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1.发明申请公开(公告)号：US20110065806A1
公开(公告)日：2011-03-17
申请号：US12992666
申请日：2009-05-18
申请人： Didier Coustou , Hélène Duplan
发明人： Didier Coustou , Hélène Duplan
IPC分类号： A61K31/047 , A61P17/00
CPC分类号： A61K31/01 , A61K31/047 , A61K2300/00
摘要： The invention relates to a composition for topical use that comprises a combination of glycerol, Vaseline and liquid paraffin as an active principle, in the form of an oil-in-water or water-in-oil emulsion, said composition being used in the prevention of atopic dermatitis.
摘要翻译： 本发明涉及一种用于局部使用的组合物，其包含以水包油或油包水乳液形式的甘油，凡士林和液体石蜡作为活性成分的组合，所述组合物用于预防 的特应性皮炎。
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2.发明授权Peptidyl arginine deiminase 1 and/or 3 activator compounds in the epidermis and uses thereof 有权肽基精氨酸脱亚胺酶1和/或表面活化剂化合物及其用途公开(公告)号：US09566222B2
公开(公告)日：2017-02-14
申请号：US14110977
申请日：2012-04-11
申请人： Hélène Duplan , Sylvie Daunes-Marion , Stéphane Poigny , Marie-Claire Mechin , Guy Serre , Michel Simon
发明人： Hélène Duplan , Sylvie Daunes-Marion , Stéphane Poigny , Marie-Claire Mechin , Guy Serre , Michel Simon
IPC分类号： A61K8/49 , A61Q19/00 , A61K9/00 , A61K31/522 , A61K45/06 , A61K9/06 , A61Q1/00 , A61K47/10 , A61Q1/02 , A61Q3/00 , A61Q5/00
CPC分类号： A61K8/4953 , A61K9/0014 , A61K9/06 , A61K31/522 , A61K45/06 , A61K47/10 , A61K2800/78 , A61Q1/00 , A61Q1/02 , A61Q3/00 , A61Q5/00 , A61Q19/007 , A61K2300/00
摘要： The present invention relates to the activation of peptidyl arginine deiminase (PADs) 1 and/or 3 in the epidermis by at least one active agent used alone or in combination, namely caffeine, acefylline and/or theobromine in a cosmetic and/or pharmaceutical composition. The present invention also relates to the use of the aforementioned active agents in cosmetics and/or therapeutics, alone or in combination, in order to improve the barrier functions of the epidermis, to prevent and/or treat symptoms related to dry skin or to improve and/or promote hydration of the keratinous layer. Finally, the invention relates to increasing the activity of PAD1 and/or PAD3 in the epidermis.
摘要翻译： 本发明涉及在化妆品和/或药物组合物中单独或组合使用至少一种活性剂（即咖啡因，乙酰基和/或可可碱）活化表皮中的肽基精氨酸脱亚胺酶（PADs）1和/或3 。 本发明还涉及上述活性剂在化妆品和/或治疗剂中单独或组合用于改善表皮的屏障功能，以防止和/或治疗与干性皮肤有关的症状或改善 和/或促进角质层的水合。 最后，本发明涉及增加表皮中PAD1和/或PAD3的活性。
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3.发明申请PEPTIDYL ARGININE DEIMINASE 1 AND/OR 3 ACTIVATOR COMPOUNDS IN THE EPIDERMIS AND USES THEREOF 有权苯丙氨酸脱乙酰酶1和/或3激动剂化合物及其用途公开(公告)号：US20140030200A1
公开(公告)日：2014-01-30
申请号：US14110977
申请日：2012-04-11
申请人： Hélène Duplan , Sylvie Daunes-Marion , Stéphane Poigny , Marie-Claire Mechin , Guy Serre , Michel Simon
发明人： Hélène Duplan , Sylvie Daunes-Marion , Stéphane Poigny , Marie-Claire Mechin , Guy Serre , Michel Simon
CPC分类号： A61K8/4953 , A61K9/0014 , A61K9/06 , A61K31/522 , A61K45/06 , A61K47/10 , A61K2800/78 , A61Q1/00 , A61Q1/02 , A61Q3/00 , A61Q5/00 , A61Q19/007 , A61K2300/00
摘要： The present invention relates to the activation of peptidyl arginine deiminase (PADs) 1 and/or 3 in the epidermis by at least one active agent used alone or in combination, namely caffeine, acefylline and/or theobromine in a cosmetic and/or pharmaceutical composition. The present invention also relates to the use of the aforementioned active agents in cosmetics and/or therapeutics, alone or in combination, in order to improve the barrier functions of the epidermis, to prevent and/or treat symptoms related to dry skin or to improve and/or promote hydration of the keratinous layer. Finally, the invention relates to increasing the activity of PAD1 and/or PAD3 in the epidermis.
摘要翻译： 本发明涉及在化妆品和/或药物组合物中单独或组合使用至少一种活性剂（即咖啡因，乙酰基和/或可可碱）活化表皮中的肽基精氨酸脱亚胺酶（PADs）1和/或3 。 本发明还涉及上述活性剂在化妆品和/或治疗剂中单独或组合用于改善表皮的屏障功能，以防止和/或治疗与干性皮肤有关的症状或改善 和/或促进角质层的水合。 最后，本发明涉及增加表皮中PAD1和/或PAD3的活性。
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