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公开(公告)号：US20230416205A1
公开(公告)日：2023-12-28
申请号：US18037999
申请日：2021-11-19
发明人： Alex L. Bagdasarian , Cyril Bucher , Robert A. Craig, II , Javier de Vicente Fidalgo , Anthony A. Estrada , Brian M. Fox , Cheng Hu , Benjamin J. Huffman , Katrina W. Lexa , Lizanne G. Nilewski , Maksim Osipov , Arun Thottumkara
IPC分类号： C07D217/24 , C07D401/12 , C07D471/04 , C07D401/14 , C07D493/08 , C07D491/107 , C07D413/08 , C07D405/12 , C07D417/12 , C07D487/04 , C07D417/14 , C07D498/04 , C07D405/14 , C07D495/04
CPC分类号： C07D217/24 , C07D401/12 , C07D471/04 , C07D401/14 , C07D493/08 , C07D491/107 , C07D413/08 , C07D405/12 , C07D417/12 , C07D487/04 , C07D417/14 , C07D498/04 , C07D405/14 , C07D495/04
摘要： The present disclosure relates generally to small molecule modulators of NLR Family Pyrin Domain Containing 3 (NL-RP3), or a pharmaceutically acceptable salt, isotopically enriched analog, stereoisomer, mixture of stereoisomers, or prodrug thereof, methods of making and intermediates thereof, and methods of using thereof.
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公开(公告)号：US11851433B2
公开(公告)日：2023-12-26
申请号：US17494336
申请日：2021-10-05
发明人： Giorgio Bonanomi , Anthony A. Estrada , Jianwen A. Feng , Brian Fox , Cinzia Maria Francini , Cheng Hu , Colin Philip Leslie , Maksim Osipov , Anantha Sudhakar , Zachary K. Sweeney , Javier De Vicente Fidalgo
IPC分类号： C07D267/08 , A61K31/553 , A61P25/00 , A61P25/16 , A61P25/28 , C07D487/04 , C07D498/04
CPC分类号： C07D487/04 , C07D498/04
摘要： The present disclosure relates generally to methods and compositions for preventing or arresting cell death and/or inflammation.
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公开(公告)号：US11591316B2
公开(公告)日：2023-02-28
申请号：US17401833
申请日：2021-08-13
发明人： Javier de Vicente Fidalgo , Anthony A. Estrada , Jianwen A. Feng , Joseph P. Lyssikatos , Zachary K. Sweeney
IPC分类号： C07D403/12 , C07D401/14 , C07D413/14 , C07D417/14 , C07D491/20 , C07D498/04 , C07B59/00 , C07D403/14 , C07D405/14 , C07D409/14 , C07D487/04
摘要： The present disclosure relates generally to LRRK2 inhibitors, or a pharmaceutically acceptable salt, deuterated analog, prodrug, tautomer, stereoisomer, or mixture of stereoisomers thereof, and methods of making and using thereof.
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公开(公告)号：US20220411433A1
公开(公告)日：2022-12-29
申请号：US17531039
申请日：2021-11-19
发明人： Robert A. Craig, II , Javier de Vicente Fidalgo , Anthony A. Estrada , Jianwen A. Feng , Brian M. Fox , Christopher R.H. Hale , Katrina W. Lexa , Maksim Osipov , Travis Remarchuk , Zachary K. Sweeney
IPC分类号： C07D491/048 , C07C235/22 , C07D207/27 , C07D233/36 , C07D233/42 , C07D233/61 , C07D233/64 , C07D249/04 , C07D249/08 , C07D257/04 , C07D261/04 , C07D261/08 , C07D263/32 , C07D263/38 , C07D263/56 , C07D271/06 , C07D271/10 , C07D291/04 , C07D401/12 , C07D403/04 , C07D403/12 , C07D413/04 , C07D413/06 , C07D413/12 , C07D417/04 , C07D471/04 , C07D487/04
摘要： The present disclosure relates generally to eukaryotic initiation factor 2B modulators, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers or prodrug thereof, and methods of making and using thereof.
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公开(公告)号：US11203600B2
公开(公告)日：2021-12-21
申请号：US16684340
申请日：2019-11-14
发明人： Javier De Vicente Fidalgo , Anthony A. Estrada , Jianwen A. Feng , Brian Fox , Cinzia Maria Francini , Christopher R. H. Hale , Cheng Hu , Colin Philip Leslie , Maksim Osipov , Elena Serra , Zachary K. Sweeney , Arun Thottumkara
IPC分类号： A61K31/553 , A61P43/00 , C07D498/04 , C07D223/16 , C07D267/04 , C07D267/14 , C07D413/14 , C07D519/00
摘要： The present disclosure relates generally to compounds and compositions, intermediates, processes for their preparation, and their use as kinase inhibitors.
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公开(公告)号：US10709692B2
公开(公告)日：2020-07-14
申请号：US15780620
申请日：2016-12-02
发明人： Giorgio Bonanomi , Anthony A. Estrada , Jianwen A. Feng , Brian Fox , Colin Philip Leslie , Joseph P. Lyssikatos , Carmela Napolitano , Alfonso Pozzan , Anantha Sudhakar , Zachary K. Sweeney , Federica Tonelli , Javier de Vicente Fidalgo
IPC分类号： A61K31/422 , C07D413/04 , C07D261/02 , A61P1/00 , A61P29/00 , A61K31/4439
摘要： The present disclosure relates generally to methods and compositions for preventing or arresting cell death and/or inflammation.
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公开(公告)号：US20180353480A1
公开(公告)日：2018-12-13
申请号：US15780620
申请日：2016-12-02
发明人： Giorgio Bonanomi , Anthony A. Estrada , Jianwen A. Feng , Brian Fox , Colin Philip Leslie , Joseph P. Lyssikatos , Carmela Napolitano , Alfonso Pozzan , Anantha Sudhakar , Zachary K. Sweeney , Federica Tonelli , Javier de Vicente Fidalgo
IPC分类号： A61K31/422 , A61K31/4439 , A61P1/00 , A61P29/00
CPC分类号： A61K31/422 , A61K31/4439 , A61K2121/00 , A61P1/00 , A61P29/00 , C07D261/02 , C07D413/04
摘要： The present disclosure relates generally to methods and compositions for preventing or arresting cell death and/or inflammation.
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公开(公告)号：US09896458B2
公开(公告)日：2018-02-20
申请号：US15721419
申请日：2017-09-29
IPC分类号： C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D419/12 , C07D419/14 , C07D513/04 , C07D261/18 , C07D417/12 , C07D491/048 , C07D267/14 , C07D487/04 , C07D495/04 , C07D498/14 , C07D403/12 , C07D471/04 , C07D498/04
CPC分类号： C07D513/04 , C07D261/18 , C07D267/14 , C07D403/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D487/04 , C07D491/048 , C07D495/04 , C07D498/04 , C07D498/14
摘要： The present disclosure relates generally to compounds and compositions, and their use as kinase inhibitors.
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公开(公告)号：US20230114472A1
公开(公告)日：2023-04-13
申请号：US17702718
申请日：2022-03-23
发明人： Robert A. Craig, II , Javier de Vicente Fidalgo , Anthony A. Estrada , Jianwen A. Feng , Brian M. Fox , Maksim Osipov , Arun Thottumkara
IPC分类号： C07D413/04 , C07D271/113 , C07D413/14 , C07D417/04 , C07D417/14 , C07D493/08
摘要： The present disclosure relates generally to eukaryotic initiation factor 2B modulators, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or prodrug thereof, and methods of making and using thereof.
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公开(公告)号：US20220220094A1
公开(公告)日：2022-07-14
申请号：US17602480
申请日：2020-04-10
IPC分类号： C07D403/12
摘要： The present disclosure relates generally to LRRK2 inhibitors, or a pharmaceutically acceptable salt, isotopically enriched analog, tautomer, stereoisomer, mixture of stereoisomers, prodrug, or pharmaceutical composition thereof, and methods of making and using thereof.
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