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6 条记录 (耗时 0.015 秒)

    Process and device for the specific adsorption of heparin
    1.
    发明授权
    Process and device for the specific adsorption of heparin 失效
    肝素特异性吸附的方法和装置

    公开(公告)号：US4935204A

    公开(公告)日：1990-06-19

    申请号：US271368

    申请日：1988-11-14

    申请人： Dietrich Seidel ,  Wolfgang Feller ,  Gerhard Rosskopf

    发明人： Dietrich Seidel ,  Wolfgang Feller ,  Gerhard Rosskopf

    IPC分类号： C08B37/10 ,  A61K35/14 ,  A61K35/16 ,  A61M1/36

    CPC分类号： A61M1/3679 ,  A61M1/3675 ,  Y10S435/803 ,  Y10S514/822 ,  Y10S514/833

    摘要： A process for the specific adsorption of heparin and other heparin-like substances which comprises flowing a buffered solution of whole blood, from which corpuscular blood constituents have been removed, plasma and/or solutions containing whole blood or plasma through an adsorber capsule containing a medium that adsorbs heparin and other heparin-like substances at an acid pH, preferably in the range of 4.0 to 5.5. Preferably, the process is carried out in a closed, extracorporeal circulation and the medium possesses anion exchange resin properties.

    摘要翻译： 一种用于特异性吸附肝素和其他肝素样物质的方法，其包括将已经去除血球成分的全血缓冲溶液流经血浆和/或含有全血或血浆的溶液通过含有介质的吸附剂胶囊 其在酸性pH下吸附肝素和其他类肝素物质，优选在4.0至5.5的范围内。 优选地，该方法在闭合的体外循环中进行，并且该介质具有阴离子交换树脂性质。

    Process for the selective extracorporeal precipitation of low-density lipoproteins
    2.
    发明授权
    Process for the selective extracorporeal precipitation of low-density lipoproteins 失效
    低密度脂蛋白选择性体外沉淀的方法

    公开(公告)号：US4908354A

    公开(公告)日：1990-03-13

    申请号：US124394

    申请日：1987-11-20

    申请人： Dietrich Seidel ,  Heinrich Wieland ,  Gerhard Rosskopf ,  Wolfgang Feller

    发明人： Dietrich Seidel ,  Heinrich Wieland ,  Gerhard Rosskopf ,  Wolfgang Feller

    IPC分类号： C08B37/10 ,  A61K35/14 ,  A61K35/16 ,  A61M1/36

    CPC分类号： A61M1/3687 ,  A61M2202/046

    摘要： A method of precipitating low-density lipoproteins which comprises administering to a volume of blood, plasma or solutions containing blood or plasma a therapeutically or diagnostically effective amount of a low-density lipoprotein precipitating substance at an acid pH such that an anticoagulent effect associated with heparin is minimized or eliminated. The substances utilized in such a method include hydrolyzed heparin, hydrolyzed heparin acylated at free amine groups, sulfated glycosamino glycan and sulfated polysaccharides.

    摘要翻译： 一种沉淀低密度脂蛋白的方法，其包括给予一定体积的血液，血浆或含有血液或血浆的溶液，治疗或诊断有效量的酸性pH下的低密度脂蛋白沉淀物质，使得与肝素相关的抗凝血作用 被最小化或消除。 在这种方法中使用的物质包括水解的肝素，游离胺基酰化的水解肝素，硫酸化糖胺基聚糖和硫酸化多糖。

    Process for the selective extracorporeal precipitation of low-density lipoproteins from whole serum or plasma
    3.
    发明授权
    Process for the selective extracorporeal precipitation of low-density lipoproteins from whole serum or plasma 失效
    来自全血清或血浆的低密度脂蛋白选择性体外沉淀的方法

    公开(公告)号：US4923439A

    公开(公告)日：1990-05-08

    申请号：US172953

    申请日：1988-03-23

    申请人： Dietrich Seidel ,  Heinrich Wieland ,  Gerhard Rosskopf ,  Dieter Rath

    发明人： Dietrich Seidel ,  Heinrich Wieland ,  Gerhard Rosskopf ,  Dieter Rath

    IPC分类号： A61M1/34 ,  A61M1/36 ,  G01N33/92

    CPC分类号： A61M1/3472 ,  A61M1/3479 ,  A61M1/3482 ,  G01N33/92 ,  A61M1/3675 ,  A61M2202/046 ,  A61M2205/7554 ,  G01N2800/044 ,  Y10T436/104165

    摘要： Processes are described for the selective extracorporeal precipitation of low density lipoproteins or beta-lipoproteins from whole serum or plasma, wherein a treating agent comprising heparin or a polyanion, such as dextran sulfate or sodium-phosphorus tungstate, in a buffer is added to the whole serum or plasma and the beta-llipoprotein-complex which thereupon forms with the treating agent is precipitated at the isoelectric point at a pH value in the range of from about 5.05 to about 5.25, and is then separated. Optionally, the precipitate or respecively the filtrate is further analyzed for diagnostic purposes. When heparin is employed, the process may be employed therapeutically.Apparatus is described for the continuous therapeutic practice of such a process, employing heparin, including means for flushing to reduce clogging of the filter employed to separate the precipitated lipoprotein-complex.

    摘要翻译： 对来自全血清或血浆的低密度脂蛋白或β-脂蛋白的选择性体外沉淀的方法进行了描述，其中在缓冲液中将包含肝素或聚阴离子如硫酸葡聚糖或磷酸钠磷酸钠的处理剂全部加入 血浆或血浆和随后与处理剂形成的β-IIipoprotein-复合物在等电点处沉淀，pH值在约5.05至约5.25范围内，然后分离。 任选地，沉淀物或分开的滤液进一步分析用于诊断目的。 当使用肝素时，该方法可以在治疗上使用。 描述了用于这种方法的连续治疗实践的装置，其使用肝素，包括用于冲洗以减少用于分离沉淀的脂蛋白复合物的过滤器堵塞的装置。

    Method for triggering an alarm in an infusion syringe
    6.
    发明授权
    Method for triggering an alarm in an infusion syringe 失效
    用于在输注注射器中触发警报的方法

    公开(公告)号：US4560979A

    公开(公告)日：1985-12-24

    申请号：US591558

    申请日：1984-03-20

    申请人： Gerhard Rosskopf

    发明人： Gerhard Rosskopf

    IPC分类号： A61M5/20 ,  A61M5/00 ,  A61M5/145 ,  A61M5/168 ,  G08B21/00

    CPC分类号： A61M5/1456 ,  A61M5/16831 ,  Y10S128/01

    摘要： An infusion syringe pump for forcing an infusion liquid out of the syringe comprises a sensor which is actuated at a certain displacement of a movable piston in the syringe. The residual infusion time before the syringe is completely empty is calculated from the residual volume of liquid left in the infusion syringe upon activation of the sensor, and from the infusion rate. At a given time before expiration of the residual infusion time, an alarm is produced by an alarm device. The alarm is thus always given independently of the particular infusion rate of the syringe and at a predetermined time (e.g. three minutes) before the end of infusion.

    摘要翻译： 用于将注射液强迫注射器的输注注射器泵包括在注射器中可移动活塞的特定位移致动的传感器。 在注射器完全空出之前的残留输液时间是从传感器启动时和输注速率的输液注射器中残留的液体体积计算出来的。 在残留输液时间到期前的给定时间，报警装置产生报警。 因此，警报总是独立于注射器的特定输注速率，并且在输注结束之前的预定时间（例如三分钟）。