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    Conjugates for dual imaging and radiochemotherapy: composition, manufacturing, and applications
    1.
    发明申请
    Conjugates for dual imaging and radiochemotherapy: composition, manufacturing, and applications 有权
    双重成像和放射化学治疗的结合体：组成，制造和应用

    公开(公告)号：US20060182687A1

    公开(公告)日：2006-08-17

    申请号：US11326117

    申请日：2006-01-05

    申请人： David Yang ,  Dongfang Yu ,  Mithu Chanda ,  Ali Azhdarinia ,  Changsok Oh ,  E. Kim

    发明人： David Yang ,  Dongfang Yu ,  Mithu Chanda ,  Ali Azhdarinia ,  Changsok Oh ,  E. Kim

    IPC分类号： A61K49/10 ,  C08B37/00 ,  A61B10/00

    CPC分类号： A61K47/48092 ,  A61K47/549 ,  A61K47/61 ,  A61K49/0002 ,  A61K49/0438 ,  A61K51/0491 ,  C08B37/00 ,  C08B37/003

    摘要： Compositions and methods for dual imaging and for dual chemotherapy and radiotherapy are disclosed. More particularly, the invention concerns compounds comprising the structure X1-Y-X2, wherein Y comprises two or more carbohydrate residues covalently attached to one another, X1 and X2 are diagnostic or therapeutic moieties covalently attached to Y, provided that when Y does not comprise a glucosamine residue, X1 and X2 are diagnostic moieties. The present invention also concerns methods of synthesis of these compounds, application of such compounds for dual imaging and treatment of hyperproliferative disease, and kits for preparing a radiolabeled therapeutic or diagnostic compound.

    摘要翻译： 公开了用于双重成像和双重化疗和放疗的组合物和方法。 更具体地，本发明涉及包含结构X 1 -YX 2 2的化合物，其中Y包含彼此共价连接的两个或更多个碳水化合物残基，X 1， / SUB和X 2是与Y共价连接的诊断或治疗部分，条件是当Y不包含葡糖胺残基时，X 1和X 2 < / SUB>是诊断部分。 本发明还涉及这些化合物的合成方法，这种化合物在双成像和治疗过度增殖性疾病中的应用，以及用于制备放射性标记的治疗或诊断化合物的试剂盒。

    Conjugates for dual imaging and radiochemotherapy: composition, manufacturing, and applications
    3.
    发明授权
    Conjugates for dual imaging and radiochemotherapy: composition, manufacturing, and applications 有权
    双重成像和放射化学治疗的结合体：组成，制造和应用

    公开(公告)号：US08147805B2

    公开(公告)日：2012-04-03

    申请号：US11326117

    申请日：2006-01-05

    申请人： David Yang ,  Dongfang Yu ,  Mithu Chanda ,  Ali Azhdarinia ,  Changsok Oh ,  E. Edmund Kim

    发明人： David Yang ,  Dongfang Yu ,  Mithu Chanda ,  Ali Azhdarinia ,  Changsok Oh ,  E. Edmund Kim

    IPC分类号： A61K49/04 ,  A61K51/00 ,  A61M36/14

    CPC分类号： A61K47/48092 ,  A61K47/549 ,  A61K47/61 ,  A61K49/0002 ,  A61K49/0438 ,  A61K51/0491 ,  C08B37/00 ,  C08B37/003

    摘要： Compositions and methods for dual imaging and for dual chemotherapy and radiotherapy are disclosed. More particularly, the invention concerns compounds comprising the structure X1—Y—X2, wherein Y comprises two or more carbohydrate residues covalently attached to one another, X1 and X2 are diagnostic or therapeutic moieties covalently attached to Y, provided that when Y does not comprise a glucosamine residue, X1 and X2 are diagnostic moieties. The present invention also concerns methods of synthesis of these compounds, application of such compounds for dual imaging and treatment of hyperproliferative disease, and kits for preparing a radiolabeled therapeutic or diagnostic compound.

    摘要翻译： 公开了用于双重成像和双重化疗和放疗的组合物和方法。 更具体地，本发明涉及包含结构X1-Y-X2的化合物，其中Y包含彼此共价连接的两个或更多个碳水化合物残基，X1和X2是共价连接到Y的诊断或治疗部分，条件是当Y不包含 氨基葡萄糖残基X1和X2是诊断部分。 本发明还涉及这些化合物的合成方法，这种化合物在双成像和治疗过度增殖性疾病中的应用，以及用于制备放射性标记的治疗或诊断化合物的试剂盒。

    Automated system for formulating radiopharmaceuticals
    4.
    发明授权
    Automated system for formulating radiopharmaceuticals 失效
    配制放射性药物的自动化系统

    公开(公告)号：US07586102B2

    公开(公告)日：2009-09-08

    申请号：US11726853

    申请日：2007-03-23

    申请人： Firas Mourtada ,  Ali Azhdarinia ,  David Yang ,  Changsok Oh

    发明人： Firas Mourtada ,  Ali Azhdarinia ,  David Yang ,  Changsok Oh

    IPC分类号： G01N33/53

    CPC分类号： G21G4/08 ,  B01D15/10 ,  B01D15/325 ,  B01D15/362 ,  B01D15/363 ,  G21G1/0005 ,  G21H5/02

    摘要： The present invention provides automated systems for the purification of radioisotopes, the formulation of radiopharmaceuticals or both. In preferred embodiments the radioisotopes are produced by a generator. In further preferred embodiments the automated systems comprise replaceable cassettes for easy replacement of the system's networks of tubing. Also provided are replaceable cassettes and kits for use with the automated systems of the invention.The invention further provides methods of using an automated system to purify radioisotopes, formulate radiopharmaceuticals or to do both in series.

    摘要翻译： 本发明提供用于纯化放射性同位素的自动化系统，放射性药物的配方或两者。 在优选实施方案中，放射性同位素由发生器产生。 在进一步的优选实施例中，自动化系统包括可更换的盒，用于容易地更换系统的管道网络。 还提供了与本发明的自动化系统一起使用的可更换盒和套件。 本发明还提供了使用自动化系统来净化放射性同位素，配制放射性药物或两者串联的方法。

    Automated system for formulating radiopharmaceuticals
    5.
    发明申请
    Automated system for formulating radiopharmaceuticals 失效
    空值

    公开(公告)号：US20080035542A1

    公开(公告)日：2008-02-14

    申请号：US11726853

    申请日：2007-03-23

    申请人： Firas Mourtada ,  Ali Azhdarinia ,  David Yang ,  Changsok Oh

    发明人： Firas Mourtada ,  Ali Azhdarinia ,  David Yang ,  Changsok Oh

    IPC分类号： B01D21/30 ,  B01D15/08

    CPC分类号： G21G4/08 ,  B01D15/10 ,  B01D15/325 ,  B01D15/362 ,  B01D15/363 ,  G21G1/0005 ,  G21H5/02

    摘要： The present invention provides automated systems for the purification of radioisotopes, the formulation of radiopharmaceuticals or both. In preferred embodiments the radioisotopes are produced by a generator. In further preferred embodiments the automated systems comprise replaceable cassettes for easy replacement of the system's networks of tubing. Also provided are replaceable cassettes and kits for use with the automated systems of the invention.The invention further provides methods of using an automated system to purify radioisotopes, formulate radiopharmaceuticals or to do both in series.

    摘要翻译： 本发明提供用于纯化放射性同位素的自动化系统，放射性药物的配方或两者。 在优选实施方案中，放射性同位素由发生器产生。 在进一步的优选实施例中，自动化系统包括可更换的盒，用于容易地更换系统的管道网络。 还提供了与本发明的自动化系统一起使用的可更换盒和套件。 本发明还提供了使用自动化系统来净化放射性同位素，配制放射性药物或两者串联的方法。

    Poly(peptide) as a chelator: methods of manufacture and uses
    6.
    发明申请
    Poly(peptide) as a chelator: methods of manufacture and uses 审中-公开
    聚（肽）作为螯合剂：制造和使用方法

    公开(公告)号：US20060246005A1

    公开(公告)日：2006-11-02

    申请号：US11394664

    申请日：2006-03-31

    申请人： David Yang ,  Dong-Fang Yu ,  Chang Oh ,  Saady Kohanim ,  E. Kim ,  Ali Azhdarinia

    发明人： David Yang ,  Dong-Fang Yu ,  Chang Oh ,  Saady Kohanim ,  E. Kim ,  Ali Azhdarinia

    IPC分类号： A61K51/00

    CPC分类号： A61K51/088 ,  A61K47/64 ,  A61K51/0478 ,  A61K51/0497

    摘要： Novel compositions for imaging that include (a) a polypeptide that includes two or more consecutive amino acids that will function to non-covalently bind valent metal ions and (2) a valent metal ion chelated to at least one of the two consecutive amino acids, are disclosed. Also disclosed are methods of imaging using these novel compositions, such as methods of imaging a tumor within a subject. Methods of synthesizing an imaging agent and kits for preparing an imaging agent are also disclosed. Methods for determining the effectiveness of a candidate substance as an imaging agent that involve conjugating or chelating the candidate substance with a polypeptide that includes two or more consecutive amino acids that will function to non-covalently bind valent metal ions.

    摘要翻译： 用于成像的新型组合物包括（a）包含两个或更多个连续氨基酸的多肽，所述两个或多个连续的氨基酸将用于非共价结合价金属离子，和（2）螯合至两个连续氨基酸中的至少一个的价金属离子， 被披露。 还公开了使用这些新型组合物成像的方法，例如在受试者内成像肿瘤的方法。 还公开了合成显影剂的方法和用于制备显影剂的试剂盒。 用于确定作为显像剂的候选物质的有效性的方法，所述显像剂涉及使候选物质与包含两个或更多个连续氨基酸的多肽共轭或螯合候选物质，所述多个连续的氨基酸将用于非共价结合价金属离子。

    System and method for an automated synthesis of gallium-68 generator-based radiopharmaceutical agents
    9.
    发明申请
    System and method for an automated synthesis of gallium-68 generator-based radiopharmaceutical agents 审中-公开
    用于自动合成镓-68发生器的放射性药剂的系统和方法

    公开(公告)号：US20050276751A1

    公开(公告)日：2005-12-15

    申请号：US11038631

    申请日：2005-01-19

    申请人： K.S. Chao ,  David Yang ,  Firas Mourtada ,  Ali Azhdarinia

    发明人： K.S. Chao ,  David Yang ,  Firas Mourtada ,  Ali Azhdarinia

    IPC分类号： A61K51/00 ,  A61K51/02 ,  C07F5/00

    CPC分类号： A61K51/02

    摘要： Systems and methods are described for efficiently producing a radiopharmaceutical agent. The system includes a generator that provides an admixture comprising hydrochloric acid and gallium-68 (Ga-68). A heater initiates a removal process by evaporating the hydrochloric acid from the admixture resulting in a substantially purified Ga-68. A plurality of valves provides a buffer and a prodrug that gets mixed with the Ga-68 to produce Ga-68 radiopharmaceutical agent. Additionally, the valves may provide water or a transchelator to the Ga-68 radiopharmaceutical agent to optimize the yield. A method includes providing an admixture comprising hydrochloric acid and Ga-68. The method also includes removing the hydrochloric acid by heating the admixture and subsequently evaporating the hydrochloric acid, resulting in a substantially purified Ga-68. The method further includes adding a buffer and a prodrug to the substantially purified Ga-68 to produce the Ga-68 radiopharmaceutical agent.

    摘要翻译： 描述了用于有效地生产放射性药剂的系统和方法。 该系统包括提供包含盐酸和镓-68（Ga-68）的混合物的发生器。 加热器通过从混合物中蒸发盐酸来引发去除过程，导致基本上纯化的Ga-68。 多个阀提供与Ga-68混合以制备Ga-68放射性药剂的缓冲液和前药。 此外，阀门可以向Ga-68放射性药剂提供水或转运器以优化产量。 一种方法包括提供包含盐酸和Ga-68的混合物。 该方法还包括通过加热混合物并随后蒸发盐酸除去盐酸，得到基本纯化的Ga-68。 该方法还包括向基本纯化的Ga-68中加入缓冲液和前药以制备Ga-68放射性药剂。