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公开(公告)号：US08034906B2
公开(公告)日：2011-10-11
申请号：US11977677
申请日：2007-10-25
申请人： David W. Borhani , Wolfgang Fraunhofer , Hans-Juergen Krause , Anette Koenigsdorfer , Gerhard Winter , Stefan Gottschalk
发明人： David W. Borhani , Wolfgang Fraunhofer , Hans-Juergen Krause , Anette Koenigsdorfer , Gerhard Winter , Stefan Gottschalk
CPC分类号： C07K16/241 , A61K9/50 , A61K39/3955 , C07K2299/00 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to a batch crystallization method for crystallizing an anti-hTNFalpha antibody which allows the production of said antibody on an industrial scale; antibody crystals as obtained according to said method; compositions containing said crystals as well as methods of use of said crystals and compositions.
摘要翻译： 本发明涉及一种用于使抗hTNFα抗体结晶的分批结晶方法，其允许以工业规模生产所述抗体; 根据所述方法获得的抗体晶体; 含有所述晶体的组合物以及所述晶体和组合物的使用方法。
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公开(公告)号：US20080292642A1
公开(公告)日：2008-11-27
申请号：US12079434
申请日：2008-03-27
申请人： David W. Borhani , Wolfgang Fraunhofer , Hans-Juergen Krause , Anette Koenigsdorfer , Gerhard Winter , Stefan Gottschalk
发明人： David W. Borhani , Wolfgang Fraunhofer , Hans-Juergen Krause , Anette Koenigsdorfer , Gerhard Winter , Stefan Gottschalk
CPC分类号： C07K16/244 , A61K39/39591 , C07K2299/00 , C30B7/00 , Y02A50/401
摘要： The invention relates to batch crystallization methods for crystallizing an anti-hIL-12 antibody that allows the production of the antibody on an industrial scale, antibody crystals obtained according to the methods, compositions containing the crystals, and methods of using the crystals and the compositions.
摘要翻译： 本发明涉及用于结晶能够以工业规模生产抗体的抗-hIL-12抗体的分批结晶方法，根据该方法获得的抗体晶体，含有晶体的组合物，以及使用晶体和组合物的方法 。
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公开(公告)号：US20100034823A1
公开(公告)日：2010-02-11
申请号：US11977677
申请日：2007-10-25
申请人： David W. Borhani , Wolfgang Fraunhofer , Hans-Juergen Krause , Anette Koenigsdorfer , Gerhard Winter , Stefan Gottschalk
发明人： David W. Borhani , Wolfgang Fraunhofer , Hans-Juergen Krause , Anette Koenigsdorfer , Gerhard Winter , Stefan Gottschalk
IPC分类号： A61K39/395 , C07K1/00 , C07K16/18 , A61P19/10 , A61P19/02 , A61P37/08 , A61P37/06 , A61P11/00 , A61P1/00 , A61P9/00 , A61P19/00 , A61P7/00 , A61P17/00 , A61P11/06 , A61P3/10 , A61P17/06 , A61P25/28 , A61P31/12 , A61P35/00 , A61P27/02
CPC分类号： C07K16/241 , A61K9/50 , A61K39/3955 , C07K2299/00 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to a batch crystallization method for crystallizing an anti-hTNFalpha antibody which allows the production of said antibody on an industrial scale; antibody crystals as obtained according to said method; compositions containing said crystals as well as methods of use of said crystals and compositions.
摘要翻译： 本发明涉及一种用于使抗hTNFα抗体结晶的分批结晶方法，其允许以工业规模生产所述抗体; 根据所述方法获得的抗体晶体; 含有所述晶体的组合物以及所述晶体和组合物的使用方法。
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公开(公告)号：US20120251550A1
公开(公告)日：2012-10-04
申请号：US13225281
申请日：2011-09-02
申请人： David W. Borhani , Wolfgang Fraunhofer , Hans-Juergen Krause , Anette Koenigsdorfer , Gerhard Winter , Stefan Gottschalk
发明人： David W. Borhani , Wolfgang Fraunhofer , Hans-Juergen Krause , Anette Koenigsdorfer , Gerhard Winter , Stefan Gottschalk
IPC分类号： C07K16/24 , A61K39/395 , A61P37/00 , A61P29/00 , A61P19/02 , A61P37/08 , A61P25/00 , A61P31/00 , A61P37/06 , A61P35/00 , A61P7/00 , A61P1/00 , A61P9/00 , A61P19/08 , A61P31/14 , A61P7/02 , A61P17/02 , A61P9/10 , A61P1/02 , A61P3/04 , A61P3/00 , A61P7/06 , A61P1/16 , A61P17/00 , A61P11/06 , A61P11/00 , A61P17/06 , A61P25/28 , A61P19/04 , A61P1/18 , A61P13/12 , A61P19/06 , A61P27/02 , A61P13/08 , C07K1/30
CPC分类号： C07K16/241 , A61K9/50 , A61K39/3955 , C07K2299/00 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to a batch crystallization method for crystallizing an anti-hTNFalpha antibody which allows the production of said antibody on an industrial scale; antibody crystals as obtained according to said method; compositions containing said crystals as well as methods of use of said crystals and compositions.
摘要翻译： 本发明涉及一种用于使抗hTNFα抗体结晶的分批结晶方法，其允许以工业规模生产所述抗体; 根据所述方法获得的抗体晶体; 含有所述晶体的组合物以及所述晶体和组合物的使用方法。
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公开(公告)号：US20120177704A1
公开(公告)日：2012-07-12
申请号：US13396563
申请日：2012-02-14
申请人： David W. Borhani , Wolfgang Fraunhofer , Hans-Juergen Krause , Anette Koenigsdorfer , Gerhard Winter , Stefan Gottschalk
发明人： David W. Borhani , Wolfgang Fraunhofer , Hans-Juergen Krause , Anette Koenigsdorfer , Gerhard Winter , Stefan Gottschalk
IPC分类号： A61K9/00 , C07K16/24 , A61K39/395 , A61P29/00 , A61P19/02 , A61P37/06 , A61P1/00 , A61P19/04 , A61P3/10 , A61P1/04 , A61P11/06 , A61P37/08 , A61P17/06 , A61P17/00 , A61P9/10 , A61P7/02 , A61P13/12 , A61P43/00 , A61P1/16 , A61P27/02 , A61P31/00 , A61P33/00 , A61P25/00 , A61P25/16 , A61P25/28 , A61P7/06 , A61P35/00 , A61P9/04 , A61P5/38 , A61P11/00 , A61P17/14 , A61P9/00 , A61P15/08 , A61P15/00 , A61P3/08 , A61P9/12 , A61P5/14 , C07K1/00
CPC分类号： C07K16/244 , A61K39/39591 , C07K2299/00 , C30B7/00 , Y02A50/401
摘要： The invention relates to batch crystallization methods for crystallizing an anti-hIL-12 antibody that allows the production of the antibody on an industrial scale, antibody crystals obtained according to the methods, compositions containing the crystals, and methods of using the crystals and the compositions.
摘要翻译： 本发明涉及用于结晶能够以工业规模生产抗体的抗-hIL-12抗体的分批结晶方法，根据该方法获得的抗体晶体，含有晶体的组合物，以及使用晶体和组合物的方法 。
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公开(公告)号：US08436149B2
公开(公告)日：2013-05-07
申请号：US13225281
申请日：2011-09-02
申请人： David W. Borhani , Wolfgang Fraunhofer , Hans-Juergen Krause , Anette Koenigsdorfer , Gerhard Winter , Stefan Gottschalk
发明人： David W. Borhani , Wolfgang Fraunhofer , Hans-Juergen Krause , Anette Koenigsdorfer , Gerhard Winter , Stefan Gottschalk
CPC分类号： C07K16/241 , A61K9/50 , A61K39/3955 , C07K2299/00 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to a batch crystallization method for crystallizing an anti-hTNFalpha antibody which allows the production of said antibody on an industrial scale; antibody crystals as obtained according to said method; compositions containing said crystals as well as methods of use of said crystals and compositions.
摘要翻译： 本发明涉及一种用于使抗hTNFα抗体结晶的分批结晶方法，其允许以工业规模生产所述抗体; 根据所述方法获得的抗体晶体; 含有所述晶体的组合物以及所述晶体和组合物的使用方法。
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公开(公告)号：US08404819B2
公开(公告)日：2013-03-26
申请号：US13396563
申请日：2012-02-14
申请人： David W. Borhani , Wolfgang Fraunhofer , Hans-Juergen Krause , Anette Koenigsdorfer , Gerhard Winter , Stefan Gottschalk
发明人： David W. Borhani , Wolfgang Fraunhofer , Hans-Juergen Krause , Anette Koenigsdorfer , Gerhard Winter , Stefan Gottschalk
CPC分类号： C07K16/244 , A61K39/39591 , C07K2299/00 , C30B7/00 , Y02A50/401
摘要： The invention relates to batch crystallization methods for crystallizing an anti-hIL-12 antibody that allows the production of the antibody on an industrial scale, antibody crystals obtained according to the methods, compositions containing the crystals, and methods of using the crystals and the compositions.
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公开(公告)号：US08168760B2
公开(公告)日：2012-05-01
申请号：US12079434
申请日：2008-03-27
申请人： David W. Borhani , Wolfgang Fraunhofer , Hans-Juergen Krause , Anette Koenigsdorfer , Gerhard Winter , Stefan Gottschalk
发明人： David W. Borhani , Wolfgang Fraunhofer , Hans-Juergen Krause , Anette Koenigsdorfer , Gerhard Winter , Stefan Gottschalk
CPC分类号： C07K16/244 , A61K39/39591 , C07K2299/00 , C30B7/00 , Y02A50/401
摘要： The invention relates to batch crystallization methods for crystallizing an anti-hIL-12 antibody that allows the production of the antibody on an industrial scale, antibody crystals obtained according to the methods, compositions containing the crystals, and methods of using the crystals and the compositions.
摘要翻译： 本发明涉及用于结晶能够以工业规模生产抗体的抗-hIL-12抗体的分批结晶方法，根据该方法获得的抗体晶体，含有晶体的组合物，以及使用晶体和组合物的方法 。
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公开(公告)号：US08753839B2
公开(公告)日：2014-06-17
申请号：US12228038
申请日：2008-08-08
IPC分类号： C12P21/06 , A61K39/395 , A01N61/00 , C07K16/24 , A61K39/00
CPC分类号： C07K16/241 , A61K2039/505 , C07K1/306 , C07K2299/00 , C07K2317/14 , C07K2317/54 , C07K2317/76 , C30B29/58 , Y02A50/388
摘要： The present invention relates to a batch crystallization method for crystallizing anti-human TNFalpha (hTNFalpha) antibody and antibody fragments which allows the production of said antibody on an industrial scale; a method of controlling the size of antibody crystals, for example, crystals of anti-hTNFalpha antibody fragments, compositions containing said crystals as well as methods of use of said crystals and compositions.
摘要翻译： 本发明涉及用于结晶抗人TNFα（hTNFα）抗体的分批结晶方法和允许以工业规模生产所述抗体的抗体片段; 控制抗体晶体大小的方法，例如抗hTNFα抗体片段的晶体，含有所述晶体的组合物以及使用所述晶体和组合物的方法。
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公开(公告)号：US20090148513A1
公开(公告)日：2009-06-11
申请号：US12228038
申请日：2008-08-08
IPC分类号： A61K39/395 , C07K16/00 , C12P21/08 , A61K9/48
CPC分类号： C07K16/241 , A61K2039/505 , C07K1/306 , C07K2299/00 , C07K2317/14 , C07K2317/54 , C07K2317/76 , C30B29/58 , Y02A50/388
摘要： The present invention relates to a batch crystallization method for crystallizing anti-human TNFalpha (hTNFalpha) antibody and antibody fragments which allows the production of said antibody on an industrial scale; a method of controlling the size of antibody crystals, for example, crystals of anti-hTNFalpha antibody fragments, compositions containing said crystals as well as methods of use of said crystals and compositions.
摘要翻译： 本发明涉及用于结晶抗人TNFα（hTNFα）抗体的分批结晶方法和允许以工业规模生产所述抗体的抗体片段; 控制抗体晶体大小的方法，例如抗hTNFα抗体片段的晶体，含有所述晶体的组合物以及所述晶体和组合物的使用方法。
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