公开(公告)号：US20160136088A1

公开(公告)日：2016-05-19

申请号：US14896612

申请日：2014-06-18

申请人： DELSITECH OY

发明人： Mika JOKINEN ,  Harry JALONEN ,  Ari-Pekka FORSBACK

IPC分类号： A61K9/00 ,  A61K9/14 ,  A61K9/19 ,  A61K9/16 ,  A61K49/00 ,  A61K31/455

CPC分类号： A61K9/0024 ,  A61K9/143 ,  A61K9/1611 ,  A61K9/19 ,  A61K31/455 ,  A61K49/0073

摘要： This invention relates to a silica hydrogel composite obtainable by mixing silica particles, comprising an encapsulated agent, with a silica sol, wherein obtained hydrogel composite is shear-thinning. The present invention also relates to use of the silica hydrogel composite according to the invention for an injectable, flowing or extrudable formulation. The present invention further relates to a method for preparing the silica hydrogel.

摘要翻译： 本发明涉及一种二氧化硅水凝胶复合物，其通过将包含胶囊的二氧化硅颗粒与二氧化硅溶胶混合而获得，其中所得的水凝胶复合物是剪切稀化的。 本发明还涉及根据本发明的二氧化硅水凝胶复合物用于可注射，流动或可挤压制剂的用途。 本发明还涉及一种制备二氧化硅水凝胶的方法。

公开(公告)号：US20180311150A1

公开(公告)日：2018-11-01

申请号：US15770034

申请日：2016-10-21

申请人： DelSiTech Oy

发明人： Lasse LEINO ,  Harry JALONEN ,  Ari-Pekka FORSBACK ,  Mika JOKINEN ,  Panu NOPPARI

IPC分类号： A61K9/00 ,  A61K9/16 ,  A61K31/522 ,  A61K9/10

CPC分类号： A61K9/0024 ,  A61K9/0048 ,  A61K9/10 ,  A61K9/1611 ,  A61K31/522 ,  A61K47/02 ,  A61M5/329

摘要： This invention relates to a depot formulation comprising a biodegradable silica hydrogel composite incorporating a nucleotide or nucleoside analogue reverse transcriptase inhibitor, wherein the silica hydrogel composite is obtainable by mixing silica particles comprising said nucleotide or nucleoside analogue reverse transcriptase inhibitor and having a maximum diameter of ≤1 000 μm, as such or as a suspension, with silica sol wherein the hydrogel composite is non-flowing and structurally stable when stored at rest and shear-thinning when shear stress is applied by injection. The present invention also relates to use of the depot formulation for treatment of chronic viral infections and prevention of chronic viral reinfection. The present invention further relates to a prefilled syringes comprising said depot formulation.

公开(公告)号：US20140057996A1

公开(公告)日：2014-02-27

申请号：US13971766

申请日：2013-08-20

申请人： DelSiTech Oy

发明人： Mika JOKINEN ,  Harry JALONEN ,  Ari-Pekka FORSBACK ,  Mika KOSKINEN

IPC分类号： A61K47/02

CPC分类号： A61K47/02 ,  A23L29/06 ,  A23L29/294 ,  A23P10/47 ,  A61K9/0019 ,  A61K9/06 ,  A61K9/08 ,  A61K38/00 ,  C01B13/32 ,  C01B33/152 ,  C01B33/157 ,  C01G23/053 ,  C01G25/02 ,  C01P2006/22

摘要： A method for producing a flowing silica composition including a sol-gel transfer, where redispersion is carried out. The redispersion includes adding, after having reached gel point of the sol-gel transfer, liquid into the gel formed by the sol-gel transfer, and the addition being made within a sufficiently short time period after reaching the gel point, to result, after mixing of the gel and the liquid, in a rheologically homogenous flowing silica composition, which is and remains injectable as such, or by short stirring

摘要翻译： 一种制备流动二氧化硅组合物的方法，其包括进行再分散的溶胶 - 凝胶转移。 再分散包括在溶胶 - 凝胶转移的凝胶点达到液体进入通过溶胶 - 凝胶转移形成的凝胶中并在达到凝胶点之后在足够短的时间内进行添加，结果是在 在流变均匀的流动二氧化硅组合物中混合凝胶和液体，其仍然是可注射的，或通过短的搅拌<30秒，通过薄的22G针。 还公开了流动的二氧化硅组合物和可通过本发明的方法获得的凝胶，以及流动的二氧化硅组合物的用途。