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公开(公告)号：US09459260B2
公开(公告)日：2016-10-04
申请号：US14122349
申请日：2012-05-23
IPC分类号： G01N31/00 , G01N33/53 , G01N33/68 , G01N33/564 , C07K16/18
CPC分类号： G01N33/6887 , C07K16/18 , G01N33/564 , G01N33/6842 , G01N2333/78 , G01N2800/102
摘要： An assay for citrullinated fragments of SOCS-2, Alpha 1 anti tyrpsin, versican, biglycan, laminin, or other protein having a terminal antibody binding site comprising citrulline in a blood derived sample shows diagnostic relevance in relation to rheumatoid arthritis or fibrotic disease.
摘要翻译： 在血液衍生的样品中具有包含瓜氨酸的末端抗体结合位点的SOCS-2，α1抗酪氨酸蛋白酶，多核苷酸，二聚糖，层粘连蛋白或其他蛋白质的瓜氨酸化片段的测定显示与类风湿性关节炎或纤维化疾病有关的诊断意义。
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2.发明申请In Vitro Assessment of Cardiovascular Events by Assay for Neo-Eptitopes of Titin Protein 有权通过测定蛋白质新蛋白的体外评估心血管事件公开(公告)号：US20140295469A1
公开(公告)日：2014-10-02
申请号：US14232405
申请日：2012-07-06
CPC分类号： G01N33/6887 , C07K14/4716 , C07K16/18 , C07K2317/34 , G01N33/566 , G01N33/6893 , G01N2333/4712 , G01N2800/32
摘要： A bioassay for the quantification of peptide fragments comprising a neo-epitope formed by cleavage of a titin protein by a proteinase comprises contacting a sample with an antibody specifically binding said neo-epitope and determining the level of binding. Partial sequences of titin that may be detected include: 13519′ ↓GEYVCDCGTD ′13528 13532′ NVTVEARLIK↓ ′13542 13543′ ↓VEKPLYGVEV ′1553
摘要翻译： 用于定量肽片段的生物测定法，其包含通过蛋白酶切割titin蛋白质而形成的新表位，包括使样品与特异性结合所述新表位的抗体接触并确定结合水平。 可能检测到的部分滴度的序列包括：13519'↓GEYVCDCGTD'13528 13532'NVTVEARLIK↓'13542 13543'↓VEKPLYGVEV'1553
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