A61K31/5377 , A61K45/00 , A61K45/06 , A61N5/10 , C07D209/08 , C07D209/14 , C07D231/54 , C07D231/56 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12
摘要: Disclosed are compounds and pharmaceutically acceptable salts of Formula I wherein R1, R2, R3, R4, R5, R6, R7, n, Q1, Q2, Q3, Y, and X1-X4 are as defined herein. Compounds of Formula I are useful in the treatment of diseases and/or conditions related to cell proliferation, such as cancer, inflammation, arthritis, angiogenesis, or the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.
摘要翻译: 公开了式I的化合物和药学上可接受的盐,其中R1,R2,R3,R4,R5,R6,R7,n,Q1,Q2,Q3,Y和X1-X4如本文所定义。 式I化合物可用于治疗与细胞增殖相关的疾病和/或病症,例如癌症,炎症,关节炎,血管生成等。 还公开了包含本发明化合物的药物组合物和使用这些化合物治疗上述病症的方法。
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公开(公告)号:US20090163493A9
公开(公告)日:2009-06-25
申请号:US11959784
申请日:2007-12-19
申请人: Kenneth Huang , Jeron Eaves , Gunnar Hanson , James Veal , Thomas Barta , Lifeng Geng , Lindsay Hinkley
发明人: Kenneth Huang , Jeron Eaves , Gunnar Hanson , James Veal , Thomas Barta , Lifeng Geng , Lindsay Hinkley
IPC分类号: A61K31/404 , A61K31/416 , A61K31/4439 , A61K31/454 , A61K31/5377 , A61P19/02 , A61P25/00 , A61P29/00 , A61P3/00 , A61P31/00 , A61P35/00 , A61P37/00 , A61P9/00 , C07D209/08 , C07D231/56 , C07D401/02 , C07D405/02 , C07D409/02 , C07D413/02
CPC分类号: C07D409/12 , A61K31/404 , A61K31/416 , A61K31/4439 , A61K31/454 , A61K31/5377 , A61K45/00 , A61K45/06 , A61N5/10 , C07D209/08 , C07D209/14 , C07D231/54 , C07D231/56 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12
摘要: Disclosed are compounds and pharmaceutically acceptable salts of Formula I wherein R1, R2, R3, R4, R5, R6, R7, n, Q1, Q2, Q3, Y, and X1-X4 are as defined herein. Compounds of Formula I are useful in the treatment of diseases and/or conditions related to cell proliferation, such as cancer, inflammation, arthritis, angiogenesis, or the like. Also disclosed are pharmaceutical compositions comprising compounds of the invention and methods of treating the aforementioned conditions using such compounds.
摘要翻译: 公开了式I的化合物和药学上可接受的盐,其中R1,R2,R3,R4,R5,R6,R7,n,Q1,Q2,Q3,Y和X1-X4如本文所定义。 式I化合物可用于治疗与细胞增殖相关的疾病和/或病症,例如癌症,炎症,关节炎,血管生成等。 还公开了包含本发明化合物的药物组合物和使用这些化合物治疗上述病症的方法。
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公开(公告)号:US20080269193A1
公开(公告)日:2008-10-30
申请号:US12102128
申请日:2008-04-14
申请人: Kenneth He Huang , Andy J. Ommen , Thomas E. Barta , Philip F. Hughes , James Veal , Wei Ma , Emilie D. Smith , Angela R. Woodward , W. Stephen McCall
发明人: Kenneth He Huang , Andy J. Ommen , Thomas E. Barta , Philip F. Hughes , James Veal , Wei Ma , Emilie D. Smith , Angela R. Woodward , W. Stephen McCall
IPC分类号: A61K31/55 , A61K31/404 , C07D405/12 , A61K31/416 , A61P35/00 , C07D231/54 , C07D403/14
CPC分类号: C07D231/56 , C07D401/12 , C07D403/12 , C07D405/12 , C07D405/14
摘要: The invention provides indole and indazole compounds of Formula (I) or pharmaceutically acceptable salts thereof which are useful for treating and/or preventing diseases and/or disorders ameliorated by the inhibition of Heat-Shock Protein 90. The invention further provides pharmaceutical compositions comprising compounds of Formula (I) and methods of preparing compounds of Formula (I).
摘要翻译: 本发明提供了可用于治疗和/或预防通过抑制热休克蛋白90改善的疾病和/或障碍的式(I)的吲哚和吲唑化合物或其药学上可接受的盐。本发明还提供包含化合物 的式(I)化合物和式(I)化合物的制备方法。
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