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公开(公告)号：US11174262B2
公开(公告)日：2021-11-16
申请号：US16683970
申请日：2019-11-14
发明人： Giorgio Bonanomi , Anthony A. Estrada , Jianwen A. Feng , Brian Fox , Cinzia Maria Francini , Cheng Hu , Colin Philip Leslie , Maksim Osipov , Anantha Sudhakar , Zachary K. Sweeney , Javier De Vicente Fidalgo
IPC分类号： C07D487/10 , C07D495/14 , C07D495/20 , A61K31/55 , A61K31/551 , A61K31/553 , A61K31/554 , A61P25/00 , A61P25/16 , A61P25/28 , C07D487/04 , C07D498/04
摘要： The present disclosure relates generally to methods and compositions for preventing or arresting cell death and/or inflammation.
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公开(公告)号：US11834438B2
公开(公告)日：2023-12-05
申请号：US16955717
申请日：2018-12-19
发明人： Travis Remarchuk , Anantha Sudhakar
IPC分类号： C07D403/12
CPC分类号： C07D403/12
摘要： The present disclosure relates to methods of making LRRK2-inhibiting, pyrimidinyl-4-aminopyrazole compounds and intermediates of formulae I and IV: The compounds are useful as LRRK2 inhibitors in the treatment of LRRK2 mediated diseases, and as intermediates for their manufacture.
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3.发明申请公开(公告)号：US20210087176A1
公开(公告)日：2021-03-25
申请号：US17105870
申请日：2020-11-27
发明人： Travis Remarchuk , Anantha Sudhakar
IPC分类号： C07D403/12
摘要： The present disclosure relates to crystalline polymorph and amorphous forms of 2-methyl-2-(3-methyl-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-1H-pyrazol-1-yl)propanenitrile or solvates, tautomers, and pharmaceutically acceptable salts or cocrystals thereof, and processes for their preparation.
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4.发明授权公开(公告)号：US10370361B2
公开(公告)日：2019-08-06
申请号：US16197037
申请日：2018-11-20
发明人： Travis Remarchuk , Anantha Sudhakar
IPC分类号： C07D403/12 , A61P25/28 , A61K9/20
摘要： The present disclosure relates to crystalline polymorph and amorphous forms of 2-methyl-2-(3-methyl-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-1H-pyrazol-1-yl)propanenitrile or solvates, tautomers, and pharmaceutically acceptable salts or cocrystals thereof, and processes for their preparation.
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公开(公告)号：US11851433B2
公开(公告)日：2023-12-26
申请号：US17494336
申请日：2021-10-05
发明人： Giorgio Bonanomi , Anthony A. Estrada , Jianwen A. Feng , Brian Fox , Cinzia Maria Francini , Cheng Hu , Colin Philip Leslie , Maksim Osipov , Anantha Sudhakar , Zachary K. Sweeney , Javier De Vicente Fidalgo
IPC分类号： C07D267/08 , A61K31/553 , A61P25/00 , A61P25/16 , A61P25/28 , C07D487/04 , C07D498/04
CPC分类号： C07D487/04 , C07D498/04
摘要： The present disclosure relates generally to methods and compositions for preventing or arresting cell death and/or inflammation.
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公开(公告)号：US10709692B2
公开(公告)日：2020-07-14
申请号：US15780620
申请日：2016-12-02
发明人： Giorgio Bonanomi , Anthony A. Estrada , Jianwen A. Feng , Brian Fox , Colin Philip Leslie , Joseph P. Lyssikatos , Carmela Napolitano , Alfonso Pozzan , Anantha Sudhakar , Zachary K. Sweeney , Federica Tonelli , Javier de Vicente Fidalgo
IPC分类号： A61K31/422 , C07D413/04 , C07D261/02 , A61P1/00 , A61P29/00 , A61K31/4439
摘要： The present disclosure relates generally to methods and compositions for preventing or arresting cell death and/or inflammation.
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公开(公告)号：US20180353480A1
公开(公告)日：2018-12-13
申请号：US15780620
申请日：2016-12-02
发明人： Giorgio Bonanomi , Anthony A. Estrada , Jianwen A. Feng , Brian Fox , Colin Philip Leslie , Joseph P. Lyssikatos , Carmela Napolitano , Alfonso Pozzan , Anantha Sudhakar , Zachary K. Sweeney , Federica Tonelli , Javier de Vicente Fidalgo
IPC分类号： A61K31/422 , A61K31/4439 , A61P1/00 , A61P29/00
CPC分类号： A61K31/422 , A61K31/4439 , A61K2121/00 , A61P1/00 , A61P29/00 , C07D261/02 , C07D413/04
摘要： The present disclosure relates generally to methods and compositions for preventing or arresting cell death and/or inflammation.
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8.发明授权公开(公告)号：US11427571B2
公开(公告)日：2022-08-30
申请号：US17105870
申请日：2020-11-27
发明人： Travis Remarchuk , Anantha Sudhakar
IPC分类号： C07D403/12 , A61P25/28 , A61K9/20
摘要： The present disclosure relates to crystalline polymorph and amorphous forms of 2-methyl-2-(3-methyl-4-(4-(methylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-1H-pyrazol-1-yl)propanenitrile or solvates, tautomers, and pharmaceutically acceptable salts or cocrystals thereof, and processes for their preparation.
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公开(公告)号：US20210009566A1
公开(公告)日：2021-01-14
申请号：US16955717
申请日：2018-12-19
发明人： Travis Remarchuk , Anantha Sudhakar
IPC分类号： C07D403/12
摘要： The present disclosure relates to methods of making LRRK2-inhibiting, pyrimidinyl-4-aminopyrazole compounds and intermediates of formulae I and IV: The compounds are useful as LRRK2 inhibitors in the treatment of LRRK2 mediated diseases, and as intermediates for their manufacture.
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公开(公告)号：US20200079784A1
公开(公告)日：2020-03-12
申请号：US16683970
申请日：2019-11-14
发明人： Giorgio Bonanomi , Anthony A. Estrada , Jianwen A. Feng , Brian Fox , Cinzia Maria Francini , Cheng Hu , Colin Philip Leslie , Maksim Osipov , Anantha Sudhakar , Zachary K. Sweeney , Javier De Vicente Fidalgo
IPC分类号： C07D487/04 , C07D498/04
摘要： The present disclosure relates generally to methods and compositions for preventing or arresting cell death and/or inflammation.
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