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公开(公告)号：US09459260B2
公开(公告)日：2016-10-04
申请号：US14122349
申请日：2012-05-23
IPC分类号： G01N31/00 , G01N33/53 , G01N33/68 , G01N33/564 , C07K16/18
CPC分类号： G01N33/6887 , C07K16/18 , G01N33/564 , G01N33/6842 , G01N2333/78 , G01N2800/102
摘要： An assay for citrullinated fragments of SOCS-2, Alpha 1 anti tyrpsin, versican, biglycan, laminin, or other protein having a terminal antibody binding site comprising citrulline in a blood derived sample shows diagnostic relevance in relation to rheumatoid arthritis or fibrotic disease.
摘要翻译： 在血液衍生的样品中具有包含瓜氨酸的末端抗体结合位点的SOCS-2，α1抗酪氨酸蛋白酶，多核苷酸，二聚糖，层粘连蛋白或其他蛋白质的瓜氨酸化片段的测定显示与类风湿性关节炎或纤维化疾病有关的诊断意义。
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2.发明申请In Vitro Assessment of Cardiovascular Events by Assay for Neo-Eptitopes of Titin Protein 有权通过测定蛋白质新蛋白的体外评估心血管事件公开(公告)号：US20140295469A1
公开(公告)日：2014-10-02
申请号：US14232405
申请日：2012-07-06
CPC分类号： G01N33/6887 , C07K14/4716 , C07K16/18 , C07K2317/34 , G01N33/566 , G01N33/6893 , G01N2333/4712 , G01N2800/32
摘要： A bioassay for the quantification of peptide fragments comprising a neo-epitope formed by cleavage of a titin protein by a proteinase comprises contacting a sample with an antibody specifically binding said neo-epitope and determining the level of binding. Partial sequences of titin that may be detected include: 13519′ ↓GEYVCDCGTD ′13528 13532′ NVTVEARLIK↓ ′13542 13543′ ↓VEKPLYGVEV ′1553
摘要翻译： 用于定量肽片段的生物测定法，其包含通过蛋白酶切割titin蛋白质而形成的新表位，包括使样品与特异性结合所述新表位的抗体接触并确定结合水平。 可能检测到的部分滴度的序列包括：13519'↓GEYVCDCGTD'13528 13532'NVTVEARLIK↓'13542 13543'↓VEKPLYGVEV'1553
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3.发明授权In vitro assessment of cardiovascular events by assay for neo-eptitopes of titin protein 有权通过测定滴度蛋白质的新视力来评估心血管事件公开(公告)号：US09500659B2
公开(公告)日：2016-11-22
申请号：US14232405
申请日：2012-07-06
CPC分类号： G01N33/6887 , C07K14/4716 , C07K16/18 , C07K2317/34 , G01N33/566 , G01N33/6893 , G01N2333/4712 , G01N2800/32
摘要： An immunoassay for the quantification of fragments having an N- or a C-terminal neo-epitope formed by cleavage of a titin protein by a proteinase is provided. The immunoassay includes the steps of contacting a sample with an antibody specifically binding to the N- or C-terminal neo-epitope of the fragments and determining the level of binding.
摘要翻译： 提供了通过用蛋白酶切割蛋白质所产生的具有N-或C-末端新表位的片段进行定量的免疫测定。 免疫测定包括使样品与特异性结合片段的N-或C-末端新表位的抗体接触并确定结合水平的步骤。
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公开(公告)号：US09891234B2
公开(公告)日：2018-02-13
申请号：US14116924
申请日：2012-05-04
CPC分类号： G01N33/6893 , C07K14/4725 , C07K16/18 , C07K2317/34 , C12Q1/37 , G01N33/6878 , G01N2800/32 , G01N2800/323
摘要： A method of bioassay for the quantification of peptide fragments comprising a neo-epitope formed by cleavage of mimecan, a protein of an atherosclerotic plaque, by a proteinase is provided. In the method a sample, such as urine or serum, is contacted with an antibody reactive with the neo-epitope and the level of binding of the antibody to peptide fragments in the sample is determined. The assay is predictive of risk of cardiovascular disease events.
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5.发明申请Pathology indicating measure related to cartilage structure and automatic quantification thereof 有权病理学指标与软骨结构相关的测量及其自动定量公开(公告)号：US20100220907A1
公开(公告)日：2010-09-02
申请号：US12311153
申请日：2007-09-19
申请人： Erik B. Dam , Arish Qazi , Morten Karsdal , Paola C. Petterson , Mads Nielsen , Claus Christiansen
发明人： Erik B. Dam , Arish Qazi , Morten Karsdal , Paola C. Petterson , Mads Nielsen , Claus Christiansen
IPC分类号： G06K9/00
CPC分类号： G06T7/0012 , G06K9/34 , G06K2209/055 , G06T2207/30008
摘要： A method for the analysis of three dimensional scan data representing an articular cartilage is provided to extract a quantitative parameter indicative of joint pathology. A measure representative of cartilage homogeneity is derived from this three dimensional image data. The measured value is compared with similar measured values previously established in respect of healthy joints and/or joints characterised by a pathology.
摘要翻译： 提供了用于分析表示关节软骨的三维扫描数据的方法，以提取指示关节病理学的定量参数。 软骨同质性的代表性度量来源于该三维图像数据。 将测量值与先前在由病理学特征的健康关节和/或关节建立的类似测量值进行比较。
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6.发明申请公开(公告)号：US20060160856A1
公开(公告)日：2006-07-20
申请号：US10526208
申请日：2003-09-04
申请人： Bjarne Dahl , Palle Christophersen , Michael En G Sig , Morten Karsdal , Niels Foged , Flemming Jensen
发明人： Bjarne Dahl , Palle Christophersen , Michael En G Sig , Morten Karsdal , Niels Foged , Flemming Jensen
IPC分类号： A61K31/454 , A61K31/41 , C07D403/02
CPC分类号： C07D213/75 , C07C275/26 , C07C275/30 , C07C275/42 , C07C2601/14 , C07D207/16 , C07D209/40 , C07D213/81 , C07D231/40 , C07D257/04 , C07D277/48 , C07D295/192 , C07D307/68 , C07D333/36 , C07D401/12 , C07F9/383 , C07F9/3834 , C07F9/3882 , C07F9/58
摘要： The present invention relates to novel diarylurea derivatives useful as chloride channel blockers. In other aspects the invention relates to the use of these compounds in a method for therapy, such as for the treatment of bone metabolic diseases, diseases responsive to modulation of the mast cell or basophil activity, diseases responsive to inhibition of angiogenesis, or sickle cell anaemia, and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译： 本发明涉及可用作氯化物通道阻断剂的新型二芳基脲衍生物。 在其它方面，本发明涉及这些化合物在治疗方法中的用途，例如用于治疗骨代谢疾病，对调节肥大细胞或嗜碱性粒细胞活性有响应的疾病，对抑制血管生成有反应的疾病或镰状细胞 贫血，以及包含本发明化合物的药物组合物。
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公开(公告)号：US20160223568A1
公开(公告)日：2016-08-04
申请号：US15014241
申请日：2016-02-03
申请人： Federica Genovese , Mette Juul Nielsen , Lise Larsen , Diana Julie Oersnes-Leeming , Morten Karsdal
发明人： Federica Genovese , Mette Juul Nielsen , Lise Larsen , Diana Julie Oersnes-Leeming , Morten Karsdal
IPC分类号： G01N33/68 , G01N33/577
CPC分类号： G01N33/6893 , G01N33/577 , G01N2333/78 , G01N2800/085 , G01N2800/52 , G01N2800/7052
摘要： Provided herein is a sandwich immunoassay for detecting cross-linked PIIINP that has at least two strands of PIIINP joined together by inter-strand cross-linking each having a C-terminal neo-epitope of PIIINP that is generated by N-protease cleavage of intact type III procollagen. A biological sample having the cross-linked PIIINP is contacted with a first surface-bound monoclonal antibody and then by a second monoclonal antibody, both specifically reactive with a neoepitope in the C-terminal sequence of PIIINP, and then binding of the second monoclonal antibody is determined. Also provided is a method for evaluating the efficacy of an antagonist drug targeting lysyl oxidases via the immunoassay and a kit containing a solid support binding the first monoclonal antibody and containing the second monoclonal antibody.
摘要翻译： 本文提供了一种夹心免疫测定法，用于检测交联的PIIINP，其具有通过链间交联连接在一起的至少两条PIIINP链，每条链均具有由完整的N-蛋白酶切割产生的PIIINP的C-末端新表位 III型原胶原。 将具有交联的PIIINP的生物样品与第一表面结合的单克隆抗体接触，然后与第二单克隆抗体接触，所述第二单克隆抗体与PIIINP的C末端序列中的新表皮特异性反应，然后与第二单克隆抗体 决心，决意，决定。 还提供了用于通过免疫测定法评估靶向赖氨酰氧化酶的拮抗剂药物的功效的方法，以及含有结合第一单克隆抗体并含有第二单克隆抗体的固体支持物的试剂盒。
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公开(公告)号：US09835631B2
公开(公告)日：2017-12-05
申请号：US15014241
申请日：2016-02-03
申请人： Federica Genovese , Mette Juul Nielsen , Lise Larsen , Diana Julie Oersnes-Leeming , Morten Karsdal
发明人： Federica Genovese , Mette Juul Nielsen , Lise Larsen , Diana Julie Oersnes-Leeming , Morten Karsdal
IPC分类号： G01N33/53 , G01N33/68 , G01N33/577
CPC分类号： G01N33/6893 , G01N33/577 , G01N2333/78 , G01N2800/085 , G01N2800/52 , G01N2800/7052
摘要： Provided herein is a sandwich immunoassay for detecting cross-linked PIIINP that has at least two strands of PIIINP joined together by inter-strand cross-linking each having a C-terminal neo-epitope of PIIINP that is generated by N-protease cleavage of intact type III procollagen. A biological sample having the cross-linked PIIINP is contacted with a first surface-bound monoclonal antibody and then by a second monoclonal antibody, both specifically reactive with a neoepitope in the C-terminal sequence of PIIINP, and then binding of the second monoclonal antibody is determined. Also provided is a method for evaluating the efficacy of an antagonist drug targeting lysyl oxidases via the immunoassay and a kit containing a solid support binding the first monoclonal antibody and containing the second monoclonal antibody.
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公开(公告)号：US09733260B2
公开(公告)日：2017-08-15
申请号：US14130927
申请日：2012-07-04
CPC分类号： G01N33/6896 , C07K14/4711 , C07K16/18 , C07K2317/32 , C07K2317/33 , C07K2317/34 , C12Q1/37 , G01N2333/47 , G01N2333/96486 , G01N2800/2821 , G01N2800/56
摘要： Provided herein is a method of bioassay for the quantification of peptide fragments relevant to neurodegenerative conditions. The method comprises cleaving a Tau protein by a secretase, such as ADAM10, to form a neo-epitope. The method comprises contacting a blood derived sample with an antibody specific for the neo-epitope and determining the level of binding of the antibody to peptide fragments comprising the neo-epitope in the sample. Neo-epitope containing peptide levels are found to be inversely correlated to cognitive function.
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公开(公告)号：US20160282362A1
公开(公告)日：2016-09-29
申请号：US15173852
申请日：2016-06-06
IPC分类号： G01N33/68 , C07K14/78 , C07K14/77 , G01N33/577
CPC分类号： G01N33/6878 , C07K14/77 , C07K14/775 , C07K14/78 , C12Q1/37 , G01N33/542 , G01N33/577 , G01N33/6893 , G01N2800/32 , G01N2800/50 , G01N2800/52
摘要： Provided is a method of bioassay for the quantification of peptide fragments comprising a neo-epitope formed by cleavage of a protein of an atherosclerotic plaque such as lumican, versican, perlecan, deocrin, biglycan, collagen type III, CRP, ApoE, or elastin by a proteinase. The method comprises contacting a sample such as urine or serum with an antibody reactive with the neo-epitope and determining the level of binding of the immunological binding partner to peptide fragments in the sample. The assay is predictive of risk of cardiovascular disease events.
摘要翻译： 提供了一种用于定量肽片段的生物测定方法，其包括通过切割动脉粥样硬化斑块的蛋白质如lumican，versican，perlecan，deocrin，双糖链球蛋白，III型胶原，CRP，ApoE或弹性蛋白而形成的新表位， 蛋白酶。 该方法包括使诸如尿液或血清的样品与可与neo表位反应的抗体接触并确定免疫结合配偶体与样品中肽片段的结合水平。 该测定法预测心血管疾病事件的风险。
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