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1.发明授权1,2,4-triazol-5-ones and analogs exhibiting anti-cancer and anti-proliferative activities 有权1,2,4-三唑-5-酮和具有抗癌和抗增殖活性的类似物公开(公告)号：US09193719B2
公开(公告)日：2015-11-24
申请号：US14214160
申请日：2014-03-14
发明人： Daniel L. Flynn , Gary E. L. Brandt , Michael D. Kaufman , Hanumaiah Telikepalli , Timothy Malcolm Caldwell , Thiwanka Samarakoon
IPC分类号： A61K31/506 , C07D417/14 , C07D401/14 , C07D405/14 , C07D413/14 , A61K31/444
CPC分类号： C07D417/14 , A61K31/444 , A61K31/506 , C07D401/14 , C07D405/14 , C07D413/14
摘要： Described are compounds of Formula I which find utility in the treatment of cancer, autoimmune diseases and metabolic bone disorders through inhibition of c-FMS (CSF-1R), c-KIT, and/or PDGFR kinases. These compounds also find utility in the treatment of other mammalian diseases mediated by c-FMS, c-KIT, or PDGFR kinases.
摘要翻译： 描述了通过抑制c-FMS（CSF-1R），c-KIT和/或PDGFR激酶在治疗癌症，自身免疫疾病和代谢性骨骼疾病中有用的式I化合物。 这些化合物也可用于治疗由c-FMS，c-KIT或PDGFR激酶介导的其它哺乳动物疾病。
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2.发明申请1,2,4-TRIAZOL-5-ONES AND ANALOGS EXHIBITING ANTI-CANCER AND ANTI-PROLIFERATIVE ACTIVITIES 有权1,2,4-TRIAZOL-5-ONES和模拟物展示抗癌和抗增殖活性公开(公告)号：US20140296252A1
公开(公告)日：2014-10-02
申请号：US14214160
申请日：2014-03-14
发明人： Daniel L. Flynn , Gary E. L. Brandt , Michael D. Kaufman , Hanumaiah Telikepalli , Timothy Malcolm Caldwell , Thiwanka Samarakoon
IPC分类号： C07D417/14 , C07D405/14 , C07D413/14 , C07D401/14
CPC分类号： C07D417/14 , A61K31/444 , A61K31/506 , C07D401/14 , C07D405/14 , C07D413/14
摘要： Described are compounds of Formula I which find utility in the treatment of cancer, autoimmune diseases and metabolic bone disorders through inhibition of c-FMS (CSF-1R), c-KIT, and/or PDGFR kinases. These compounds also find utility in the treatment of other mammalian diseases mediated by c-FMS, c-KIT, or PDGFR kinases.
摘要翻译： 描述了通过抑制c-FMS（CSF-1R），c-KIT和/或PDGFR激酶在治疗癌症，自身免疫疾病和代谢性骨骼疾病中有用的式I化合物。 这些化合物也可用于治疗由c-FMS，c-KIT或PDGFR激酶介导的其它哺乳动物疾病。
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