公开(公告)号：US20230114472A1

公开(公告)日：2023-04-13

申请号：US17702718

申请日：2022-03-23

Applicant: Denali Therapeutics Inc.

Inventor： Robert A. Craig, II ,  Javier de Vicente Fidalgo ,  Anthony A. Estrada ,  Jianwen A. Feng ,  Brian M. Fox ,  Maksim Osipov ,  Arun Thottumkara

IPC: C07D413/04 ,  C07D271/113 ,  C07D413/14 ,  C07D417/04 ,  C07D417/14 ,  C07D493/08

Abstract: The present disclosure relates generally to eukaryotic initiation factor 2B modulators, or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or prodrug thereof, and methods of making and using thereof.

公开(公告)号：US20220220094A1

公开(公告)日：2022-07-14

申请号：US17602480

申请日：2020-04-10

Applicant: DENALI THERAPEUTICS INC.

Inventor： Javier de Vicente Fidalgo ,  Anthony A. Estrada ,  Jianwen A. Feng ,  Zachary K. Sweeney

IPC: C07D403/12

Abstract: The present disclosure relates generally to LRRK2 inhibitors, or a pharmaceutically acceptable salt, isotopically enriched analog, tautomer, stereoisomer, mixture of stereoisomers, prodrug, or pharmaceutical composition thereof, and methods of making and using thereof.

公开(公告)号：US20220153728A1

公开(公告)日：2022-05-19

申请号：US17590012

申请日：2022-02-01

Applicant: DENALI THERAPEUTICS INC.

Inventor： Anthony A. Estrada ,  Jianwen A. Feng ,  Javier De Vicente Fidalgo ,  Zachary K. Sweeney

IPC: C07D403/12

Abstract: The present disclosure relates generally to LRRK2 inhibitors, or a pharmaceutically acceptable salt, deuterated analog, prodrug, tautomer, stereoisomer, or mixture of stereoisomers thereof, and methods of making and using thereof.

公开(公告)号：US20220024938A1

公开(公告)日：2022-01-27

申请号：US17494336

申请日：2021-10-05

Applicant: Denali Therapeutics Inc.

Inventor： Giorgio Bonanomi ,  Anthony A. Estrada ,  Jianwen A. Feng ,  Brian Fox ,  Cinzia Maria Francini ,  Cheng Hu ,  Colin Philip Leslie ,  Maksim Osipov ,  Anantha Sudhakar ,  Zachary K. Sweeney ,  Javier De Vicente Fidalgo

IPC: C07D487/04 ,  C07D498/04

Abstract: The present disclosure relates generally to methods and compositions for preventing or arresting cell death and/or inflammation.

公开(公告)号：US11072618B2

公开(公告)日：2021-07-27

申请号：US16434533

申请日：2019-06-07

Applicant: Denali Therapeutics Inc.

Inventor： Anthony A. Estrada ,  Jianwen A. Feng ,  Brian Fox ,  Cheng Hu ,  Maksim Osipov ,  Zachary K. Sweeney ,  Javier de Vicente Fidalgo ,  Arun Thottumkara

IPC: C07D487/04 ,  G01N33/50 ,  C07K14/00 ,  G01N33/574 ,  G01N33/68

Abstract: The present disclosure relates generally to methods and compositions for preventing or arresting cell death and/or inflammation.

公开(公告)号：US20190300537A1

公开(公告)日：2019-10-03

申请号：US16434533

申请日：2019-06-07

Applicant: Denali Therapeutics Inc.

Inventor： Anthony A. Estrada ,  Jianwen A. Feng ,  Brian Fox ,  Cheng Hu ,  Maksim Osipov ,  Zachary K. Sweeney ,  Javier de Vicente Fidalgo ,  Arun Thottumkara

IPC: C07D487/04

Abstract: The present disclosure relates generally to methods and compositions for preventing or arresting cell death and/or inflammation.

公开(公告)号：US20180208582A1

公开(公告)日：2018-07-26

申请号：US15927920

申请日：2018-03-21

Applicant: Denali Therapeutics Inc.

Inventor： Anthony A. Estrada ,  Jianwen A. Feng ,  Joseph P. Lyssikatos ,  Zachary K. Sweeney ,  Javier de Vicente Fidalgo

IPC: C07D403/12 ,  C07D498/04 ,  C07D491/20 ,  C07D417/14 ,  C07D413/14 ,  C07D401/14 ,  C07B59/00 ,  C07D409/14 ,  C07D405/14 ,  C07D403/14 ,  C07D487/04

Abstract: The present disclosure relates generally to LRRK2 inhibitors, or a pharmaceutically acceptable salt, deuterated analog, prodrug, tautomer, stereoisomer, or mixture of stereoisomers thereof, and methods of making and using thereof.

公开(公告)号：US20180099981A1

公开(公告)日：2018-04-12

申请号：US15721470

申请日：2017-09-29

Applicant: Denali Therapeutics Inc.

Inventor： Anthony A. Estrada ,  Jianwen A. Feng ,  Brian Fox ,  Colin Philip Leslie ,  Joseph P. Lyssikatos ,  Alfonso Pozzan ,  Zachary K. Sweeney ,  Javier de Vicente Fidalgo

IPC: C07D513/04 ,  C07D491/048 ,  C07D498/14 ,  C07D498/04 ,  C07D495/04 ,  C07D487/04 ,  C07D261/18 ,  C07D413/14 ,  C07D413/12 ,  C07D403/12 ,  C07D267/14 ,  C07D471/04 ,  C07D417/12

CPC classification number: C07D513/04 ,  C07D261/18 ,  C07D267/14 ,  C07D403/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D471/04 ,  C07D487/04 ,  C07D491/048 ,  C07D495/04 ,  C07D498/04 ,  C07D498/14

Abstract: The present disclosure relates generally to compounds and compositions, and their use as kinase inhibitors.

公开(公告)号：US20170362206A1

公开(公告)日：2017-12-21

申请号：US15624566

申请日：2017-06-15

Applicant: Denali Therapeutics Inc.

Inventor： Anthony A. Estrada ,  Jianwen A. Feng ,  Joseph P. Lyssikatos ,  Zachary K. Sweeney ,  Javier de Vicente Fidalgo

IPC: C07D403/12 ,  C07D405/14 ,  C07B59/00 ,  C07D403/14 ,  C07D487/04 ,  C07D409/14

Abstract: The present disclosure relates generally to LRRK2 inhibitors, or a pharmaceutically acceptable salt, deuterated analog, prodrug, tautomer, stereoisomer, or mixture of stereoisomers thereof, and methods of making and using thereof.

公开(公告)号：US12129263B2

公开(公告)日：2024-10-29

申请号：US17511193

申请日：2021-10-26

Applicant: Denali Therapeutics Inc.

Inventor： Javier de Vicente Fidalgo ,  Anthony A. Estrada ,  Jianwen A. Feng ,  Brian Fox ,  Cinzia Maria Francini ,  Christopher R. H. Hale ,  Cheng Hu ,  Colin Philip Leslie ,  Maksim Osipov ,  Elena Serra ,  Zachary K. Sweeney ,  Arun Thottumkara

IPC: C07D498/04 ,  A61K31/553 ,  A61P3/10 ,  A61P9/00 ,  A61P11/00 ,  A61P25/00 ,  A61P27/02 ,  A61P37/00 ,  A61P43/00 ,  C07D223/16 ,  C07D267/04 ,  C07D267/14 ,  C07D413/14 ,  C07D498/10 ,  C07D519/00

CPC classification number: C07D498/04 ,  C07D223/16 ,  C07D267/04 ,  C07D267/14 ,  C07D413/14 ,  C07D519/00

Abstract: The present disclosure relates generally to compounds and compositions, intermediates, processes for their preparation, and their use as kinase inhibitors.