公开(公告)号：US20160355496A1

公开(公告)日：2016-12-08

申请号：US15158733

申请日：2016-05-19

申请人： Deutsches Krebsforschungszentrum ,  Ruprecht-Karls-Universität Heidelberg

发明人： Michael BOUTROS ,  Rajendra-Prasad MASKEY ,  Corinna KOCH ,  Florian FUCHS ,  Sandra STEINBRINK ,  Daniel GILBERT

IPC分类号： C07D311/92 ,  C07D413/04 ,  C07D493/04 ,  C07D491/052

CPC分类号： C07D311/92 ,  C07D311/04 ,  C07D311/96 ,  C07D413/04 ,  C07D491/04 ,  C07D491/052 ,  C07D493/04

摘要： Compounds of formula (IIc); wherein X3 and X4 independently from each other are N or CR8 wherein R8 may be same or different; Y1, Y2, Y3 and Y4 independently from each other are N or CR9 wherein R9 may be same or different and wherein up to 3 of the group Y1, Y2, Y3 and Y4 may be N; their solvates, hydrates, and pharmaceutically acceptable salts, their use for modulating the Wnt signalling pathway activity and their use as a medicament, preferably for the treatment of cancer.

公开(公告)号：US20180334442A1

公开(公告)日：2018-11-22

申请号：US16046578

申请日：2018-07-26

申请人： Deutsches Krebsforschungszentrum ,  Ruprecht-Karls-Universität Heidelberg

发明人： Michael BOUTROS ,  Rajendra-Prasad MASKEY ,  Corinna KOCH ,  Florian FUCHS ,  Sandra STEINBRINK ,  Daniel GILBERT

IPC分类号： C07D311/92 ,  C07D493/04 ,  C07D491/052 ,  C07D311/04 ,  C07D413/04 ,  C07D311/96 ,  C07D491/04

CPC分类号： C07D311/92 ,  C07D311/04 ,  C07D311/96 ,  C07D413/04 ,  C07D491/04 ,  C07D491/052 ,  C07D493/04

摘要： Compounds of formula (IIc); wherein X3 and X4 independently from each other are N or CR8 wherein R8 may be same or different; Y1, Y2, Y3 and Y4 independently from each other are N or CR9 wherein R9 may be same or different and wherein up to 3 of the group Y1, Y2, Y3 and Y4 may be N; their solvates, hydrates, and pharmaceutically acceptable salts, their use for modulating the Wnt signalling pathway activity and their use as a medicament, preferably for the treatment of cancer.