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公开(公告)号：US20100291179A1
公开(公告)日：2010-11-18
申请号：US12762230
申请日：2010-04-16
申请人： Dieter Stoll , Reinout Stoop , Juliana Vaz Nürnberger , Christoph Gaissmaier , Michael Ahlers , Claudia Bohnsack
发明人： Dieter Stoll , Reinout Stoop , Juliana Vaz Nürnberger , Christoph Gaissmaier , Michael Ahlers , Claudia Bohnsack
CPC分类号： A61L27/24 , A61L27/50 , A61L27/54 , A61L2300/25 , A61L2300/414 , A61L2300/416 , A61L2300/602
摘要： The present invention relates to a composite biomaterial and a process for producing a composite biomaterial with controlled release of active ingredients, comprising a three-dimensional polymer-based support structure, and a polymer-based matrix structure. The active ingredients are in this case incorporated into the composite biomaterial via the matrix structure, and the composite biomaterial is obtainable by introducing the matrix structure into the support structure. The active ingredients may in this case be incorporated for example adhesively, via specific binder molecules or via enzyme-labile linker molecules via the matrix structure into the composite biomaterial.
摘要翻译： 本发明涉及一种复合生物材料和一种具有控释活性成分的复合生物材料的制备方法，其包含三维聚合物基支撑结构和基于聚合物的基质结构。 在这种情况下，活性成分通过基质结构并入复合生物材料中，并且复合生物材料可通过将基质结构引入载体结构中获得。 在这种情况下，活性成分可以例如通过特异性粘合剂分子或通过酶不稳定连接体分子通过基质结构粘合到复合生物材料中。
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公开(公告)号：US09726664B2
公开(公告)日：2017-08-08
申请号：US13885199
申请日：2011-11-14
申请人： Robert Kleemann , Reinout Stoop , Johan Hendrikus Verheijen , Peter Ydo Wielinga , Teake Kooistra
发明人： Robert Kleemann , Reinout Stoop , Johan Hendrikus Verheijen , Peter Ydo Wielinga , Teake Kooistra
CPC分类号： G01N33/5088 , G01N33/6893 , G01N2800/042 , G01N2800/347
摘要： The invention relates to the surprising find that low density lipoprotein receptor-deficient mice (LDLr−/−) mice when fed with high energy diets produce controllable and consistent diabetic complications, especially renal damage, similar to the human pathophysiology and biological response. The invention thus comprises a method for discovering a preventive or therapeutic regimen for the prevention or treatment of diabetic micro- or macrovascular complications, comprising the steps of: a. feeding LDLr−/− mice, which have not been treated with streptozotocin, with a high energy diet; b. before, during and/or after this diet treating the mice with the preventive or therapeutic regimen; c. checking whether any change in the micro- or macrovascular system of the animal occurs. Specifically in such a method renal damage is assessed. Also use of said mice fed with a high energy diet for studying the diabetic micro- and macrovascular complications is part of the invention.
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公开(公告)号：US20100322993A1
公开(公告)日：2010-12-23
申请号：US12844750
申请日：2010-07-27
申请人： Juergen Mollenhauer , Karin Benz , Barbara Platz , Helmut Wurst , Reinout Stoop
发明人： Juergen Mollenhauer , Karin Benz , Barbara Platz , Helmut Wurst , Reinout Stoop
CPC分类号： A61K9/0024
摘要： The invention relates to an injectable biocompatible composition based on a polymeric support as well as to a method for producing it, which composition which comprises at least one hydrophilic polymer, wherein the polymer is polymerizable in situ to form a gel, and wherein the hydrophilic polymer is crosslinkable serum albumin or crosslinkable serum protein. The composition can be used in the restoration, the reconstruction, and/or the replacement of tissues and/or organs, or as a drug release implant in mammals. The composition is particularly suitable for treating cartilage disorders of a diseased or injured articular site in a mammal.
摘要翻译： 本发明涉及一种基于聚合物支持物的可注射生物相容性组合物及其生产方法，该组合物包含至少一种亲水性聚合物，其中聚合物可原位聚合以形成凝胶，并且其中亲水聚合物 是可交联血清白蛋白或可交联血清蛋白。 该组合物可用于组织和/或器官的恢复，重建和/或置换，或用作哺乳动物中的药物释放植入物。 该组合物特别适用于治疗哺乳动物中患病或受伤的关节部位的软骨疾病。
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公开(公告)号：US20130324423A1
公开(公告)日：2013-12-05
申请号：US13885199
申请日：2011-11-14
申请人： Robert Kleemann , Reinout Stoop , Johan Hendrikus Verheijen , Peter Ydo Wielinga , Teake Kooistra
发明人： Robert Kleemann , Reinout Stoop , Johan Hendrikus Verheijen , Peter Ydo Wielinga , Teake Kooistra
IPC分类号： G01N33/50
CPC分类号： G01N33/5088 , G01N33/6893 , G01N2800/042 , G01N2800/347
摘要： The invention relates to the surprising find that low density lipoprotein receptor-deficient mice (LDLr−/−) mice when fed with high energy diets produce controllable and consistent diabetic complications, especially renal damage, similar to the human pathophysiology and biological response. The invention thus comprises a method for discovering a preventive or therapeutic regimen for the prevention or treatment of diabetic micro- or macrovascular complications, comprising the steps of: a. feeding LDLr−/− mice, which have not been treated with streptozotocin, with a high energy diet; b. before, during and/or after this diet treating the mice with the preventive or therapeutic regimen; c. checking whether any change in the micro- or macrovascular system of the animal occurs. Specifically in such a method renal damage is assessed. Also use of said mice fed with a high energy diet for studying the diabetic micro- and macrovascular complications is part of the invention.
摘要翻译： 本发明涉及令人惊奇的发现，当喂食高能量饮食时，低密度脂蛋白受体缺陷小鼠（LDLr - / - ）小鼠产生可控和一致的糖尿病并发症，特别是肾损伤，类似于人类的病理生理学和生物反应。 因此，本发明包括用于发现用于预防或治疗糖尿病微血管和大血管并发症的预防或治疗方案的方法，包括以下步骤：a。 喂食没有用链脲佐菌素治疗的低能量饮食的LDLr - / - 小鼠; b。 在用该预防或治疗方案治疗小鼠之前，期间和/或之后; C。 检查动物的微血管或大血管系统是否发生变化。 特别是在这种方法中，评估肾损伤。 饲喂高能饮食的所述小鼠也可以使用研究糖尿病微血管和大血管并发症的一部分是本发明的一部分。
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