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    Conjugates for dual imaging and radiochemotherapy: composition, manufacturing, and applications
    1.
    发明申请
    Conjugates for dual imaging and radiochemotherapy: composition, manufacturing, and applications 有权
    双重成像和放射化学治疗的结合体：组成，制造和应用

    公开(公告)号：US20060182687A1

    公开(公告)日：2006-08-17

    申请号：US11326117

    申请日：2006-01-05

    申请人： David Yang ,  Dongfang Yu ,  Mithu Chanda ,  Ali Azhdarinia ,  Changsok Oh ,  E. Kim

    发明人： David Yang ,  Dongfang Yu ,  Mithu Chanda ,  Ali Azhdarinia ,  Changsok Oh ,  E. Kim

    IPC分类号： A61K49/10 ,  C08B37/00 ,  A61B10/00

    CPC分类号： A61K47/48092 ,  A61K47/549 ,  A61K47/61 ,  A61K49/0002 ,  A61K49/0438 ,  A61K51/0491 ,  C08B37/00 ,  C08B37/003

    摘要： Compositions and methods for dual imaging and for dual chemotherapy and radiotherapy are disclosed. More particularly, the invention concerns compounds comprising the structure X1-Y-X2, wherein Y comprises two or more carbohydrate residues covalently attached to one another, X1 and X2 are diagnostic or therapeutic moieties covalently attached to Y, provided that when Y does not comprise a glucosamine residue, X1 and X2 are diagnostic moieties. The present invention also concerns methods of synthesis of these compounds, application of such compounds for dual imaging and treatment of hyperproliferative disease, and kits for preparing a radiolabeled therapeutic or diagnostic compound.

    摘要翻译： 公开了用于双重成像和双重化疗和放疗的组合物和方法。 更具体地，本发明涉及包含结构X 1 -YX 2 2的化合物，其中Y包含彼此共价连接的两个或更多个碳水化合物残基，X 1， / SUB和X 2是与Y共价连接的诊断或治疗部分，条件是当Y不包含葡糖胺残基时，X 1和X 2 < / SUB>是诊断部分。 本发明还涉及这些化合物的合成方法，这种化合物在双成像和治疗过度增殖性疾病中的应用，以及用于制备放射性标记的治疗或诊断化合物的试剂盒。

    Poly(peptide) as a chelator: methods of manufacture and uses
    3.
    发明申请
    Poly(peptide) as a chelator: methods of manufacture and uses 审中-公开
    聚（肽）作为螯合剂：制造和使用方法

    公开(公告)号：US20060246005A1

    公开(公告)日：2006-11-02

    申请号：US11394664

    申请日：2006-03-31

    申请人： David Yang ,  Dong-Fang Yu ,  Chang Oh ,  Saady Kohanim ,  E. Kim ,  Ali Azhdarinia

    发明人： David Yang ,  Dong-Fang Yu ,  Chang Oh ,  Saady Kohanim ,  E. Kim ,  Ali Azhdarinia

    IPC分类号： A61K51/00

    CPC分类号： A61K51/088 ,  A61K47/64 ,  A61K51/0478 ,  A61K51/0497

    摘要： Novel compositions for imaging that include (a) a polypeptide that includes two or more consecutive amino acids that will function to non-covalently bind valent metal ions and (2) a valent metal ion chelated to at least one of the two consecutive amino acids, are disclosed. Also disclosed are methods of imaging using these novel compositions, such as methods of imaging a tumor within a subject. Methods of synthesizing an imaging agent and kits for preparing an imaging agent are also disclosed. Methods for determining the effectiveness of a candidate substance as an imaging agent that involve conjugating or chelating the candidate substance with a polypeptide that includes two or more consecutive amino acids that will function to non-covalently bind valent metal ions.

    摘要翻译： 用于成像的新型组合物包括（a）包含两个或更多个连续氨基酸的多肽，所述两个或多个连续的氨基酸将用于非共价结合价金属离子，和（2）螯合至两个连续氨基酸中的至少一个的价金属离子， 被披露。 还公开了使用这些新型组合物成像的方法，例如在受试者内成像肿瘤的方法。 还公开了合成显影剂的方法和用于制备显影剂的试剂盒。 用于确定作为显像剂的候选物质的有效性的方法，所述显像剂涉及使候选物质与包含两个或更多个连续氨基酸的多肽共轭或螯合候选物质，所述多个连续的氨基酸将用于非共价结合价金属离子。

    Ethylenedicysteine (EC)-drug conjugates, compositions and methods for tissue specific disease imaging
    7.
    发明申请
    Ethylenedicysteine (EC)-drug conjugates, compositions and methods for tissue specific disease imaging 有权
    亚乙基半胱氨酸（EC） - 药物共轭物，组织特异性疾病成像的组合物和方法

    公开(公告)号：US20050084448A1

    公开(公告)日：2005-04-21

    申请号：US10672763

    申请日：2003-09-26

    申请人： David Yang ,  Chun Liu ,  Dong-Fang Yu ,  E. Kim

    发明人： David Yang ,  Chun Liu ,  Dong-Fang Yu ,  E. Kim

    IPC分类号： A61K51/04 ,  A61K51/08 ,  A61K51/00

    CPC分类号： A61K51/088 ,  A61K51/04 ,  A61K51/0478 ,  A61K51/0491 ,  A61K51/0497 ,  A61K51/087

    摘要： The invention provides, in a general sense, a new labeling strategy employing 99mTc chelated with ethylenedicysteine (EC). EC is conjugated with a variety of ligands and chelated to 99mTc for use as an imaging agent for tissue-specific diseases. The drug conjugates of the invention may also be used as a prognostic tool or as a tool to deliver therapeutics to specific sites within a mammalian body. Kits for use in tissue-specific disease imaging are also provided.

    摘要翻译： 本发明在一般意义上提供了采用与乙二
    氨酸（EC）螯合的99m Tc的新标记策略。 EC与各种配体缀合并螯合至99m Tc以用作组织特异性疾病的显像剂。 本发明的药物缀合物也可用作预后工具或用作将治疗剂递送至哺乳动物体内特定部位的工具。 还提供了用于组织特异性疾病成像的试剂盒。

    Ethylenedicysteine (EC)-drug conjugates, compositions and methods for tissue specific disease imaging
    8.
    发明申请
    Ethylenedicysteine (EC)-drug conjugates, compositions and methods for tissue specific disease imaging 有权
    亚乙基半胱氨酸（EC） - 药物共轭物，组织特异性疾病成像的组合物和方法

    公开(公告)号：US20050079133A1

    公开(公告)日：2005-04-14

    申请号：US10672142

    申请日：2003-09-26

    申请人： David Yang ,  Chun Liu ,  Dong-Fang Yu ,  E. Kim

    发明人： David Yang ,  Chun Liu ,  Dong-Fang Yu ,  E. Kim

    IPC分类号： A61K51/04 ,  A61K51/08 ,  A61K51/00

    CPC分类号： A61K51/088 ,  A61K51/04 ,  A61K51/0478 ,  A61K51/0491 ,  A61K51/0497 ,  A61K51/087

    摘要： The invention provides, in a general sense, a new labeling strategy employing 99mTc chelated with ethylenedicysteine (EC). EC is conjugated with a variety of ligands and chelated to 99mTc for use as an imaging agent for tissue-specific diseases. The drug conjugates of the invention may also be used as a prognostic tool or as a tool to deliver therapeutics to specific sites within a mammalian body. Kits for use in tissue-specific disease imaging are also provided.

    摘要翻译： 本发明在一般意义上提供了采用与乙二
    氨酸（EC）螯合的99m Tc的新标记策略。 EC与多种配体缀合并螯合至<99m Tc，用作组织特异性疾病的显像剂。 本发明的药物缀合物也可用作预后工具或用作将治疗剂递送至哺乳动物体内特定部位的工具。 还提供了用于组织特异性疾病成像的试剂盒。

    Ethylenedicysteine (EC)-Drug Conjugates Compositions and Methods for Tissue Specific Disease Imaging
    9.
    发明申请
    Ethylenedicysteine (EC)-Drug Conjugates Compositions and Methods for Tissue Specific Disease Imaging 有权
    亚乙基半胱氨酸（EC） - 药物偶联物组合物和组织特异性疾病成像方法

    公开(公告)号：US20070122342A1

    公开(公告)日：2007-05-31

    申请号：US11627299

    申请日：2007-01-25

    申请人： David Yang ,  Chun Liu ,  Dong-Fang Yu ,  E. Kim

    发明人： David Yang ,  Chun Liu ,  Dong-Fang Yu ,  E. Kim

    IPC分类号： A61K51/00

    CPC分类号： A61K51/088 ,  A61K51/04 ,  A61K51/0478 ,  A61K51/0491 ,  A61K51/0497 ,  A61K51/087

    摘要： The invention provides, in a general sense, a new labeling strategy employing 99mTc chelated with ethylenedicysteine (EC). EC is conjugated with a variety of ligands and chelated to 99mTc for use as an imaging agent for tissue-specific diseases. The drug conjugates of the invention may also be used as a prognostic tool or as a tool to deliver therapeutics to specific sites within a mammalian body. Kits for use in tissue-specific disease imaging are also provided.

    摘要翻译： 本发明在一般意义上提供了采用与乙二
    氨酸（EC）螯合的99m Tc的新标记策略。 EC与各种配体缀合并螯合至99m Tc以用作组织特异性疾病的显像剂。 本发明的药物缀合物也可用作预后工具或用作将治疗剂递送至哺乳动物体内特定部位的工具。 还提供了用于组织特异性疾病成像的试剂盒。

    MEMS vascular sensor
    10.
    发明申请
    MEMS vascular sensor 有权
    MEMS血管传感器

    公开(公告)号：US20060081064A1

    公开(公告)日：2006-04-20

    申请号：US11196849

    申请日：2005-08-04

    申请人： Tzung Hsiai ,  Gopikrishnan Soundararajan ,  E. Kim ,  Hongyu Yu ,  Mahsa Rouhanizadeh ,  Tiantian Lin

    发明人： Tzung Hsiai ,  Gopikrishnan Soundararajan ,  E. Kim ,  Hongyu Yu ,  Mahsa Rouhanizadeh ,  Tiantian Lin

    IPC分类号： G01N3/24

    CPC分类号： B81C1/00246 ,  G01N3/24

    摘要： A micromachined sensor for measuring vascular parameters, such as fluid shear stress, includes a substrate having a front-side surface, and a backside surface opposite the front-side surface. The sensor includes a diaphragm overlying a cavity etched within the substrate, and a heat sensing element disposed on the front-side surface of the substrate and on top of the cavity and the diaphragm. The heat sensing element is electrically couplable to electrode leads formed on the backside surface of the substrate. The sensor includes an electronic system connected to the backside surface and configured to measure a change in heat convection from the sensing element to surrounding fluid when the sensing element is heated by applying an electric current thereto, and further configured to derive from the change in heat convection vascular parameters such as the shear stress of fluid flowing past the sensing element.

    摘要翻译： 用于测量诸如流体剪切应力的血管参数的微加工传感器包括具有前侧表面的基底和与前侧表面相对的背侧表面。 传感器包括覆盖在衬底内蚀刻的空腔的膜片，以及设置在衬底的前侧表面上并且在空腔和隔膜顶部上的感热元件。 热敏元件可电连接到形成在基板的背面上的电极引线。 所述传感器包括连接到所述背面的电子系统，并且被配置为当通过向其施加电流来加热所述感测元件时，测量从所述感测元件到周围流体的热对流变化，并进一步被配置为从热变化 对流血管参数，例如流过感测元件的流体的剪切应力。